Oishi Motoi

Affiliation

Faculty of Pure and Applied Sciences

Official title

Associate Professor

URL

http://www.ims.tsukuba.ac.jp/~oishi_lab/

Research projects

ナノ粒子の界面設計に基づいたDNAウォーカーによる感染症のその場診断法の開発	2020 -- 2022	大石 基	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B)	18,070,000Yen
DNAクリック連鎖反応に最適なナノ界面の構築によるアルツハイマーの客観的早期診断	2015 -- 2017	大石　基	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,940,000Yen
刺激応答性ポリサイラミン/ポリエチレングリコールブロック共重合体によるインテリジェントセンサーおよび薬物キャリアの創製	2006-03 -- (current)		熊谷科学技術振興財団/国内共同研究	1,000,000Yen
siRNAのピンポイントデリバリーを可能とする高分子ナノ組織体の創製	2006-04 -- (current)		細胞科学研究財団/国内共同研究	3,000,000Yen
中性子捕捉療法を可能とする高分子ボロン会合体の創製	2007-10 -- (current)		公益信託三菱化学/国内共同研究	1,000,000Yen
ピンポイント中性子捕捉療法を目指したPEG化ホウ素ナノゲル粒子によるDDS	2007-12 -- (current)		財団法人東京生化学研究会/国内共同研究	1,500,000Yen
医工学連携によるガンのピンポイント診断・治療を目指したナノデバイスの創製	2009-12 -- (current)		財団法人国際科学技術財団/国内共同研究	1,000,000Yen
ガンのピンポイントイメージング・治療を可能とする金コロイド内包型PEG化ナノゲル粒子の創製	2009-04 -- (current)		財団法人宇部興産学術振興財団/国内共同研究	1,000,000Yen
１９Ｆ－ＮＭＲタグを有する磁性ナノ粒子による多次元化遺伝子診断システムの開発	2012 -- 2014		Japan Society of for the Promotion of Science/基盤研究(C)	3,900,000Yen
体内での核酸の送達・可視化・定量を目指した金ナノ粒子内包型デバイスの設計と創製	2010 -- 2011		Japan Society of for the Promotion of Science/若手研究(B)	4,160,000Yen

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Honors & Awards

2008-05-29

高分子研究奨励賞

Articles

• Simple Single-Legged DNA Walkers at Diffusion-Limited Nanointerfaces of Gold Nanoparticles Driven by a DNA Circuit Mechanism
  Oishi Motoi; Saito Kosuke
  ACS Nano/14(3)/pp.3477-3489, 2020-2
  PubMed
• Dynamically Programmed Switchable DNA Hydrogels Based on a DNA Circuit Mechanism
  Oishi Motoi; Nakatani Kazuki
  Small (Weinheim an der Bergstrasse, Germany)/15(15), 2019-03
  PubMed
• Comparative Study of DNA Circuit System-Based Proportional and Exponential Amplification Strategies for Enzyme-Free and Rapid Detection of miRNA at Room Temperature
  Oishi Motoi
  ACS OMEGA/3(3)/pp.3321-3329, 2018-03
  PubMed Tsukuba Repository
• An Efficient Particle-Based DNA Circuit System: Catalytic Disassembly of DNA/PEG-Modified Gold Nanoparticle-Magnetic Bead Composites for Colorimetric Detection of miRNA
  Oishi Motoi; Sugiyama Satomi
  Small/12(37)/pp.5153-5158, 2016-07
  PubMed
• Synthesis, characterization, and biomedical applications of core-shell-type stimuli-responsive nanogels - Nanogel composed of poly[2-(N,N-diethylamino)ethyl methacrylate] core and PEG tethered chains
  Oishi Motoi; Nagasaki Yukio
  REACTIVE & FUNCTIONAL POLYMERS/67(11)/pp.1311-1329, 2007-11
• Enzyme-Free and Isothermal Detection of microRNA Based on Click-Chemical Ligation-Assisted Hybridization Coupled with Hybridization Chain Reaction Signal Amplification
  Oishi Motoi
  Analytical and Bioanalytical Chemistry/407(14)/pp.4165-4172, 2015-05
  PubMed
• Kinetic study of DNA hybridization on DNA-modified gold nanoparticles with engineered nano-interfaces
  Takashima Akari; Oishi Motoi
  RSC ADVANCES/5(93)/pp.76014-76018, 2015
• Ultrasensitive Detection of DNA and RNA Based on Enzyme-Free Click Chemical Ligation Chain Reaction on Dispersed Gold Nanoparticles
  Kato Daiki; Oishi Motoi
  ACS NANO/8(10)/pp.9988-9997, 2014-10
• Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles
  Yasui Hironobu; Takeuchi Ryo; Nagane Masaki; Meike Shunsu...
  Cancer Letter/347(1)/pp.151-158, 2014
  PubMed
• Enzyme-free fluorescent-amplified aptasensors based on target-responsive DNA strand displacement via toehold-mediated click chemical ligation
  Oishi Motoi; Nakao Shingo; Kato Daiki
  CHEMICAL COMMUNICATIONS/50(8)/pp.991-993, 2014-01
• Rational Design of a Fluorescence-Amplified Aptasensor Based on Enzyme-Assisted Target Recycling Strategy
  Nakao Shingo; Oishi Motoi
  Chemistry Letters/42(10)/pp.1122-1124, 2013-10
  CiNii
• Pharmacokinetics of core-polymerized, boron-conjugated micelles designed for boron neutron capture therapy for cancer
  Sumitani Shogo; Oishi Motoi; Yaguchi Tatsuya; Murotani Hi...
  BIOMATERIALS/33(13)/pp.3568-3577, 2012-05
  PubMed Tsukuba Repository
• Dependence of the swelling behavior of a pH-responsive PEG-modified nanogel on the cross-link density
  Tamura Goshu; Shinohara Yuya; Tamura Atsushi; Sanada Yusu...
  POLYMER JOURNAL/44(3)/pp.240-244, 2012-03
  CiNii
• Pharmacokinetics of Core-Polymerized, Boron-Conjugated Micelles Designed for Boron Neutron Capture Therapy for Cancer
  Shogo Sumitani; Motoi Oishi; Tatsuya Yaguchi; Hiroki Muro...
  Biomaterials/33/p.3568-3577, 2012-01
• Carborane confined nanoparticles for boron neutron capture therapy: Improved stability, blood circulation time and tumor accumulation
  Sumitani Shogo; Oishi Motoi; Nagasaki Yukio
  REACTIVE & FUNCTIONAL POLYMERS/71(7)/pp.684-693, 2011-07
• Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid
  Hatakeyama Hiroto; Akita Hidetaka; Ito Erika; Hayashi Yas...
  BIOMATERIALS/32(18)/pp.4306-4316, 2011-06
• Carborane Confined Nanoparticles for Boron Neutron Capture Therapy: Improved Stability, Blood Circulation Time and Tumor Accumulation
  Shogo Sumitani; Motoi Oishi; and Yukio Nagasaki
  Reactive & Functional Polymers/71/p.684-693, 2011-01
• Efficient siRNA delivery based on PEGylated and partially quaternized polyamine nanogels: Enhanced gene silencing activity by the cooperative effect of tertiary and quaternary amino groups in the core
  Tamura Atsushi; Oishi Motoi; Nagasaki Yukio
  JOURNAL OF CONTROLLED RELEASE/146(3)/pp.378-387, 2010-09
  PubMed
• Nanodevices in pinpoint cancer diagnostic and therapy : current status and future prospects
  大石 基
  バイオマテリアル : 生体材料 : Journal of Japanese Society for Biomaterials/28(3)/pp.163-164, 2010-07
  CiNii
• Stimuli-responsive smart nanogels for cancer diagnostics and therapy
  Oishi Motoi; Nagasaki Yukio
  NANOMEDICINE/5(3)/pp.451-468, 2010-04
• Large payloads of gold nanoparticles into the polyamine network core of stimuli-responsive PEGylated nanogels for selective and noninvasive cancer photothermal therapy
  Nakamura Takahito; Tamura Atsushi; Murotani Hiroki; Oishi...
  NANOSCALE/2(5)/pp.739-746, 2010-01
  PubMed
• Preparation and Molecular Recognition of SERS Probe Based on Gold Nanoparticles Constructed from PEG-Oligoamine Copolymer Possessing a Coumarin Group between PEG and Oligoamine
  Furusho Hitoshi; Oishi Motoi; Kishi Tetsuo; Yasumori Atsu...
  CHEMISTRY LETTERS/39(1)/pp.52-53, 2010-01
  CiNii
• Stimuli-Responsive Smart Nanogels for Cancer Diagnostics and Therapy
  Oishi Motoi; Nagasaki Yukio
  Nanomedicine/5(3)/pp.451-468, 2010-01
  PubMed
• A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo
  Hatakeyama Hiroto; Ito Erika; Akita Hidetaka; Oishi Motoi...
  JOURNAL OF CONTROLLED RELEASE/139(2)/pp.127-132, 2009-10
• Enhanced Cytoplasmic Delivery of siRNA Using a Stabilized Polyion Complex Based on PEGylated Nanogels with a Cross-Linked Polyamine Structure
  Tamura Atsushi; Oishi Motoi; Nagasaki Yukio
  BIOMACROMOLECULES/10(7)/pp.1818-1827, 2009-07

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Books

• 光学活性ケイ素化合物の重合による光学活性および立体規則性ポリシロキサンの合成
  大石 基; 川上 雄資
  高分子加工, 2000-01
• RNAi法とアンチセンス法—RNAの科学と応用(3-5, アンチセンス法による遺伝子治療—ナノ粒子による遺伝子治療)
  大石 基; 長崎 幸夫; 片岡 一則
  講談社, 2005-01
• Polymeric Drug Delivery Systems "Functional PEG for drug delivery Chapter 2"
  Motoi Oishi; Yukio Nagasaki; and Kazunori Kataoka
  Taylor & Francis Group, 2005-01
• 「医療ゲルの最新技術と開発—バイオミメティックゲルの応用」応用編】第６章　ナノゲルによるピンポイント治療・診断システムへの展開
  大石 基; 長崎 幸夫
  シーエムシー出版, 2008-01
• “Block Copolymer Synthesis for Nanoscale Drug and Gene Delivery” Chapter 2 in the book entitled “Nanotechnology in Drug Delivery”
  Moyoi Oishi anf Yukio Nagasaki; +大石 基
  Springer-Verlag Inc. New York, 2008-01
• PEG-siRNA Conjugate Bearing 27 bp siRNA to Form Novel PEGylated Polyplexes with Improved Stability
  Tatsumi Taiga; Oishi Motoi; Kataoka Kazunori; Nagasaki Yukio
  TRANSACTIONS OF THE MATERIALS RESEARCH SOCIETY OF JAPAN, VOL 33, NO 3, MATERIALS RESEARCH SOCIETY JAPAN-MRS-J, pp.807-810, 2008-01
• Application of Stimuli-Responsive Nanogels for High-Performance Nanoreactor and Nanoreservoir of Gold Nanoparticles
  Nakamura Takahito; Oishi Motoi; Nagasaki Yukio
  TRANSACTIONS OF THE MATERIALS RESEARCH SOCIETY OF JAPAN, VOL 33, NO 3, MATERIALS RESEARCH SOCIETY JAPAN-MRS-J, pp.799-802, 2008-01

Conference, etc.

• Runtime DVFS Control with instrumented code in Power-scalable Cluster System
  Tatsumi Taiga; Oishi Motoi; Kataoka Kazunori; Nagasaki Yukio
  Joint Symposium of the Materials-Research-Society-of-Japan
• Application of Stimuli-Responsive Nanogels for High-Performance Nanoreactor and Nanoreservoir of Gold Nanoparticles
  Nakamura Takahito; Oishi Motoi; Nagasaki Yukio
  Joint Symposium of the Materials-Research-Society-of-Japan
• POLY 549-pH-Responsive PEGylated nanogels as smart nanodevice for cancer diagnosis and therapy
  Oishi Motoi; Nagasaki Yukio
  236th National Meeting of the American-Chemical-Society/2008-08
• Development of Efficient siRNA Delivery System to Tumor Cells by Combining Octaarginine, GALA and Enzymatically-Cleavable PEG-Lipid
  Sakurai Yu; Hatakeyama Hiroto; Akita Hidetaka; Oishi Moto...
  12th Annual Meeting of the American Society of Gene Therapy/2009-05

Teaching

2020-10 -- 2021-02	Research in Chemistry and Engineering of Materials and Biomaterials VA	University of Tsukuba.
2020-10 -- 2021-02	Research in Chemistry and Engineering of Materials and Biomaterials IIIA	University of Tsukuba.
2020-04 -- 2020-08	Research in Chemistry and Engineering of Materials and Biomaterials VA	University of Tsukuba.
2020-04 -- 2020-08	Research in Chemistry and Engineering of Materials and Biomaterials IVB	University of Tsukuba.
2020-10 -- 2021-02	Research in Chemistry and Engineering of Materials and Biomaterials IA	University of Tsukuba.
2020-04 -- 2020-08	Research in Chemistry and Engineering of Materials and Biomaterials VB	University of Tsukuba.
2020-10 -- 2021-02	Research in Chemistry and Engineering of Materials and BiomaterialsIVA	University of Tsukuba.
2020-10 -- 2021-02	Research in Chemistry and Engineering of Materials and Biomaterials VB	University of Tsukuba.
2020-10 -- 2021-02	Research in Chemistry and Engineering of Materials and BiomaterialsVA	University of Tsukuba.
2020-04 -- 2020-08	Research in Chemistry and Engineering of Materials and Biomaterials VA	University of Tsukuba.

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(Last updated: 2020-03-30)