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Watanabe Yukihide

Faculty of Medicine
Official title
Assistant Professor
Experimental Pathology
Research projects
腫瘍形成におけるTMEPAIの分子機構の解明2016 -- 2017渡邊 幸秀Japan Society for the Promotion of Science/Grant-in-Aid for Young Scientists(B)4,030,000Yen
特殊環状ペプチドを用いた抗腫瘍薬の開発2016-03 -- 2016-12渡邊幸秀上原記念生命科学財団 研究奨励金/2,000,000Yen
腫瘍形成におけるTMEPAIの分子機構の解明2016-04 -- 2018-03渡邊幸秀MEXT/科学研究費 若手B
TMEPAIの腫瘍の発生・悪性化における役割と臨床への応用2013 -- 2014渡邊 幸秀Japan Society for the Promotion of Science/若手研究(B)4,290,000Yen
Career history
2010-06 -- 2011-05University of Tsukuba 人間総合科学研究科 博士研究員
2010-04 -- 2010-06University of Tsukuba 大学院人間総合科学研究科 博士特別研究員
2008-04 -- 2010-03日本学術振興会 特別研究員(DC2)
2010-03Ph.DUniversity of Tsukuba
  • Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation.
    Watanabe Yukihide; Papoutsoglou Panagiotis; Maturi Varun;...
    J Biol Chem./291(24)/pp.12706-12723, 2016-06
  • The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.
    Raja Erna; Tzavlaki Kalliopi; Vuilleumier Robin; Edlund K...
    Oncotarget/7(2)/pp.1120-1143, 2016-01
  • Cooperative induction of transmembrane prostate androgen induced protein TMEPAI/PMEPA1 by transforming growth factor-b and epidermal growth factor signaling.
    Azami S; Vo Nguyen TT; Watanabe Yukihide; Kato M
  • Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling.
    Dahl M; Maturi V; Lönn P; Papoutsoglou P; Zieba A; Vanlan...
    PLoS One/9, 2014-08
  • Transcriptional induction of salt-inducible kinase 1 by transforming growth factor-b leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.
    Lönn P; Vanlandewijck M; Raja E; Kowanetz M; Watanabe Yuk...
    J. Biol. Chem./287/pp.12867-12878, 2012-02
  • Requirement of TCF7L2 for TGF-β-dependent transcriptional activation of the TMEPAI gene.
    Nakano N; Itoh S; Watanabe Yukihide; Maeyama K; Itoh F; K...
    J. Biol. Chem./285/pp.38023-38033, 2010-09
  • TMEPAI, a transmembrane TGF-β-inducible protein, sequesters Smad proteins from active participation in TGF-β signaling.
    Watanabe Yukihide; Itoh S; Goto T; Ohnishi E; Inamitsu M;...
    Mol. Cell./37/pp.123-134, 2010-01
  • ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrext of prostate cells.
    Noda D; Itoh S; Watanabe Yukihide; Inamitsu M; Dennler S;...
    Oncogene/25/pp.5591-5600, 2006-09
  • TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells.
    Thanh Thao Vo Nguyen; Watanabe Yukihide; Shiba Aya; Noguc...
    Cancer science/105(3)/pp.334-341, 2014-03
  • C18ORF1: A Novel Negative Regulator of TGF-β Signaling.
    Nakano Naoko; Maeyama Kota; Sakata Nobuo; Itoh Fumiko; Ak...
    JOURNAL OF BIOLOGICAL CHEMISTRY/289(18)/pp.12680-12692, 2014-05
  • TMEPAI/PMEPA1 enhances Tumorigenic Activities in Lung Cancer Cells.
    Vo Nguyen Thanh Thao; Watanabe Yukihide; Shiba Aya; Noguc...
    Cancer Sci./105/pp.334-341, 2014
  • TGF-β 解説編、TGF-β 診断編
    渡邊 幸秀
    病理診断に役立つ分子生物学/pp.432-439, 2011-01
  • がんの増殖・進展とTGF-b
    渡邊 幸秀
    慢性炎症とがん/pp.54-59, 2016-02
2014-04 -- 2016-08Human Pathologyヒューマンバイオロジー学位プログラム
2014-04 -- 2016-08人体病理学概論フロンティア医科学
2014-10 -- 2016-08細胞システム学医学群医療科学類医療科学
2014-10 -- 2017-03English Communication for Medical Sciences IIUniversity of Tsukuba.
Other educational activities
2016-01 -- 2016-01Molecular Biology Course in Ho Chi Minh CityInstutute of Tropical Biology
2015-01 -- 2015-01Molecular Biology Course in Ho Chi Minh CityInstitute of Tropical Biology
2014-03 -- 2014-03Molecular Biology Course in Ho Chi Minh CityInstutute of Tropical Biology
Other activities
2011-08 -- 2013-08頭脳循環を活性化する若手研究者海外派遣事業 派遣先:スウェーデンウプサラ大学(ルードヴィッグ癌研究所)

(Last updated: 2017-05-09)