MIZUNO Seiya
- Affiliation
- Institute of Medicine
- Official title
- Professor
- Office
- Laboratory Animal Science
- Research projects
新規direct-cKOシステムでの必須遺伝子探索とその網羅的解析基盤の構築 2022 -- (current) 水野 聖哉 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B) 小胞輸送因子が制御する卵母細胞インテグリティ制御機構の解明 2021 -- 2022 水野 聖哉 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research on Innovative Areas (Research in a Proposed Research Area) 9,360,000Yen CRISPRランダム切除ミュータジェネシスによる非遺伝子ゲノム領域の機能解明 2021 -- 2022 水野 聖哉 Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Research (Exploratory) 6,500,000Yen ポストゲノム編集時代のマウス発生工学技術基盤の構築 2019 -- 2021 水野 聖哉 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B) 17,420,000Yen 無駄のない遺伝子改変動物実験を促進する遺伝型解析技術の開発 2018-05 -- 2019-03 水野聖哉 株式会社ケー・エー・シー/株式会社ケー・エー・シー創立40周年記念研究助成 - Career history
2017-04 -- (current) 筑波大学医学医療系助教 - Degree
2012-03 博士(医学) 筑波大学 - Academic societies
2021-04 -- (current) 日本生化学会 2015-04 -- (current) 日本ゲノム編集学会 2008-08 -- (current) LAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE - Articles
- Proximity-dependent biotinylation reveals an interaction between ubiquitin-specific peptidase 46 and centrosome-related proteins
Yoshioka Kazuma; Nakagawa Reiko; Nguyen Chi Lieu Kim; ...
FEBS open bio/Epub, 2024-10-31 - PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis
Hsiao Yung Ting; Yoshida Yohko; Okuda Shujiro; Abe Ma...
EMBO JOURNAL/Epub, 2024-08-19 - Vaccine Therapy for Heart Failure Targeting the Inflammatory Cytokine Igfbp7
Katoh Manami; Nomura Seitaro; Yamada Shintaro; Ito Ma...
CIRCULATION/150(5)/pp.374-389, 2024-07-30 - ANALYSIS OF A MOUSE MODEL FOR MCTO DUE TO THE MUTATION OF MAFB TRANSACTIVATION DOMAIN
USUI Toshiaki; Morito Naoki; Tsunakawa Yuki; JEON Hyo...
Nephrology Dialysis Transplantation, 2020-06 - MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis
Lee Dong-Joon; Kim Pyunggang; Kim Hyun-Yi; Park Jinah...
EXPERIMENTAL AND MOLECULAR MEDICINE/56(7)/pp.1606-1619, 2024-07 - Establishment and visual analysis of CBA/J- Pde6b Y347Y/Y347X and C3H/HeJ- Pde6b Y347Y/Y347X mice
Shindo Miyuki; Terao Miho; Takada Shuji; Ichinose Min...
EXPERIMENTAL ANIMALS/73(2)/pp.203-210, 2024-04-01 - Impaired Glycosylation of Gastric Mucins Drives Gastric Tumorigenesis and Serves as a Novel Therapeutic Target
Arai Junya; Hayakawa Yoku; Tateno Hiroaki; Murakami K...
Gastroenterology/167(3)/p.505-521.e19, 2024-08-01 - Structure and Function of Neuronal Circuits linking Ventrolateral Preoptic Nucleus and Lateral Hypothalamic Area
Prokofeva Kseniia; Saito Yuki C; Niwa Yasutaka; Mizuno...
JOURNAL OF NEUROSCIENCE/43(22)/pp.4075-4092, 2023-04-27 - Dual-specificity phosphatases 13 and 27 as key switches in muscle stem cell transition from proliferation to differentiation
Takuto Hayashi; Shunya Sadaki; Ryosuke Tsuji; Risa Ok...
Stem Cells/42(9)/pp.830-847, 2024-09 - Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation
Kong Xiangduo; Nguyen Nam Viet; Li Yumeng; Sakr Jasmi...
ISCIENCE/27(4), 2024-04-19 - Regional random mutagenesis driven by multiple sgRNAs and diverse on-target genome editing events to identify functionally important elements in non-coding regions
Morimoto Kento; Suzuki Hayate; Kuno Akihiro; Daitoku ...
Open biology/14(4), 2024-04-03 - Development of two mouse strains conditionally expressing bright luciferases with distinct emission spectra as new tools for in vivo imaging
Nakashiba Toshiaki; Ogoh Katsunori; Iwano Satoshi; Sug...
LAB ANIMAL/52(10)/pp.247-+, 2023-10 - SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination
Ha Jihoon; Kim Minbeom; Park Jin Seok; Lee Yerin; Lee...
CELL REPORTS/43(2), 2024-02-27 - Null mutation of exocyst complex component 3-like does not affect vascular development in mice
Takashima Satsuki; Okamura Eiichi; Ichiyama Yusuke; Ni...
EXPERIMENTAL ANIMALS/73(1)/pp.93-100, 2024-04-01 - Design of Specific and Efficient sgRNA for CRISPR/Cas9 System to Knockout Superoxide Dismutase 2 in Breast Cancer Stem Cells
Arumsari Sekar; Wanandi Septelia Inawati; Syahrani Res...
INTERNATIONAL JOURNAL OF TECHNOLOGY/15(2)/pp.353-363, 2024-02-05 - MAX controls meiotic entry in sexually undifferentiated germ cells
Suzuki Ayumu; Uranishi Kousuke; Nishimoto Masazumi; Mi...
SCIENTIFIC REPORTS/14(1), 2024-03-04 - A rare olive compound oleacein functions as a TrkB agonist and mitigates neuroinflammation both in vitro and in vivo
Wakasugi Daiki; Kondo Shinji; FERDOUSI Farhana; Mizuno...
CELL COMMUNICATION AND SIGNALING/22(1), 2024-06 - Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss
Park Sujin; Heo Jin Sun; Mizuno Seiya; Kim Minwoo; An...
METABOLISM-CLINICAL AND EXPERIMENTAL/151, 2024-02 - Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis
Tamura Ryutaro; Sabu Yusuke; Mizuno Tadahaya; Mizuno ...
NATURE COMMUNICATIONS/14(1), 2023-11-21 - Role of inter-alpha-trypsin inhibitor heavy chain 4 and its citrullinated form in experimental arthritis murine models
Iwai Tamaki; Ohyama Ayako; Osada Atsumu; Nishiyama Ta...
CLINICAL AND EXPERIMENTAL IMMUNOLOGY/215(3)/pp.302-312, 2024-02-19 - A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta
Kimura Kenichi; Motoyama Eri; Kanki Sachiko; Asano Ke...
Biorxiv, 2024-05-07 - Kinase signalling in excitatory neurons regulates sleep quantity and depth
Kim Staci J; Hotta-Hirashima Noriko; Asano Fuyuki; Kit...
NATURE/612(7940)/pp.512-518, 2022-12-01 - Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice
Mikami Natsuki; Nguyen Chi Lieu Kim; Osawa Yuki; Kato ...
Experimental animals/73(3)/pp.286-292, 2024-06-09 - Landscape of driver mutations and their clinical effects on Down syndrome-related myeloid neoplasms
Sato Tomohiko; Yoshida Kenichi; Toki Tsutomu; Kanezaki...
Blood/143(25)/pp.2627-2643, 2024-03-21 - Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function
Sekiya Motohiro; Ma Yang; Kainoh Kenta; Yamazaki Daic...
CELL REPORTS/42(8), 2023-08-29 - more...
- Proximity-dependent biotinylation reveals an interaction between ubiquitin-specific peptidase 46 and centrosome-related proteins
- Books
- 脳梁欠損症―マウスから解明される脳梁形成機構.
水野 聖哉; Tra Thi Huong Dinh; 杉山 文博
Clinical Neuroscience., 2015 - CRISPR-Cas9(ゲノム編集)
水野 聖哉
炎症と免疫, 2015
- 脳梁欠損症―マウスから解明される脳梁形成機構.
- Conference, etc.
- Autism-associated Sparcl1/Hevin mutant has impacts on persistent angiogenesis
TAKETOMI Takumi; YASUDA Takunori; UEDA Kentaro; MORITA...
Society for Neuroscience 2024/2024-10-5--2024-10-9 - Efficient Direct-cKO method for rapid in vivo functional analysis
Kang Woojin; Okamoto Eiichi; Matsumoto Shoma; Ema Mas...
9th Asian Federation of Laboratory Animal Science Associations Congress 2023/2023-09-13--2023-09-15 - Induction of recombination by oral administration of Tamofixen during pregnancy
Chi Lieu Kim Nguyen; Woojin Kang; Fumihiro Sugiyama; S...
第10回東京理科大学・筑波大学合同リトリート/2023-07-01 - The impairment in subcellular localisation of c-KIT and GDF9 caused by the loss of a complex membrane trafficking factor component in oocyte
Chi Lieu Kim Nguyen; Woojin Kang; Fumihiro Sugiyama; S...
第46回日本分子生物学会年会/2023-12-06--2023-12-08 - 迅速なin vivo機能解析を可能とする効率的direct cKO法の確立
康 宇鎭; 岡村 永一; 松本 翔馬; 依馬 正次; 高橋 智; 水野 聖哉
第10回東京理科大学・筑波大学合同リトリート/2023-07-01 - 迅速なin vivo機能解析を可能とする効率的direct cKO法の確立
康 宇鎭; 岡村 永一; 松本 翔馬; 依馬 正次; 高橋 智; 水野 聖哉
日本ゲノム編集学会 第8回大会/2023-06-07 - 多中心性手根足根骨溶解症(MCTO)関連腎症に対するMAFB-IGF1-PI3K/AKTシグナル抑制は潜在的な治療選択肢である
石橋 駿; 臼井 俊明; 森戸 直記; 濱田 理人; 久野 朗広; 水野 聖哉; 田中 亮二郎; 高橋 智; 山...
第67回日本腎臓学会学術総会/2024-06-28--2024-06-30 - 三胚葉形成の評価に有用なES細胞の作製
鈴木 颯; Dinh Thi Huong Tra; 大徳 陽子; 加藤 花名子; 谷本 陽子; 村田 ...
第68回日本実験動物学会総会/2021-05-19--2021-05-21 - A novel creation of reporter mouse model for visualizing germ layer formation
Hayate Suzuki; Tra Thi Huong Dinh; Yoko Daitoku; Kanak...
第54回日本発生生物学会年会/2021-06-17--2021-06-18 - 三胚葉を同時に可視化するES細胞の作製
鈴木 颯; 濱田 優子; 谷本 陽子; 村田 知弥; 水野 聖哉; 杉山 文博
第94回日本生化学大会/2021-11-03--2021-11-05 - 三胚葉形成を可視化するトリプルノックインレポーターシステムの開発
鈴木 颯; 村田 知弥; 大徳 陽子; 濱田 優子; 谷本 陽子; 水野 聖哉; 杉山 文博
第69回日本実験動物学会総会/2022-05-18--2022-05-20 - 新規トリプルノックインレポーターシステムを用いたマウス原腸胚における三胚葉形成の評価系の確立
鈴木 颯; 村田 知弥; 大徳 陽子; 谷本 陽子; 水野 聖哉; 杉山 文博
第63回日本先天異常学会学術集会/2023-07-28--2023-07-30 - Hevin/Sparcl1の変異によるASD病態形成への新たな洞察
武富巧; 保田拓範; 森田陸離; 原田隆平; 重田育照; 水野聖哉; 高橋智; 鶴田文憲
第46回日本神経科学大会/2023-08-01--2023-08-04 - EFFECTIVENESS OF IMATINIB FOR MCTO NEPHROPATHY
Usui Toshiaki; Morito Naoki; Ishibashi Shun; Gogoleva ...
60th ERA Congress/2023-06-15--2023-06-18 - ASD-associated SPARCL1 mutant accumulates in the endoplasmic reticulum: implication for a novel mechanism underlying ASD pathogenesis
Taketomi Takumi; Yasuda Takunori; Morita Rikuri; Shigeta ...
36th International mammalian Genome society/2023-03-28--2023-03-31 - MAFB変異疾患 (MCTO)モデルマウスのポドサイト障害に対するイマチニブの治療効果
臼井俊明; 森戸直記; 石橋駿; 西野哲平; 金井真帆; Natalia Gogoleva; 井上由理; 布施谷清香; 久野朗広...
第65回日本腎臓学会学術総会/2022-06-10--2022-06-12 - オートファジー選択的基質p62/Sqstm1の細胞質−核間シャトリング異常はポドサイト障害を引き起こす
蕨栄治; Ning Baoshuo; 布施谷清香; 臼井 俊明; 森戸直記; 柳川徹; 水野聖哉; 川西邦夫; 高橋智
第6回ポドサイト研究会/2022-03-26--2022-03-26 - 新規遺伝子改変マウスによる骨格筋幹細胞の運命制御機構の解明
藤田 諒; 水野聖哉; 貞廣威太郎; 杉山文博; 高橋智; 家田真樹
第7回日本筋学会学術集会(Young Investigator's Award 受賞候補者発表会)/2021-12-11--2021-12-12 - Molecular analysis of the mutant gene for the peroneal muscular atrophy mouse
Keino-Masu Kazuko; Kato Chika; Mitani Yuta; Hayashi Yasu...
第41回日本神経科学大会/2018-07 - 先天的腓骨神経欠損マウスの原因遺伝子の同定
桝 和子; 加藤 千賀; 三谷 優太; 石井 万由子; 林 康紀; 村谷 匡史; 水野 聖哉; 杉山 文博; 高橋 智; 加藤 秀...
先端モデル動物支援プラットフォーム成果発表会/2019-01 - 先天的腓骨神経欠損マウスの原因遺伝子の同定
桝 和子; 加藤 千賀; 三谷 優太; 石井 万由子; 林 康紀; 村谷 匡史; 水野 聖哉; 杉山 文博; 高橋 智; 加藤 秀...
先端モデル動物支援プラットフォーム成果発表会/2020-02 - The difference of the disease mechanism for focal segmental glomerulosclerosis due to the variance of the MAFB gene mutation position
臼井俊明; 森戸直記; 金井真帆; 綱川祐貴; 濱田理人; 全 孝静; 水野 聖哉; 高橋 智; 山縣 邦弘
第64回日本腎臓学会学術総会/2021-06-18--2021-06-20 - ANALYSIS OF A MOUSE MODEL FOR MCTO DUE TO THE MUTATION OF MAFB TRANSACTIVATION DOMAIN
Usui Toshiaki; Morito Naoki; Tsunakawa Yuki; Jeon Hyojun...
57th EDTA/ERA/2020-06-06--2020-06-09 - ポドサイト特異的転写因子MAFBの変異による巣状分節性糸球体硬化症の発症メカニズムの検討
臼井 俊明; 森戸 直記; 金井 真帆; 綱川 祐貴; 全 孝静; 濱田 理人; 水野 聖哉; 高橋 智; 山縣 邦弘
第5回ポドサイト研究会/2021-03-06--2021-03-06 - Analysis of the disease-model mouse for MCTO nephropathy
Usui Toshiaki; Morito Naoki; Tsunakawa Yuki; Hyojung Jeo...
The 10th Chronic Kidney Disease Frontier Meeting/2021-02-28--2021-02-28 - more...
- Autism-associated Sparcl1/Hevin mutant has impacts on persistent angiogenesis
- Teaching
2024-10 -- 2025-02 Basic Experiments in Human Biology University of Tsukuba. 2024-04 -- 2024-08 Special Seminars in Human Biology I University of Tsukuba. 2024-10 -- 2025-02 Special Seminars in Human Biology II University of Tsukuba. 2024-10 -- 2025-02 Special Lectures in Human Biology II University of Tsukuba. 2024-10 -- 2025-02 Special Research in Human Biology II University of Tsukuba. 2024-04 -- 2024-08 Special Lectures in Human Biology I University of Tsukuba. 2024-04 -- 2024-08 Laboratory Training in Human Biology I University of Tsukuba. 2024-04 -- 2024-08 Lecture and Discussion in Human Medical Biology I University of Tsukuba. 2024-10 -- 2025-02 Lecture and Discussion in Human Medical Biology II University of Tsukuba. 2024-10 -- 2025-02 Laboratory Training in Human Biology I University of Tsukuba. more... - Other educational activities
2018-02 -- (current) Biomedical Research Partnership Workshop 2018 筑波大学
(Last updated: 2024-09-03)