Mizuno Seiya

Affiliation

Faculty of Medicine

Official title

Associate Professor

Office

Laboratory Animal Science

Research projects

ポストゲノム編集時代のマウス発生工学技術基盤の構築	2019 -- 2021	水野 聖哉	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B)	17,420,000Yen
無駄のない遺伝子改変動物実験を促進する遺伝型解析技術の開発	2018-05 -- 2019-03	水野聖哉	株式会社ケー・エー・シー/株式会社ケー・エー・シー創立40周年記念研究助成

Career history

2017-04 -- (current)

筑波大学 医学医療系 助教

Degree

2012-03

博士(医学)

筑波大学

Academic societies

2015-04 -- (current)

日本ゲノム編集学会

Articles

• ANALYSIS OF A MOUSE MODEL FOR MCTO DUE TO THE MUTATION OF MAFB TRANSACTIVATION DOMAIN
  Usui Toshiaki; Morito Naoki; Tsunakawa Yuki; Jeon Hyojung...
  NEPHROLOGY DIALYSIS TRANSPLANTATION/35(3)/pp.134-134, 2020-06
• c-MAF deletion in adult C57BL/6J mice induces cataract formation and abnormal differentiation of lens fiber cells
  Fujino Mitsunori; Tagami Asuka; Ojima Masami; Mizuno Seiy...
  Experimental animals/69(2)/pp.242-249, 2020-04
  CiNii PubMed
• Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β
  Nakai Ayaka; Fujiyama Tomoyuki; Nagata Nanae; Kashiwagi M...
  Genetics/Epub, 2020-09
  PubMed
• Reverse genetics reveals single gene of every candidate on Hybrid sterility, X Chromosome QTL 2 (Hstx2) are dispensable for spermatogenesis
  Morimoto Kento; Numata Koki; Daitoku Yoko; Hamada Yuko; K...
  SCIENTIFIC REPORTS/10(1), 2020-06
  PubMed
• Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need
  Park Minjeong; Miyoshi Chika; Fujiyama Tomoyuki; Kakizaki...
  SCIENTIFIC REPORTS/10(1), 2020-05
  PubMed
• Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction
  Honda Takato; Takata Yohko; Cherasse Yoan; Mizuno Seiya; ...
  iScience/23(6), 2020-06
  PubMed
• Generation of bicistronic reporter knockin mice for visualizing germ layers
  SUZUKI Hayate; SUGIYAMA Fumihiro; DINH Tra Thi Huong; DAI...
  Experimental Animals/68(4)/pp.499-509, 2019-06
  CiNii
• Generation of B6-Ddx4 , a novel CreERT2 knock-in line, for germ cell lineage by CRISPR/Cas9
  Le Hoai Thu; Hasegawa Yoshikazu; Daitoku Yoko; Kato Kanak...
  Genesis/Epub, 2020-04
  PubMed
• Efficient production of large deletion and gene fragment knock-in mice mediated by genome editing with Cas9-mouse Cdt1 in mouse zygotes
  Mizuno-Iijima Saori; Ayabe Shinya; Kato Kanako; Matoba Sh...
  Methods, 2020-04
  PubMed
• Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice
  Yamazaki Hiromi; Kasai Shuya; Mimura Junsei; Ye Peng; Ino...
  PLoS genetics/16(4), 2020-04
  PubMed
• Modulation of methotrexate-induced intestinal mucosal injury by dietary factors
  Higuchi Takashi; Yoshimura Mika; Oka Shomi; Tanaka Kosei;...
  Hum Exp Toxicol/39(4)/pp.500-513, 2019-12
  PubMed
• Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4
  Yasuda Daisuke; Kobayashi Daiki; Akahoshi Noriyuki; Ohto-...
  The Journal of clinical investigation/129(10)/pp.4332-4349, 2019-07
  PubMed
• Regulations of bile acid metabolism in mouse models with hydrophobic bile acid composition
  Honda Akira; Miyazaki Teruo; Iwamoto Junichi; Hirayama Ta...
  Journal of lipid research/61(1)/pp.54-69, 2020-01
  PubMed
• Uncovering the role of MAFB in glucagon production and secretion in pancreatic α-cells using a new α-cell-specific Mafb conditional knockout mouse model
  Chang Yu-Hsin; Katoh Megumi C; Abdellatif Ahmed M; Xiafuk...
  Experimental animals/69(2)/pp.178-188, 2019-12
  CiNii PubMed
• Clec10a regulates mite-induced dermatitis
  Kanemaru Kazumasa; Noguchi Emiko; Tahara-Hanaoka Satoko; ...
  Science immunology/4(42), 2019-12
  PubMed
• Highly efficient CRISPR-targeting of the murine Hipp11 intergenic region supports inducible human transgene expression
  Browning Jill; Rooney Michael; Hams Emily; Takahashi Sato...
  Molecular biology reports/47(2)/pp.1491-1498, 2019-12
  PubMed
• Forward-genetics analysis of sleep in randomly mutagenized mice
  Funato Hiromasa; Miyoshi Chika; Fujiyama Tomoyuki; Kanda ...
  NATURE, 2016-11
• Forward-genetics analysis of sleep in randomly mutagenized mice
  Funato Hiromasa; Miyoshi Chika; Fujiyama Tomoyuki; Kanda ...
  NATURE, 2016-11
• Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720
  Fukuda Aya; Honda Shiho; Fujioka Norie; Sekiguchi Yuya; M...
  PloS one/14(11), 2019-11
  PubMed Tsukuba Repository
• Overview of Genome Editing and Its Application
  高橋 智; 水野 聖哉; 杉山 文博
  The Journal of The Japanese Society for Cataract Research/31(1)/pp.9-16, 2019
  CiNii
• Functional analysis of Exocyst complex in mice spermatogenesis
  大澤 優生; エルツエフタウイー アフドゥアジー; 八神 健一; ...
  The Journal of Reproduction and Development Supplement/112/pp.P-32-P-32, 2019
  CiNii
• Functional analysis of Exocyst complex in mouse oocytes
  久場 ゆめの; SHAWKI Hossam; 八神 健一; 水野 聖哉; 杉山 文博
  The Journal of Reproduction and Development Supplement/112/pp.P-53-P-53, 2019
  CiNii
• Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation
  Gurumurthy Channabasavaiah B; O'Brien Aidan R; Quadros Ro...
  Genome biology/20(1)/p.171, 2019-08
  PubMed Tsukuba Repository
• Generation of bicistronic reporter knockin mice for visualizing germ layers
  SUZUKI Hayate; SUGIYAMA Fumihiro; DINH Tra Thi Huong; DAI...
  Experimental Animals/68(4)/pp.499-509, 2019
  CiNii PubMed
• The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells
  Miyagi Satoru; Sroczynska Patrycja; Kato Yuko; Nakajima-T...
  Blood/133(23)/pp.2495-2506, 2019-03
  PubMed

more...

Books

• 脳梁欠損症―マウスから解明される脳梁形成機構.
  水野 聖哉; Tra Thi Huong Dinh; 杉山 文博
  Clinical Neuroscience., 2015
• CRISPR-Cas9（ゲノム編集）
  水野 聖哉
  炎症と免疫, 2015

Conference, etc.

• MAFB転写活性化領域の変異疾患であるMCTOモデルマウス作製とその解析
  臼井 俊明; 森戸　直記; 綱川　祐貴; 全　孝静; 濱田　理人; ...
  第63回日本腎臓学会学術総会/2020-08-19--2020-08-21
• ANALYSIS OF A MOUSE MODEL FOR MCTO DUE TO THE MUTATION OF MAFB TRANSACTIVATION DOMAIN
  Usui Toshiaki; Naoki Morito; Tsunakawa Yuki; Hyojung Jeon...
  the 57th ERA-EDTA Congress/2020-06-06--2020-06-09
• Clec10a regulates mite-induced dermatitis
  Kanemaru Kazumasa; Noguchi Emiko; Tahara-Hanaoka Satoko; ...
  1st International Symposium on Inflammation Cellular Sociology/2019-11-26
• 多中⼼性⼿根⾻⾜根⾻融解症の病態理解のための分子的基盤 -遺伝⼦⽋損から疾患変異へ-
  綱川　祐貴; 濱田 理人; 篠原　正浩; 布施谷　清香; 全　孝静...
  第42回日本分子生物学会年会/2019-12
• MCTOモデルマウスは患者と同様の腎症を示す
  綱川　祐貴; 濱田 理人; 篠原　正浩; 松永　友里菜; 布施谷　...
  第５回日本骨免疫学会/2019-06
• 食餌によるメトトレキサート毒性の増強
  樋口貴士; 吉村美郁; 岡笑美; 川﨑綾; 蕨栄治; 水野聖哉; 小...
  第22回腸内細菌学会/2018-05-31--2018-06-01
• 生殖隔離機構を制御する候補遺伝子領域の解析
  水野 聖哉; 大徳 陽子; 濱田 優子; 小林 慶子; 加藤 花名子; ...
  第65回日本実験動物学会/2018-05-16--2018-05-18
• CRISPR/Cas9を用いたGdf9-BiCreノックインマウスの開発
  水野 聖哉; 長谷川 賀一; 加藤 花名子; 飯島 沙織; 大徳 陽子...
  第64回日本実験動物学会/2017-05-25--2017-05-27
• Overall evaluation of gene modified mouse production by embryo-based genome editing.
  Mizuno Seiya; Satoru Takahashi Fumihiro Sugiyama
  14th Transgenic Technology Meeting/2017-10-01--2017-10-04
• 順・逆遺伝学的手法を駆使した変異マウスの異常形質原因遺伝子の解析
  水野 聖哉
  第63回日本実験動物学会/2016-05-18--2016-05-20
• CRISPR/Cas9システムを用いた多様な遺伝子改変マウス作製の実際
  水野 聖哉; 高橋智 杉山文博
  第89回日本生化学会大会/2016-09-25--2016-09-27
• CRISPR/Casを用いたマウスゲノム編集の実際
  水野 聖哉; 高橋 智 杉山 文博 八神 健一
  第121回日本解剖学会総会/2016-03-28--2016-03-30
• 早期胚発生致死を示すWS変異マウスにおける原因遺伝子の同定
  水野 聖哉; 高見幸平 飯島沙織 加藤花名子 大徳陽子 谷本陽子...
  第62回日本実験動物学会/2015-05-28--2015-05-30
• HLA-A*31:01遺伝子導入マウスを用いたメトトレキサート誘導性間質性肺炎モデルの作成と評価
  吉村 美郁; 樋口 貴士; 岡 笑美; 川崎 綾; 蕨 栄治; 水野 聖...
  Japanese Journal of Clinical Immunology/2016-09-09--2016-09-09
• UCP1発現脂肪細胞の非侵襲イメージング法の作製
  福田 綾; 本多志帆; 水野聖哉; 杉山文博; 岡松優子; 斉藤昌之...
  第40回日本分子生物学会年会/2017-12
• Production of a non-invasive monitoring system of Uncoupling protein 1-expressing adipocytes
  FUKUDA AYA; HONDA SHIHO; SEIYA MIZUNO; FUMIHIRO SUGIYAMA;...
  Tsukuba Global Science Week 2017/2017-09
• 食餌によるメトトレキサート毒性の増強
  樋口 貴士; 吉村 美郁; 岡 笑美; 川﨑 綾; 蕨 栄治; 水野 聖...
  第28回日本リウマチ学会関東支部学術集会/2017-12-09
• 食餌によるメトトレキサート毒性の増強.
  樋口 貴士; 吉村 美郁; 岡 笑美; 川﨑 綾; 蕨 栄治; 水野 聖...
  第３８回日本臨床薬理学会学術総会/2017-12-07

Teaching

2020-10 -- 2021-02	Special Seminars in Human Biology II	University of Tsukuba.
2020-04 -- 2020-08	Special Seminars in Human Biology II	University of Tsukuba.
2020-10 -- 2021-02	Internship II	University of Tsukuba.
2020-04 -- 2020-08	Internship II	University of Tsukuba.
2020-04 -- 2020-08	Seminar on Basic Medical Sciences	University of Tsukuba.
2020-10 -- 2021-02	Seminar on Basic Medical Sciences	University of Tsukuba.
2020-04 -- 2020-08	Lecture and Discussion in Human Medical Biology I	University of Tsukuba.
2020-04 -- 2020-08	Internship I	University of Tsukuba.
2020-10 -- 2021-02	Internship I	University of Tsukuba.
2020-05 -- 2020-07	Laboratory Animal Science and Animal Experimentation	University of Tsukuba.

more...

Other educational activities

2018-02 -- (current)

Biomedical Research Partnership Workshop 2018

筑波大学

(Last updated: 2019-12-04)