Funakoshi Yuji

Affiliation

Faculty of Medicine

Official title

Assistant Professor

Research fields

Biological pharmacy

General physiology

Research keywords

脂質性シグナル伝達

低分子量G蛋白質

Research projects

非定型RabGAPによるクラスリン非依存性カーゴ蛋白質の細胞内膜輸送制御	2017 -- 2019	船越 祐司	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,810,000Yen
脱ユビキチン化酵素TRE17によるクラスリン非依存性カーゴ蛋白質の細胞内輸送制御	2014 -- 2016	船越　祐司	Japan Society for the Promotion of Science/基盤研究(C)	4,940,000Yen
低分子量Ｇ蛋白質Ａｒｆ６／リン脂質キナーゼＰＩＰ５Ｋによる脳内βアミロイドの調節	2012 -- 2013		Japan Society of for the Promotion of Science/若手研究(B)	2,340,000Yen

Career history

2005-04 -- 2008-03

RIKEN Special Postdoctral Researcher

Academic societies

2009 -- (current)	Japan Society for Cell Biology
2009 -- (current)	THE JAPANESE BIOCHEMICAL SOCIETY
2005 -- (current)	The Molecular Biology Society of Japan

Articles

• Physiological function of phospholipase D2 in anti-tumor immunity: regulation of CD8 T lymphocyte proliferation
  Ngo Thai Bich Van; Hongu Tsunaki; Miura Yuki; Katagiri Na...
  Scientific reports/8(1)/p.6283, 2018-04
  PubMed
• The small G protein Arf6 expressed in keratinocytes by HGF stimulation is a regulator for skin wound healing
  Miura Yuki; Ngo Thai Bich Van; Furuya Momoko; Hasegawa Hi...
  Scientific Reports/(7)/p.46649, 2017-04
  PubMed
• ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons
  Miura Yuki; Hongu Tsunaki; Yamauchi Yohei; Funakoshi Yuji...
  BIOCHEMICAL JOURNAL/473(17)/pp.2591-2602, 2016-09
  PubMed
• Tissue- and development-dependent expression of the small GTPase Arf6 in mice.
  Akiyama Masahiro; Zhou Miao; Sugimoto Rika; Hongu Tsunaki...
  Developmental Dynamics, 2010-12
  PubMed
• Pathological functions of the small GTPase Arf6 in cancer progression: Tumor angiogenesis and metastasis.
  本宮 綱記; 山内 庸平; 船越 祐司; 片桐 尚宏; 大林 典彦; 金...
  Small GTPases/7(2)/pp.47-53, 2016-04
  PubMed
• Activation of the Small G Protein Arf6 by Dynamin2 through Guanine Nucleotide Exchange Factors in Endocytosis
  Okada Risa; Yamauchi Yohei; Hongu Tsunaki; Funakoshi Yuji...
  SCIENTIFIC REPORTS/5, 2015-10
  PubMed
• Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling.
  Tsunaki Hongu; Yuji Funakoshi; Shigetomo Fukuhara; Teruhi...
  NATURE COMMUNICATIONS/6/p.7925, 2015-08
  PubMed
• TRE17/USP6 regulates ubiquitylation and trafficking of cargo proteins that enter cells by clathrin-independent endocytosis
  Funakoshi Yuji; Chou Margaret M.; Kanaho Yasunori; Donald...
  JOURNAL OF CELL SCIENCE/127(21)/pp.4750-4761, 2014-11
  PubMed
• Molecular mechanisms of fMLP-induced superoxide generation generation and degranulation in mouse neutrophils.
  Kanaho Yasunori; Sato Takanobu; Hongu Tsunaki; Funakoshi ...
  Adv Biol Regul./53(1)/pp.128-134, 2013-01
• Molecular mechanisms of fMLP-induced superoxide generation and degranulation in mouse neutrophils.
  Kanaho Yasunori; Sato Takanobu; Hongu Tsunaki; Funakoshi ...
  Advances in Biological Regulation/63/pp.128-134, 2013-01
• Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic polyadenylation element-binding protein CPEB.
  Ogami Koichi; Hosoda Nao; Funakoshi Yuji; Hoshino Shin-ichi
  Oncogene/33/pp.55-64, 2014
• Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable.
  Sato Takanobu; Hongu Tsunaki; Sakamoto Megumi; Funakoshi ...
  MOLECULAR AND CELLULAR BIOLOGY/33(1)/pp.136-145, 2013-01
• Translation termination factor eRF3 mediates mRNA decay through the regulation of deadenylation.
  Nao Hosoda; Tetsuo Kobayashi; Naoyuki Uchida; Yuji Funako...
  J. Biol. Chem./278/p.38287-38291, 2003-01
• The GTP-binding release factor eRF3 as a key mediator coupling translation termination to mRNA decay.
  Tetsuo Kobayashi; Yuji Funakoshi; Shin-ichi Hoshino; and ...
  J. Biol. Chem./279/p.45693-45700, 2004-01
• Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases
  Yuji Funakoshi; Yusuke Doi; Nao Hosoda; Naoyuki Uchida; M...
  Genes & Dev/21/p.3135-3148, 2007-01
• Activation mechanisms of PIP5K isozymes by the small GTPase ARF6
  Yuji Funakoshi; Hiroshi Hasegawa; Yasunori Kanaho
  Advances in Enzyme Regulation/50/p.72-80, 2010-01
• Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase
  Nao Hosoda*; Yuji Funakoshi*; Masato Hirasawa; Ryota Yama...
  EMBO Journal/30/p.1311-1323, 2011-01
• Phosphatidylinositol 4-Phosphate 5-Kinase Is Indispensable for Mouse Spermatogenesis
  Hasegawa Hiroshi; Noguchi Junko; Yamashita Misuzu; Okada ...
  BIOLOGY OF REPRODUCTION/86(5), 2012-05
  PubMed
• NMDA Receptor-Mediated PIP5K Activation to Produce PI(4,5)P-2 Is Essential for AMPA Receptor Endocytosis during LTD
  Unoki Takamitsu; Matsuda Shinji; Kakegawa Wataru; Ngo Tha...
  NEURON/73(1)/pp.135-148, 2012-01
  PubMed
• Regulation of PIP5K Activity by Arf6 and Its Physiological Significance
  Funakoshi Yuji; Hasegawa Hiroshi; Kanaho Yasunori
  JOURNAL OF CELLULAR PHYSIOLOGY/226(4)/pp.888-895, 2011-04
• ホスファチジルイノシトール4-リン酸5-キナーゼ欠損マウスにおける精子形成不全
  長谷川 潤; 杉本 里香; 山下 美鈴; 野口 純子; 岡田 理沙; 鵜...
  脂質生化学研究/52/pp.162-164, 2010-05
  CiNii
• Phospholipase D signalling and its involvement in neurite outgrowth
  Kanaho Yasunori; Funakoshi Yuji; Hasegawa Hiroshi
  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS/1791(9:::Sp. Iss. SI)/pp.898-904, 2009-09
  PubMed
• The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons
  Suzuki Atsushi; Arikawa Chihiro; Kuwahara Yuji; Itoh Koui...
  FEBS LETTERS/584(13)/pp.2801-2806, 2010-07
• Tissue- and Development-Dependent Expression of the Small GTPase Arf6 in Mice
  Akiyama Masahiro; Zhou Miao; Sugimoto Rika; Hongu Tsunaki...
  DEVELOPMENTAL DYNAMICS/239(12)/pp.3416-3435, 2010-12

Books

• 翻訳終結と共役したmRNA分解制御機構の解析
  船越 祐司
  2005-03
• Novel function of the eukaryotic polypeptide-chain releasing factor 3 (eRF3/GSPT) in the mRNA degradation pathway
  Shin-ichi Hoshino; Nao Hosoda; Yasuhiro Araki; Tetsuo Kob...
  Biochemistry (Moscow), 1999-01
• 真核生物におけるmRNA分解制御の分子機構
  船越 祐司; 星野 真一
  実験医学 23, 2005-01
• RT-PCRを用いたRNAの検出と定量
  星野真一; 船越祐司
  RNA 実験ノート上巻, 2008-01
• 多彩な生理機能をもつ低分子量G蛋白質Arf6
  金保安則; 本宮綱記; 鈴木輝彦; 船越祐司; 長谷川潤
  細胞The CELL, 2010-01
• ホスホリパーゼD研究の新展開
  本宮綱記; 佐藤隆信; 長谷川潤; 船越祐司; 金保安則
  実験医学, 2010-01
• Regulation of PIP5K Activity by Arf6 and Its Physiological Significance
  Yuji Funakoshi; Hiroshi Hasegawa; Yasunori Kanaho
  Journal of cellular physiology, 2011-01

Conference, etc.

• Function of TBC1D24 in clathrin-independent endocytic cargo trafficking
  Nguyen Nguyen Thi Kim; Funakoshi Yuji; Kanaho Yasunori
  2017 The 16th Joint Mini-Symposium 2017 of National Taiwan University, Kyoto University and University of Tsukuba/2017-09-24--2017-09-24
• Phospholipase D2 is a key molecule to suppress tumorigenesis through proliferation of CD8+ T lymphocytes
  Van Ngo Thai Bich; Hongu Tsunaki; Funakoshi Yuji; Kanah Y...
  2017 The 16th Joint Mini-Symposium 2017 of National Taiwan University, Kyoto University and University of Tsukuba/2017-09-24--2017-09-24
• Regulation of HGF-induced hepatocyte proliferation by the small GTPase Arf6 through the PIP2-producing enzyme PIP5K1A
  Funakoshi Yuji; Tsai Meng-Tsz; Katagiri Naohiro; Ohbayash...
  2017 The 16th Joint Mini-Symposium 2017 of National Taiwan University, Kyoto University and University of Tsukuba/2017-09-24--2017-09-24
• Involvement of Small GTPase Arf6 in PDGF-induced Dorsal Ruffling.
  金保安則; 船越祐司; 本宮綱記; 宮地泰人
  The 13th Joint Mini-symposium 2014 of NTU/2014-9-26
• Ubiquitin-specific protease TRE17/USP6 targets clathrin-independent cargo to recycling
  Funakoshi Yuji; Kanaho Yasunori; Donaldson Julie
  2012 American Society for Cell Biology, Annual Meeting/2012-12-15--2012-12-19

Teaching

2017-04 -- 2017-08	Advanced Exercise on Public Health	University of Tsukuba.
2017-10 -- 2018-02	Advanced Exercise on Public Health	University of Tsukuba.
2017-04 -- 2017-08	Internship II	University of Tsukuba.
2017-10 -- 2018-02	Internship II	University of Tsukuba.
2017-04 -- 2017-07	Topics in Biochemistry	University of Tsukuba.
2017-10 -- 2017-11	Practice of Clinical Pharmacology	University of Tsukuba.
2017-04 -- 2017-08	Clinical pharmacology	University of Tsukuba.
2017-10 -- 2018-02	Seminar on Basic Medical Sciences	University of Tsukuba.
2017-04 -- 2017-08	Seminar on Basic Medical Sciences	University of Tsukuba.
2017-04 -- 2017-07	Pharmacology	University of Tsukuba.

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(Last updated: 2018-05-29)