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Sakai Satoshi

Affiliation
Faculty of Medicine
Official title
Assistant Professor
Email
 
Phone
029-853-3210
Fax
029-853-3143
Research fields
Cardiovascular medicine
General pharmacology
Research keywords
心不全
心肥大
心筋再生
肺高血圧症
血管内皮機能
血管平滑筋増殖
アポトーシス
Research projects
腹部大動脈瘤の病態形成における好中球細胞外トラップの役割解明と治療への応用2016-04 -- 2019-03Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research (C)
肺高血圧進展におけるプロリン異性化酵素Pin1の役割解明と新規治療法の開発2016-04 -- 2019-03酒井 俊Japan Society of for the Promotion of Science/Grant in Aid for Scientific Research (B)
肺高血圧症におけるポリアミン系活性化の意義解明と新規治療法の開発2015-04 -- 2016-03酒井 俊Japan Society for the Promotion of Science/Grant-in-Aid for challenging Exploratory Research3,640,000Yen
遺伝子レスキューマウス解析による肥満肝発癌を制御する組織・細胞Nrf2の役割解明2014-04 -- 2017-03Japan Society of for the Promotion of Science/科学研究費補助金 基盤研究(B)
マイクロRNAの発現変動を切り口とした肺動脈性肺高血圧症の理解と新治療法の探索2013-04 -- 2016-03酒井 俊Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research (B)
心筋梗塞の病態形成における好中球細胞外捕捉(NETs)の役割解明と治療への応用2013-04 -- 2015-03Japan Society of for the Promotion of Science/Japanese Grant-in Japanese Grant-in-Aid Sicientific Research3,770,000Yen
高血圧性心病変の形成におよぼす脂質合成系転写因子SREBP-1の役割2011-04 -- 2014-03Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research (C)5,330,000Yen
心不全進展における慢性炎症の機序解明と新たな治療法の探索2011-04 -- 2013-03Japan Society of for the Promotion of Science/Japanese Grant-in Japanese Grant-in-Aid Sicientific Research3,770,000Yen
心肥大から心不全発症におけるRNAポリメラーゼの脱リン酸化調節による役割解明2010-04 -- 2012-03Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research (C)4,420,000Yen
新規肥満モデルが血圧上昇をきたすメカニズムの解明と高血圧の予防・治療への応用2010-04 -- 2013-03酒井 俊Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research (C)4,290,000Yen
Career history
2003 -- 2006米国ベイラー医科大学 Research Associate
2006 -- (current)筑波大学 臨床医学域 講師
Academic background
-- 1990University of Tsukuba School of MedicineGraduated
-- 1996University of Tsukuba Graduate School, Division of Medicine 生理系Graduated
Degree
博士(医学)University of Tsukuba
Academic societies
2016-04 -- (current)日本肺高血圧・肺循環学会
-- (current)International Society for Heart Research
2010 -- (current)Physiological Society
-- (current)THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
-- (current)THE JAPANESE CIRCULATION SOCIETY
2012 -- (current)日本心血管内分泌代謝学会
1999 -- (current)JAPANESE COLLEGE OF CARDIOLOGY
-- (current)JAPANESE HEART FAILURE SOCIETY
-- (current)THE JANPANESE SOCIETY OF INTERNAL MEDICINE
2012 -- 2016日本肺循環学会
Honors & Awards
1999-09第47回日本心臓病学会 Young Investigator's Award
1996-06第38回国際血管病学会 Young Investigator's Award
1996-03第1回筑波大学博士課程医学研究科最優秀英語論文賞
1995-04第4回国際エンドセリン学会 Young Investigator's Award
Articles
Books
  • エンドセリンの心肥大・心不全発症における役割
    前田清司; 酒井 俊; 宮内 卓
    心臓における生命現象の分子生物学, 東京 メディカルレビュー社, pp.111-123, 2001-01
  • 心肥大作製法──圧負荷・容量負荷・運動負荷による心肥大
    宮内 卓; 酒井 俊; 杉下靖郎
    実験医学, 1996-01
  • エンドセリン拮抗薬
    酒井 俊; 宮内 卓
    Heart View, 1997-01
  • エンドセリン受容体拮抗薬による心不全治療効果
    宮内 卓; 酒井 俊; 杉下靖郎
    「心不全」.東京:医薬ジャーナル社, 1997-01
  • 症候・病態の分子メカニズム;心肥大
    酒井 俊; 宮内 卓
    Molecular Medicine, 1998-01
  • エンドセリン拮抗薬と心不全
    宮内 卓; 酒井 俊; 杉下靖郎
    呼吸と循環, 1999-01
  • エンドセリン受容体拮抗薬の循環器疾患治療薬としての可能性
    酒井 俊; 宮内 卓
    循環器科, 1999-01
  • エンドセリンと病態
    酒井 俊; 宮内 卓
    「脳血管1999 文献レビュー」.京都:金芳堂, 1999-01
  • 心不全におけるエンドセリン系とエンドセリン受容体遮断薬の効果
    酒井 俊
    進歩する心臓研究, 2000-01
  • 心不全の病態におけるエンドセリン
    酒井 俊; 宮内 卓
    最新医学, 2000-01
  • エンドセリンと病態
    酒井 俊; 宮内 卓
    「脳血管2000 文献レビュー」.京都:金芳堂, 2000-01
  • エンドセリンと心血管リモデリング
    酒井 俊; 宮内 卓
    CARDIAC PRACTICE, 2001-01
  • エンドセリン拮抗薬・抗サイトカイン療法の現状
    酒井 俊; 宮内 卓
    「別冊・医学のあゆみ・循環器疾患 ver.2--state of arts」.東京:医歯薬出版, 2001-01
  • 期外収縮
    酒井 俊
    「納得できる心電図の読み方」.東京:メジカルセンス, 2001-01
  • エンドセリンと虚血性心疾患のあらたな展開ーエンドセリン受容体遮断薬の展望ー
    酒井 俊; 宮内 卓
    「別冊・医学のあゆみ 虚血性心疾患」・東京:医歯薬出版, 2001-01
  • Endothelin拮抗薬
    酒井 俊; 宮内 卓
    「Annual Review 循環器」.中外医学社(東京), 2002-01
  • エンドセリン受容体拮抗薬
    酒井 俊; 宮内 卓
    「KEY WORD 分子高血圧」。先端医学社(東京), 2002-01
  • エンドセリン受容体拮抗薬tezosentanは心不全治療に有用か?-VERITASスタディー-
    酒井 俊; 下條信威; 宮内裕美; 宮内 卓
    EBM 循環器疾患の治療2010-2011。中外医学社(東京), 2009-09
  • 血管作動性物質―生合成、分泌生理作用―エンドセリン
    下條信威; 酒井 俊; 宮内裕美; 宮内 卓
    日本臨床、日本臨床社, 2009-10
  • 副腎皮質ステロイド合併症としてみられる病態ー高血圧ー
    酒井 俊; 河野 了; 青沼和隆
    GUIDELINE 膠原病・リウマチ ー治療ガイドラインをどう読むかー 第2版・ 診断と治療社, 2010-08
  • 肺高血圧モデル
    前田清司・宮内裕美・酒井 俊・宮内 卓; +酒井 俊
    ANIMAL MODELS, 2010-08
Conference, etc.
  • MAIR-II deficiency prevents excessive inflammation and fibrosis protecting against cardiac dysfunction post-myocardial infarction
    Yonebayashi Saori; Tajiri Kazuko; Murakoshi Nobuyuki; Fum...
    The 2nd JCS Council Forum on Basic CardioVascular Research/2018-09-22--2018-09-23
  • The Glucagon-like Peptide-1 Receptor Agonist Ameliorates Hypoxia Induced Pulmonary Hypertension in Mice Model
    Honda Junya; Kimura Taizo; Sakai Satoshi; Maruyama Hideka...
    第21回日本心不全学会学術集会/2017-10-12--2017-10-14
  • ヒト気道上皮細胞におけるトルエン及びキシレン由来二次生成粒子ばくろの影響
    細谷純一; 荻野浩之; 伊藤剛; 酒井俊; 小林隆弘; 坂元和彦; ...
    第57回 大気環境学会年会/2016-09-07--2016-09-09
  • Aggravation of myocardial infarction by tenascin-C over expression in mice
    Sakai Satoshi; Kimura Taizo; Tajiri Kazuko; Sato Akira; A...
    第81回日本循環器学会学術集会/2017-03-17--2017-03-19
  • Suppressor of Cytokine Signaling 1 in Dendritic Cells Inhibits Myocardial Inflammation in Experimental Autoimmune Myocarditis
    Tajiri Kazuko; Imanaka-Yoshida Kyoko; Hiroe Michiaki; Shi...
    Basic Cardiovascular Sciences Scientific Session/2012-07-23--2012-07-26
  • Initial Experience of Tolvaptan in Patients with Refractory Heart Failure
    Seo Yoshihiro; Ishizu Tomoko; Sakai Satoshi; Kawano Sator...
    15th Annual Scientific Meeting of the Japanese-Heart-Failure-Society/2011-10-13--2011-10-15
  • The Efficacy and Safety of Tolvaptan Treatment in Patients with Congestive Heart Failure
    Seo Yoshihiro; Ishizu Tomoko; Sakai Satoshi; Kawano Sator...
    the 15th Annual Scientific Meeting of the Japanese-Heart-Failure-Society/2011-10-13--2011-10-15
  • ID-based key agreement for dynamic peer groups in mobile computing environments
    Machino Tomoko; Sakai Satoshi; Yamamoto Masayoshi; Baba M...
    12th Annual Scientific Meeting of the Japanese-Heart-Failure-Society/2008-10-16--2008-10-18
  • Contrast Medium-Induced Renal Damage is Tightly Associated with Endothelial Injury in Patients
    Tajiri Kazuko; Maruyama Hidekazu; Sakai Satoshi; Shimojo ...
    81st Annual Scientific Session of the American-Heart-Association/2008-11-8--2008-11-12
  • Increased blood pressure at resting phase in A170-knockout mice, an Obese Model
    Sakai Satoshi; Warabi Eiji; Inaba Hiroko; Harada Harumi; ...
    82nd Annual Meeting of the Japanese-Pharmacological-Society/2009-3-17
  • Alteration of Endothelial Cells in Patients with Pulmonary Arterial Hypertension Estimated by Endothelial Cell-Derived Microparticles
    Maruyama Hidekazu; Sakai Satoshi; Sumida Takayuki; Goto D...
    10th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology/2009-4-29--2009-5-1
  • Different Mechanisms for Endothelial Dysfunction in Patients with Atrial Fibrillation and Patients with Stable Angina Pectoris
    Maruyama Hidekazu; Igarashi Miyako; Baba Masako; Sakai Sa...
    Basic Cardiovascular Sciences Conference 2009/2009-7-20--2009-7-23
  • Estrogen Prevention Mechanism for ET-1-Induced Cardiomyocyte Hypertrophy Is Linked with Erk and VEGF System Through Both Genomic and Nongenomic Pathway
    Shimojo Nobutake; Jesmin Subrina; Sakai Satoshi; Ogata Ta...
    Basic Cardiovascular Sciences Conference 2009/2009-7-20--2009-7-23
  • Establishment of Obese Model with Increase in Blood Pressure by Sequestosome 1 Knockout Gene
    Sakai Satoshi; Warabi Eiji; Inaba Hiroko; Harada Harumi; ...
    Basic Cardiovascular Sciences Conference 2009/2009-7-20--2009-7-23
  • Optical Coherence Tomographic Findings of Macrophage Accumulation Atherosclerotic Lesions
    Nakagawa Yoshitsugu; Watanabe Shigeyuki; Liang Jingyan; T...
    82nd Scientific Session of the American-Heart-Association/2009-11-14--2009-11-18
  • Coronary Artery Spatial Distribution, Morphology, and Composition of Non-culprit Vulnerable Plaques by 64-slice Computed Tomography Angiography in Patients With Acute Myocardial Infarction
    Sato Akira; Nozato Toshihiro; Hikita Hiroyuki; Seo Yoshih...
    82nd Scientific Session of the American-Heart-Association/2009-10-14--2009-10-18
Teaching
2018-10 -- 2019-02Dissertation in Medical SciencesUniversity of Tsukuba.
2018-10 -- 2019-02Internship IUniversity of Tsukuba.
2018-10 -- 2019-02Internship IIUniversity of Tsukuba.
2018-10 -- 2019-02Seminar on Basic Medical SciencesUniversity of Tsukuba.
2018-10 -- 2019-02Advanced Exercise on Public HealthUniversity of Tsukuba.
2018-04 -- 2018-08Dissertation in Medical SciencesUniversity of Tsukuba.
2018-04 -- 2018-08Internship IUniversity of Tsukuba.
2018-04 -- 2018-08Internship IIUniversity of Tsukuba.
2018-04 -- 2018-08Seminar on Basic Medical SciencesUniversity of Tsukuba.
2018-04 -- 2018-08Advanced Exercise on Public HealthUniversity of Tsukuba.
Talks
  • Deficiency of sequestosome 1 accelerates neointimal hyperplasia and carotid artery remodeling
    Satoshi Sakai; Eiji Warabi; Satoru Katayanagi; Toru Yanag...
    Molecular Mechanisms of Stress Response in Disease/2012-04-06
  • 肺高血圧症治療におけるエンドセリン受容体拮抗薬の位置づけ
    酒井 俊
    いばらきPAH講演会/2012-02-02
  • 肺動脈性肺高血圧症の治療におけるエンドセリン拮抗薬の現在
    酒井 俊
    山形地区肺高血圧症セミナー/2011-10-25
  • エンドセリンと拮抗薬
    酒井 俊
    第3回 茨城県南臨床肺高血圧症研究会/2011-09-29
  • Cardiomyocyte hypertrophy incuded by endothelin-1 is regulated by transcription factor II-F interacting C-terminal domain phosphatase (FCP1) of RNA polymerase II
    Satoshi Sakai; Kazutaka Aonuma; Takashi Miyauchi
    The 12th International Conference on Endothelin/2011-09-14
  • Granulocyte Colony-Stimulating Factor Administration Reduced the Inducibility of Ventricular Tachyarrhythmias in Cardiac Hypertrophied Rats Through Phosphorylated Connexin-43
    Nobutake Shimojo; Takeshi Machino; Donzhu Xu; Taizo Kimur...
    Basic Cardiovascular Sciences Conference 2011/2011-07-19
  • Non-dipper-like hypertension in sequestosome1/p62/A170 deficient mice in early phase of obesity
    Warabi E; Sakai S; Suzuki E; Tomoo T; Yanagawa T; Mann GE...
    Physiology 2011/2011-07-13
  • Slowly Progressed Inflammatory Responses May Contribute to the Angiotensin II-Induced Cardiac Dysfunction
    Satoshi Sakai; Yoshimi Nakagawa; Nobutake Shimojoh; Kazuk...
    第75回 日本循環器学会総会・学術集会/2011-08-03
  • Tracking Imaging Detects Early Myocardial Contraction Abnormality in Dahl Salt-sensitive Rat
    Rumi Koshizuka; Tomoko Ishizu; Yuri Kameda; Taizo Kimura;...
    第75回 日本循環器学会総会・学術集会/2011-08-03
  • 造影剤による酸化ストレスと造影後慢性期の腎機能の関係についての検討
    田尻和子; 酒井俊; 丸山秀和; 佐藤明; 下條信威; 斉藤巧; 遠...
    腎と心血管障害研究会/2010-07-01
  • Cardiac Hypertrophy and Activation of RNA polymerase II
    Satoshi Sakai
    Seminar of Physiology in King's College London/2010-06-01
  • Deficiency of sequestosome1/p62/A170 in mice is associated with metabolic syndrome: (III) Non-dipper type hypertension.
    Warabi E; Sakai S; Suzuki E; Tomoo T; Tomoike S; Enomoto ...
    International Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species/2010-05-01
  • Deficiency of sequestosome1/p62/A170 in mice is associated with metabolic syndrome: (II) Enhanced neointimal hyperplasia and carotid artery remodeling.
    Warabi E; Sakai S; Yanagawa T; Harada H; Siow RCM; Mann G...
    International Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species/2010-05-01
  • Possible involvement of SREBP-1 in the cardiac dysfunction via reducion of anti-oxidant genes.
    Sakai S; Nakagawa Y; Shimojo N; Ishigaki N; Aonuma K; Shi...
    XXth World Congress of the International Society for Heart Research/2010-05-01
  • Possible involvement of SREBP-1 in development of angiotensin II-induced cardiac function.
    Sakai S; Simojoh N; Yoshida K; Hayashi S; Ishigaki N; Sim...
    第74回 日本循環器学会総会・学術集会/2010-03-01
  • Abnormal vascular endothelial function after pacritaxel-eluting stent implantation. A comparison among bare-metal, sirolimus- and pacritaxel-eluting stents.
    Yoshida-Tajiri K; Watanabe S; Nakagawa Y; Liang J; Seo Y;...
    第74回 日本循環器学会総会・学術集会/2010-03-01
  • Lack of Sequestosome 1 accelerates neointimal hyperplasia and carotid artery remodeling
    Satoshi Sakai; Eiji Warabi; Rika Sugimoto; Satoru Katayan...
    82th American Heart Association scientific sessions/2009-11-01
  • Can Intravascular Optical Cohenrence Tomographic Findings of Macrophage Accumulation in Atherosclerosis Lesions
    Nakagawa Y; Liang J; Watanabe S; Liang J; Tajiri K; Seo Y...
    第73回 日本循環器学会総会・学術集会/2009-03-01
  • 高血圧ガイドライン2009・改訂のポイント
    酒井 俊
    筑西医師会学術講演会/2009-04-01
  • 脂質転写調節因子SREBP-1の心機能障害および心筋線維化における役割解明
    酒井俊・下條信威・石垣直美・青沼和隆・島野仁; +酒井 俊
    第4回 高血圧と冠動脈疾患研究会/2009-12-01
  • Involvement of endothelin-1 in habitual aerobic exercise-induced increase in arterial compliance.
    Seiji Maeda; Jun Sugawara; Nobutake Shimojo; Subrina Jesm...
    The 11th APS International Conference on Endothelin/2009-09-01
  • Endothelin-1-induced cardiac hypertrophy is regulated by C-terminal domain phosphatase of RNA polymerase II
    Satoshi Sakai; Nobutake Shimojo; Takehiro Ogata; Kazutaka...
    The 11th APS International Conference on Endothelin/2009-09-01
  • Alteration of endothelial cells in patients with pulmonary arterial hypertension estimated by endothelial cell-derived microparticles.
    Maruyama H; Sakai S; Sumida T; Goto D; Kawano S; Ishizu T...
    European Society of Cardiology, Congress 2009/2009-08-01
  • 新規肥満モデルSQSTM1/A170/p62遺伝子欠損マウスはnon-dipper型血圧上昇を示す
    酒井 俊; 蕨 栄治; 稲葉博子; 原田春美; 柳川 徹; 鈴木栄子; ...
    第32回日本高血圧学会総会/2009-10-01
  • JSH2009の改定点と新規レニン・アンギオテンシン系阻害薬の話題
    酒井 俊
    茨城県立中央病院・病診連携クリニカルレクチャー/2009-09-01
Professional activities
2012 -- (current)日本肺循環学会評議員
1996 -- (current)JAPANESE HEART FAILURE SOCIETY評議員
2010 -- (current)The Japanese Pharmacological Society評議員

(Last updated: 2018-11-19)