Yasuhiro Shinkai
- Affiliation
- Faculty of Medicine
- Official title
- Associate Professor
- Research fields
Environmental and hygienic pharmacy - Research keywords
Metal Environmental electrophiles Sulfane sulfur - Research projects
環境中親電子物質の解毒に働くサルフェン硫黄結合タンパク質の同定とその機能解析 2020 -- 2023 新開 泰弘 /Grant-in-Aid for Scientific Research (B) カドミウムの毒性防御を担う小胞体ストレス応答系と活性イオウ分子産生系の協調的役割 2015 -- 2017 新開 泰弘 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C) 4,940,000Yen 大気中親電子物質1,4ーナフトキノンに対する細胞の生存シグナル制御機構 2012 -- 2014 Japan Society of for the Promotion of Science/基盤研究(C) 5,330,000Yen 重金属毒性に対する転写因子Nrf1の防御的役割とその応答機構の解析 2010 -- 2011 Japan Society of for the Promotion of Science/若手研究(B) 4,030,000Yen カドミウムの血管毒性防御の分子機構を担う転写因子Nrf2 2008 -- 2009 Japan Society of for the Promotion of Science/若手研究(B) 4,420,000Yen - Career history
2007-04 -- 2009-10 北陸大学学術フロンティア博士研究員 - Academic background
2003-04 -- 2007-03 University of Tsukuba Graduate School of Comprehensive Human Sciences Doctoral Program in Life System Medical Sciences - Degree
2007-03 Ph.D. University of Tsukuba - Academic societies
2003 -- (current) THE PHARMACEUTICAL SOCIETY OF JAPAN 2007 -- (current) The Japanese Society of Toxicology 2010 -- (current) THE JAPANESE SOCIETY FOR HYGIENE - Honors & Awards
2015-09 平成27年度日本薬学会環境・衛生部会賞・金原賞 環境化学物質の生体内運命とそれに対する防御応答の分子機構 2013-12-11 平成25年度メチル水銀研究ミーティング 若手研究奨励賞受賞 メチル水銀とそのグルタチオン抱合体によるKeap1/Nrf2経路の活性化 2012-07-18 日本毒性学会奨励賞 2008-08 第27回チョークトーク 生体と金属・化学物質に関する研究会 櫻井賞受賞 2008-06 第35回日本トキシコロジー学会学術年会 優秀研究発表賞受賞 2005-10 フォーラム2005:衛生薬学・環境トキシコロジー 優秀若手研究者賞受賞 - Articles
- Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain
Unoki Takamitsu; Akiyama Masahiro; Shinkai Yasuhiro; Kuma...
The Journal of toxicological sciences/47(1)/pp.31-37, 2022-01 - Fibroblast Growth Factor-2 Upregulates Reactive Sulfur Species Production via ERK1/2 Signal-Mediated Cystathionine γ-Lyase Induction in Cultured Bovine Aortic Endothelial Cells
Takahashi Musubu; Kubota Ayaka; Fujie Tomoya; Shinkai Ya...
BPB Reports/4(6)/pp.175-181, 2021-11 - Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β: Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways
Takahashi Musubu; Fujie Tomoya; Nakano Tsuyoshi; Hara Ta...
International journal of molecular sciences/22(21), 2021-10 - Glycoprotein non-metastatic melanoma protein B functions with growth factor signaling to induce tumorigenesis through its serine phosphorylation
Wang Chen; Okita Yukari; Zheng Ling; Shinkai Yasuhiro; Ma...
Cancer science/112(10)/pp.4187-4197, 2021-07 - Redox regulation by sulfane sulfur and phase zero reaction of environmental electrophiles
新開 泰弘; 熊谷 嘉人
Annual Meeting of the Japanese Society of Toxicology/47/pp.S30-4, 2020 - Protective role of reactive sulfur species under electrophilic stress
鵜木 隆光; 秋山 雅博; 新開 泰弘; 熊谷 嘉人; 藤村 成剛
Annual Meeting of the Japanese Society of Toxicology/47/pp.S30-5, 2020 - Signal transduction pathways associated with protection against environmental electrophiles and its regulation by reactive sulfur species
新開 泰弘; 熊谷 嘉人
Annual Meeting of the Japanese Society of Toxicology/47/pp.W6-2, 2020 - Chemical and Biological Characterization of Particulate Matter (PM 2.5) and Volatile Organic Compounds Collected at Different Sites in the Los Angeles Basin
Cho Arthur K.; Shinkai Yasuhiro; Schmitz Debra A.; Di Ste...
APPLIED SCIENCES-BASEL/10(9), 2020-05 - カドミウムによる親電子シグナル伝達経路の活性化と活性イオウ分子を介した制御
新開 泰弘; 秋山 雅博; 熊谷 嘉人
硫酸と工業/73(4)/p.41, 2020-04 - Repression of mercury accumulation and adverse effects of methylmercury exposure is mediated by cystathionine γ-lyase to produce reactive sulfur species in mouse brain
Akiyama Masahiro; Unoki Takamitsu; Yoshida Eiko; Ding Yu...
Toxicology letters/330(15)/pp.128-133, 2020-05 - Identification, Characterization and Three-Dimensional Structure Modeling of Metallothionein-3 as a Sulfane Sulfur- and Zinc-MH2Binding Protein
Shinkai Yasuhiro; Ding Yunjie; Akiyama Masahiro; Unoki T...
FREE RADICAL BIOLOGY AND MEDICINE/145(1)/pp.S38-S38, 2019-12 - Aggregation of β-crystallin through covalent binding to 1,2-naphthoquinone is rescued by α-crystallin chaperone
Shinkai Yasuhiro; Ding Yunjie; Miura Takashi; Kumagai Yo...
The Journal of toxicological sciences/45(1)/pp.37-43, 2020-04 - Nrf2 and CSE act as critical molecules in parallel pathways for regulation of electrophilic stress in mice
秋山 雅博; 鵜木 隆光; 新開 泰弘; 石井 功; 赤池 孝章; 山本 雅之; 熊谷 嘉人
Annual Meeting of the Japanese Society of Toxicology/46/pp.P-229, 2019 - Defense systems against heavy metal toxicity in vascular endothelial cells
新開 泰弘; 熊谷 嘉人
Annual Meeting of the Japanese Society of Toxicology/46/pp.W8-2, 2019 - Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload
Nishimura Akiyuki; Shimoda Kakeru; Tanaka Tomohiro; Toyam...
Science signaling/12(587), 2019-06 - Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both.
Masahiro Akiyama; T Unoki; Yasuhiro Shinkai; I Ishii; T ...
Environmental Health Perspectives, 2019-06 - Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells
Fujie Tomoya; Takenaka Fukuta; Yoshida Eiko; Yasuike Shu...
The Journal of Toxicological Sciences/44(5)/pp.327-333, 2019-04 - Sulfane sulfur in toxicology: A novel defense system against electrophilic stress.
Shinkai Yasuhiro; Kumagai Yoshito
TOXICOLOGICAL SCIENCES/p.kfz091, 2019 - Role of reactive sulfur species in regulation of health risk of methylmercury
秋山 雅博; 外山 喬士; 吉田 映子; 鵜木 隆光; 安孫子 ユミ; 新開 泰弘; 熊谷 嘉人
Annual Meeting of the Japanese Society of Toxicology/43/pp.P-8, 2016 - Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling
安孫子 ユミ; 新開 泰弘; 鵜木 隆光; 広瀬 玲子; 上原 孝; 熊谷 嘉人
Annual Meeting of the Japanese Society of Toxicology/44, 2017 - The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications
Lin Joseph; Akiyama Masahiro; Bica Iris; Long Faith T; He...
Chemical research in toxicology/32(3:::SI)/pp.447-455, 2019-02 - The capture of cadmium by reactive polysulfides attenuates cadmium-induced hepatotoxicity
新開 泰弘; 秋山 雅博; 鵜木 隆光; 石井 功; 熊谷 嘉人
Annual Meeting of the Japanese Society of Toxicology/45, 2018-08 - Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis
Kawaguchi Hoshimi; Matsumoto Isao; Osada Atsumu; Kurata ...
Arthritis research & therapy/20(1)/p.66, 2018-04 - Reactive sulfur species: protective role against electrophilic stress and reductive stress mediated by its intracellular excess accumulation
秋山 雅博; 鵜木 隆光; 蕨 栄治; 新開 泰弘; 石井 功; 赤池 孝章; 熊谷 嘉人
Annual Meeting of the Japanese Society of Toxicology/45, 2018-08 - The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity
Akiyama Masahiro; Shinkai Yasuhiro; Unoki Takamitsu; Shim...
Chemical research in toxicology, 2017-11 - more...
- Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain
- Books
- Intracellular Accumulation of Arsenic, Resulting in its Cytotoxicity and a Cellular Defense System Against Arsenic
新開 泰弘
2007-03
- Intracellular Accumulation of Arsenic, Resulting in its Cytotoxicity and a Cellular Defense System Against Arsenic
- Conference, etc.
- サルフェン硫黄から紐解くメタロチオネインのレドックス制御
新開 泰弘; 熊谷 嘉人
第48回日本毒性学会学術年会 生体金属部会シンポジウム 〜メタロチオネイン機能の新たな展開〜/2021-07 - サルフェン硫黄(sulfane sulfur)結合タンパク質としてのメタロチオネイン -3 の分子構造解析.
新開泰弘; Yunjie Ding; 秋山雅博; Sumeet Mahajan; 熊谷 嘉人
メタルバイオサイエンス研究会2020/2020-11 - Molecular structure analysis of metallothionein-3 by Raman spectroscopy.
新開泰弘; Yunjie Ding; 秋山雅博; Sumeet Mahajan; 熊谷 嘉人
フォーラム2020:衛生薬学・環境トキシコロジー/2020-09 - 環境中親電子物質の毒性防御に働くシグナル伝達経路と活性イオウ分子による制御
新開泰弘; 熊谷 嘉人
第47回日本毒性学会学術年会/2020-07 - サルフェン硫黄によるレドックス制御と環境中親電子物質のフェーズゼロ反応
新開泰弘; 熊谷 嘉人
第47回日本毒性学会学術年会/2020-07 - 活性イオウ分子を介した親電子ストレス防御
鵜木隆光; 秋山雅博; 新開泰弘; 熊谷 嘉人; 藤村成剛
第47回日本毒性学会学術年会/2020-07 - Phase-zero Reaction as a Primary Defense System Against Electrophilic Stress in out of Cell: Involvement of Reactive Persulfides
Akiyama Masahiro; Unoki Takamitsu; Warabi Eiji; Motohashi...
26th Annual Meeting of the Society-for-Redox-Biology-and-Medicine (SFRBM) - サルフェン硫黄結合タンパク質の同定とその機能解析
新開泰弘; Yunjie Ding; 秋山雅博; 井田智章; 赤池孝章; 熊谷 嘉人
第19回分子予防環境医学研究会/2020-03 - Nrf2 and CSE act as critical molecules in parallel pathways for repression of environmental electrophile-mediated toxicity in mice.
Y Shinkai; Ding Yunjie; M Akiyama; Fukuto Jon M; T Akaik...
1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine/2019-09 - Phase-zero reaction as a primary defense systeme against electrophilic stress in out of cell: Involvement of reactive persulfides.
M Akiyama; T Unoki; E Warabi; Y Shinkai; Y Abiko; I Ishi...
1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine/2019-09 - Nrf2 and CSE act as critical molecules in parallel pathways for regulation of electrophilic stress in mice.
M Akiyama; T Unoki; Y Shinkai; I Ishii; T Ida; T Akaike; ...
The Environmental Response V / 17th JBS Biofrontier Symposium/2019-09 - Metallothionein-3 as a sulfur binding protein: Identification, characterization and 3D structure modeling.
Y Shinakai; Ding Yunjie; M Akiyama; Fukuto Jon M; T Akai...
The Environmental Response V / 17th JBS Biofrontier Symposium/2019-09 - 1,4-Naphthoquinone-mediated activation of PTEN/Akt/CREB signaling and cytotoxicity are negatively regulated by sodium tetrasulfide.
R Hirose; Y Abiko; Shinkai; Kumagai Yoshito
The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM 2019)/2019-11 - Identification, characterization and a three-dimensional structure modeling of metallothionein-3 as a sulfane sulfur- and zinc-binding protein.
Y Shinkai; Ding Yunjie; M Akiyama; T Unoki; T Ida; T Aka...
The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM 2019)/2019-11 - Regulation of electrophilic stress by reactive persulfide released in out of cell:Phase-zero reaction.
M Akiyama; T Unoki; E Warabi; Y Shinkai; I Ishii; Lin Jo...
The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM 2019)/2019-11 - A 3D structure modeling of metallothionein-3 and its related function as a sulfane sulfur binding protein.
Ding Yunjie; Y Shinkai; M Akiyama; Kumagai Yoshito
フォーラム2019:衛生薬学・環境トキシコロジー/2019-09 - サルフェン硫黄結合タンパク質としてのメタロチオネイン-3 の機能と3 次元構造モデリング.
新開泰弘; Yunjie Ding; 秋山雅博; 熊谷 嘉人
フォーラム2019:衛生薬学・環境トキシコロジー/2019-09 - 活性イオウ分子排出輸送機構によるレドックス制御.
秋山雅博; 鵜木隆光; 蕨栄治; 新開泰弘; 安孫子ユミ; 石井功; 山本雅之; 赤池孝章; 熊谷 嘉人
第92回日本生化学会大会/2019-09 - 亜鉛結合タンパク質のモデルとしてのメタロチオネイン-3 におけるサルフェン硫黄の役割.
Yunjie Ding; 新開泰弘; 秋山雅博; 熊谷 嘉人
メタルバイオサイエンス研究会2019/2019-10 - カドミウム誘導性の生体応答および肝毒性は活性イオウ分子によって抑制される.
新開泰弘; 秋山雅博; 鵜木隆光; 石井功; 熊谷 嘉人
メタルバイオサイエンス研究会2019/2019-10 - Nrf2 and CSE act as critical molecules in parallel pathways for regulation of electrophilic stress in mice
秋山 雅博; 鵜木 隆光; 新開 泰弘; 石井 功; 赤池 孝章; 山本 雅之; 熊谷 嘉人
第46回日本毒性学会学術年会/2019-06 - Defense systems against heavy metal toxicity in vascular endothelial cells
新開 泰弘; 熊谷 嘉人
第46回日本毒性学会学術年会/2019-06 - Nrf2 とCSE はメチル水銀中毒症状を抑制する鍵分子である
秋山雅博; 鵜木隆光; 新開泰弘; 石井功; 山本雅之; 赤池孝章; 熊谷 嘉人
フォーラム2018:衛生薬学・環境トキシコロジー/2018-09 - CSEとNrf2は異なる経路を介して親電子性重金属毒性を抑制する鍵分子である
秋山雅博; 鵜木隆光; 新開泰弘; 石井功; 山本雅之; 熊谷 嘉人
メタルバイオサイエンス研究会2018/2018-11 - 活性イオウ分子によるカドミウムの不活性化を介した肝毒性の防御機構
新開泰弘; 秋山雅博; 鵜木隆光; 石井功; 熊谷 嘉人
第91回日本生化学会大会/2018-09 - more...
- サルフェン硫黄から紐解くメタロチオネインのレドックス制御
- Teaching
2021-10 -- 2022-02 Seminar in Environmental Sciences 1F University of Tsukuba. 2021-11 -- 2021-11 Forum on Sustainable Environmental Studies II University of Tsukuba. 2021-10 -- 2021-12 Forum on Sustainable Environmental Studies I University of Tsukuba. 2021-10 -- 2022-02 Seminar in Environmental Sciences 1F [Japanese] University of Tsukuba. 2021-04 -- 2021-08 Seminar in Environmental Sciences 2S [Japanese] University of Tsukuba. 2021-04 -- 2021-08 Seminar in Environmental Sciences 1S [Japanese] University of Tsukuba. 2021-10 -- 2022-02 Environmental Health Perspective University of Tsukuba. 2021-10 -- 2022-02 Environmental Studies Practicum II University of Tsukuba. 2021-04 -- 2021-08 Environmental Studies Practicum II University of Tsukuba. 2021-10 -- 2022-02 Internship in Environmental Studies II University of Tsukuba. more... - Professional activities
2019-06 -- (current) THE JAPANESE SOCIETY OF TOXICOLOGY The Journal of Toxicological Sciences Associate Editor 2016-06 -- (current) THE JAPANESE SOCIETY OF TOXICOLOGY 評議員 2014 -- (current) The Japanese Society of Toxicology Fundamental Toxicological Sciences Editorial Board 2010-01 -- (current) THE JAPANESE SOCIETY OF TOXICOLOGY The Journal of Toxicological Sciences Editorial Board - University Management
2019-06 -- (current) 筑波大学 国際連携食料健康科学専攻 安全委員会 委員長 2019-06 -- (current) 筑波大学 国際連携食料健康科学専攻 広報委員会 委員長 2014-04 -- (current) 筑波大学 医学共通機器MS管理担当教員 2014-04 -- 2019-03 環境系専攻カリキュラム委員 2014-04 -- 2019-05 環境系専攻SUSTEP委員 2011-04 -- 2017-03 生命システム医学専攻教務委員(キャリア支援)
(Last updated: 2021-08-17)