Chiba Tomoki

Affiliation

Faculty of Life and Environmental Sciences

Official title

Professor

Research fields

Molecular biology

Cell biology

Research keywords

Ubiquitin

posttranslational modification

protein degradation

stress response

Research projects

The Biology of the Ubiquitin system	-- (current)		/Grant-in-Aid for Scientific Research
プロテアソーム活性化因子の機能的相互作用の解析	2011 -- 2013		Japan Society of for the Promotion of Science/基盤研究(C)	4,420,000Yen
ユビキチンシステムの個体生物学	2006 -- 2010		Ministry of Education, Culture, Sports, Science and Technology, Japan/特定領域研究	55,300,000Yen

Career history

2005-11 -- (current)	University of Tsukuba 大学院生命環境科学研究科 Professor
1998-07 -- 2005-11	東京都医学研究機構 東京都臨床医学総合研究所 主事

Degree

1994-01

博士(医学)

University of Tsukuba

Academic societies

-- (current)	THE JAPANESE BIOCHEMICAL SOCIETY
-- (current)	The Molecular Biology Society of Japan
-- (current)	Japan Society for Cell Biology

Articles

• Quantification of Endosome and Lysosome Motilities in Cultured Neurons Using Fluorescent Probes
  Tsuruta Fuminori; Okajima Tomomi; Yano Sarasa; Chiba Tomoki
  Journal of visualized experiments : JoVE, 2017-05
• Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis
  Qian MX; Pang Y; Liu CH; Haratake K; Du BY; Ji DY; Wang G...
  Cell/153(5)/pp.1012-1024, 2013-5
• A method for inducing antigen-specific IgG production by in vitro immunization
  Kato Mieko; Yan Huimin; Tsuji Noriko M.; Chiba Tomoki; Ha...
  JOURNAL OF IMMUNOLOGICAL METHODS/386(1-2)/pp.60-69, 2012-12
• Smad7-deficient mice show growth retardation with reduced viability
  Tojo Masayoshi; Takebe Ai; Takahashi Satoru; Tanaka Keiji...
  JOURNAL OF BIOCHEMISTRY/151(6)/pp.621-631, 2012-06
  CiNii
• Guidelines for the use and interpretation of assays for monitoring autophagy
  Klionsky Daniel J.; Abdalla Fabio C.; Abeliovich Hagai; A...
  AUTOPHAGY/8(4)/pp.445-544, 2012-04
• Spermatogenesis arrest caused by conditional deletion of Hsp90α in adult mice
  Kajiwara C; Kondo S; Uda S; Dai L; Ichiyanagi T; Chiba T;...
  Biology Open/1/p.977-982, 2012
• Inhibition of Gaussia luciferase Activity by a Monoclonal Antibody
  Chiba Tomoki
  Current Enzyme Inhibition/7(4)/pp.229-235, 2011-12
• Cell activation by CpG ODN leads to improved electrofusion in hybridoma production
  Kato Mieko; Sasamori Eriko; Chiba Tomoki; Hanyu Yoshiro
  JOURNAL OF IMMUNOLOGICAL METHODS/373(1-2)/pp.102-110, 2011-10
• Ubiquitin Ligase Activity of Cul3-KLHL7 Protein Is Attenuated by Autosomal Dominant Retinitis Pigmentosa Causative Mutation
  Kigoshi Yu; Tsuruta Fuminori; Chiba Tomoki
  JOURNAL OF BIOLOGICAL CHEMISTRY/286(38)/pp.33613-33621, 2011-09
  PubMed
• PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo
  de Graaf Natascha; van Helden Mary J. G.; Textoris-Taube ...
  EUROPEAN JOURNAL OF IMMUNOLOGY/41(4)/pp.926-935, 2011-04
• Bioluminescence Assay for Detecting Cell Surface Membrane Protein Expression
  Kato Mieko; Chiba Tomoki; Li Min; Hanyu Yoshiro
  ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES/9(1)/pp.31-39, 2011-02
• Bioluminescence assay for detecting cell surface membrane protein expression.
  Kato M; Chiba T; Li M; Hanyu Y.
  Assay Drug Dev Technol./9/pp.31-39, 2010-01
• 2Ep14 The analysis of gene expression in vitro immune-system
  加藤 三恵子; 笹森 えりこ; 千葉 智樹; 羽生 義郎
  日本生物工学会大会講演要旨集/21/p.64, 2009-08
  CiNii
• The mechanism of poly-NEDD8 chain formation in vitro
  Ohki Yu; Konishi Natsumi; Funatsu Norikazu; Chiba Tomoki
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/381(3)/pp.443-447, 2009-04
  PubMed
• PML Activates Transcription by Protecting HIPK2 and p300 from SCFFbx3-Mediated Degradation
  Shima Yutaka; Shima Takito; Chiba Tomoki; Irimura Tatsuro...
  MOLECULAR AND CELLULAR BIOLOGY/28(23)/pp.7126-7138, 2008-12
• Hsp90-mediated assembly of the 26 S proteasome is involved in major histocompatibility complex class I antigen processing
  Yamano Taketoshi; Mizukami Shusaku; Murata Shigeo; Chiba ...
  JOURNAL OF BIOLOGICAL CHEMISTRY/283(42)/pp.28060-28065, 2008-10
• A new ubiquitin ligase involved in p57(KIP2) proteolysis regulates osteoblast cell differentiation
  Kim Minsoo; Nakamoto Takashi; Nishimori Shigeki; Tanaka K...
  EMBO REPORTS/9(9)/pp.878-884, 2008-09
• Allele-selective effect of PA28 in MHC class I antigen processing
  Yamano Taketoshi; Sugahara Hidetoshi; Mizukami Shusaku; M...
  JOURNAL OF IMMUNOLOGY/181(3)/pp.1655-1664, 2008-08
• Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.
  Koyama S; Hata S; Witt CC; Ono Y; Lerche S; Ojima K; Chib...
  J Mol Biol./376/pp.1224-1236, 2008-01
• PML activates transcription by protecting HIPK2 and p300 from SCFFbx3- mediated degradation.
  Shima Y; Shima T; 千葉 智樹; Irimura T; Pandolfi PP; Kita...
  Mol. Cell Biol./28/pp.7126-7138, 2008-01
• A novel ubiquitin ligase involved in p57Kip2 proteolysis regulates osteoblast cell differentiation.
  Kim M; Nakamoto K; Nishimori S; Tanaka K; 千葉 智樹
  EMBO rep./9/pp.878-884, 2008-01
• PML protects HIPK2 and p300 from SCF-mediated ubiquitin-dependent degradation to activate transcription
  Shima Yutaka; Shima Takito; Chiba Tomoki; Irimura Tatsuro...
  BLOOD/110(11:Part 1)/p.26530, 2007-11
• Dioxin receptor is a ligand-dependent E3 ubiquitin ligase
  Ohtake Fumiaki; Baba Atsushi; Takada Ichiro; Okada Maiko;...
  NATURE/446(7135)/pp.562-566, 2007-03
• Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity
  Sakata Eri; Yamaguchi Yoshiki; Miyauchi Yasuhiro; Iwai Ka...
  NATURE STRUCTURAL & MOLECULAR BIOLOGY/14(2)/pp.167-168, 2007-02
• TBP-interacting protein 120b (TIP120B) /cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiaton.
  Shiraishi S; Zhou C; Aoki T; Sato N; Chiba T; Tanaka K; Y...
  J Biol Chem./282/p.9017-9028, 2007-01

more...

Books

• 生物学事典
  千葉 智樹
  東京化学同人, 2010-12
• CELL BIOLOGY
  沼田治; 中野賢太郎; 中田和人; 千葉 智樹
  化学同人, 2012
• ヒトの生物学
  千葉 智樹
  2007-01
• 分子細胞生物学事典
  千葉 智樹
  2009-01

Conference, etc.

• Analysis of male infertility in proteasome-associated protein PA200/Ecm29 double knockout mouse.
  佐藤 伴; 千葉智樹
  Consortium of Biological Sciences 2017/2017-12-07
• The Regulation of Nrf2-Keap1 Antioxidant Response by a Novel Cullin-like Protein
  Chiba Tomoki
  Cold Spring Harbor Laboratory Meeting (The Ubiquitin Family)/2013-05-14
• A novel NEDD8-binding protein modulates NF-kappa B signaling pathway
  Takashima Osamu; Tsuruta Fuminori; Ebina Manato; Kigoshi ...
  8th Meeting of the Global Arthritis Research Network (GARN)/1st Bio-Rheumatology International Congress (BRIC)/2011-11-14--2011-11-16

Teaching

2020-10 -- 2021-02	Methodology on Molecular and Cellular Biology IIF	University of Tsukuba.
2020-10 -- 2021-02	Special Practice in Human Biology II	University of Tsukuba.
2020-04 -- 2020-08	Special Practice in Human Biology II	University of Tsukuba.
2020-04 -- 2020-08	Seminar on Molecular and Cellular Biology IIS	University of Tsukuba.
2020-10 -- 2021-02	Special Seminars in Human Biology II	University of Tsukuba.
2020-04 -- 2020-08	Methodology on Molecular and Cellular Biology IIS	University of Tsukuba.
2020-04 -- 2020-08	Special Lectures in Human Biology II	University of Tsukuba.
2020-10 -- 2021-02	Special Research in Human Biology II	University of Tsukuba.
2020-10 -- 2021-02	Seminar on Molecular and Cellular Biology IIF	University of Tsukuba.
2020-04 -- 2020-08	Seminar on Molecular and Cellular Biology AI	University of Tsukuba.

more...

Professional activities

-- (current)

THE JAPANESE BIOCHEMICAL SOCIETY

評議員

(Last updated: 2019-08-29)