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Ohneda Osamu

Affiliation
Faculty of Medicine
Official title
Professor
Email
 
Fax
029-853-2938
Research fields
Cell biology
Developmental biology
Research projects
2型糖尿病由来間葉系幹細胞の単離およびその機能解析2016 -- 2018大根田 修Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)4810000
2型糖尿病由来間葉系幹細胞の単離およびその機能解析2016 -- 2018大根田修JSPS/基盤研究(C)4810000
ヒト初代培養乳癌幹細胞における浸潤・転移能獲得の分子機能解明2013 -- 2015坂東裕子JSPS/Kiban Kenkyu (c)4940000
機能性間葉系幹細胞の単離とその機能解析2012 -- 2014大根田修Japan Society of for the Promotion of Science/基盤研究(C)5590000
虚血性疾患治療に効果的な血管内皮前駆細胞の機能解析2008 -- 2010大根田修Japan Society of for the Promotion of Science/基盤研究(C)4550000
"新規ケモカイン""WECHE""の造血・発生における機能解析"2002 -- (current)大根田修Japan Society of for the Promotion of Science/基盤研究(C)6000000
脳腫瘍に対する血管新生抑制療法の展開:新規治療法と抵抗性の克服2009 -- 2011高野晋吾JSPS/Kiban Kenkyu B17550000
Academic background
-- 1987Tohoku University Faculty of MedicineGraduated
-- 1993Tohoku University Graduate School, Division of Medicine 内科学Completed
Degree
Doctor of MedicineTohoku University
Academic societies
-- (current)The Japanese Cancer Association
-- (current)THE JAPANESE SOCIETY OF HEMATOLOGY
-- (current)THE JAPANESE BIOCHEMICAL SOCIETY
-- (current)The Molecular Biology Society of Japan
-- (current)THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
-- (current)THE JAPANESE CIRCULATION SOCIETY
-- (current)American Society of Hematology
Honors & Awards
2000日本血液学会奨励賞
Articles
  • Uremic Toxins Affect the Imbalance of Redox State and Overexpression of Prolyl Hydroxylase 2 in Human Adipose Tissue-Derived Mesenchymal Stem Cells Involved in Wound Healing
    Khanh Vuong Cat; Ohneda Kinuko; Kato Toshiki; Yamashita T...
    Stem cells and development/26(13)/pp.948-963, 2017-05
  • Microvesicles derived from Alde-Low EPCs support the wound healing capacity of AT-MSCs
    Tran Cam Tu; Yamashita Toshiharu; Kato Toshiki; Nagano Ma...
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/477(1)/pp.68-75, 2016-08
  • Umbilical cord blood-derived mesenchymal stem cells inhibit, but adipose tissue-derived mesenchymal ste cells promote, glioblastoma multiforme proliferation
    Keiko Akimoto; Kenichi Kimura; 長野 真澄; Shingo Takano; ...
    Stem Cell and Development/22(9)/pp.1370-1386, 2013-05
  • Hypoxia-inducible transcription factor-2alpha in endothelial cells regulates tumor neovascularization through activation of ephrin A1.
    Yamashita T; Ohneda K; Nagano M; Miyoshi C; Kaneko N; Miw...
    J Biol Chem/(283)/p.18926-18936, 2008
  • Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis.
    Kadri Z; Shimizu R; Ohneda O; Maouche-Chretien L; Gisselb...
    PLos Biol/(7)/p.e1000123, 2009
  • Identification of human placenta-derived mesenchymal stem cells involved in re-endothelialization.
    Tran TC; Kimura K; Nagano M; Yamashita T; Ohneda K; Sugim...
    *EMPTY*/(226)/p.224-235, 2011
  • Review of biophysical factors affecting osteogenic differentiation of human adult adipose-derived stem cells
    Georgina To'a Salazar; Ohneda O
    Biophys Rev/5(1)/pp.11-28, 2013
  • Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors.(共著)
    大根田 修
    J Exp Med/(190)/p.1741 1754, 1999-01
  • WECHE : a novel hematopoietic regulatory factor.(共著)
    大根田 修
    Immunity/(12)/p.141 150, 2000-01
  • An adherent condition is required for formation of multinuclear osteoclastsin the presence of macrophage colony-stimulating factor and receptoractivator of nuclear factor kB ligand.(共著)
    大根田 修
    Blood/(96), 2000-01
  • Bifurcation of osteoclasts and dendritic cells from common progenitors.
    大根田 修
    Blood/(98)/p.2544 2554, 2001-01
  • Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation.
    Arai F; Ohneda O; Miyamoto T; Zhang XG; Suda T.
    J Exp Med/(195)/p.1549 1563, 2002-01
  • Erythroid- specific expression of erythropoietin receptor rescued its null mutant mice from lethality.
    Suzuki N; Ohneda O; Takahashi S; Higuchi M; Mukai H; Naka...
    Blood/(100)/p.2279 2288, 2002-01
  • Identification and characterization of stem cells in prepubertal spermatogenesis in mice small star, filled.
    Ohbo K; yoshida S; Ohmura M; Ohneda O; Ogawa T; Tsuchiya ...
    Dev Biol/(258)/p.209 225, 2003-01
  • Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome.
    Xu G; Nagano M; Kanezaki R; Toki T; Hayashi Y; Taketani T...
    Blood/(102)/p.2960 2968, 2003-01
  • Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levels.
    Suzuki N; Suwabe N; Ohneda O; Obara N; Imagawa S; Pan X; ...
    Blood/15(102)/p.3575 3583, 2003-01
  • Essential role of synoviolin in embryonic hematopoiesis.
    Yagishita N; Amano T; Yamasaki S; Tsuchimochi K; Shin H; ...
    Journal of Biological Chemistry/(280)/p.7909 7916, 2005-01
  • Role of hypoxia-inducible factor-2alpha in endothelial development and hematopoiesis.
    Ohneda O; Nagano M; Fujii YK.
    Methods in Enzymology/(475)/p.200 218, 2007-01
  • Molecular therapeutic targets for glioma angiogenesis.
    Takano S; Yamashita T; Ohneda O.
    Journal of Oncology/2010/p.351908, 2010-01
  • Isolation and Characterization of Renal Erythropoietin-Producing Cells: Contribution of HIF3 alpha In Vivo
    Pan Xiaoqing; Suzuki Norio; Hirano Ikuo; Yamazaki Shun; Y...
    BLOOD/116(21)/pp.656-656, 2010-11
  • HEMATOPOIESIS - CYTOKINES, SIGNAL TRANSDUCTION, APOPTOSIS AND CELL CYCLE REGULATION POSTER I
    Pan Xiaoqing; Suzuki Norio; Hirano Ikuo; Yamazaki Shun; Y...
    BLOOD/116(21)/pp.656-656, 2010-11
  • Detection of failure of bevacizumab treatment for malignant glioma based on urinary matrix metalloproteinase activity
    Takano Shingo; Mashiko Ryota; Osuka Satoru; Ishikawa Eiic...
    BRAIN TUMOR PATHOLOGY/27(2)/pp.89-94, 2010-10
  • PJ-365 CXCR4 Plays a Crucial Role for Repairing Ischemic Tissue through Regulation by HIF-2α(PJ062,Regeneration (Basic, Clinical) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
    Nagano Masumi; Ohneda Osamu
    Circulation journal : official journal of the Japanese Circulation Society/73/p.638, 2009-03
  • Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo
    Yokomizo Tomomasa; Takahashi Satoru; Mochizuki Naomi; Kur...
    EMBO JOURNAL/26(1)/pp.184-196, 2007-01
  • Protective role of hypoxia-inducible factor-2 alpha against ischemic damage and oxidative stress in the kidney
    Kojima Ichiro; Tanaka Tetsuhiro; Inagi Reiko; Kato Hideki...
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY/18(4)/pp.1218-1226, 2007-04
Conference, etc.
  • Isolation and Characterization of Renal Erythropoietin-Producing Cells: Contribution of HIF3 alpha In Vivo
    Pan Xiaoqing; Suzuki Norio; Hirano Ikuo; Yamazaki Shun; Y...
    52nd Annual Meeting of the American-Society-of-Hematology (ASH)/2010-12-04--2010-12-07
  • A Chemokine Receptor CXCR4 Plays a Crucial Role for Repairing Ischemic Tissue through Regulation of HIF-2a
    Nagano Masumi; Kimura Ken-ichi; Yamashita Toshiharu; Hama...
    50th Annual Meeting of the American- Society-of-Hematology/2008-12-6--2008-12-9
  • THE ROLE OF CHEMOKINE SDF-1 AND CXCR4 IN GLIOMA ANGIOGENESIS AND INVASIVENESS: INTERACTION BETWEEN GLIOMA AND GLIOMA-DERIVED ENDOTHELIAL CELLS
    Takano Shingo; Osuka Satoru; Mashiko Ryota; Ohneda Osamu;...
    17th International Conference on Brain Tumor Research and Therapy/2008-06-09--2008-06-12
  • THE ROLE OF CHEMOKINE SDF-1/CXCR4/CXCR7 FOR GLIOBLASTOMA ANGIOGENESIS AND GLIOBLASTOMA-DERIVED ENDOTHELIAL CELLS
    Takano Shingo; Yamashita Toshio; Nagano Masumi; Mashiko R...
    3rd Quadrennial Meeting of the World-Federation-of-Neuro-Oncoloyg/6th Meeting of the Asian-Society-for-Neuro-Oncology
Teaching
2017-10 -- 2018-02Advanced Entrepreneurship PracticeUniversity of Tsukuba.
2017-04 -- 2017-08Advanced Entrepreneurship PracticeUniversity of Tsukuba.
2017-04 -- 2017-08Advanced Exercise on Public HealthUniversity of Tsukuba.
2017-10 -- 2018-02Advanced Exercise on Public HealthUniversity of Tsukuba.
2017-04 -- 2017-08Internship IIUniversity of Tsukuba.
2017-10 -- 2018-02Internship IIUniversity of Tsukuba.
2017-10 -- 2017-12Entrepreneurship TrainingUniversity of Tsukuba.
2017-04 -- 2017-06Stem Cell TherapyUniversity of Tsukuba.
2017-06 -- 2017-06Practice of Transfusion MedicineUniversity of Tsukuba.
2017-10 -- 2018-02Seminar on Basic Medical SciencesUniversity of Tsukuba.
Talks
  • 治療効果の高い間葉系幹細胞の単離およびその機能解析.
    大根田 修
    日本生化学会 関東支部例会/2009-04-01
  • ヒト間葉系幹細胞を用いたグリオグラストーマの細胞治療と機能解析.
    大根田 修
    日本生化学会 関東支部例会/2009-04-01
  • ヒト間葉系幹細胞を用いたグリオグラストーマの細胞治療に向けた研究開発.
    大根田 修
    第8回 日本再生医療学会総会/2009-04-01
  • 治療効果の高い間葉系幹細胞の単離およびその機能解析.
    大根田 修
    第8回 日本再生医療学会総会/2009-04-01
  • Differential Potential of Endothelial Progenitor Cells to Promote Arteriogenesis and Angiogenesis.
    大根田 修
    Cardiovascular Research Technologies/2009-04-01
  • CXCR4 Plays a Crucial Role for Repairing Ischemic Tissue through Regulation by HIF-2a.
    大根田 修
    第73回 日本循環器学会総会・学術集会/2009-04-01
  • 赤血球分化における低酸素応答転写因子HIF-2aの機能解析.
    大根田 修
    第70回 日本血液学会総会/2008-04-01
  • 虚血改善効果の高いヒト血管内皮前駆細胞における低酸素応答転写因子の機能解析.
    大根田 修
    第70回 日本血液学会総会/2008-04-01
  • 膠芽腫由来血管内皮細胞の特性から考える血管新生抑制療法.
    大根田 修
    第67回 日本癌学会学術総会/2008-04-01
  • 生体内におけるHIF-3a /IPAS発現部位の同定.
    大根田 修
    第6回 がんとハイポキシア研究会/2008-04-01
  • HIF-3aによる負の転写制御機構解明.
    大根田 修
    第6回 がんとハイポキシア研究会/2008-04-01
  • A Chemokine Receptor CXCR4 Plays a Crucial Role for Repairing Ischemic Tissue through Regulation of HIF-2a.
    大根田 修
    50th ASH Annual Meeting/2008-04-01
  • 虚血改善効果の高いヒト血管内皮前駆細胞の単離および機能解析
    大根田 修
    第4回 麒麟塾/2008-04-01
  • ヒト臍帯血由来間葉系幹細胞の単離と同定.
    大根田 修
    第7回 日本再生医療学会/2008-04-01
  • 治療効果・安全性が高い細胞単離/保存方法の開発
    大根田 修
    TX テクノロジー・ショーケース イン ツクバ 2008/2008-01-01
  • Analyses of functional roles of HIFs in endothelial cells
    大根田 修
    ERATO シンポジウム/2007-11-01
  • 虚血改善効果の高いヒト血管内皮前駆細胞の単離および機能解析
    大根田 修
    第5回がんとハイポキシア研究会/2007-11-01
  • 新規bHLH/PAS転写因子 NEPAS の機能解析
    大根田 修
    第5回がんとハイポキシア研究会/2007-11-01
  • 虚血改善効果の高いヒト血管内皮前駆細胞の単離および機能解析
    大根田 修
    第69回日本血液学会/2007-10-01
  • GATA-1遺伝子変異細胞株(GAK14)を用いたGATA-1N末端の機能解析
    大根田 修
    第69回日本血液学会/2007-10-01
  • HIF-2α in endothelial cells regulates tumor neovascularization through activation of ephrin A1
    大根田 修
    第66回日本癌学会/2007-10-01
  • 虚血改善効果の高いヒト血管内皮前駆細胞の単離および機能解析
    大根田 修
    第6回日本再生医療学会/2007-03-01
  • 新規bHLH/pas転写因子の機能解析
    大根田 修
    第29回日本分子生物学会/2006-12-01
  • 血管内皮前駆細胞を用いたグリオーマに対する血管新生抑制療法
    大根田 修
    第14回日本血管生物医学会/2006-12-01
  • ヒト臍帯血由来間葉系幹細胞の遊走能解析
    大根田 修
    第11回つくばバイオマテリアル研究会「再生医療とナノメディシン」/2006-11-01
Professional activities
-- (current)THE JAPANESE BIOCHEMICAL SOCIETY評議委員
-- (current)THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE評議委員

(Last updated: 2017-05-31)