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Hayata Tadayoshi

Affiliation
Faculty of Medicine
Official title
Associate Professor
Email
 
Office
高細精医療イノベーション棟
Research fields
Developmental biology
Orthopaedic surgery
Functional basic dentistry
Research keywords
Bone Metabolism
Cartilage Metabolism
Pharmacology
Developmental Medicine
Mechanobiology
Molecular Biology
Cell Biology
Research projects
筋骨格系疾患に関する研究2017-04 -- 2018-03早田 匡芳ファイザー株式会社/Academic Contributions500000
骨粗鬆症領域における基礎医学研究2017-08 -- 2018-03早田匡芳中外製薬株式会社/研究活動への支援200000
骨粗鬆症における小胞体ストレス応答の解明2017-08 -- 2018-03早田匡芳東京医科歯科大学/東京医科歯科大学難治疾患共同研究拠点共同研究課題400000
「筋骨格系疾患領域」に対する研究2016-04 -- 2017-04早田匡芳アステラス製薬株式会社/Research Support500000
筋骨格系疾患に関する研究2016-04 -- 2017-03早田匡芳ファイザー株式会社/Academic Contributions500000
力学的刺激を模倣する新型骨粗鬆症治療薬の開発を目指した力覚情報処理機構の解明2015-11 -- 2016-09早田匡芳公益財団法人住友電工グループ社会貢献基金/学術・研究助成1150000
力覚情報を骨形成へ変換する情報処理機構の分子基盤の解明と新型骨粗鬆治療薬開発への応用2015-11 -- 2016-12早田匡芳公益財団法人持田記念医学薬学振興財団/持田記念研究助成金3000000
力学的負荷を模倣する新型骨粗鬆症治療薬の開発を目指した力覚情報処理機構の解明2015-09 -- 2016-09早田匡芳the Ichiro Kanehara Foundation/第30回基礎医学医療研究助成金500000
筋骨格系疾患に関する研究2015-04 -- 2016-03早田匡芳ファイザー株式会社/Academic Contributions500000
骨粗鬆症における選択的スプライシング機構の解析2015-04 -- 2016-03早田匡芳中冨健康科学振興財団研究助成/1500000
Career history
2000-04 -- 2001-06東京大学大学院 総合文化研究科広域科学専攻生命環境科学系 日本学術振興会特別研究員
2001-06 -- 2002-03University of California, Irvine Department of Developmental & Cell Biology 日本学術振興会特別研究員
2002-04 -- 2005-08University of California, Irvine Department of Developmental & Cell Biology Postgraduate Researcher
2005-09 -- 2014-04Tokyo Medical & Dental University Medical Research Institute Assistant Professor
2008-01 -- 2008-03Harvard Medical School Department of Genetics Visiting Scholar
2014-05 -- 2014-11筑波大学 教育イニシアティブ機構 准教授
2014-12 -- (current)筑波大学 Department of Biological Signaling and Regulation, Division of Biomedical Sciences, Faculty of Medicine Associate Professor
Academic background
1988-04 -- 1991-03茨城県立下館第一高等学校Graduated
1992-04 -- 1994-03東京大学 教養学部 理科二類
1994-04 -- 1996-03The University of Tokyo Faculty of Science Department of Biology (animal)Graduated
1996-04 -- 1998-03The University of Tokyo Graduate School of Arts and Sciences Department of Life Sciences, Master courseCompleted
1998-04 -- 2001-03The University of Tokyo Graduate School of Arts and Sciences Department of Life Sciences, Doctor courseCompleted
Degree
2001-03PhDThe University of Tokyo
Licenses and qualifications
2013-09TOEIC score 970
Academic societies
2016-08 -- (current)The Japanese Pharmacological Society
2015-05 -- (current)日本骨免疫学会
2014 -- (current)Japan Society of Cartilage Metabolism
2013 -- (current)International Society for Bone and Mineral Research
2013-08 -- (current)The Molecular Biology Society of Japan
2013 -- (current)Japanese Society of Developmental Biologists
2010-09 -- 2012-05The Molecular Biology Society of Japan
2008 -- (current)Japanese Society for Bone and Mineral Research
2008 -- (current)JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
2007 -- (current)American Society for Bone and Mineral Research
Honors & Awards
2016-02第21回日本軟骨代謝学会賞第29回日本軟骨代謝学会
2015-08OUTSTANDING POSTER AWARD12th Bone Biology Forum
2014-09Plenary Poster PresentationAnnual meeting of American Society for Bone and Mineral Research
2013-10Poster AwardThe 3rd international symposium by JSPS Core-to-Core Program “Cooperative International Framework in TGF-ß Family Signaling
2012-07ANZBMS Travel Award第30回日本骨代謝学会学術集会
2009-09Plenary Poster PresentationAnnual meeting of American Society for Bone and Mineral Research
Articles
Books
  • Mechanical Stress and Bone
    Noda M; Hayata Tadayoshi; Nakamoto T; Notomi T; Ezura Y
    Mechanosensing Biology/pp.71-86, 2011
  • Finding Gene Expression Changes using Microarray Technology.
    Hayata Tadayoshi; Cho KW
    Principles of Developmental Genetics/pp.32-44, 2007
  • 両生類のクローン研究と再生工学
    早田 匡芳; 浅島 誠
    生命工学—新しい生命へのアプローチ/pp.218-227, 2002
Conference, etc.
  • Dullard deficiency causes hemorrhage in the adult ovarian follicles.
    Hayata Tadayoshi; Masahiko C Ezura Y Asashima M Katabuchi...
    第50回日本発生生物学会/2017-05-11--2017-05-13
  • Skeletal anomaly caused by the phosphatase Dullard gene deficiency is ameliorated by administration of TGF-β receptor inhibitor.
    早田 匡芳; 江面 陽一; 浅島 誠; 西中村 隆一; 野田 政樹
    第90回日本薬理学会年会/2017-03-15--2017-03-17
  • Profilin1 Deficiency in Osteoclasts Causes Osteolytic Erlenmeyer-Flask Deformity of the Femurs Due to the Increased Migratory Potential.
    Shirakawa J; Ezura Y; Hayata Tadayoshi; Izu Y; Botcher R;...
    American Society for Bone and Mineral Research/2016-09-16--2016-09-19
  • Osteoclasts require the Profilin1 for postnatal skeletal growth, remodeling and homeostasis.
    Shirakawa J; Böttcher RT; Hayata Tadayoshi; Izu Y; Fässle...
    The Joint Annual Scientific Meetings of the Endocrine Society of Australia and the Society for Reproductive Biology and the Australian and New Zealand Bone and Mineral Society/2016-08-21--2016-08-24
  • Dullard/Ctdnep1遺伝子は、TGF-βシグナルの抑制を介して、内軟骨性骨化を制御する
    早田 匡芳; 江面 陽一; 浅島 誠; 西中村 隆一; 野田 政樹
    第21回日本軟骨代謝学会/2016-02-19--2016-02-20
  • Dokアダプターによる破骨細胞の分化制御機構
    梶川 修平; 田口 祐; 早田 匡芳; 江面 陽一; 有村 純暢; 井上...
    第38回 日本分子生物学会年会/2015-12-01--2015-12-04
  • Ciliary Protein BBS3 is required for normal patterning of cranial base.
    Kawasaki M; Hayata Tadayoshi; Izu Y; Ezura Y; Noda M
    Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting 2015/2015-11-01--2015-11-04
  • 副甲状腺ホルモン(PTH)による骨量増加作用に対するTobの機能解析
    守屋 秀一; 早田 匡芳; 伊豆 弥生; 江面 陽一; 鈴木 亨; 金子...
    第30回日本整形外科学会基礎学術集会/2015-10-22--2015-10-23
  • Bardet-Biedl Syndrome 3 Is Involved in the Development of Cranial Base.
    Kawasaki M; Hayata Tadayoshi; Izu Y; Ezura Y; Noda M
    American Society for Bone and Mineral Reserch 2015 Annual Meeting/2015-10-09--2015-10-12
  • Interleukin-1β Suppresses Expression of Osteoblastic Genes as well as the Regulators of Ecto-nucleotides and Pyrophosphate That Negatively Regulate Bio-mineralization in Mouse Bone Marrow Stromal Cells.
    Ezura Y; Hatta A; Shin L; Izu Y; Hayata Tadayoshi; Noda M
    American Society for Bone and Mineral Reserch 2015 Annual Meeting/2015-10-09--2015-10-12
  • Negative regulation of TGF-β signaling by Dullard is required for endochondral ossification.
    Hayata Tadayoshi; Ezura Y; Asashima M; Nishinakamura R; N...
    12th Bone Biology Forum/2015-08-21--2015-08-22
  • 一次繊毛関連分子BBS3の頭蓋顔面領域における骨格形成制御
    川崎 真希理; 早田 匡芳; 伊豆 弥生; 江面 陽一; 野田 政樹
    第33回日本骨代謝学会学術集会/2015-07-23--2015-07-25
  • 脱リン酸化酵素Dullard/Ctdnep1は、TGF-βシグナルの抑制を介してマウス内軟骨性骨化を制御する
    早田 匡芳; 江面陽一; 浅島誠; 西中村隆一; 野田政樹
    第1回日本骨免疫学会/2015-06-30--2015-07-02
  • Dullard/Ctdnep1 regulates endochondral ossification via suppression of TGF-ß signaling.
    Hayata Tadayoshi; Ezura Y; Asashima M; Nishinakamura R; N...
    13th Congress of the International Society of Bone Morphometry/2015-04-27--2015-04-29
  • β2-adrenergic receptor expression in osteoblastic MC3T3-E1 cells is regulated by PTH
    Moriya S; Hayata Tadayoshi; Yamada T; Shirakawa J; Kawasa...
    13th Congress of the International Society of Bone Morphometry/2015-04-27--2015-04-29
  • BMP-induced alkaline phosphatase expression in osteoblast-like MC3T3E1 cells is suppressed by β2 adrenergic receptor activation
    Yamada T; Ezura Y; Hayata Tadayoshi; Moriya S; Shirakawa ...
    13th Congress of the International Society of Bone Morphometry/2015-04-27--2015-04-29
  • TGF-beta impairs cilia morphology via suppression of Ift88 expression in chondrocytic ATDC5 cells.
    Kawasaki M; Hayata Tadayoshi; Nakamoto T; Notomi T; Moriy...
    13th Congress of the International Society of Bone Morphometry/2015-04-27--2015-04-29
  • Morphological and dynamic analysis of migration linked to FUCCI-indicated cell cycle under the influence of PTH and mechanical flow signals.
    Shirakawa J; Ezura Y; Moriya S; Kawasaki M; Yamada T; Not...
    13th Congress of the International Society of Bone Morphometry/2015-04-27--2015-04-29
  • Dullard regulates endochondral ossification via suppression of TGF- β signaling.
    早田 匡芳; 江面陽一; 浅島誠; 西中村隆一; 野田政樹
    第28回日本軟骨代謝学会/2015-03-06--2015-03-07
Teaching
2017-04 -- 2017-09Doctor's Internship SpringUniversity of Tsukuba.
2017-10 -- 2018-03Life Science Innovation Doctor's Special Seminar II FallUniversity of Tsukuba.
2017-10 -- 2018-03Master's Internship Abroad FallUniversity of Tsukuba.
2017-04 -- 2017-09Life Science Innovation Doctor's Special Seminar III SpringUniversity of Tsukuba.
2017-10 -- 2018-03Doctor's Internship FallUniversity of Tsukuba.
2017-10 -- 2018-03Life Science Innovation Master’s Special Seminar II FallUniversity of Tsukuba.
2017-10 -- 2018-03Life Science Innovation Doctor's Special Seminar III FallUniversity of Tsukuba.
2017-04 -- 2017-09Doctor's Internship Abroad SpringUniversity of Tsukuba.
2017-10 -- 2018-03Life Science Innovation Doctor's Special Research III FallUniversity of Tsukuba.
2017-10 -- 2018-03Life Science Innovation Doctor's Special Research II FallUniversity of Tsukuba.
Talks
  • 科学者という仕事
    早田 匡芳
    茨城県立下館第一高等学校 キャリアパス教育講演会/2017-05-18
University Management
2016-04 -- (current)筑波大学大学院ライフイノベーション学位プログラム教務委員会委員長
2016-04 -- (current)筑波大学大学院ライフイノベーション学位プログラム財務委員会委員
2016-04 -- 2016-12つくばグローバルサイエンスウィーク実施委員会委員
2015-04 -- 2016-03筑波大学大学院ライフイノベーション学位プログラム教務委員会 委員
2015-04 -- 2016-03筑波大学大学院ライフイノベーション学位プログラム財務委員会委員長
2014-05 -- 2015-03筑波大学大学院ライフイノベーション学位プログラム開設準備室教育課程の編成
Other activities
-- (current)Peer-review Journal of Bone Mineral Research, International Journal of Developmental Biology, KEIO SFC Journal
Message
We study molecular and cellular biology of the skeleton with a view to finding new treatments for skeletal disorders including osteoporosis, osteoarthritis and skeletal dysplasia. As aging, bone mass decreases and fracture risk increases. QOL (quality of life) and life prognosis of the patients who have bone fracture and become bedridden significantly decrease.Therefore, maintaining bone health is very important for super-aging societies. We use molecular, cellular and chemical biology approaches to investigate how bone cells including osteoblasts, chondrocytes, osteoclasts differentiate and how the bone mass is maintained in adults and is decreased in the elderly. Identifying molecules responsible for bone mass maintenance has a practical significance. If our approach is successful, it should be possible to apply our research achievement to therapy and drug development.

(Last updated: 2017-08-31)