XU Dong-Zhu
- Affiliation
- Institute of Medicine
- Official title
- Associate Professor
- ORCID
- 0000-0001-6507-1959
- KAKEN ID
- 20616651
- I/,y&%|:IE ,Czy,P/,ty&%|1},:IE$yC+*,",wvCvxC!'
- Other affiliation
Indiana University School of Medicine (USA) Division of Cardiovascular Medicine - Research fields
Cardiovascular medicine - Research projects
The role of BET bromodomain on the mechanism of Atrial fibrillation 2024-04 -- 2027-03 Dong-Zhu XU Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C) 4,680,000Yen AMED橋渡し研究戦略的推進プログラム(シーズA) 2021-04 -- 2022-03 Japan Agency for Medical Research and Development (AMED)/ 1,000,000Yen The role of Nicotinamide phosphoribosyltransferase (Nampt) in atrial fibrillation(Fostering Joint International Research) 2016-04 -- 2018-03 DongZhu XU Japan Society for the Promotion of Science(JSPS)/Grant-in-Aid for Publication of Scientific Research Results (Enhancement of International Dissemination of Information) 14,300,000Yen The role of Nicotinamide phosphoribosyltransferase (Nampt) in atrial fibrillation 2015 -- 2016 XU Dong-Zhu Japan Society for the Promotion of Science/Grant-in-Aid for Young Scientists(B) 4,030,000Yen 不整脈の発症機序解明と治療 -- (current) / Vulnerability of Atrial Fibrillation is Increased in a Rat Model of Metabolic Syndrome Via Phosphorylation of Calcium-Calmodulin-Dependent Protein Kinase II 2012-04 -- 2014-03 XU Dong-Zhu Japan Society for the Promotion of Science/Grant-in-Aid for Young Scientists(B) 4,290,000Yen - Career history
2023-12 -- (current) Indiana University School of MedicineDivision of Cardiovascular MedicineResearch Faulty 2018-07 -- (current) 筑波大学医学医療系 循環器内科准教授 2015-10 -- 2018-06 Indiana University School of MedicineKrannert Institute of CardiologyResearch fellow 2011-04 -- 2017-12 University of Tsukuba医学医療系 循環器内科助教 1999 -- 2001 中国吉林省延吉市立病院内科医師 - Academic background
2007-04 -- 2011-03 University of Tsukuba Graduate School, Division of Medicine Cardiovascular Division Institute of Clinical Medicine - Degree
2011-03 Ph.D. University of Tsukuba - Academic societies
2012-08 -- (current) 日本心臓電気生理学会 2007 -- (current) THE JAPANESE CIRCULATION SOCIETY 2005-08 -- (current) Japan Primary Care Association - Articles
- Metabolic remodeling and calcium handling abnormality in induced pluripotent stem cell-derived cardiomyocytes in dilated phase of hypertrophic cardiomyopathy with MYBPC3 frameshift mutation
Mori Haruka; Xu Dongzhu; Shimoda Yuzuno; Yuan Zixun; ...
Scientific reports/14(1), 2024-07-04 - Metabolic remodeling and calcium handling abnormality in induced pluripotent stem cell-derived cardiomyocytes in dilated phase of hypertrophic cardiomyopathy with MYBPC3 frameshift mutation
Mori Haruka; Xu Dongzhu; Shimoda Yuzuno; Yuan Zixun; ...
Scientific reports/14(1), 2024-07-04 - Impact of isorhamnetin for suppression of action potential aberrations associated with atrial fibrillation
Aonuma K.; Xu D.; Murakoshi N.; Tajiri K.; Yuan Z.; ...
EUROPEAN HEART JOURNAL/44(2), 2023-11 - An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice
Okabe Yuta; Murakoshi Nobuyuki; Kurebayashi Nagomi; In...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA/121(17), 2024-04-23 - Early Detection and Prediction of Anthracycline-Induced Cardiotoxicity - A Prospective Cohort Study
Inoue Keiko; Machino-Ohtsuka Tomoko; Nakazawa Yoko; Ii...
Circulation journal : official journal of the Japanese Circulation Society/88(5), 2024-03-08 - Rev-erb agonist improves adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism.
EN Stujanna; N Murakoshi; K Tajiri; Dong-Zhu Xu; T Kimu...
PLoS One/12(12(12)), 2017-12 - Electrical, structural, and autonomic atrial remodeling underlies atrial fibrillation in inflammatory atrial cardiomyopathy
Murakata Yoshiko; Yamagami Fumi; Murakoshi Nobuyuki; X...
FRONTIERS IN CARDIOVASCULAR MEDICINE/9, 2022-04-01 - Editorial: Directing Stem Cell Fate Using Plant Extracts and Their Bioactive Compounds
Ferdousi Farhana; Sasaki Kazunori; Xu Dongzhu; Zheng ...
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY/10, 2022-06 - Neutrophil Elastase Deficiency Ameliorates Myocardial Injury Post Myocardial Infarction in Mice
Ogura Yukino; Tajiri Kazuko; Murakoshi Nobuyuki; Xu Dong...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/22(2), 2021-01 - Neutrophil Elastase Deficiency Ameliorates Myocardial Injury Post Myocardial Infarction in Mice
Ogura Yukino; Tajiri Kazuko; Murakoshi Nobuyuki; Xu Dong...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/22(2), 2021-01 - Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation
Aonuma Kazuhiro; Xu DongZhu; Murakoshi Nobuyuki; Tajir...
CLINICAL SCIENCE/136(24)/pp.1831-1849, 2022-12-22 - Risk Factors and In-Hospital Outcomes of Perioperative Atrial Fibrillation for Patients with Cancer: A Meta-Analysis
Inoue Keiko; Tajiri Kazuko; Xu DongZhu; Murakoshi Nob...
Annals of surgical oncology, 2022-10-22 - ASO Visual Abstract: Risk Factors and In-Hospital Outcomes of Perioperative Atrial Fibrillation in Patients with Cancer: A Meta-analysis
Inoue Keiko; Tajiri Kazuko; Xu DongZhu; Murakoshi Nob...
Annals of surgical oncology, 2022-11-17 - Identification of potential dilated cardiomyopathy-related targets by meta-analysis and co-expression analysis of human RNA-sequencing datasets
Yuan Zixun; Murakoshi Nobuyuki; Xu Dongzhu; Tajiri Ka...
LIFE SCIENCES/306, 2022-07-13 - Generation of a human induced pluripotent stem cell line derived from a patient with dilated cardiomyopathy carrying LMNA nonsense mutation
Shimoda Yuzuno; Murakoshi Nobuyuki; Mori Haruka; Xu D...
STEM CELL RESEARCH/62, 2022-04-14 - Loss of nocturnal dipping pattern of skin sympathetic nerve activity during and following an extended-duration work shift in residents in training
Chen Mu; Sun Jian; Chen Tai-Zhong; Xu Dong-Zhu; Wan ...
Journal of cardiology/78(6)/pp.509-516, 2021-07-16 - Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway
Feng Duo; Xu DongZhu; Murakoshi Nobuyuki; Tajiri Kazuko; ...
International journal of molecular sciences/21(13), 2020-06 - Right bundle branch block and risk of cardiovascular mortality: the Ibaraki Prefectural Health Study
Nakazawa Naomi; Ishizu Tomoko; Sairenchi Toshimi; Yama...
HEART AND VESSELS/37(4)/pp.609-618, 2021-09 - Loss of nocturnal dipping pattern of skin sympathetic nerve activity during and following an extended-duration work shift in residents in training
Chen Mu; Sun Jian; Chen Tai-Zhong; Xu Dong-Zhu; Wan ...
Journal of cardiology/78(6)/pp.509-516, 2021-07-16 - Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats
Xu DongZhu; Murakoshi Nobuyuki; Tajiri Kazuko; Duo Feng; ...
Clinical science (London, England : 1979)/135(20)/pp.2409-2422, 2021-08-13 - Neutrophil Elastase Deficiency Ameliorates Myocardial Injury Post Myocardial Infarction in Mice
Ogura Yukino; Tajiri Kazuko; Murakoshi Nobuyuki; Xu Dong...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/22(2), 2021-01 - Programmed Death-Ligand 2 Deficiency Exacerbates Experimental Autoimmune Myocarditis in Mice
Li Siqi; Tajiri Kazuko; Murakoshi Nobuyuki; Xu DongZhu; Y...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/22(3), 2021-02 - MAIR-II deficiency ameliorates cardiac remodelling post-myocardial infarction by suppressing TLR9-mediated macrophage activation
Yonebayashi Saori; Tajiri Kazuko; Murakoshi Nobuyuki; Xu ...
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE/24(24)/pp.14481-14490, 2020-11 - Utility of Circadian Variability Patterns in Differentiating Origins of Premature Ventricular Complexes
Chen Mu; Wang Qunshan; Sun Jian; Zhang Peng-Pai; Li ...
Journal of interventional cardiology/2020, 2020-04 - Effects of Isorhamnetin in Human Amniotic Epithelial Stem Cells and Its Cardioprotective Effects
Aonuma Kazuhiro; Ferdousi Farhana; Xu DongZhu; Tominaga ...
Frontiers in cell and developmental biology/8, 2020-09 - more...
- Metabolic remodeling and calcium handling abnormality in induced pluripotent stem cell-derived cardiomyocytes in dilated phase of hypertrophic cardiomyopathy with MYBPC3 frameshift mutation
- Books
- Directing stem cell fate using plant extracts and their bioactive compounds
Isoda Hiroko; Szele Francis G.; Zheng Yun-Wen; Xu Don...
Directing stem cell fate using plant extracts and their bioactive compounds/FRONTIERS MEDIA SA, 2023 - Atrial fibrillation rat model induced by transvenous catheter pacing and PPAR-γ activator as upstream therapy for age-related atrial fibrillation
許 東洙
2011-03
- Directing stem cell fate using plant extracts and their bioactive compounds
- Conference, etc.
- Impact of isorhamnetin for suppression of action potential aberrations associated with atrial fibrillation
Aonuma K.; Xu D.; Murakoshi N.; Tajiri K.; Yuan Z.; ...
Annual Meeting of the European-Society-of-Cardiology (ESC)/2023-08-25--2023-08-28 - Deletion of EIF4EBP3 prevents heart failure progression through maintaining mitochondrial function
Yuan Zixun; Murakoshi Nobuyuki; Xu Dongzhu; Tajiri Ka...
第87回日本循環器学会学術集会/2023-03-10--2023-03-12 - Molecular Mechanisms of a Newly Established Inherited Arrhythmia Mouse Model and Its Clinical Application
岡部 雄太; 村越 伸行; 井藤 葉子; 三好 千香; 船戸 弘正; 石井 光一郎; 井上 華; 村...
第87回日本循環器学会学術集会/2023-03-10--2023-03-12 - The effect of BET inhibitor on pathogenesis of atrial fibrillation
Song Zonghu; Murakoshi Nobuyuki; Xu Dongzhu; Murakata ...
第87回日本循環器学会学術集会/2023-03-10--2023-03-12 - The therapeutic effect of BET inhibitor on atrial fibrillation
Song Zonghu; Murakoshi Nobuyuki; Xu Dongzhu; Murakata ...
Cardiovascular Metabolic Week (CVMW) 2022/2022-12-17--2022-12-17 - Heart Failure related Potential Key Molecule was Identified by Human RNA-sequencing datasets and Mouse Model
Yuan Zixun; Murakoshi Nobuyuki; Murakoshi Nobuyuki; Xu...
第26回日本心不全学会/2022-10-21--2022-10-23 - Underlying mechanisms Related with Heart Failure are Identified by Meta-Analysis and Consensus Analysis of RNA-sequencing
Yuan Zixun; Murakoshi Nobuyuki; Xu Dongzhu; Li Siqi; ...
第26回日本心不全学会/2022-10-21--2022-10-23 - Generation and Analyses of iPSC-derived Cardiomyocytes from a Dilated Phase Hypertrophic Cardiomyopathic Patient Carrying MYBPC3 Frameshift Mutation
Mori Haruka; Murakoshi Nobuyuki; Shimoda Yuzuno; Xu D...
第26回日本心不全学会/2022-10-21--2022-10-23 - Heart Failure-related Potential Molecule Identified by Bioinformatics analysis and Mouse Model
袁 梓勛; 村越 伸行; 許 東洙; 田尻 和子; 李 思琪; 村方 好子; 岡部 雄太; 宋 宗虎...
第8回日本心筋症研究会/2022-05-14--2022-05-14 - 4E-BP3 Deficiency Ameliorates the Development of Autoimmune Myocarditis in Mice.
SIQI LI; 許 東洙; Kazuko Tajiri; Nobuyuki Murakoshi
NORTH AMERICAN MEETING OF THE INTERNATIONAL SOCIETY OF HEART RESEARCH/2023-06-26--2023-06-30 - Establishment of induced pluripotent stem cell lines derived from dilated cardiomyopathic patients with LMNA mutations and generation of pathological models
Shimoda Yuzuno; Murakoshi Nobuyuki; Mori Haruka; Kobayash...
CiRA 2022 International Symposium/2022-02-16--2022-02-16 - Cardiomyopathy-Related Hub Genes and Upstream Regulators by Meta-analysis of RNA-Sequencing datasets
袁 梓勛; 村越 伸行; 許 東洙; 田尻 和子; 岡部 雄太; 李 思琪; 馮 鐸; 米林 沙織; 青沼 和宏...
第86回日本循環器学会学術集会/2022-03-13--2022-03-13 - LMNA遺伝子変異に起因する拡張型心筋症患者由来iPS細胞の樹立と病態モデルの作製
下田 柚須乃; 村越 伸行; 森 遥香; 小林 和真; 田尻 和子; 許 東洙; 佐藤 伊織; 辺見 康子; 林 ...
第21回日本再生医療学会総会/2022-03-17--2022-03-17 - Natural compound Isorhamnetin Inhibits Angiotensin II-induced Atrial Fibrillation Vulnerability Through Electrophysiological and Structural Reverse Remodeling in Mice
Aonuma Kazuhiro; Dong-Zhu Xu; Murakoshi Nobuyuki; Tajiri...
THE 85TH ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY/2021-03-26--2021-03-28 - Isorhamnetin Reverses Angiotensin II-induced Atrial Fibrillation Vulnerability Through Electrophysiological and Structural Reverse Remodeling in Mice
Dong-Zhu Xu; Aonuma Kazuhiro; Murakoshi Nobuyuki; Tajiri...
American Heart Association Scientific Sessions 2020/2020-11-13--2020-11-17 - MAIR-II deficiency ameliorates cardiac remodeling post-myocardial infarction by suppressing TLR9-mediated pro-inflammatory macrophage activation
Yonebayashi Saori; Tajiri Kazuko; Murakoshi Nobuyuki; Xu ...
Tsukuba Global Science Week 2020/2020-09-28--2020-09-30 - The role of immune checkpoints in the development of autoimmune myocarditis in mice
Li Siqi; Tajiri Kazuko; Yonebayashi Saori; Yuan Zixun; Fe...
Tsukuba Global Science Week 2020/2020-09-28--2020-09-30 - 4E-BP3 deficiency attenuates cardiac inflammation in mice with experimental autoimmune myocarditis.
Li Siqi; Tajiri Kazuko; Yonebayashi Saori; Yuan Zixun; Fe...
Tsukuba Global Science Week 2020/2020-09-28--2020-09-30 - 4E-BP3 deficiency protects against autoimmune myocarditis in mice
Li Siqi; Tajiri Kazuko; Yonebayashi Saori; Yuan Zixun; Fe...
第24回日本心不全学会学術集会/2020-10-15--2020-10-17 - 4E-BP3 Deficiency Attenuates Cardiac Inflammation in Mice with Experimental Autoimmune Myocarditis
Li Siqi; Tajiri Kazuko; Yonebayashi Saori; Yuan Zixun; Fe...
第85回日本循環器学会学術集会/2021-03-26--2021-03-28 - PD-L2 Protects Against Autoreactive CD4+ T-cell Expansion and Inflammation in Autoimmune Myocarditis in Mice
Li Siqi; Tajiri Kazuko; Yonebayashi Saori; Yuan Zixun; Ok...
CVMW2020/2021-03-12--2021-03-13 - PD-L2 Immune Checkpoint Protein Protects Against Autoimmune Myocarditis in Mice
Li Siqi; Tajiri Kazuko; Yonebayashi Saori; Yuan Zixun; Fe...
第85回日本循環器学会学術集会/2021-03-26--2021-03-28 - 翻訳開始制御分子EIF4EBP3はマウス自己免疫性心筋炎を増悪する
Li Siqi; 田尻 和子; 米林沙織; Zixun Yuan; Duo Feng; 岡部 雄太; 井上慶子; 青沼...
第3回日本腫瘍循環器学会学術集会/2020-09-11--2020-09-12 - 4E-BP3 deficiency ameliorates autoimmune myocarditis in mice
Siqi Li; 田尻 和子; 米林沙織; Zixun Yuan; 馮 鐸; 岡部雄太; 東洙 許; 村越 伸行; 家田真樹
第6回日本心筋症研究会/2020-08-21--2020-08-31 - MAIR-II deficiency improves cardiac remodeling by suppressing TLR9-mediated pro-inflammatory macrophage activation post-myocardial infarction
Yonebayashi Saori; Tajiri Kazuko; Murakoshi Nobuyuki; Xu ...
第84回日本循環器学会学術集会/2020-07-27--2020-08-02 - more...
- Impact of isorhamnetin for suppression of action potential aberrations associated with atrial fibrillation
- Teaching
2024-10 -- 2025-03 Master's Research in Life Science Innovation Ⅲ University of Tsukuba. 2024-10 -- 2025-03 Master's Research in Life Science Innovation Ⅳ University of Tsukuba. 2024-10 -- 2025-03 Life Science Innovation Master's Special Seminar I Fall University of Tsukuba. 2024-04 -- 2024-09 Master's Research in Life Science InnovationⅡ University of Tsukuba. 2024-10 -- 2025-02 Doctor's Internship II University of Tsukuba. 2024-04 -- 2024-08 Doctor's Internship II University of Tsukuba. 2024-04 -- 2024-09 Master's Research in Life Science Innovation Ⅲ University of Tsukuba. 2024-04 -- 2024-09 Master's Research in Life Science Innovation Ⅳ University of Tsukuba. 2024-10 -- 2025-03 Life Science Innovation Master's Special Research I Fall University of Tsukuba. 2024-10 -- 2025-03 Master's Research in Life Science InnovationⅠ University of Tsukuba. more... - Talks
- 『心筋梗塞後の心室頻拍に対するアブレーション治療』(Catheter ablation of postinfarction ventricular tachycardia)
DongZhu Xu; +許 東洙
第22回長城国際心臓病学会 アジア太平洋心臓大会/2011-10-15
- 『心筋梗塞後の心室頻拍に対するアブレーション治療』(Catheter ablation of postinfarction ventricular tachycardia)
(Last updated: 2024-10-15)