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Doki Kosuke

Affiliation
Faculty of Medicine
Official title
Assistant Professor
Research projects
新規経口抗凝固薬の血中薬物濃度を指標とした個別投与設計法の構築2016 -- 2018土岐 浩介Japan Society for the Promotion of Science/Grant-in-Aid for Young Scientists(B)3900000
Career history
2009-05 -- 2014-10筑波大学附属病院 病院講師
2014-11 -- (current)筑波大学 医学医療系 講師
Academic background
-- 2000-03北海道薬科大学 薬学部 生物薬学科
-- 2002-03北海道薬科大学 薬学研究科 臨床薬学
-- 2007-03筑波大学 人間総合科学研究科 疾患制御医学
Degree
2002-03修士(臨床薬学)北海道薬科大学
2007-03博士(医学)筑波大学
Licenses and qualifications
2000-06薬剤師
2007-01日本医療薬学会認定薬剤師
2010-01日本臨床薬理学会認定薬剤師
2010-12日本医療薬学会指導薬剤師
2013-01日本臨床薬理学会指導薬剤師
Academic societies
-- (current)THE PHARMACEUTICAL SOCIETY OF JAPAN
-- (current)JAPANESE SOCIETY OF PHARMACEUTICAL HEALTH CARE AND SCIENCES
-- (current)THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
-- (current)THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS
-- (current)日本TDM学会
-- (current)THE JAPANESE CIRCULATION SOCIETY
Honors & Awards
2007日本TDM学会 平成19年度 海老原賞
2012日本TDM学会 第29回日本TDM学会・学術大会 最優秀演題賞
2013日本臨床薬理学会 第34回日本臨床薬理学会学術総会 優秀演題賞
2015日本TDM学会 第32回日本TDM学会・学術大会 優秀演題賞(口演)
2017日本薬学会 平成29年度日本薬学会関東支部奨励賞
Articles
  • Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation-dependent effect of achlorhydria
    Doki Kosuke; Darwich Adam S; Patel Nikunjkumar; Rostami-H...
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences/109/pp.111-120, 2017-08
  • Guidelines for Therapeutic Drug Monitoring of Cardiovascular Drugs Clinical Use of Blood Drug Concentration Monitoring (JCS 2015) - Digest Version.
    Doki Kosuke; Homma Masato
    Circulation journal/81(4)/pp.581-612, 2017-05
  • Improved Open-Well Stability of Affinity Column-Mediated Immunoassay Reagent for Determining Blood Tacrolimus
    Suzuki Yoshiharu; Kohno Keisuke; Doki Kosuke; Ohkohchi No...
    Ther Drug Monit/39(2)/pp.202-203, 2017-04
  • beta 1-Adrenergic receptor Arg389Gly polymorphism affects the antiarrhythmic efficacy of flecainide in patients with coadministration of beta-blockers
    Doki Kosuke; Sekiguchi Yukio; Kuga Keisuke; Aonuma Kazuta...
    PHARMACOGENETICS AND GENOMICS/26(10)/pp.481-485, 2016-10
  • 循環器薬の薬物血中濃度モニタリングに関するガイドライン, 日本循環器学会/日本TDM学会合同ガイドライン(2013-2014年度合同研究班報告)
    土岐 浩介
    循環器病ガイドシリーズ/pp.3-89, 2016-02
  • 優秀演題賞を受賞して「プロパフェノンのTDMにおける採血時間の検討」
    土岐 浩介
    TDM研究/32(4)/p.218, 2015-12
  • Serum flecainide S/R ratio reflects the CYP2D6 genotype and changes in CYP2D6 activity
    Kousuke Doki; Yukio Sekiguchi; Keisuke Kuga; Kazutaka Aon...
    Drug Metabolism and Pharmacokinetics/30(4)/pp.257-262, 2015-08
  • 臨床試験のモニタリングと監査に関するガイドライン
    土岐 浩介
    臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS/46(3)/p.133, 2015-05
  • A Survey on Trial Site Visit Activities of Clinical Research Associates: A Consideration Toward Improving the Efficiency of Clinical Trials
    飯村 美波; 土岐 浩介; 嶋田 沙織; 鶴嶋 英夫; 松村 明; 本間...
    Jpn. J. Clin. Pharmacol. Ther./46(2)/pp.71-75, 2015
  • Stereoselective analysis of flecainide enantiomers using reversed-phase liquid chromatography for assessing CYP2D6 activity
    Kousuke Doki; Sekiguchi Yukio; Kuga Keisuke; Aonuma Kazut...
    BIOMEDICAL CHROMATOGRAPHY/28(9)/pp.1193-1198, 2014-09
  • SCN5A promoter haplotype affects the therapeutic range for serum flecainide concentration in Asian patients
    Doki Kosuke
    Pharmacogenet Genomics/23(7)/pp.349-354, 2013
  • CYP2D6 genotype affects age-related decline in flecainide clearance: a population pharmacokinetic analysis
    Doki Kosuke
    Pharmacogenet Genomics/22(11)/pp.777-783, 2012
  • Difference in blood tacrolimus concentration between ACMIA and MEIA in samples with low haematocrit values
    Doki Kosuke
    J Pharm Pharmacol/62(9)/pp.1185-1188, 2010
  • Open-well stability of reagent cartridge for affinity column-mediated immunoassay of blood tacrolimus concentration
    Doki Kosuke
    Clin Chim Acta/411(11-12)/pp.888-889, 2010
  • Effects of CYP2D6 genotypes on age-related change of flecainide metabolism: involvement of CYP1A2-mediated metabolism
    Doki Kosuke
    Br J Clin Pharmacol/68(1)/pp.89-96, 2009
  • Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy
    Doki Kosuke
    Br J Clin Pharmacol/67(1)/pp.44-49, 2009
  • Investigation of glucocorticoid-induced side effects in patients with autoimmune diseases
    土岐 浩介
    Yakugaku Zasshi/129(4)/pp.445-450, 2009
  • 処方オーダーシステムと連動した麻薬管理システムの導入と評価
    土岐 浩介
    日本病院薬剤師会雑誌/45/pp.1099-1101, 2009
  • Impact of CYP3A5 genetic polymorphism on pharmacokinetics of tacrolimus in healthy Japanese subjects
    Doki Kosuke
    Br J Clin Pharmacol/66(1)/pp.154-155, 2008
  • Impact of serum flecainide level on control of atrial fibrillation in a case treated with cardiac resynchronization therapy
    Doki Kosuke
    J Clin Pharm Ther/32(4)/pp.409-411, 2007
  • Gender-associated differences in pharmacokinetics and anti-arrhythmic effects of flecainide in Japanese patients with supraventricular tachyarrhythmia
    Doki Kosuke
    Eur J Clin Pharmacology./63(10)/pp.951-957, 2007
  • Effect of CYP2D6 genotype on flecainide pharmacokinetics in Japanese patients with supraventricular tachyarrhythmia
    Doki Kosuke
    Eur J Clin Pharmacol/62(11)/pp.919-926, 2006
  • Assessment of serum flecainide trough levels in patients with tachyarrhythmia
    Doki Kosuke
    J Pharm Pharmacol/57(1)/pp.47-51, 2005
  • Drug interaction of tizanidine and fluvoxamine
    Doki Kosuke
    Clin Pharmacol Ther/76(5), 2004
  • Simultaneous determination of serum flecainide and its metabolites by using high performance liquid chromatography
    Doki Kosuke
    J Pharm Biomed Anal/35(5)/pp.1307-1312, 2004
Books
  • 治療薬物モニタリング(TDM)
    Doki Kosuke
    標準薬剤学 改訂第4版, 2017-04
  • 治療薬物モニタリング各論 循環器用薬
    土岐 浩介
    個別化医療を目指した臨床薬物動態学/pp.238-254, 2016-03
Teaching
2017-04 -- 2017-08Advanced Exercise on Public HealthUniversity of Tsukuba.
2017-10 -- 2018-02Advanced Exercise on Public HealthUniversity of Tsukuba.
2017-04 -- 2017-08Internship IIUniversity of Tsukuba.
2017-10 -- 2018-02Internship IIUniversity of Tsukuba.
2017-10 -- 2018-02Seminar on Basic Medical SciencesUniversity of Tsukuba.
2017-04 -- 2017-08Seminar on Basic Medical SciencesUniversity of Tsukuba.
2018-01 -- 2018-02Introduction for clinical pharmacologyUniversity of Tsukuba.
2017-04 -- 2017-08Dissertation in Medical SciencesUniversity of Tsukuba.
2017-10 -- 2018-02Dissertation in Medical SciencesUniversity of Tsukuba.
2017-10 -- 2017-12Pharmaceutical SciencesUniversity of Tsukuba.

(Last updated: 2017-09-19)