Nishikii Hidekazu

Affiliation

Faculty of Medicine

Official title

Associate Professor

Research projects


ヒト造血幹細胞の不均一性の解明と機能制御	2022 -- 2024	錦井秀和	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,160,000Yen
造血器腫瘍における造血ニッチ細胞の遺伝子・機能異常解析	2018 -- 2020	錦井秀和	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,550,000Yen
同種骨髄移植後の新規免疫モニタリングシステムと免疫寛容メカニズムの解明	2015 -- 2017	錦井　秀和	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,810,000Yen
巨核球・血小板分化における転写因子ＨＥＳ１が担う制御機構の解明	2012 -- 2013		Japan Society of for the Promotion of Science/若手研究(B)	2,080,000Yen
巨核球分化におけるＮｏｔｃｈシグナルが担う造血制御機構	2010 -- 2011		Japan Society of for the Promotion of Science/若手研究(B)	4,030,000Yen

Articles

Triple-negative Thrombocythemia and Subsequent Acute Lymphoblastic Leukemia with Additional Somatic Mutations
Tsuboi Yuri; Sakamoto Tatsuhiro; Makishima Kenichi; Su...
Internal medicine (Tokyo, Japan), 2022-09-13
PubMed
Administration of brentuximab vedotin to a Hodgkin lymphoma patient with liver dysfunction due to vanishing bile duct syndrome resulting in a partial response without any severe adverse events
Ishitsuka Kantaro; Yokoyama Yasuhisa; Baba Naoko; Mats...
Journal of clinical and experimental hematopathology : JCEH, 2022-07-12
PubMed
A Case of Cardiac Tamponade as a Recurrence of Angioimmunoblastic T-Cell Lymphoma with the Detection of a p.Gly17Val RHOA Mutation in the Pericardial Effusion
Tsuboi Yuri; Iimura Yumoe; Matsumura Fumiaki; Nanmoku To...
Internal medicine (Tokyo, Japan), 2022-06-21
PubMed
A Case of Cardiac Tamponade as a Recurrence of Angioimmunoblastic T-Cell Lymphoma with the Detection of a p.Gly17Val RHOA Mutation in the Pericardial Effusion
Tsuboi Yuri; Iimura Yumoe; Matsumura Fumiaki; Nanmoku To...
Internal medicine (Tokyo, Japan), 2022-06-21
PubMed
[Acquired platelet dysfunction with severe bleeding tendency in triple-negative myelofibrosis]
Momose Haruka; Nishikii Hidekazu; Kozuma Yukinori; Ota-Ts...
[Rinsho ketsueki] The Japanese journal of clinical hematology/62(9)/pp.1406-1411, 2021-09
PubMed
Salvage Cord Blood Transplantation Using a Short-term Reduced-intensity Conditioning Regimen for Graft Failure.
Suma S; Yokoyama Y; Momose H; Makishima K; Kiyoki Y; Saka...
INTERNAL MEDICINE/61(11)/pp.1673-1679, 2021-11
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling
Abe Yoshiaki; Sakata-Yanagimoto Mamiko; Fujisawa Manab...
Nature cell biology/24(4)/pp.565-578, 2022-03
PubMed
[IgG-variant Bing-Neel syndrome diagnosed by detecting MYD88 L265P mutation in the cerebrospinal fluid cells]
Maruyama Yumiko; Nishikii Hidekazu; Matsuoka Ryota; Makis...
[Rinsho ketsueki] The Japanese journal of clinical hematology/62(10)/pp.1493-1498, 2021-10
PubMed
Early administration of cyclosporine may reduce the incidence of cytokine release syndrome after HLA-haploidentical hematopoietic stem-cell transplantation with post-transplant cyclophosphamide
Kurita Naoki; Sakamoto Tatsuhiro; Kato Takayasu; Kusakabe...
Annals of hematology/100(5)/pp.1295-1301, 2021-02
PubMed
Regulatory mechanism of megakaryocyte-lineage differentiation in hematopoietic stem cells
錦井秀和
Japanese Journal of Thrombosis and Hemostasis/31(5)/pp.479-484, 2020
CiNii
Haploidentical transplantation from a related donor as first-line treatment for fulminant aplastic anemia
槇島健一; 長谷川雄一; 千葉滋; 小原直; 坂本竜弘; 加藤貴康; 日下部学; 錦井秀和; 栗田...
Rinsho Ketsueki/61(10)/pp.1464-1468, 2020-10
CiNii PubMed
FDG-PET imaging and histopathology in neuroleukemiosis with acute myeloid leukemia
Kiyoki Yusuke; Matsuoka Ryota; Kaneta Tomohiro; Nishikii ...
International journal of hematology/112/pp.433-434, 2020-08
PubMed
Aggressive conjunctival carcinoma arising on sun-damaged areas with poorly controlled graft-versus-host disease
Konishi Risa; Ishitsuka Yosuke; Inoue Sae; Saito Akimasa...
EUROPEAN JOURNAL OF DERMATOLOGY/30(3)/pp.313-314, 2020-06
PubMed
Philadelphia chromosome-positive acute lymphoblastic leukemia complicated by bone marrow necrosis during consolidation chemotherapy
Ishitsuka Kantaro; Obara Naoshi; Suyama Takuya; Matsuoka ...
Rinsho Ketsueki/61(5)/pp.462-467, 2020-05
CiNii PubMed
Dasatinib Is an Effective Treatment for Angioimmunoblastic T-cell Lymphoma.
TB Nguyen; M Sakata-Yanagimoto; M Fujisawa; S Tanzima Nu...
Cancer Res/80(9)/pp.1875-1884, 2020-02
PubMed
Salvage Cord Blood Transplantation Using a Short-Term Reduced-Intensity Preparative Regimen for Graft Failure
Suma-Sugimoto Sakurako; Yokoyama Yasuhisa; Yoshida Chika...
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA/19(1)/pp.S261-S262, 2019-09
The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery
Eto Koji; Nishikii Hidekazu; Ogaeri Takunori; Suetsugu...
Blood/110(10)/pp.3637-3647, 2007-11-15
PubMed
Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors
Takayama Naoya; Nishikii Hidekazu; Usui Joichi; Tsukui...
Blood/111(11)/pp.5298-5306, 2008-06-01
PubMed
Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells
Nishikii Hidekazu; Eto Koji; Tamura Noriko; Hattori K...
The Journal of experimental medicine/205(8)/pp.1917-1927, 2008-08-04
PubMed
Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo
Takizawa Hitoshi; Nishimura Satoshi; Takayama Naoya; O...
The Journal of clinical investigation/120(1)/pp.179-190, 2010-01-01
PubMed
On-chip separation and analysis of RNA and DNA from single cells
Shintaku Hirofumi; Nishikii Hidekazu; Marshall Lewis A...
Analytical chemistry/86(4)/pp.1953-1957, 2014-02-18
PubMed
Engraftment of embryonic stem cells and differentiated progeny by host conditioning with total lymphoid irradiation and regulatory T cells
Pan Yuqiong; Leveson-Gower Dennis B; de Almeida Patric...
Cell reports/10(11)/pp.1793-1802, 2015-03-24
PubMed
Donor Requirements for Regulatory T Cell Suppression of Murine Graft-versus-Host Disease
Pierini Antonio; Colonna Lucrezia; Alvarez Maite; Schn...
Journal of immunology (Baltimore, Md. : 1950)/195(1)/pp.347-355, 2015-07-01
PubMed
TNF-α priming enhances CD4+FoxP3+ regulatory T-cell suppressive function in murine GVHD prevention and treatment
Pierini Antonio; Strober William; Moffett Caitlin; Bak...
Blood/128(6)/pp.866-871, 2016-04
PubMed
Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion
Chopra Martin; Biehl Marlene; Steinfatt Tim; Brandl A...
The Journal of experimental medicine/213(9)/pp.1881-1900, 2016-04
PubMed
more...

Books

制御性T細胞による骨髄環境制御
錦井秀和
医学のあゆみ/医歯薬出版/pp.1177-1182, 2019-03
Chapter 14 Hematopoietic differentiation from Embryonic Stem Cells
Yokoyama Y; Nishikii H; Chiba S
Embryonic Stem Cells - Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine/InTech/pp.251-272, 2011-03

Conference, etc.

高度な骨髄線維化を認め診断に苦慮したリンパ形質細胞性リンパ腫の１例
宝田亜矢子; 百瀬春佳; 栗田尚樹; 坂本竜弘; 加藤貴康; 服部圭一朗; 末原泰人; 横山泰久...
第16回日本血液学会関東甲信越地方会/2022-03-19--2022-03-19
Birt-Hogg-Dube症候群に合併した多発性骨髄腫の1例
松村文明; 坂本竜弘; 甲斐平康; 加藤貴康; 栗田尚樹; 横山泰久; 錦井秀和; 坂田(柳元) ...
第675回日本内科学会関東地方会/2022-02-12--2022-02-12
A Single-Cell Atlas of Nonhematopoietic Cells in Human Lymph Node and Lymphoma Reveals Landscape of Stromal Remodeling
Abe Yoshiaki; Sakata-Yanagimoto Mamiko; Fujisawa Manabu; ...
63rd ASH Annual Meeting and Exposition/2021-12-11--2021-12-14
Real-world experience of Ph（-）ALL treated with a pediatric regimen: a single center study
Yuki Yoshizawa; Takayasu Kato; Kenichi Makishima; Yufu I...
第83回日本血液学会学術集会/2021-09-23--2021-09-25
Repeated immunosuppressive therapy using rabbit anti-thymocyte globulin for aplastic anemia
Tatsuhiro Sakamoto; Naoshi Obara; Takayasu Kato; Naoki K...
第83回日本血液学会学術集会/2021-09-23--2021-09-25
A comprehensive single-cell atlas of human lymph node stroma in homeostasis and lymphoma
Abe Yoshiaki; Sakata-Yanagimoto Mamiko; Fujisawa Manabu; ...
第83回日本血液学会学術集会/2021-09-23--2021-09-25
妊娠中に再発したびまん性大細胞性B細胞リンパ腫の1例
法岡菜月; 錦井秀和; 加村雄哉; 坂田(柳元) 麻実子; 日下部学; 小畠真奈; 千葉滋
第671回日本内科学会関東地方会/2021-09-12--2021-09-12
腫瘍細胞の神経浸潤による末梢神経障害を合併した原発性マクログロブリン血症
法岡菜月; 栗田尚樹; 加村雄哉; 日下部学(医学医療系); 坂本竜弘; 加藤貴康; 横山泰久; 錦井 ...
第15回日本血液学会関東甲信越地方会/2021-07-10--2021-07-10
A Comprehensive Single-Cell Atlas of Nonhematopoietic Cells in Human Lymph Node and Lymphoma for Dissecting Stromal Remodeling
安部佳亮; 坂田(柳元) 麻実子; 藤澤学; 三好寛明; 末原泰人; 服部圭一朗; 日下部学; 坂本 ...
第61回日本リンパ網内系学会総会/2021-06-24--2021-06-26
A Comprehensive Single-Cell Atlas of Nonhematopoietic Cells in Human Lymph Node and Lymphoma Reveals Landscape of Stromal Remodeling
Abe Yoshiaki; Sakata-Yanagimoto Mamiko; Fujisawa Manabu; ...
The 26th EHA 2021 Congress/2021-06-09--2021-06-17
不明熱に胆道系優位の肝障害を伴いランゲルハンス細胞組織球症(Langerhans’cell histiocytosis: LCH)と診断した成人の一例
鈴木李理; 舛本祥一; 鈴木將玄; 錦井秀和; 松岡亮太; 永井純子; 前野哲博
第665回日本内科学会関東地方会/2020-12
特発性血小板減少性紫斑病におけるエルトロンボパグの血中濃度が肝障害発現に及ぼす影響
本間真人; 柳町直哉; 土岐浩介; 小原直; 錦井秀和; 坂田麻実子; 長谷川雄一; 千葉滋
第41回日本臨床薬理学会学術総会/2020-12-03--2020-12-05
タクロリムスとレテルモビルの薬物相互作用が疑われた造血幹細胞移植の一症例
森山侑太; 横田直之; 錦井秀和; 千葉滋; 鈴木嘉治; 本間真人
第41回日本臨床薬理学会学術総会/2020-12-03--2020-12-05
サイモグロブリン，シクロスポリン，エルトロンボパグ併用療法が奏効したHIV感染合併再生不良性貧血
加村雄哉; 小原直; 石塚幹太郎; 服部圭一朗; 丸山ゆみ子; 坂本竜弘; 日下部学; 加藤貴康; 栗田尚樹; 横山泰久; 錦井秀和; ...
第14回日本血液学会関東甲信越地方会/2021-03-20--2021-03-20
Leukemic proliferation-stress induces the defect of stem cell niche and normal hematopoiesis
Mizuki Saito; Saki Tanaka; Hidekazu Nishikii; Yusuke Kiy...
第82回　日本血液学会学術集会/2020-10-10--2020-11-08
A retrospective, single-center analysis on conditioning regimens of cord blood transplantation
Yumoe Sakamoto-Iimura; Naoki Kurita; Tatsuhiro Sakamoto; ...
第82回　日本血液学会学術集会/2020-10-10--2020-11-08
Treatment outcomes for FLT3-ITD mutated AML with gilteritinib: a single center retrospective study
Yuki Yoshizawa; Takayasu Kato; Kenichi Makishima; Tatsuhi...
第82回　日本血液学会学術集会/2020-10-10--2020-11-08
Somatic mutations of the BM in aplastic anemia patients during TPO-RA treatment
Tatsuhiro Sakamoto; Naoshi Obara; Yasuhito Nannya; Manabu...
第82回　日本血液学会学術集会/2020-10-10--2020-11-08
造血幹細胞移植患者におけるタクロリムスとレテルモビルの薬物相互作用　タクロリムスの投与経路が薬物相互作用に及ぼす影響
森山侑太; 鈴木嘉治; 加藤貴康; 錦井秀和; 千葉滋; 本間真人
日本薬学会第140年会/2020-03
Transplantation from an HLA halotype mismatched related donar as a first-line treatment for fulminant type aplastic anemia
槇島健一; 小原直; 石塚幹太郎; 助川慎一郎; 百瀬春佳; 丸山ゆみ子; 坂本竜弘; 加藤貴康; 日下部学; 栗田尚樹; 横山泰...
第42回　日本造血細胞移植学会/2020-03-05--2020-03-07
Distinct Bone Marrow Microenvironment Abnormalities in MDS and MPN with Fibrosis
Luan Cao Sy; Takahoko Yoshiaki; Nishikii Hidekazu; Obara ...
61st ASH Annual Meeting and Exposition/2019-12-07--2019-12-10
特発性血小板減少性紫斑病患者における血清エルトロンボパグ濃度が肝障害発現に及ぼす影響
柳町直哉; 小原直; 横山泰久; 錦井秀和; 坂田(柳元)麻実子; 長谷川雄一; 大越靖; 千葉滋; 土岐浩介; 本間真人
第81回日本血液学会学術集会/2019-10-11--2019-10-13
再発難治性血管免疫芽球性T細胞リンパ腫を対象としたT細胞受容体シグナルに対する標的治療
坂田(柳元)麻実子; 清木祐介; トランヌエン; 藤澤学; 南谷泰仁; 石塚幹太郎; 百瀬春佳; 品川篤司; 周山拓也; 佐...
第81回日本血液学会学術集会/2019-10-11--2019-10-13
Targeting T-Cell Receptor Signaling as Angioimmunoblastic T-CellLymphoma Treatment
Nguyen Tran B.; Sakata-Yanagimoto Mamiko; Fujisawa Manab...
The 78th Annual Meeting of the Japanese Cancer Association/2019-09-26--2019-09-28
地固め療法中に骨髄壊死を認めたフィラデルフィア染色体陽性急性リンパ芽球性白血病
石塚幹太郎; 小原直; 坂本竜弘; 加藤貴康; 日下部学; 栗田尚樹; 横山泰久; 錦井秀和; 坂田(柳元)麻実子; 長谷川雄一...
第11回日本血液学会関東甲信越地方会/2019-07-27--2019-07-27
more...

Teaching


2022-04 -- 2022-08	Advanced Seminar in Medical Sciences	University of Tsukuba.
2022-10 -- 2023-02	Advanced Seminar in Medical Sciences	University of Tsukuba.
2023-01 -- 2023-02	Hematology for Beginners	University of Tsukuba.
2022-10 -- 2022-12	Outline of Internal Medicine	University of Tsukuba.
2022-10 -- 2022-12	English Communication for Medical Sciences I	University of Tsukuba.
2022-04 -- 2022-08	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2022-10 -- 2023-02	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2021-10 -- 2022-02	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2021-04 -- 2021-08	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2021-10 -- 2021-12	Outline of Internal Medicine	University of Tsukuba.
more...

(Last updated: 2023-01-16)