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Saito Shinji

Faculty of Medicine
Official title
Associate Professor
Birth date
Research fields
Bacteriology (including mycology)
Research keywords
Staphylococcus aureus
Infection Immunity
Innate Immunity
Research projects
フローラを含むヒト鼻腔粘膜上皮環境モデルの構築と新規アレルギー制御特性の探索2017 -- 2019齋藤 慎二Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)4,680,000Yen
黄色ブドウ球菌、常在細菌群のアレルギー性鼻炎病態に及ぼす影響、その基礎的検討2013 -- 2015齋藤 慎二Japan Society for the Promotion of Science/基盤研究(C)5,070,000Yen
細菌感染、および自然免疫応答における傷害的活性の発現に対する調節機構の解明2006 -- (current)斎藤慎二University of Tsukuba/ロケット・スタート支援研究プロジェクト支援費2,040,000Yen
細菌リポ多糖LPSによる傷害活性の発現に対する調節機構の解明2005 -- 2006松浦基博Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research (C)
新生児・乳幼児における細菌性スーパー抗原による感染症の免疫学的病態解析2004 -- 2006高橋尚人Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research (C)
新生児TSS様発疹症と川崎病の病態解析2002 -- 2003高橋尚人Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research (C)
細菌リポ多糖による内因性インターフェロン-γの産生機構とその役割の解明2001 -- 2002松浦基博Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research (C)
細菌リポ多糖によるマクロファージ活性化及び機能発現に関わるシグナル伝達分子の解明2001 -- 2002斎藤慎二独立行政法人 日本学術振興会/Grant-in-Aid for Scientific Research (C)
Career history
2011-10 -- (current)筑波大学 医学医療系 准教授
2007-04 -- 2011-09筑波大学 大学院人間総合科学研究科 准教授
2006-07 -- 2007-03University of Tsukuba Graduate School of Comprehensive Human Sciences Associate Professor
1990-03 -- 2006-06Jichi Medical School 医学部 Assistant Proffessor
1987-04 -- 1990-02Tokyo Women's Medical College 医学部 Research Assistant
Academic background
1981-04 -- 1985-03Hokkaido University Faculty of Science Department of ChemistryGraduated
1985-04 -- 1987-03Hokkaido University Graduate School, Division of Natural Science ChemistryCompleted
1996-08Doctor of PhilosophyJichi Medical School
1987-03Master of ScienceHokkaido University
Academic societies
2009 -- (current)The Molecular Biology Society of Japan
1996 -- (current)International Endotoxin and Innate Immunity Society
  • Staphylococcus aureus dry stress survivors have a heritable fitness advantage in subsequent dry exposure.
    Maudsdotter L; Imai S; Ohniwa Ryosuke; Saito S; Morikawa K
    Microbes and Infection/17(6)/pp.456-461, 2015-06
  • Oral nanotherapeutics: Effect of redox nanoparticle on microflora in mice with dextran sodium sulfate-induced colitis.
    Long Binh Vong; Toru Yoshitomi; Morikawa Kazuya; Shinji S...
    JOURNAL OF GASTROENTEROLOGY/49(5)/pp.806-813, 2014-05
  • Nucleoid compaction by MrgAAsp56Ala/Glu60Ala does not contribute to staphylococcal cell survival against oxidative stress and phagocytic killing by macrophage.
    Ushijima Y; Ohniwa Ryosuke; Maruyama A; Saito S; Tanaka Y...
    FEMS MICROBIOLOGY LETTERS/360(2)/pp.144-151, 2014-11
  • Atomic force microscopy analysis of the role of major DNA-binding proteins in organization of the nucleoid in Escherichia coli.
    Ohniwa Ryosuke; Muchaku H; Saito S; Wada C; Morikawa K
    PLOS ONE/p.e72954, 2013-08
  • Proteomic Analyses of Nucleoid-Associated Proteins in Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus
    Ohniwa Ryosuke L.; Ushijima Yuri; Saito Shinji; Morikawa ...
    PLOS ONE/6(4), 2011-04
  • Staphylococcus aureus requires cardiolipin for survival under conditions of high salinity
    Tsai Melody; Ohniwa Ryosuke L.; Kato Yusuke; Takeshita Sa...
    BMC MICROBIOLOGY/11/p.130, 2011-01
  • Immunomodulatory effects of Yersinia pestis lipopolysaccharide on human macrophages
    M. Matsuura H. Takahashi H. Watanabe S. Saito K. Kawahara...
    Clinical and Vaccine Immunology/17(1)/p.49-55, 2010-01
  • Staphylococcus aureus surface protein SasG contributes to intercellular autoaggregation of Staphylococcus aureus
    Kuroda Makoto; Ito Ryuta; Tanaka Yoshikazu; Yao Min; Mato...
  • The sigH gene sequence can subspeciate staphylococci
    Morikawa Kazuya; Ohniwa Ryosuke L.; Kumano Miyuki; Okamur...
  • Regulation of lipopolysaccharide-induced interleukin-12 production by activation of repressor element GA-12 through hyperactivation of ERK pathway
    S. Saito; M. Matsuura; Y. Hirai
    Clin. Vac. Immunol./13(8)/p.876-883, 2006-01
  • Pathway to induce nitric oxide by bacterial LPS
    M. Matsuura; S. Saito; and Y. Hirai
    12th International Congress of Immunology and 4th Annual Conference of FOcis/p.243-246, 2004-01
  • A pathway through interferon-gamma is the main pathway for induction of nitric oxide upon stimulation with bacterial lipopolysaccharide in mouse peritoneal cells
    M. Matsuurs; S. Saito; Y. Hirai; and H. Okamura
    Eur. J. Biochem./270/p.4016-4025, 2003-01
  • Unusual interaction of a lipopolysaccharide isolated from Burkholderia cepacia with polymixin B
    H. Shimomura; M. Matsuura; S. Saito; Y. Hirai; Y. Isshiki...
    Infect. Immun./71/p.5225-5230, 2003-01
  • Lipopolysaccharide of Burkholderia cepacia and its unique character to stimulate murine macrophages with relative lack of interleukin-1 beta-inducing ability
    H. Shimomura; M. Matsuura; S. Saito; Y. Hirai; Y. Isshiki...
    Infect. Immun./69/p.3663-3669, 2001-01
  • Important role of membrane-associated CD14 in the induction of IFN-bata and subsequent nitric oxide production by murine macrophages in reponse to bacterial lipopolysaccharide
    S. Saito; M. Matsuura; K. Tominaga; T. Kirikae; and M. Na...
    Eur. J. Biochem./267/p.37-45, 2000-01
  • Lipopolysaccharide tolerance in murine peritoneal macrophages induces downregulation of the lipopolysaccharide signal transduction pathway through mitogen-activated protein kinase and nuclear factor-kappa B cascades, but not lipopolysaccharide-incorporation steps
    K. Tominaga; S. Saito; M. Matsuura; and M. Nakano
    Biochemica et Biophysica Acta/1450/p.130-144, 1999-01
  • Lipopolysaccharide-and paclitaxel (Taxol)-induced tolerance in murine peritoneal macrophages
    M. Nakano; K. Tominaga; S.Saito; F. Kirikae; S. Lin; C. L...
    J. Endotoxin Res./5/p.102-106, 1999-01
  • Role of IFN-gamma on dissociation between nitric oxide and TNF / IL-6 production by murine peritoneal cells after restimulation with bacterial lipopolysaccharide
    K; Tominaga; S. Saito; M. Matsuura; K. Funatogawa; H. Mat...
    J. Leukoc. Biol./66/p.974-980, 1999-01
  • Lipopolysaccharide (LPS) stimulates the production of tumor necrosis factor (TNF)-alpha and expression of inducible nitric oxide synthase (iNOS) by osteoclasts (OCL) in murine bone marrow cell culture
    I. Kikkawa; S. Saito; K. Tominaga; Y. Hoshino; Y. Ooi; an...
    Microbiol. Immunol./42/p.591-598, 1998-01
  • Biological characterization of endotoxins released from antibiotic treated Pseudomonas aeruginosa and Escherichia coli
    T. Kirikae; F. Kirikae; S. Saito; K. Tominaga; H. Uemura;...
    Antimicrob. Agents Chemother./42/p.1015-1021, 1998-01
  • Nitric oxide production by peritoneal macrophages of Mycobacterium bovis BCG-infected or non-infected mice: regulatory roles of T lymphocyte and cytokines
    S. Saito; and M. Nakano
    J. Leukoc. Biol./59/p.908-915, 1996-01
2017-04 -- 2017-08MicrobiologyUniversity of Tsukuba.
2017-04 -- 2017-08Advanced Exercise on Public HealthUniversity of Tsukuba.
2017-10 -- 2018-02Advanced Exercise on Public HealthUniversity of Tsukuba.
2017-04 -- 2017-08Internship IIUniversity of Tsukuba.
2017-10 -- 2018-02Internship IIUniversity of Tsukuba.
2017-04 -- 2017-06Freshmen SeminarUniversity of Tsukuba.
2017-10 -- 2017-12BacteriologyUniversity of Tsukuba.
2017-04 -- 2017-08Seminar on Basic Medical SciencesUniversity of Tsukuba.
2017-10 -- 2018-02Seminar on Basic Medical SciencesUniversity of Tsukuba.
2017-10 -- 2018-02MicrobiologyUniversity of Tsukuba.
Other educational activities
2016-04 -- 2016-04遺伝子組換え実験従事者講習会筑波大学
2015-04 -- 2015-04遺伝子組換え実験従事者講習会筑波大学
2014-04 -- 2014-04遺伝子組換え実験従事者講習会筑波大学
2012-04 -- 2012-04遺伝子組換え実験従事者講習会筑波大学
2011-04 -- 2011-04遺伝子組換え実験従事者講習会筑波大学
2008-04 -- 2010-03クラス担任University of Tsukuba.
Professional activities
2008-08 -- 2010-07文部科学省学術調査官
2010-07 -- 2010茗溪学園個人課題研究援助
2011-06 -- 2011-06テレビ朝日「モーニングバード」取材協力・出演
University Management
2016-04 -- 2019-03遺伝子組換え実験安全主任者安全主任者
2014-04 -- 2018-03医の倫理委員会専門委員
2014-04 -- 2018-03付属病院臨床研究倫理審査委員専門委員
2007-04 -- 2019-03遺伝子組替え実験安全委員会委員
2007-04 -- 2019-03バイオセーフティ委員会副委員長
2008-04 -- 2018-03付属病院感染対策委員会委員
2007-04 -- 2018-03医学安全管理小委員会フロア担当責任者
2011-04 -- 2013-03学生生活支援室副室長
2011-04 -- 2013-03教員免許更新講習委員会委員
2010-04 -- 2011-03学生生活支援室員学生支援部会、紫峰会顧問
Other activities
2011-06 -- 2011-06テレビ朝日「モーニングバード」取材協力 「実験 直箸で菌はどれだけ感染するの?」
2013-08 -- 2013-08日本免疫学会主催「免疫ふしぎ未来2013」協力委員
2012-08 -- 2012-08日本免疫学会主催「免疫ふしぎ未来2012」協力委員

(Last updated: 2017-08-09)