Obara Naoshi
- Affiliation
- Faculty of Medicine
- Official title
- Professor
- Research projects
造血不全における造血支持細胞異常と赤芽球島形成障害の解明 2021 -- 2023 小原 直 日本学術振興会/基盤研究(C)/ 4,290,000Yen 特発性寒冷凝集素症に関連する異常クローンの解明 2019 -- 2020 JB奨学寄付/ 300,000Yen 特発性寒冷凝集素症に関わる異常クローンの解明 2018 -- 2019 JB奨学寄附/ 300,000Yen 骨髄異形成症候群における造血支持細胞の異常および病態解明 2012 -- 2013 小原 直 大阪癌研究会/ 500,000Yen 骨髄赤芽球造血ニッチの解明 2015 -- 2017 日本学術振興会/挑戦的萌芽研究/ 3,640,000Yen 低酸素応答系遺伝子発現における転写制御の解明 2007 -- 2008 小原 直 日本学術振興会/若手研究(B)/ 3,690,000Yen エリスロポエチン遺伝子の組織特異的遺伝子発現に関する研究 2010 -- 2011 小原 直 日本腎臓財団/ エリスロポエチン遺伝子のGATA転写因子による発現調節機構の解明 2011 -- 2012 小原 直 日本腎臓財団/ エリスロポエチン産生細胞における神経系マーカーの発現・機能解析 2013 -- 2014 小原 直 日本腎臓財団/ 800,000Yen エリスロポエチン産生細胞におけるNotchシグナルの解析 2014 -- 2015 小原 直 日本腎臓財団/ 2,000,000Yen more... - Degree
2005-03 博士(医学) 筑波大学 - Licenses and qualifications
日本輸血・細胞治療学会認定医 日本血液学会認定指導医 日本血液学会認定専門医 日本内科学総合内科専門医 日本内科学会認定内科認定医 医師免許証 - Academic societies
-- (current) 日本輸血細胞治療学会 -- (current) 日本医学史 -- (current) The Molecular Biology Society of Japan -- (current) 日本造血幹細胞移植学会 -- (current) THE JAPANESE SOCIETY OF HEMATOLOGY -- (current) THE JANPANESE SOCIETY OF INTERNAL MEDICINE - Articles
- Triple-negative Thrombocythemia and Subsequent Acute Lymphoblastic Leukemia with Additional Somatic Mutations
Tsuboi Yuri; Sakamoto Tatsuhiro; Makishima Kenichi; Su...
Internal medicine (Tokyo, Japan), 2022-09-13 - 特集 内科疾患の診断基準・病型分類・重症度
小原 直
内科/127(4)/pp.917-919, 2021-04 - Administration of brentuximab vedotin to a Hodgkin lymphoma patient with liver dysfunction due to vanishing bile duct syndrome resulting in a partial response without any severe adverse events
Ishitsuka Kantaro; Yokoyama Yasuhisa; Baba Naoko; Mats...
Journal of clinical and experimental hematopathology : JCEH, 2022-07-12 - A Case of Cardiac Tamponade as a Recurrence of Angioimmunoblastic T-Cell Lymphoma with the Detection of a p.Gly17Val RHOA Mutation in the Pericardial Effusion
Tsuboi Yuri; Iimura Yumoe; Matsumura Fumiaki; Nanmoku To...
Internal medicine (Tokyo, Japan), 2022-06-21 - A Case of Cardiac Tamponade as a Recurrence of Angioimmunoblastic T-Cell Lymphoma with the Detection of a p.Gly17Val RHOA Mutation in the Pericardial Effusion
Tsuboi Yuri; Iimura Yumoe; Matsumura Fumiaki; Nanmoku To...
Internal medicine (Tokyo, Japan), 2022-06-21 - Long-term follow-up of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: post-marketing surveillance in Japan
Ikezoe Takayuki; Noji Hideyoshi; Ueda Yasutaka; Kanda ...
INTERNATIONAL JOURNAL OF HEMATOLOGY/115(4)/pp.470-480, 2022-02-11 - [Acquired platelet dysfunction with severe bleeding tendency in triple-negative myelofibrosis]
Momose Haruka; Nishikii Hidekazu; Kozuma Yukinori; Ota-Ts...
[Rinsho ketsueki] The Japanese journal of clinical hematology/62(9)/pp.1406-1411, 2021-09 - Salvage Cord Blood Transplantation Using a Short-term Reduced-intensity Conditioning Regimen for Graft Failure.
Suma S; Yokoyama Y; Momose H; Makishima K; Kiyoki Y; Saka...
INTERNAL MEDICINE/61(11)/pp.1673-1679, 2021-11 - [IgG-variant Bing-Neel syndrome diagnosed by detecting MYD88 L265P mutation in the cerebrospinal fluid cells]
Maruyama Yumiko; Nishikii Hidekazu; Matsuoka Ryota; Makis...
[Rinsho ketsueki] The Japanese journal of clinical hematology/62(10)/pp.1493-1498, 2021-10 - Early administration of cyclosporine may reduce the incidence of cytokine release syndrome after HLA-haploidentical hematopoietic stem-cell transplantation with post-transplant cyclophosphamide
Kurita Naoki; Sakamoto Tatsuhiro; Kato Takayasu; Kusakabe...
Annals of hematology/100(5)/pp.1295-1301, 2021-02 - A simple HPLC assay for determining eltrombopag concentration in human serum
Yanagimachi Naoya; Obara Naoshi; Sakata-Yanagimoto Mam...
BIOMEDICAL CHROMATOGRAPHY/Epub, 2020-12 - The clinical significance of PNH-phenotype cells accounting for < 0.01% of total granulocytes detected by the Clinical and Laboratory Standards Institute methods in patients with bone marrow failure
Hosokawa Kohei; Ishiyama Ken; Ikemoto Toshiyuki; Sugim...
ANNALS OF HEMATOLOGY/Epub, 2020-10 - Haploidentical transplantation from a related donor as first-line treatment for fulminant aplastic anemia
槇島 健一; 長谷川 雄一; 千葉 滋; 小原 直; 坂本 竜弘; 加藤 貴康; 日下部 学; 錦井 秀和; 栗田...
Rinsho Ketsueki/61(10)/pp.1464-1468, 2020-10 - Reference guide for the treatment of aplastic anemia
小原 直
Rinsho Ketsueki/61(9)/pp.1071-1079, 2020-09 - Eltrombopag in Combination with Rabbit Anti-thymocyte Globulin/Cyclosporine A in Immunosuppressive Therapy-naïve Patients with Aplastic Anemia in Japan
Imada Kazunori; Obara Naoshi; Iida Hiroatsu; Imajo Kenji...
Internal Medicine/60(8)/pp.1159-1168, 2020-11 - Philadelphia chromosome-positive acute lymphoblastic leukemia complicated by bone marrow necrosis during consolidation chemotherapy
Ishitsuka Kantaro; Obara Naoshi; Suyama Takuya; Matsuoka ...
Rinsho Ketsueki/61(5)/pp.462-467, 2020-05 - Dasatinib Is an Effective Treatment for Angioimmunoblastic T-cell Lymphoma.
TB Nguyen; M Sakata-Yanagimoto; M Fujisawa; S Tanzima Nu...
Cancer Res/80(9)/pp.1875-1884, 2020-02 - Salvage Cord Blood Transplantation Using a Short-Term Reduced-Intensity Preparative Regimen for Graft Failure
Suma-Sugimoto Sakurako; Yokoyama Yasuhisa; Yoshida Chika...
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA/19(1)/pp.S261-S262, 2019-09 - Hematologic recovery induced by eltrombopag in Japanese patients with aplastic anemia refractory or intolerant to immunosuppressive therapy
Yamazaki Hirohito; Ohta Kensuke; Iida Hiroatsu; Imada ...
International journal of hematology/110(2)/pp.187-196, 2019-06 - Fatal exacerbations of chronic active Epstein-Barr virus infection subsequent to cytotoxic chemotherapy
須摩 桜子; 横山 泰久; 坂田(柳元) 麻実子; 小原 直; 長谷川 雄一; 千葉 滋; 栗田 尚樹; 馬場 ...
Rinsho Ketsueki/60(4)/pp.286-290, 2019-04 - Notch Signaling in Nestin-Expressing Cells in the Bone Marrow Maintains Erythropoiesis via Macrophage Integrity
Sakamoto Tatsuhiro; Obara Naoshi; Nishikii Hidekazu; Kato...
Stem cells (Dayton, Ohio)/37(7)/pp.924-936, 2019-04 - Chronic Graft-versus-host Disease Presenting with Multiple Punctate Intracranial Lesions on Contrast-enhanced Magnetic Resonance Imaging
Makoto Terada; Nakamagoe Kiyotaka; Naoshi Obara; Shinichi...
Internal Medicine., 2017-02 - Chronic Graft-versus-host Disease Presenting with Multiple Punctate Intracranial Lesions on Contrast-enhanced Magnetic Resonance Imaging
Makoto Terada; Nakamagoe Kiyotaka; Naoshi Obara; Shinichi...
Internal Medicine., 2018-02 - Chronic Graft-versus-host Disease Presenting with Multiple Punctate Intracranial Lesions on Contrast-enhanced Magnetic Resonance Imaging
Makoto Terada; Nakamagoe Kiyotaka; Naoshi Obara; Shinichi...
Internal Medicine., 2017-02 - Effectiveness of random skin biopsies for intravascular large B-cell lymphoma with or without central nervous system involvement
E Yamada; Ishikawa Eiichi; R Watanabe; H Matsumura; N Sa...
World Neurosurgery, 2019-01 - more...
- Triple-negative Thrombocythemia and Subsequent Acute Lymphoblastic Leukemia with Additional Somatic Mutations
- Books
- Ⅱ.赤血球系疾患 10.腎性貧血
小原 直
EBM 血液疾患の治療 2019-2020/中外医学社/pp.69-74, 2018-10 - Use of gene-manipulated mice in the study of Erythropoietin gene expression
Suzuki Norio; Obara Naoshi; Yamamoto Masayuki
OXYGEN BIOLOGY AND HYPOXIA/ELSEVIER ACADEMIC PRESS INC/pp.157-0, 2007-01
- Ⅱ.赤血球系疾患 10.腎性貧血
- Conference, etc.
- COMPOSER Part 4: an optimized dosing strategy for crovalimab in patients with PNH
Obara Naoshi; Latour Regis Peffault de; Sica Simona; Ramo...
第83回日本血液学会学術集会/2021-09-23--2021-09-25 - 発作性夜間ヘモグロビン尿症患者(PNH)に対するラブリズマブ特定使用成績調査の中間解析
臼杵 憲祐; 池添 隆之; 石山 謙; 神田 善伸; 後藤 明彦; 松田 貴久; 下野 明彦; 秋山 仁泉; 小原...
第83回日本血液学会学術集会/2021-09-23--2021-09-25 - 高度な骨髄線維化を認め診断に苦慮したリンパ形質細胞性リンパ腫の1例
宝田 亜矢子; 百瀬 春佳; 栗田 尚樹; 坂本 竜弘; 加藤 貴康; 服部 圭一朗; 末原 泰人; 横山 泰久...
第16回 日本血液学会関東甲信越地方会/2022-03-19--2022-03-19 - Birt-Hogg-Dube症候群に合併した多発性骨髄腫の1例
松村 文明; 坂本 竜弘; 甲斐 平康; 加藤 貴康; 栗田 尚樹; 横山 泰久; 錦井 秀和; 坂田(柳元) ...
第675回日本内科学会関東地方会/2022-02-12--2022-02-12 - Clinical Significance of Small PNH-Type Cell Populations in Bone Marrow Failure Syndromes - an Interim Analysis of Japanese Multicentrer Prospective Study -
Ueda Yasutaka; Hosokawa Kohei; Ishiyama Ken; Takamori Hi...
63rd ASH Annual Meeting and Exposition/2021-12-11--2021-12-14 - Real-world experience of Ph(-)ALL treated with a pediatric regimen: a single center study
Yuki Yoshizawa; Takayasu Kato; Kenichi Makishima; Yufu I...
第83回日本血液学会学術集会/2021-09-23--2021-09-25 - Repeated immunosuppressive therapy using rabbit anti-thymocyte globulin for aplastic anemia
Tatsuhiro Sakamoto; Naoshi Obara; Takayasu Kato; Naoki K...
第83回日本血液学会学術集会/2021-09-23--2021-09-25 - 腫瘍細胞の神経浸潤による末梢神経障害を合併した原発性マクログロブリン血症
法岡菜月; 栗田 尚樹; 加村 雄哉; 日下部 学(医学医療系); 坂本 竜弘; 加藤 貴康; 横山 泰久; 錦井 ...
第15回 日本血液学会関東甲信越地方会/2021-07-10--2021-07-10 - 特発性血小板減少性紫斑病におけるエルトロンボパグの血中濃度が肝障害発現に及ぼす影響
本間 真人; 柳町 直哉; 土岐 浩介; 小原 直; 錦井 秀和; 坂田 麻実子; 長谷川 雄一; 千葉 滋
第41回日本臨床薬理学会学術総会/2020-12-03--2020-12-05 - Streptococcus pneumoniae菌血症(莢膜型33B)を契機に診断された分類不能型免疫不全(CVID)の一例
鈴木 広道; 竹内優都; 劉彦伯; 小原直
革新的進歩を遂げる迅速核酸増幅検査と感染症専門医による医療現場での最適化について/2020-08-19--2020-08-21 - サイモグロブリン,シクロスポリン,エルトロンボパグ併用療法が奏効したHIV感染合併再生不良性貧血
加村雄哉; 小原直; 石塚幹太郎; 服部圭一朗; 丸山ゆみ子; 坂本竜弘; 日下部学; 加藤貴康; 栗田尚樹; 横山泰久; 錦井秀和; ...
第14回 日本血液学会関東甲信越地方会/2021-03-20--2021-03-20 - Leukemic proliferation-stress induces the defect of stem cell niche and normal hematopoiesis
Mizuki Saito; Saki Tanaka; Hidekazu Nishikii; Yusuke Kiy...
第82回 日本血液学会学術集会/2020-10-10--2020-11-08 - A retrospective, single-center analysis on conditioning regimens of cord blood transplantation
Yumoe Sakamoto-Iimura; Naoki Kurita; Tatsuhiro Sakamoto; ...
第82回 日本血液学会学術集会/2020-10-10--2020-11-08 - Treatment outcomes for FLT3-ITD mutated AML with gilteritinib: a single center retrospective study
Yuki Yoshizawa; Takayasu Kato; Kenichi Makishima; Tatsuhi...
第82回 日本血液学会学術集会/2020-10-10--2020-11-08 - Somatic mutations of the BM in aplastic anemia patients during TPO-RA treatment
Tatsuhiro Sakamoto; Naoshi Obara; Yasuhito Nannya; Manabu...
第82回 日本血液学会学術集会/2020-10-10--2020-11-08 - 再生不良性貧血診療ガイド
小原 直
第82回 日本血液学会学術集会/2020-10-10--2020-11-08 - アゾール系抗真菌薬の併用がオキシコドンの副作用症状に及ぼす影響(第2報)
渡邊 雅明; 小原 直; 千葉 滋; 本間真人
第63回日本薬学会関東支部大会/2019-09-14--2019-09-14 - Transplantation from an HLA halotype mismatched related donar as a first-line treatment for fulminant type aplastic anemia
槇島健一; 小原 直; 石塚幹太郎; 助川慎一郎; 百瀬春佳; 丸山ゆみ子; 坂本竜弘; 加藤貴康; 日下部学; 栗田尚樹; 横山泰...
第42回 日本造血細胞移植学会/2020-03-05--2020-03-07 - Distinct Bone Marrow Microenvironment Abnormalities in MDS and MPN with Fibrosis
Luan Cao Sy; Takahoko Yoshiaki; Nishikii Hidekazu; Obara ...
61st ASH Annual Meeting and Exposition/2019-12-07--2019-12-10 - 特発性血小板減少性紫斑病患者における血清エルトロンボパグ濃度が肝障害発現に及ぼす影響
柳町直哉; 小原 直; 横山泰久; 錦井秀和; 坂田(柳元)麻実子; 長谷川雄一; 大越 靖; 千葉 滋; 土岐浩介; 本間真人
第81回 日本血液学会学術集会/2019-10-11--2019-10-13 - 再発難治性血管免疫芽球性T細胞リンパ腫を対象としたT細胞受容体シグナルに対する標的治療
坂田(柳元)麻実子; 清木祐介; トラン ヌエン; 藤澤 学; 南谷泰仁; 石塚幹太郎; 百瀬春佳; 品川篤司; 周山拓也; 佐...
第81回 日本血液学会学術集会/2019-10-11--2019-10-13 - Targeting T-Cell Receptor Signaling as Angioimmunoblastic T-CellLymphoma Treatment
Nguyen Tran B.; Sakata-Yanagimoto Mamiko; Fujisawa Manab...
The 78th Annual Meeting of the Japanese Cancer Association/2019-09-26--2019-09-28 - 地固め療法中に骨髄壊死を認めたフィラデルフィア染色体陽性急性リンパ芽球性白血病
石塚幹太郎; 小原 直; 坂本竜弘; 加藤貴康; 日下部学; 栗田尚樹; 横山泰久; 錦井秀和; 坂田(柳元)麻実子; 長谷川雄一...
第11回 日本血液学会関東甲信越地方会/2019-07-27--2019-07-27 - Targeting T-cell receptor signaling pathway by dasatinib in relapsed/refractory angioimmunoblastic T-cell lymphoma
清木祐介; 坂田(柳元)麻実子; Tran B. Ngyen; 藤澤 学; 南谷泰仁; 石塚幹太郎; 百瀬春佳; 助川慎一郎...
第59回 日本リンパ網内系学会総会/2019-06-27--2019-06-29 - The relationship between the pretreatment PNH clone size and clinical course in patients with bone marrow failure syndromes: Interim analysis of Japanese multicenter prospective study
Ueda Yasutaka; Hosokawa Kohei; Ishiyama Ken; Takamori Hi...
The 24th Congress of EHA/2019-06-13--2019-06-16 - more...
- COMPOSER Part 4: an optimized dosing strategy for crovalimab in patients with PNH
- Teaching
2022-10 -- 2022-12 Introduction of Medical Science University of Tsukuba. 2022-10 -- 2023-02 Advanced Seminar in Medical Sciences University of Tsukuba. 2022-04 -- 2022-08 Advanced Seminar in Medical Sciences University of Tsukuba. 2022-10 -- 2022-12 Clinical Pathophysiology University of Tsukuba. 2022-10 -- 2022-12 Medical Quality and Safety Science: Lecture and Practice University of Tsukuba. 2022-05 -- 2022-08 Clinical Hematology University of Tsukuba. 2022-10 -- 2022-12 Practice of Clinical Hematology University of Tsukuba. 2022-05 -- 2022-08 Science of Medical Information University of Tsukuba. 2022-04 -- 2022-08 Clinical Oncology: Hematogenous Cancer University of Tsukuba. 2022-10 -- 2023-02 Clinical Oncology: Hematogenous Cancer University of Tsukuba. more... - Professional activities
2018 -- 2020 THE JAPANESE SOCIETY OF HEMATOLOGY 専門医委員会 2017 -- 2019 THE JAPANESE SOCIETY OF HEMATOLOGY 診療委員会
(Last updated: 2022-08-14)