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Kudo Takashi

Faculty of Medicine
Official title
Associate Professor
Research fields
General medical chemistry
Research projects
ムチン型糖鎖合成酵素遺伝子改変マウスによる巨核球分化機構の解明2012 -- 2015工藤 崇Japan Society of for the Promotion of Science/基盤研究(B)17,680,000Yen
O-結合型糖鎖コア1合成酵素欠損マウスの表現型解析と機能的糖タンパク質の同定2010 -- 2012工藤 崇Japan Society of for the Promotion of Science/基盤研究(C)3,120,000Yen
ムチン型糖鎖合成酵素遺伝子改変マウスによる白血球におけるムチン型糖鎖の機能解析2005 -- 2007工藤 崇Japan Society of for the Promotion of Science/基盤研究(C)3,800,000Yen
Career history
1996-04 -- 2001-03創価大学 生命科学研究所・細胞生物学部門 助手
2001-04 -- 2003-11新エネルギー・産業技術総合開発機構(NEDO)フェローおよび独立行政法人・産業技術総合研究所・糖鎖工学研究センター・糖鎖遺伝子機能解析チーム共同研究員  
2003-11 -- 2004-03筑波大学 基礎医学系 助教授(生命科学動物資源センター)
2004-04 -- (current)国立大学法人・筑波大学 人間総合科学研究科 助教授
Keio University
Academic societies
2004 -- (current)Japanese Association of Anatomists
2004 -- (current)The Molecular Biology Society of Japan
  • The effects of heat stress on morphological properties and intracellular signaling of denervated and intact soleus muscles in rats
    Ohira Takashi; Higashibata Akira; Seki Masaya; Kurata Yoi...
    Physiological reports/5(15), 2017-08
  • Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain
    Ishikawa Chihiro; Li Haiyan; Ogura Rin; Yoshimura Yuko; K...
    PloS one, 2017-06
  • Feasibility of a Short-Arm Centrifuge for Mouse Hypergravity Experiments
    Morita Hironobu; Obata Koji; Abe Chikara; Shiba Dai; Shir...
    PLOS ONE/10(7), 2015-07
  • Role of large MAF transcription factors in the mouse endocrine pancreas
    ABDELLATIF Ahmed M.; OGATA Kiyohito; KUDO Takashi; XIAFUK...
    Experimental Animals/64(3)/pp.305-312, 2015-07
  • MafB promotes atherosclerosis by inhibiting foam-cell apoptosis
    Hamada Michito; Nakamura Megumi; Mai Thi Nhu Tran; Morigu...
    NATURE COMMUNICATIONS/5/p.3147, 2014-01
  • In vivo monitoring of pancreatic b-cell mass and intrahepatic insulin gene activity in Ins1-luc BAC transgenic mice by bioluminescence imaging.
    Katsumata Tokio; Oishi Hisashi; Sekiguchi Yukari; Nagasak...
    PLoS One/8(4)/p.e60411, 2013-04
  • C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes
    Kudo Takashi; Sato Takashi; Hagiwara Kozue; Kozuma Yukino...
    Blood/122(9)/pp.1649-1657, 2013-08
  • Noninvasive Monitoring of β-Cell Mass and Fetal β-Cell Genesis in Mice Using Bioluminescence Imaging
    SEKIGUCHI Yukari; OWADA Junya; OISHI Hisashi; KATSUMATA T...
    Experimental animals/61(4)/pp.445-451, 2012-07
  • Expression of cutaneous lymphocyte-associated antigen regulated by a set of glycosyltransferases in human T cells: involvement of alpha1, 3-fucosyltransferase VII and beta1,4-galactosyltransferase I.
    Nakayama F; Teraki Y; Kudo T; Togayachi A; Iwasaki H; Tam...
    J Invest Dermatol/115(2)/p.299 306, 2000-08
  • CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV.
    Nakayama F; Nishihara S; Iwasaki H; Kudo T; Okubo R; Kane...
    J Biol Chem/276(19)/p.16100 16106, 2001-05
  • Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids.
    Togayachi A; Akashima T; Ookubo R; Kudo T; Nishihara S; I...
    J Biol Chem/276(25)/p.22032 22040, 2001-06
  • Pax6 controls the expression of Lewis x epitope in the embryonic forebrain by regulating alpha 1,3-fucosyltransferase IX expression.
    Shimoda Y; Tajima Y; Osanai T; Katsume A; Kohara M; Kudo ...
    J Biol Chem/277(3)/p.2033 2039, 2002-01
  • Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans.
    Iwai T; Inaba N; Naundorf A; Zhang Y; Gotoh M; Iwasaki H;...
    J Biol Chem/277(15)/p.12802 12809, 2002-04
  • Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine.
    Gotoh M; Yada T; Sato T; Akashima T; Iwasaki H; Mochizuki...
    J Biol Chem/277(41)/p.38179 38188, 2002-10
  • Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis.
    Gotoh M; Sato T; Akashima T; Iwasaki H; Kameyama A; Mochi...
    J Biol Chem/277(41)/p.38189 38196, 2002-10
  • Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10.
    Cheng L; Tachibana K; Zhang Y; Guo J; Kahori Tachibana K;...
    FEBS Lett/531(2)/p.115 121, 2002-11
  • Molecular cloning and characterization of a novel UDP-Gal:GalNAc(alpha) peptide beta 1,3-galactosyltransferase (C1Gal-T2), an enzyme synthesizing a core 1 structure of O-glycan.
    Kudo T; Iwai T; Kubota T; Iwasaki H; Takayma Y; Hiruma T;...
    J Biol Chem/277(49)/p.47724 47731, 2002-12
  • Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.
    Zhang Y; Iwasaki H; Wang H; Kudo T; Kalka TB; Hennet T; K...
    J Biol Chem/278(1)/p.573 584, 2003-01
  • Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate.
    Sato T; Gotoh M; Kiyohara K; Akashima T; Iwasaki H; Kamey...
    J Biol Chem/278(5)/p.3063 3071, 2003-01
  • Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14.
    Wang H; Tachibana K; Zhang Y; Iwasaki H; Kameyama A; Chen...
    Biochem Biophys Res Commun/300(3)/p.738 744, 2003-01
  • Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2.
    Iwasaki H; Zhang Y; Tachibana K; Gotoh M; Kikuchi N; Kwon...
    J Biol Chem/278(8)/p.5613 5621, 2003-02
  • A novel I-branching beta-1,6-N-acetylglucosaminyltransferase involved in human blood group I antigen expression.
    Inaba N; Hiruma T; Togayachi A; Iwasaki H; Wang XH; Furuk...
    Blood/101(7)/p.2870 2876, 2003-04
  • Alpha1,3-fucosyltransferase IX (Fut9) determines Lewis X expression in brain.
    Nishihara S; Iwasaki H; Nakajima K; Togayachi A; Ikehara ...
    Glycobiology/13(6)/p.445 455, 2003-06
  • Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities.
    Yada T; Gotoh M; Sato T; Shionyu M; Go M; Kaseyama H; Iwa...
    J Biol Chem/278(32)/p.30235 30247, 2003-08
  • Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins.
    Isshiki S; Kudo T; Nishihara S; Ikehara Y; Togayachi A; F...
    J Biol Chem/278(38)/p.36611 36620, 2003-09
  • 血液内科
    工藤崇; 高橋智
    Biological significance of mucin-type O-glycosylation in megakaryocyte differentiation, 2014-05
  • Loss of mucin-type O-glycan causes thrombocytopenia in mice
    工藤崇; 高橋智
    医学のあゆみ, 2014-05
  • 「糖鎖は生物の機能をどう決めているか」 (分担)「ヒトにおけるフコース転移酵素変異体の解析」
    西原祥子; 工藤崇; 成松久
  • 「グライコバイオロジー実験プロトコール」 (分担)「a-1,3-Fuc転移酵素」
    西原祥子; 工藤崇; 成松久
  • グライコバイオロジー実験プロトコール」 (分担)「b-1,4-Gal転移酵素」
    工藤崇; 西原祥子; 成松久
  • バイオインダストリー「糖鎖工学の最前線」 (分担)「糖鎖遺伝子研究の現状と国際競争」
    工藤崇; 栂谷内晶; 後藤雅式; 成松久
  • 「糖鎖機能:第3の生命鎖」 (分担)「フコース転移酵素の機能」
    工藤崇; 成松久
  • 「化学と生物学の接点がつくるNewバイオテクノロジー」 「糖鎖修飾を決定する糖転移酵素の網羅的解析」
    栂谷内晶; 菊池紀広; 工藤崇; 成松久
  • 「未来に拓く糖鎖科学」 「フコース転移酵素」
    工藤崇; 栂谷内晶; 成松久
  • "Experimental Glycoscience, Glycobiology" "Fucosyltransferase"
    T. Kudo; H. Narimatsu
  • モデル動物利用マニュアル・生物機能モデルと新しいリソース・リサーチツール「Fut9ノックアウトマウス」
    工藤崇; 成松久
Conference, etc.
  • 疾患モデルとしての糖転移酵素改変マウス
    Kudo Takashi
  • The role of mucin-type O-glycan in glomerular podocyte
    布施谷 清香; 岡田 理沙; 鈴木 陸; 新保 未来; 涌井 宏...
  • Mouse Habitat Cage Unit –A new space device for a comprehensive mouse analysis-
    Shimbo Miki; Kudo Takashi; Shiba Dai; Shirakawa Masaki; T...
    The 93rd Annual Meeting of the Physiological Society of Japan/2016-3-22--2016-3-24
  • 力学的荷重変動による骨代謝恒常性維持の新たなメカニズムの解明
    篠原 正浩; 工藤 崇; 新保 未来; 芝 大; 白川 正輝; 森田 啓...
  • MafBはアポトーシス細胞除去に重要である
    濱田 理人; Mai Thi Nhu Tran; 工藤 崇; 白石 梨沙子
  • 転写因子MafBは、腫瘍随伴マクロファージを介して腫瘍の成長を抑制する
    今村 優希; 濱田 理人; Mai Thi Nhu Tran; 中村 恵弥; 中...
  • Postnatal Lethality and Chondrodysplasia in Mice Lacking Both Chondroitin Sulfate N-acetylgalactosaminyltransferase-1 and -2
    新保 未来; 佐藤 隆; 萩原 梢; 成松 久; 高橋 智; 工藤 崇
  • 生体発光イメージングによるIns1-luc BACトランスジェニックマウスを用いた膵β細胞量と肝臓で のインスリン遺伝子発現活性化能の検出
    勝又斗紀夫; 大石久史; 関口有佳里; 長崎はるか; Daassi Dhou...
  • 生物発光イメージングを用いた、肝組織由来in vivoインスリン産生細胞発生におけるMafAおよびMafB転写因子の機能解析
    長崎はるか; 大石久史; 勝又斗紀夫; 関口有佳里; 工藤 崇; 高...
  • Function of MafB in tumor-associated macrophages and tumor growth
    Hamada Michito; Nakane Aya; Nakamura Megumi; Kusakabe Man...
  • MafBは泡沫細胞のアポトーシスを抑制し、動脈硬化を促進する
    濱田理人; 中村恵弥; Mai Thi Nhu Tran; 工藤 崇; 高橋智
  • MafB promotes atherosclerosis by inhibiting foam-cell apoptosis
    Hmada Michito; Nakamura Megumi; Arai Satoko; Kudo Takashi...
  • Loss of hematopoietic mucin-type O-glycan causes thrombocytopenia in mice
    工藤 崇
  • Direct Conversion of Mouse Liver Cells to Insulin-producing Cells by Defined Factors
    板垣考洋; 大石久史; 伊藤祐太朗; Tai Pei-Han; 小島正美; 長...
  • 肝細胞からインスリン産生細胞への分化誘導におけるMafAおよびMafBの機能解析
    長崎はるか; 大石久史; 勝又斗紀夫; 関口有佳里; 新保未来; ...
  • Pdx1、NeurodおよびMafAをコードするポリシストロニックアデノウイルスベクターを用いたマウス肝臓におけるインスリン産生細胞の誘導
    新保未来; 長崎はるか; 小島正美; 伊藤祐太朗; 板垣考洋; 工...
  • Mice lacking C1galt1 in the hematopoietic system display thrombocytopenia due to abnormal terminal differentiation of megakaryocytes
    工藤 崇; 佐藤隆; 萩原梢; 上妻行則; 山口高志; 池原譲; 濱田...
2017-09 -- 2017-09Bio-Medical Problems SeminarUniversity of Tsukuba.
2017-10 -- 2018-02Bio-Medical Problems SeminarUniversity of Tsukuba.
2017-04 -- 2017-08Advanced Exercise on Public HealthUniversity of Tsukuba.
2017-10 -- 2018-02Advanced Exercise on Public HealthUniversity of Tsukuba.
2017-04 -- 2017-08Internship IIUniversity of Tsukuba.
2017-10 -- 2018-02Internship IIUniversity of Tsukuba.
2017-04 -- 2017-08Seminar on Basic Medical SciencesUniversity of Tsukuba.
2017-10 -- 2018-02Seminar on Basic Medical SciencesUniversity of Tsukuba.
2017-04 -- 2017-08Dissertation in Medical SciencesUniversity of Tsukuba.
2017-10 -- 2018-02Dissertation in Medical SciencesUniversity of Tsukuba.
Other educational activities
2005-04 -- 2007-03医学類クラス担任
2013-04 -- 2015-03医学類クラス担任
University Management
2017-04 -- (current)医学教育推進委員会委員
2017-04 -- (current)医学類教育会議運営委員会 M1総コーディネータ委員
2014-04 -- (current)バイオセーフティ委員会委員
2014-04 -- (current)遺伝子組換え実験安全委員会委員
2011-04 -- (current)医学の基礎検討委員委員
2013-05 -- (current)動物実験委員会副委員長
2009-04 -- 2014-03医学医療系広報・情報委員会委員
2004-04 -- (current)安全管理小委員会委員委員
2011-07 -- (current)遺伝子組換え実験安全主任者
2007-06 -- (current)X線管理責任者

(Last updated: 2017-06-14)