TANAKA Toshiyuki

Affiliation
Institute of Life and Environmental Sciences
Official title
Professor
Research fields
Biophysics
Research keywords
Structural Biology
Bioorganic Chemistry
Research projects
炭素間三重結合導入酵素の探索と反応機構解明2016 -- 2018田中 俊之Japan Society for the Promotion of Science/Grant-in-Aid for challenging Exploratory Research3,640,000Yen
Structural Analysis of Proteins by Multi-Dimensional NMR -- (current)/
腸管上皮に発現する新奇カプサイシン受容体の栄養科学的活用　　　　　　　　　　　　2006 -- 2008Japan Society of for the Promotion of Science/萌芽研究3,400,000Yen
クロモプロテイン系抗腫瘍性抗生物質における低分子認識及び放出機構の解明2004 -- (current)Japan Society of for the Promotion of Science/基盤研究(B)15,000,000Yen
小Maf群蛋白質の構造機能相関の解明2000 -- (current)Japan Society of for the Promotion of Science/特定領域研究(A)2,300,000Yen
カルシウム－ミリストイルスイッチ機構の原子レベルでの解明1998 -- (current)Japan Society of for the Promotion of Science/基盤研究(C)3,400,000Yen
蛋白質NMR構造決定における「分子置換法」の開発1998 -- (current)Japan Society of for the Promotion of Science/基盤研究(A)7,300,000Yen
抗腫瘍性抗生物質C－1027における分子認識の解明1996 -- (current)Japan Society of for the Promotion of Science/基盤研究(C)2,100,000Yen
EFハンド型カルシウム結合タンパク質の機能構造の解明1996 -- (current)Japan Society of for the Promotion of Science/重点領域研究2,100,000Yen
Academic background
1981-04 -- 1985-03The University of Tokyo Faculty of Science Biophysics and Biochemistry
1985-04 -- 1987-03The University of Tokyo Graduate School, Division of Science Biophysics and Biochemistry
1987-04 -- 1989-03The University of Tokyo Graduate School, Division of Science Biophysics and Biochemistry
Degree
Doctor of PhilosophyTohoku University
1987-03Master of ScienceThe University of Tokyo
Academic societies
-- (current)Chemical Society of Japan
-- (current)The Nuclear Magnetic Resonance Society of Japan
-- (current)THE JAPANESE BIOCHEMICAL SOCIETY
-- (current)The Molecular Biology Society of Japan
-- (current)JAPANESE SOCIETY FOR IMMUNOLOGY
Articles
  • The N93D mutation of the human T-cell leukemia virus type 1 envelope glycoprotein found in symptomatic patients enhances neuropilin-1 b1 domain binding
    Kusunoki Hideki; Tanaka Toshiyuki; Ohshima Chinatsu; S...
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS/1869(11), 2021-11
  • NMR characterization of the interaction between Bcl-x and the BH3-like motif of hepatitis B virus X protein
    Kusunoki Hideki; Tanaka Toshiyuki; Kohno Toshiyuki; Ki...
    Biochemical and biophysical research communications/518(3)/pp.445-450, 2019-08
    PubMed
  • A novel neuropilin-1-binding sequence in the human T-cell lymphotropic virus type 1 envelope glycoprotein
    Kusunoki Hideki; Tanaka Toshiyuki; Kohno Toshiyuki; Ma...
    Biochimica et biophysica acta/1866(4)/pp.541-548, 2018-02
    PubMed
  • Expression, purification and characterization of hepatitis B virus X protein BH3-like motif-linker-Bcl-xL fusion protein for structural studies
    Hideki Kusunoki; Toshiyuki Tanaka; Toshiyuki Kohno; Hirok...
    BIOCHEMISTRY AND BIOPHYSICS REPORTS/9/pp.159-165, 2017
    PubMed
  • Structure of a plant beta-galactosidase C-terminal domain
    Rimlumduan Thipwarin; Hua Yan-ling; Tanaka Toshiyuki; Cai...
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS/1864(10)/pp.1411-1418, 2016-10
    PubMed
  • Structural characterization of the BH3-like motif of hepatitis B virus X protein
    Kusunoki Hideki; Tanaka Toshiyuki; Kohno Toshiyuki; Wakam...
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/450(1)/pp.741-745, 2014-07
    PubMed
  • Experimental Glomerulonephritis Induced by Immune Complexes of Monoclonal Antibodies Produced by Immunoglobulin Class-Switch Variants. (共著)
    X.-M.Chen; T.Tanaka; Y.Kobayashi; H.Shigematsu; K.Okumura
    Laboratory Investigation/57(6)/p.665-672, 1987-01
  • Tubulointerstitial Nephritis Induced by Monoclonal Anti-Proximal Tubular Basement Membrane Antibodies in Mice. (共著)
    X.-M.Chen; T.Tanaka; Y.Kobayashi; H.Shigematsu; K.Okumura
    Clinical Immunology and Immunopathology/54/p.40-52, 1990-01
  • Structure of a Mouse Immunoglobulin G That Lacks the Entire CH1 Domain : Protein Sequencing and Small-Angle X-ray Scattering Studies. (共著)
    T.Igarashi; M.Sato; Y.Katsube; K.Takio; T.Tanaka; M.Nakanishi; ...
    Biochemistry/29(24)/p.5727-5733, 1990-01
  • Oxidative Triggering for Aromatization of the Neocarzinostatin Chromophore. (共著)
    T.Tanaka; K.Fujiwara; M.Hirama
    Tetrahedron Letters/31(41)/p.5947-5950, 1990-01
  • A Protein Structural Change in Aglycosylated IgG3 Correlates with Loss of huFcγRI and huFcγRIII Binding and/or Activation. (共著)
    J.Lund; T.Tanaka; N.Takahashi; G.Sarmay; Y.Arata; R.Jefferis
    Molecular Immunology/27(11)/p.1145-1153, 1990-01
  • Proton NMR Studies on the Chromophore Binding Structure in Neocarzinostatin Complex. (共著)
    T.Tanaka; M.Hirama; M.Ueno; S.Imajo; M.Ishiguro; M.Mizugaki; K....
    Tetrahedron Letters/32(27)/p.3175-3178, 1991-01
  • Human FcγRI and FcγRII Interact with Distinct but Overlapping Sites on Human IgG. (共著)
    J.Lund; G.Winter; P.T.Jones; J.D.Pound; T.Tanaka; M.R.Walker; P...
    The Journal of Immunology/147(8)/p.2657-2662, 1991-01
  • The Source of the Oxygen Atom in the α-Hydroxyglycine Intermediate of the Peptidylglycine α-Amidating Reaction. (共著)
    M.Noguchi; H.Seino; H.Kochi; H.Okamoto; T.Tanaka; M.Hirama
    Biochemical Journal/283/p.883-888, 1992-01
  • Effector Functions of a Mouse IgG That Lacks the Entire CH1 Domain : C1q Binding and Complement Fixation in the Absence of Antigen. (共著)
    R.Mizutani; T.Igarashi; T.Tanaka; I.Shimada; Y.Arata
    The Journal of Immunology/150(1)/p.131-138, 1993-01
  • Solution Structure of the Antitumour Antibiotic Neocarzinostatin, a Chromophore-Protein Complex. (共著)
    T.Tanaka; M.Hirama; K.Fujita; S.Imajo; M.Ishiguro
    Journal of Chemical Society, Chemical Communications/p.1205-1207, 1993-01
  • Sythesis and Binding of Simple Neocarzinostatin Chromophore Analogues to the Apoprotein. (共著)
    K.Takahashi; T.Tanaka; T.Suzuki; M.Hirama
    Tetrahedron/50(5)/p.1327-1340, 1994-01
  • Reactions of Neocarzinostatin Chromophore Analogues with Molecular Oxygen. (共著)
    K.Fujiwara; H.Sakai; T.Tanaka; M.Hirama
    Chemistry Letters/p.457-460, 1994-01
  • Secondary Structure of Myristoylated Recoverin Determined by Three-Dimensional Heteronuclear NMR : Implications for the Calcium-Myristoyl Switch. (共著)
    J.B.Ames; T.Tanaka; L.Stryer; M.Ikura
    Biochemistry/33(35)/p.10743-10753, 1994-01
  • Amino-Terminal Myristoylation Induces Cooperative Calcium Binding to Recoverin. (共著)
    J.B.Ames; T.Porumb; T.Tanaka; M.Ikura; L.Stryer
    The Journal of Biological Chemistry/270(9)/p.4526-4533, 1995-01
  • On the Conformation of Phe78 of a Chromoprotein Antibiotic, Neocarzinostatin. (共著)
    S.Imajo; M.Ishiguro; T.Tanaka; M.Hirama; A.Teplyakov
    Bioorganic & Medicinal Chemistry/3(4)/p.429-436, 1995-01
  • Sequestration of the Membrane-Targeting Myristoyl Group of Recoverin in the Calcium-Free State. (共著)
    T.Tanaka; J.B.Ames; T.S.Harvey; L.Stryer; M.Ikura
    Nature/376(6539)/p.444-447, 1995-01
  • Calcium-Induced Conformational Transition Revealed by the Solution Structure of Apo Calmodulin. (共著)
    M.Zhang; T.Tanaka; M.Ikura
    Nature Structural Biology/2(9)/p.758-767, 1995-01
  • Nuclear Magnetic Resonance Evidence for Ca2+-Induced Extrusion of the Myristoyl Group of Recoverin. (共著)
    J.B.Ames; T.Tanaka; M.Ikura; L.Stryer
    The Journal of Biological Chemistry/270(52)/p.30909-30913, 1995-01
  • Absolute Configuration of C-1027 Chromophore. (共著)
    K.Iida; S.Fukuda; T.Tanaka; M.Hirama; S.Imajo; M.Ishiguro; K.Yo...
    Tetrahedron Letters/37(28)/p.4997-5000, 1996-01
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Books
  • (Analysis of Biological Activity of Immune Complexes Composed of Anti-Dansyl Monoclonal Antibodies Produced by Immunoglobulin Class-Swtich Variants)
    田中俊之; 陳香美; 奥村康
    Medical Immunology Medical Immunology, 1988-01
  • モノクロ-ナル抗体による腎炎発症機序解明の試み.(共著)
    田中俊之; 陳香美; 奥村康
    臨床科学　臨床科学, 1988-01
  • Bio-Claisen Condensation Catalyzed by Thiolase from Zoogloea ramigera Active Site Cystein Residues. (共著)
    T.Tanaka; M.Hirama
    Chemtracts (Organic Chemistry) Chemtracts (Organic Chemistry), 1989-01
  • (Structural Analysis of Proteins by Multi-Dimensional NMR)
    田中俊之; 伊倉光彦
    (Journal of Synthetic Organic Chemistry) (Journal of Synthetic Organic Chemistry), 1993-01
  • Molecular Recognition in Neocarzinostatin Complex : How Dose the Apoprotein Bind Specifically and Stabilize the Chromophore? (共著)
    M.Hirama; T.Tanaka
    Pure & Applied Chemistry Pure & Applied Chemistry, 1994-01
  • リカバリン-光情報伝達系のカルシウムセンサ-の構造と機能.(共著)
    田中俊之; 伊倉光彦
    ファルマシア　ファルマシア, 1994-01
  • (Structural Analysis of Proteins by Multi-Dimensional NMR)
    田中俊之
    (Chemistry and Chemical Industry) (Chemistry and Chemical Industry), 1996-01
  • Supramolecular Neocarzinostatin Complex(共著) in Comprehensive Supramolecular Chemistry
    T.Tanaka; M.Hirama; S.Imajo; M.Ishiguro
    Pergamon Press Pergamon Press, 1996-01
  • Portrait of a Myristoyl Switch Protein. (共著)
    J.B.Ames; T.Tanaka; L.Stryer; M.Ikura
    Current Opinion in Structural Biology Current Opinion in Structural Biology, 1996-01
  • カルシウム結合タンパク質リカバリン(共著)
    田中俊之; 伊倉光彦
    共立出版,ニューバイオフィジックス　共立出版,ニューバイオフィジックス, 1997-01
Teaching
2024-04 -- 2024-08Seminar in Applied Biochemistry IIF（Spring）University of Tsukuba.
2024-04 -- 2024-08Research in Applied Biochemistry IIF（Spring）University of Tsukuba.
2024-04 -- 2024-08Seminar in Life and Agricultural SciencesUniversity of Tsukuba.
2024-10 -- 2025-02Seminar in Life and Agricultural SciencesUniversity of Tsukuba.
2024-10 -- 2025-02Research in Applied Biochemistry IFUniversity of Tsukuba.
2024-04 -- 2024-08Research in Applied Biochemistry IISUniversity of Tsukuba.
2024-04 -- 2024-08Seminar in Applied Biochemistry IISUniversity of Tsukuba.
2024-10 -- 2024-12Advanced Structural BiochemistryUniversity of Tsukuba.
2024-04 -- 2024-08Dissertation in Chemical Life Science IIUniversity of Tsukuba.
2024-10 -- 2025-02Dissertation in Chemical Life Science IIUniversity of Tsukuba.
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(Last updated: 2022-06-16)