HISATAKE Koji
- Affiliation
- Institute of Medicine
- Official title
- Professor
- URL
- )BFA@?@J8ZieD;cKJLBL98c8:cAGp
- Fax
- 029-853-3929
- Research fields
General medical chemistry Biomolecular chemistry - Research keywords
adipocyte Transcription Gene Expression Chromatin Mechanisms of Transcriptional Regulation iPS Cell Regenerative Medicine - Research projects
外来性RNAに対する翻訳を介したサイレンシング機構の解析 2024-07 -- 2026-03 HISATAKE Koji Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Research (Exploratory) 6,500,000Yen Mechanistic analysis of somatic cell reprogramming using paused iPSCs 2021-04 -- 2024-03 HISATAKE Koji Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B) 17,420,000Yen A Tcl1-mediated method to generate iPSCs with reduced genomic mutations 2017-07 -- 2019-03 HISATAKE Koji Japan Society for the Promotion of Science/Challenging Research (Exploratory) 6,370,000Yen Reprogramming of cell morphology and functions by Klf4 during iPSC generation 2017-04 -- 2021-03 HISATAKE Koji Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B) 17,680,000Yen Analysis of the transcription factor network during the early stage of iPSC production 2013-04 -- 2016-03 Koji HISATAKE Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C) 5,200,000Yen Analysis of the components of a novel coactivator.the NF complex, and its regulatory mechanisms 2010-04 -- 2013-03 HISATAKE Koji Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C) 4,580,000Yen Analysis of regulatory mechanisms of chromatin phosphorylation by kinases 2006 -- 2007 HISATAKE Koji Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C) 3,890,000Yen 新規コアクチベーターによる転写過程の包括的調節機構の解析 2006 -- 2007 HISATAKE Koji Ministry of Education, Culture, Sports, Science and Technology, Japan/Grant-in-Aid for Scientific Research on Priority Areas 8,700,000Yen - Career history
1991-04 -- 1994-03 ロックフェラー大学ポストドクトラルフェロー 1994-04 -- 1994-10 ロックフェラー大学ポストドクトラルアソシエート 1994-11 -- 2000-05 埼玉医科大学医学部講師 2000-06 -- 2005-12 埼玉医科大学医学部助教授 2006-01 -- 2011-09 筑波大学人間総合科学研究科教授 2011-10 -- (current) 筑波大学医学医療系教授 - Academic background
-- 1985 岡山大学 医学部 医学科 -- 1991 東京大学大学院 医学系研究科 第二基礎医学 - Degree
医学博士 東京大学 - Academic societies
2013-01 -- (current) THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE 2002 -- (current) THE JAPANESE BIOCHEMICAL SOCIETY 1995 -- (current) The Molecular Biology Society of Japan 2003 -- (current) American Society for Biochemistry and Molecular Biology - Articles
- An engineered ligand-responsive Csy4 endoribonuclease controls transgene expression from Sendai virus vectors
Kishimoto Takumi; Nishimura Ken; Morishita Kana; Fukud...
JOURNAL OF BIOLOGICAL ENGINEERING/18(1)/p.9, 2024-01-16 - 模擬試験成績およびGPAと国家試験の合否に関わる考察
安孫子ユミ; 森川 一也; 磯辺智範; 久武幸司
臨床検査学教育/13(2)/pp.68-68, 2021-09 - Engineering Critical Residues of SOX9 Discovers a Variant With Potent Capacity to Induce Chondrocytes
Sekiguchi Yuya; Fukuda Aya; Nishimura Ken; Hisatake Koji
STEM CELLS/Epub, 2023-08-31 - Factors Affecting Undergraduate Medical Science Students’ Motivation to Study during the COVID-19 Pandemic
Mayers Thomas David; Mathis Bryan J.; Ho C. Kiong; Morika...
Education Sciences/12(9), 2022-09 - STRUCTURALLY-DISCOVERED TRANSCRIPTION FACTOR VARIANTS ACCELERATE AND STABILIZE REPROGRAMMING TO PLURIPOTENCY
Borisova Evgeniia; Nishimura Ken; An Yuri; Takami Mih...
TISSUE ENGINEERING PART A/28(1)/pp.S199-S199, 2022-04 - Locus-Specific Isolation of the Nanog Chromatin Identifies Regulators Relevant to Pluripotency of Mouse Embryonic Stem Cells and Reprogramming of Somatic Cells
Burramsetty Arun Kumar; Nishimura Ken; Kishimoto Takum...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/23(23), 2022-12-03 - The impact of the COVID-19 pandemic on medical science students’ motivation to study: Preliminary findings
Mayers Thomas David; Mathis Bryan J; Ho Kiong; Morikawa ...
Journal of Medical English Education./20(3)/pp.52-55, 2021-10 - Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency
Borisova Evgeniia; Nishimura Ken; An Yuri; Takami Miho; L...
iScience/25(1)/p.103525, 2021-12 - Downregulation of Odd-Skipped Related 2, a Novel Regulator of Epithelial-Mesenchymal Transition, Enables Efficient Somatic Cell Reprogramming
Anh Le Phuong Hoang; Nishimura Ken; Kuno Akihiro; Linh N...
Stem cells (Dayton, Ohio)/40(4)/pp.397-410, 2022-04-29 - Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming
Aizawa Shiho; Nishimura Ken; Mondejar Gonzalo Seminario; ...
Stem Cell Reports/17(1)/pp.53-67, 2022-01 - Visualization of intracellular lipid metabolism in brown adipocytes by time-lapse ultra-multiplex CARS microspectroscopy with an onstage incubator
Takei Yuki; Hirai Rie; Fukuda Aya; Miyazaki Shinichi; Shi...
JOURNAL OF CHEMICAL PHYSICS/155(12), 2021-09 - The impact of the COVID-19 pandemic on medical science students’ motivation to study: Preliminary findings
Mayers Thomas David; Mathis Bryan James; Ho C. Kiong; Mor...
Journal of Medical English Education/20(3)/pp.52-55, 2021-10 - A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation
Nishimura Ken; Aizawa Shiho; Nugroho Fransiska Liliani; S...
Stem cell reports, 2014-11 - 脂肪細胞とベージュ脂肪細胞のフロンティア-6 肥満治療へのフロンティアとなる可能性
久武 幸司
体育の科学/71(4)/pp.287-291, 2021-04 - 脂肪細胞とベージュ脂肪細胞のフロンティア-5 運動は脂肪細胞にどうかかわっていくのか
久武 幸司
体育の科学/71(3)/pp.213-217, 2021-03 - 脂肪細胞とベージュ脂肪細胞のフロンティア-4 熱代謝が肥満と代謝におよぼす影響
久武 幸司
体育の科学/71(2)/pp.131-136, 2021-02 - 脂肪細胞とベージュ脂肪細胞のフロンティア-3 ミクロメカニズムを解き明かす ー遺伝子発現と分化ー
久武 幸司
体育の科学/71(1)/pp.51-56, 2021-01 - 脂肪細胞とベージュ脂肪細胞のフロンティア-2 細胞がどう発生し,どう分化していくのか
久武 幸司
体育の科学/70(12)/pp.901-907, 2020-12 - Utilization of a novel Sendai virus vector in ex vivo gene therapy for hemophilia A
Yamaki Yuni; Fukushima Takashi; Yoshida Naomi; Nishimura ...
INTERNATIONAL JOURNAL OF HEMATOLOGY/Epub, 2021-01 - Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720
Fukuda Aya; Honda Shiho; Fujioka Norie; Sekiguchi Yuy...
PloS one/14(11), 2019-11 - Template Activating Factor-I α Regulates Retroviral Silencing during Reprogramming
Bui Phuong Linh; Nishimura Ken; Seminario Mondejar Gon...
Cell reports/29(7)/p.1909-1922.e5, 2019-11 - Mechanisms of the Metabolic Shift during Somatic Cell Reprogramming
Nishimura Ken; Fukuda Aya; Hisatake Koji
International Journal of Molecular Sciences/20(9), 2019-05 - Live-cell imaging of subcellular structures for quantitative evaluation of pluripotent stem cells
Nishimura Ken; Ishiwata Hiroshi; Sakuragi Yuta; Hayashi ...
Scientific Reports/9/p.1777, 2019-02 - Live cell imaging of X chromosome reactivation during somatic cell reprogramming
Tran Thi Hai Yen; Fukuda Aya; Aizawa Shiho; Bui Phuon...
Biochemistry and biophysics reports/15/pp.86-92, 2018-09 - Promotion of iPSC generation through a metabolic shift by Tcl1
西村 健; 久武幸司
医学のあゆみ/265(4)/pp.293-294, 2018-04 - more...
- An engineered ligand-responsive Csy4 endoribonuclease controls transgene expression from Sendai virus vectors
- Books
- 蛋白質解析法
久武 幸司
メディカルサイエンス遺伝子検査学, 2012-02 - Histone methylation and transcriptional regulation
福田 綾; 久武幸司
biochemistry The Japanese Biochemical Society, 2007-04 - Mechanism of histone H3 phosphorylation upon induction of c-fos gene transcription
嶋田美穂; 中太智義; 福田 綾; 久武幸司
Jikken Igaku, vol.25, No.10 Yodosha, 2007-06
- 蛋白質解析法
- Conference, etc.
- Mechanistic analysis of chromosome-wide epigenetic change during iPSC generation using Klf4-dose dependent reprogramming system
Nishimura Ken; Hisatake Koji; Aizawa Shiho
The 20th International Joint Mini-Symposium on Molecular and Cell Biology among KU-NTU-UT/2023-04-22--2023-04-22 - Discovery of a novel SOX9 mutant with potent capacity to induce chondrocytes
福田 綾; 関口裕也; 西村健; 久武幸司
The 36th Annual Meeting of the Japanese Society of Cartilage Metabolism/2024-02-16--2024-02-17 - Mechanistic analysis of chromosome-wide epigenetic change during iPSC generation using Klf4-dose dependent reprogramming system
Nishimura Ken; Aizawa Shiho; Hisatake Koji
The 20th International Joint Mini-Symposium on Molecular and Cell Biology among KU-NTU-UT/2023-04-22--2023-04-22 - iPS細胞誘導過程において二相性の機能を有するE2F4の解析
西村 健; 岸本 拓実; 久武 幸司
第45回日本分子生物学会年会/2022-12-01--2022-12-01 - Dual function of E2F4 on iPSC generation
Nishimura Ken; Kishimoto Takumi; Hisatake Koji
TGSW2022/2022-09-30--2022-09-30 - A dCas9 based method can identify novel regulators of Nanog and pluripotency
Nishimura Ken; Arun Burramsetty; Hisatake Koji
ISSCR2022/2022-06-17--2022-06-17 - Downregulation of Odd-Skipped Related 2, a Novel Regulator of Epithelial-Mesenchymal Transition, Enables Efficient Somatic Cell Reprogramming
Nishimura Ken; LPH Anh; NT Linh; T Kato; K Hisatake
ISSCR2021/2021-06-21--2021-06-21 - Mechanistic analysis of pluripotency acquisition by using paused iPSCs
Hamzah Muhammad; Nishimura Ken; 久武 幸司
Tsukuba Conference 2021/2021-09-29--2021-09-29 - Interleukin Enhancer Binding Factors 2 and 3 inhibit retrovirus expression
Mondejar Gonzalo Seminario; Nishimura Ken; 久武 幸司
Tsukuba Conference 2021/2021-09-30--2021-09-30 - Interleukin Enhancer Binding Factors 2 and 3 inhibit retrovirus expression
Mondejar Gonzalo Seminario; Bui Phuong Linh; Nishimura K...
第44回日本分子生物学会年会/2021-12-01--2021-12-01 - リプログラム因子のパイオニア因子としての機能と量依存性
西村 健; 久野 朗広; 久武 幸司
第21回日本再生医療学会総会/2022-03-17--2022-03-17 - 学生ワークシートの導入による実技能力修得の効率化
會田 雄一; 久武 幸司
第15回日本臨床検査学教育学会学術大会/2021-08-18--2021-08-19 - Paused iPS細胞を用いたKLF4量依存的エピジェネティクス制御機構の解析
西村 健; Arun Kumar; 岸本 拓実; 久武 幸司
第14回エピジェネティクス研究会年会/2021-03-31 - iPS細胞誘導におけるX染色体再活性化機構の解明
相澤 志穂; 西村 健; 久武 幸司
第20回日本再生医療学会総会/2021-03-11 - Analysis of KLF4 dose dependent iPSC generation in early stage of reprogramming
Yamanaka Takahiro; Nishimura Ken; Hisatake Koji
TGSW2020/2020-09-29 - Reactivation of X chromosome might start from the identical region during mouse iPSC generation
Aizawa Shiho; Bui Phuong Linh; Nishimura Ken; Hisatake Koji
ISSCR2020/2020-06-26 - ライブセルCARS顕微鏡を用いた褐色脂肪細胞の脂質動態イメージング
加納 英明; 武井 祐樹; 下平 雄貴; 島田 林太郎; 平井 理愛; 福田 綾; 久武 幸司
令和元年生細胞分光部会シンポジウム/2019-12-12--2019-12-12 - ライブセルCARS顕微鏡を用いた褐色脂肪細胞のリポクオリティイメージング
加納 英明; 武井 祐樹; 平井 理愛; 下平 雄貴; 島田 林太郎; 福田 綾; 久武 幸司
第17回医用分光学研究会/2019-11-21--2019-11-22 - 褐色脂肪細胞のライブセル非線形分光イメージング
加納 英明; 武井 祐樹; 平井 理愛; 島田 林太郎; 福田 綾; 久武 幸司
第13回分子科学討論会2019/2019-09-17--2019-09-20 - PD imaging systemを用いて生きたまま幹細胞の多能性を定量的に解析する
Nishimura Ken; Ishiwata Hiroshi; Hisatake Koji
第42回日本分子生物学会年会/2019-12-03--2019-12-06 - Dose dependent transcriptional regulation of KLF4
Kumar Burramsetty Arun; Ken Nishimura; Koji Hisatake
Tsukuba Conference 2019/2019-10-03--2019-10-04 - CARS 分光イメージングによる生体組織の ex vivo 観察
加納 英明; 湯口周; 福田綾; 久武幸司; 加野准子; 野口雅之
第16回医用分光学研究会/2018-11-21--2018-11-22 - 後方散乱配置による生体組織のex vivoマルチモーダル非線形光学イメージング
Kanou Hideaki; 湯口周; 福田綾; 久武幸司; 野口雅之
第12回分子科学討論会/2018-09-10--2018-09-13 - 非線形光学イメージングを用いた iPS 細胞のリプログラミング過程の研究
加納 英明; 丸山拓史; 米山弘亮; 西村健; 久武幸司
平成30年度 日本分光学会年次講演会/2018-05-22--2018-05-25 - 脂肪を燃焼する褐色脂肪細胞のマルチモーダル非線形光学イメージング
加納 英明; 武井祐樹; 平井理愛; 下平雄貴; 島田林太郎; 福田綾; 久武幸司
平成30年度 日本分光学会年次講演会/2018-05-22--2018-05-25 - more...
- Mechanistic analysis of chromosome-wide epigenetic change during iPSC generation using Klf4-dose dependent reprogramming system
- Intellectural property rights
- Method for induction of chondrocyte-like cells
福田 綾; 関口裕也; 久武幸司 - 軟骨細胞様細胞の分化誘導方法
福田 綾; 関口裕也; 久武幸司 - 遺伝子改変非ヒト動物及びその使用
福田 綾; HONDA SHIHO; KOJI HISATAKE
- Method for induction of chondrocyte-like cells
- Teaching
2024-10 -- 2024-11 Invitation to Arts and Sciences University of Tsukuba. 2024-04 -- 2024-07 Biochemistry and Molecular Biology University of Tsukuba. 2024-04 -- 2024-08 Seminar in Molecular Medical Sciences I University of Tsukuba. 2024-10 -- 2025-02 Practice in Diagnostic Pathology I University of Tsukuba. 2024-04 -- 2024-08 Practice in Diagnostic Pathology I University of Tsukuba. 2024-10 -- 2025-02 Seminar in Molecular Medical Sciences II University of Tsukuba. 2024-05 -- 2024-08 Medical Biochemistry University of Tsukuba. 2024-04 -- 2024-08 Lecture and Discussion in Molecular Medical Sciences I University of Tsukuba. 2024-10 -- 2024-12 Topics in Medical Sciences I University of Tsukuba. 2024-10 -- 2025-02 Practice in Diagnostic Pathology II University of Tsukuba. more... - Professional activities
2006 -- (current) THE JAPANESE BIOCHEMICAL SOCIETY 評議員 2011-12 -- (current) 日本学術振興会 科学研究費委員会専門委員 - University Management
2018-04 -- (current) 学群教育会議 委員 2017-04 -- (current) つくば機能植物イノベーション研究センター運営委員会 委員 2010-03 -- 2017-03 遺伝子実験センター運営委員会 委員 2014-04 -- 2015-03 国際教員連絡会 委員 2015-04 -- 2018-03 国際戦略会議 委員 2014-03 -- 2018-03 人間総合科学運営委員会 委員 2018-04 -- (current) 免除等選考委員会 委員 2016-04 -- (current) 若手研究者育成推進委員会 委員 2014-04 -- 2018-03 医学医療系国際連携委員会 委員長 2014-04 -- (current) フロンティア医科学教員認定委員会 委員 more...
(Last updated: 2024-10-09)