YAMASHITA Toshiharu

Affiliation
Institute of Medicine
Official title
Assistant Professor
Email
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Fax
029-853-2938
Research fields
Molecular biology
Research keywords
分子生物学
Research projects
Molecular mechanisms and target therapy of vessel co-option and mimicry for glioblastoma2018-04 -- 2024-03TAKANO ShingoJapan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (C)600,000Yen
Developmental mechanisms of glioblastoma-derived blood vessels and their effect on malignancy2015-04 -- 2018-03YAMASHITA ToshiharuJapan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (C)5,200,000Yen
the role of novel bHLH/PAS factor in hypoxic response2005 -- 2007YAMASHITA Toshiharu/
Anti-angiogenic therapy for glioma beyond VEGF inhibition based on tumor microenvironment2012-04 -- 2016-03TAKANO ShingoJapan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (B)500,000Yen
Analysis of the effects of hypoxia inducible factor for tumor metastasis2012-04 -- 2014-03YAMASHITA ToshiharuJapan Society for the Promotion of Science/Grant-in-Aid for Young Scientists (B)4,420,000Yen
A functional analysis of HIF for tumor metastasis2009 -- 2010YAMASHITA ToshiharuJapan Society for the Promotion of Science/Grant-in-Aid for Young Scientists (B)4,290,000Yen
New degenerative therapy for cerebral infarction by the functional vascular endothelial progenitor cells2009 -- 2011SUZUKI KensukeJapan Society for the Promotion of Science/Grants-in-Aid for Scientific Reseach (C)4,550,000Yen
Analysis of functional EPC for the treatment of ischemic disease2008 -- 2010OHNEDA OsamuJapan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (C)4,550,000Yen
Antiangiogenic therapy using endothelial progenitor cells for malignant tumors2006 -- 2008TAKANO ShingoJapan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (C)4,100,000Yen
Career history
2003-04 -- 2005-03JST/ERATOResearch associate
Academic background
-- 1996東北大学 理学部 化学科
-- 2003東北大学大学院 理学研究科 化学専攻
Degree
2003-04博士（理学）東北大学
Academic societies
-- (current)The Japanese Cancer Association
-- (current)THE JAPANESE SOCIETY OF HEMATOLOGY
-- (current)THE JAPANESE BIOCHEMICAL SOCIETY
-- (current)The Molecular Biology Society of Japan
Articles
Books
  • 環境応答系転写因子の分子機構の解明
    山下年晴; 山本 雅之
    化学工業, 2003-01
  • HIFのin vivoモデルによる機能解析
    山下年晴; 大根田修
    実験医学　羊土社, 2007-09
Conference, etc.
  • Virtual multi-directional optical coherence tomography
    El-Sadek Ibrahim Abd; Miyazawa Arata; Shen Larina; Fukuda...
    SPIE Photonics West/ BiOS 2020/2020-02-03--2020-02-05
  • 3D label-free dynamics imaging of liver microvasculature by optical coherence microscopy
    Mukherjee Pradipta; Miyazawa Arata; Fukuda Shinichi; Yama...
    Optics & Photonics Japan 2020/2020-11-14--2020-11-17
  • Revealing renal tubular structural metabolism without labeling by functional optical coherence tomography
    Mukherjee Pradipta; Fukuda Shinichi; Lukmanto Donny; Yama...
    Optics & Photonics Japan 2022/2022-11-13--2022-11-16
  • Assessment of renal functional changes in obstructed nephropathy using optical coherence tomography
    Mukherjee Pradipta; Fukuda Shinichi; Lukmanto Donny; Yama...
    Optics and Photonics Japan/2021-10-26--2021-10-29
  • Multi-functional optical coherence microscopy for in-vitro and ex-vivo tissue investigation
    Yasuno Yoshiaki; El-Sadek Ibrahim Abd; Miyazawa Arata; Sh...
    European Conference on Biomedical Optics/2021-06-20--2021-06-24
  • Volumetric multi-contrast dynamics imaging for ex vivo liver microvasculature activity visualization using Jones matrix optical coherence tomography
    Mukherjee Pradipta; Miyazawa Arata; Shen L. T. W.; Fukuda...
    Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, Photonics West BiOS/2021-03-06--2021-03-11
  • Three-dimensional imaging of mouse liver dynamics by polarization-sensitive optical coherence tomography
    Mukherjee Pradipta; Miyazawa Arata; Fukuda Shinichi; Yama...
    Label-free Biomedical Imaging and Sensing (LBIS) 2021, Photonics West BiOS/2021-03-06--2021-03-11
  • Renal tubular structure and metabolism revealed by dynamic optical coherence tomography and OCT angiography
    Mukherjee Pradipta; Fukuda Shinichi; Lukmanto Donny; Yama...
    Dynamics and Fluctuations in Biomedical Photonics XX, Photonics West BiOS/2023-01-29--2023-01-30
  • Transformed Extracellular Vesicles with High Angiogenic Ability as Therapeutics of Distal Ischemic Tissues
    Ngo Nhat-Hoang; Khanh Vuong Cat; Yamashita Toshiharu; Ohn...
    Tsukuba Global Science Week 2022/2022-09-29
  • Extracellular vesicles derived from Wharton’s Jelly mesenchymal stem cells inhibit the tumor environment via the miR-125b/HIF1α signaling pathway
    Yun-Hsuan Chang; Vuong Cat Khanh; Toshiharu Yamashita; Os...
    Tsukuba Global Science Week 2022/2022-09-30
  • SARS-CoV-2 M Protein Facilitates Malignant Transformation of Breast Cancer Cells
    Nguyen Hoai-Nga Thi; Khanh Vuong Cat; Yamashita Toshihar...
    Tsukuba Global Science Week 2022/2022-09-29
  • より高い治療効果を持つ機能性血管内皮前駆細胞 (EPC) の作成
    佐藤悠樹; Vuong Cat Khanh; Toshiharu Yamashita; Osamu Ohneda
    第18回日本再生医療学会総会/2019-03-21--2019-03-23
  • 老化による脂肪組織由来間葉系幹細胞の創傷治癒能に対する影響の解析
    原彩美; Vuong Cat Khanh; Toshiharu Yamashita; Osamu Ohneda
    第18回日本再生医療学会総会/2019-03-21--2019-03-23
  • Study the effects of type 2 diabetes mellitus on functions of Wharton jelly's Mesenchymal stem cells for the treatment of diabetic foot ulcer
    Sipayung Shinta Masyta; Khanh Vuong Cat; Yamashita Toshi...
    The Joint Young Research Meeting in Biomedical Science/2020-01-10--2020-01-11
  • Impairment of Sirt1 plays the key role in the dysfunction of mesenchymal stem cells in beige adipogenesis
    Vuong Cat Khanh; Yamashita Toshiharu; Ohneda Osamu
    The Joint Young Research Meeting in Biomedical Science/2020-01-10--2020-01-11
  • Effects of aging on mesenchymal stem cells
    VUONG CAT KHANH; Yamashita Toshiharu; Ohneda Osamu
    The 1st University of Tsukuba-University of Science Vietnam Joint Symposium 2019/2019-02-23
  • Nicotine and SARS-CoV-2 Protein Induce the Malignancy of Lung Cancer Cell. International Student Presentations of Medical and Life Sciences Session.
    Lomanto Markus Yovian Widjaja; Nguyen Hoai-Nga Thi; Khanh...
    Tsukuba Global Science Week 2022/2022-09-29
  • Study the effects of Type 2 diabetes mellitus on beige adipogenesis of Mesenchymal stem cells
    Takeuchi Kosuke; Khanh Vuong Cat; Yamashita Toshiharu; Oh...
    Tsukuba Science Week 2018/2018-09-20
  • Assessment of renal functional changes in obstructed nephropathy using optical coherence tomography
    Mukherjee Pradipta; Fukuda Shinichi; Lukmanto Donny; Yama...
    Optics and Photonics Japan/2021-10-26--2021-10-29
  • Quantification of ex-vivo tissue activity by polarization dynamics imaging using Jones matrix optical coherence tomography
    Mukherjee Pradipta; Miyazawa Arata; Shen Larina; Fukud...
    Biomedical Imaging and Sensing Conference 2020/2020-08-24--2020-09-04
  • Quantification of ex vivo tissue activity by short and long time-course analysis of multifunctional OCT signals
    El-Sadek Ibrahim Abd; Miyazawa Arata; Shen Larina; Fukuda...
    SPIE Photonics West/ BiOS 2020/2020-02-01--2020-02-06
  • Short and long time-course ex vivo tissues activity quantification by multifunctional OCT
    El-Sadek Ibrahim Abd; Miyazawa Arata; Shen Larina; Fukuda...
    Optics Photonics Japan 2019 （日本光学会年次講演会）/2019-12-2--2019-12-05
  • Birefringence dynamics imaging for ex-vivo tissue activity quantification using polarization-sensitive optical coherence tomography
    Mukherjee Pradipta; El-Sadek Ibrahim Abd; Miyazawa Arata...
    Optics Photonics Japan 2019 （日本光学会年次講演会）/2019-12-2--2019-12-05
  • Effect of soy protein intake on weak bones by the food restriction in young female rats
    Y Aikawa; T Narukawa; K Kioka; T Yamashita; N Sasai; M O...
    Human High Performance International Forum 2020/2020-02-17--2020-02-17
  • The ectopic FOXA1 expression correlates to the luminal breast cancer stem cells
    Tachi K.; Shiraishi A.; Bando H.; Yamashita T.; Tsuboi I...
    San Antonio Breast Cancer Symposium/2016-12-06--2016-12-10
  • more...
Teaching
2024-04 -- 2024-07Stem Cell TherapyUniversity of Tsukuba.
2024-07 -- 2024-07Practice of Blood TransfusionUniversity of Tsukuba.
2024-07 -- 2024-07Transfusion MedicineUniversity of Tsukuba.
2024-04 -- 2024-07Stem Cell TherapyUniversity of Tsukuba.
2023-04 -- 2023-06Stem Cell TherapyUniversity of Tsukuba.
2023-07 -- 2023-07Practice of Blood TransfusionUniversity of Tsukuba.
2023-10 -- 2024-02Special Practice in Human Biology IUniversity of Tsukuba.
2023-04 -- 2023-06Stem Cell TherapyUniversity of Tsukuba.
2023-07 -- 2023-07Transfusion MedicineUniversity of Tsukuba.
2022-04 -- 2022-06Stem Cell TherapyUniversity of Tsukuba.
more...
Other educational activities
2015-04 -- (current)実習（OSLE）委員筑波大学医療科学類
2018-04 -- (current)HBP教務委員筑波大学
2017 -- 2017フロンティア医科学　入試問題作製委員筑波大学
2014 -- (current)CREILセンター 遺伝子組換え実験担当CREILセンター
2011 -- 2011フロンティア医科学　入試問題作成委員University of Tsukuba.
Talks
  • More effective repair of ischemic regions by adipose tissue-derived MSCs is associated with stronger expression of CCL5
    木村健一; 長野真澄; 山下年晴; Georgina Salazar; 秋本恵子; 三島初; 松島昌之助; 大根田修
    The 9th Annual Meeting of International Society for Stem Cell Research/2011-06-15
  • Analysis of Function of Endothelial progenitor cells for Retinitis Pigmentosa
    Shinichi Fukuda; Masumi Nagano; Toshiharu Yamashita; Tets...
    World Congress of Ophthalmology/2012-02-16
  • Endothelial Progenitor Cells from Umbilical Cord Blood rescued Vessel and Photoreceptor with Retinal Degeneration
    Shinichi Fukuda; Masumi Nagano; Toshiharu Yamashita; Tets...
    ARVO Annual Meeting/2011-05-01
  • 機能性が高い血管内皮前駆細胞の網膜色素変性症モデルマウスへの投与効果の検討
    福田慎一; 長野真澄; 山下年晴; 大鹿哲郎; 大根田修
    第115回日本眼科学会/2011-05-12
  • Analysis of erythropoiesis in HIF-alpha –gene targeted mice
    坪井一輝; 山下年晴; 木村健一; 大根田修
    第9回がんとハイポキシア研究会/2011-11-26
  • マウス造血微小環境におけるHIF-2alphaの機能解析
    坪井一輝; 山下年晴; 木村健一; 大根田修
    第34回日本分子生物学学会/2011-12-13
  • Identification of the characteristic differences between human adipose tissue-derived mesenchymal stem cells from diabetic and non-diabetic donors.
    Trinh Nhu Thuy; Kenichi Kimura; Toshiharu Yamashita; Goer...
    The 10th NTU-Japan International mini-symposium on Molecular and Cell Biology & Promotion of Academic Exchange and Collaborations for NTU-Japan/2012-01-08
  • Analysis of primary breast cancer cells in association with ALDH activity
    白石章; 木村健一; 長野真澄; 山下年晴; 坂東裕子; 原尚人; 大根田修
    第9回がんとハイポキシア研究会/2011-11-26
  • 乳がん細胞における低酸素応答転写因子HIF-1alphaの機能解析
    白石章; 木村健一; 長野真澄; 山下年晴; 坂東裕子; 原尚人; 大根田修
    第34回　日本分子生物学学会/2011-12-13
  • ステロイド治療による脂肪組織由来間葉系幹細胞の分化に対する影響
    木村健一; 長野真澄; 山下年晴; 秋本恵子; 野澤大輔; 落合直之; 大根田修
    第10回日本再生医療学会総会/2011-03-01
  • 血管内皮細胞におけるHIF因子とがん転移との関連性の解析
    山下年晴; 小林里美; 坪井一輝; 長野真澄; 大根田修
    第8回がんとハイポキシア研究会/2011-01-29
  • マウス肺の内皮細胞におけるHIF-3alphaの機能解析
    小林里美; 山下年晴; 長野真澄; 木村健一; 大根田修
    第8回がんとハイポキシア研究会/2011-01-29
  • 原発性乳がん細胞を用いた低酸素応答性における機能解析
    白石章; 木村健一; 長野真澄; 山下年晴; 坂東裕子; 原尚人; 大根田修
    第8回がんとハイポキシア研究会/2011-01-29
  • マウス造血微小環境におけるHIF-2alphaの機能解析
    坪井一輝; 山下年晴; 木村健一; 大根田修
    第8回がんとハイポキシア研究会/2011-01-29
  • Glioblastoma抑制に関するヒト間葉系幹細胞の影響についての機能解析
    秋本恵子; 木村健一; 長野真澄; 高野晋吾; 山下年晴; 大根田修
    第8回がんとハイポキシア研究会/2011-01-29
  • 低酸素応答性の高い間葉系幹細胞を用いた骨治療
    木村健一; 長野真澄; 山下年晴; 野澤大輔; 濱田洋美; 落合直之; 吉川裕之; 大根田修
    第8回がんとハイポキシア研究会/2011-01-29
  • 機能性が高い血管内皮前駆細胞の網膜色素変性症モデルマウスへの投与効果の検討
    福田慎一; 長野真澄; 山下年晴; 大鹿哲郎; 大根田修
    第8回がんとハイポキシア研究会/2011-01-29
  • 腫瘍血管内皮細胞におけるHIF機能の解析
    山下年晴; 小林里美; 坪井一輝; 長野真澄; 大根田修
    第33回日本分子生物学会/2010-12-07
  • マウス肺の内皮細胞におけるHIF-3alphaの機能解析
    小林里美; 山下年晴; 長野真澄; 木村健一; 大根田修
    第33回日本分子生物学会/2010-12-07
  • マウス造血微小環境におけるHIF-2alphaの機能解析
    坪井一輝; 山下年晴; 木村健一; 大根田修
    第33回日本分子生物学会/2010-12-07
  • グリオブラストーマ抑制に関するヒト間葉系幹細胞の影響についての機能解析.
    秋本恵子; 木村健一; 長野真澄; 高野晋吾; 山下年晴; 大根田修
    第69回日本癌学会/2010-09-22
  • 低酸素応答性における乳がん細胞の機能解析
    白石章; 木村健一; 長野真澄; 山下年晴; 坂東裕子; 原尚人; 大根田修
    第69回日本癌学会/2010-09-22
  • グリオグラストーマにおけるHIF-2aの役割
    秋本恵子; 木村健一; 長野真澄; 高野晋吾; 山下年晴; 大根田修
    第6回 がんとハイポキシア研究会/2008-04-01
  • ヒト間葉系幹細胞を用いたグリオグラストーマの細胞治療に向けた研究開発
    秋本恵子; 木村健一; 長野真澄; 高野晋吾; 山下年晴; 大根田修
    第8回 日本再生医療学会総会/2009-04-01
  • 治療効果の高い間葉系幹細胞の単離およびその機能解析
    木村健一; 長野真澄; 山下年晴; 野澤大輔; 濱田洋実; 落合直之; 吉川裕之; 大根田修
    第8回 日本再生医療学会総会/2009-04-01
  • more...
University Management
2024-04 -- (current)HBP入試委員
2018-04 -- (current)研究管理指導員
2019-04 -- (current)HBP教務委員
2014-04 -- 2016-03付属病院臨床研究倫理審査委員会専門委員
2014-04 -- 2016-03医の倫理委員会専門委員
-- (current)安全管理委員会小委員

(Last updated: 2024-11-15)