Kokubo Toshio

Affiliation

International Institute for Integrative Sleep Medicine

Official title

Professor

Research fields

Medical pharmacy

Drug development chemistry

Cell biology

Molecular biology

Career history

2013-06 -- (current)	筑波大学 国際統合睡眠医科学研究機構 教授／事務部門長
2013-02 -- 2013-05	筑波大学 国際統合睡眠医科学研究機構 教授／副事務部門長
2011-04 -- 2013-01	武田薬品工業（株） 医薬研究本部アライアンス室 主席部員
2010-04 -- 2011-03	武田薬品工業（株） 医薬研究本部筑波研究推進グループ グループマネジャー
2005-12 -- 2010-03	武田薬品工業（株） 医薬研究本部バイオ医薬研究室 室長
2004-08 -- 2005-11	武田薬品工業（株） 医薬研究本部バイオ医薬研究室 リサーチマネジャー
2003-04 -- 2004-07	武田薬品工業（株） 医薬研究本部医薬探索センター リサーチマネジャー
2002-08 -- 2003-03	武田薬品工業（株） 医薬研究本部医薬探索センター 主席研究員
1997-10 -- 2002-07	バイエル薬品（株） 中央研究所 部長（主席研究員）
1988-07 -- 1997-09	日本チバガイギー（株） 国際科学研究所 プロジェクトリーダー／グループリーダー

more...

Academic background

1980-04 -- 1983-03	京都大学大学院 工学研究科 合成化学専攻	Accomplished credits for doctoral program
1978-04 -- 1980-03	京都大学大学院 工学研究科 合成化学専攻	Completed
1974-04 -- 1978-03	京都大学 工学部 合成化学	Graduated

Degree

1983-05

工学博士（京都大学）

Kyoto University

Articles

• Sequential analysis of gene expression after an osteogenic stimulus: c-fos expression is induced in osteocytes
  Inaoka T; Lean J M; Bessho T; Chow J W; Mackay A; Kokubo ...
  Biochemical and biophysical research communications/217(1)/pp.264-270, 1995-12
  PubMed
• Conversion of L-lactate oxidase to a long chain alpha-hydroxyacid oxidase by site-directed mutagenesis of alanine 95 to glycine
  Yorita K; Aki K; Ohkuma-Soyejima T; Kokubo T; Misaki H; M...
  The Journal of biological chemistry/271(45)/pp.28300-28305, 1996-11
  PubMed
• The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma
  Littlewood-Evans A J; Bilbe G; Bowler W B; Farley D; Wlod...
  Cancer research/57(23)/pp.5386-5390, 1997-12
  PubMed
• Conformational studies on the specific cleavage site of Type I collagen (alpha-1) fragment (157-192) by cathepsins K and L by proton NMR spectroscopy
  Nosaka A Y; Kanaori K; Teno N; Togame H; Inaoka T; Takai ...
  Bioorganic & medicinal chemistry/7(2)/pp.375-379, 1999-02
  PubMed
• Analysis of a local fitness landscape with a model of the rough Mt. Fuji-type landscape: application to prolyl endopeptidase and thermolysin
  Aita T; Uchiyama H; Inaoka T; Nakajima M; Kokubo T; Husimi Y
  Biopolymers/54(1)/pp.64-79, 2000-07
  PubMed
• Directed evolution to improve the thermostability of prolyl endopeptidase
  Uchiyama H; Inaoka T; Ohkuma-Soyejima T; Togame H; Shiban...
  Journal of biochemistry/128(3)/pp.441-447, 2000-09
  PubMed
• New immunosuppressive reagent, FTY 720, spares immunologic memory
  Lei G; Amemiya H; Suzuki S; Goto T; Kokubo T; Miyamoto M;...
  Transplantation proceedings/32(7)/p.1628, 2000-11-01
  PubMed
• Microchimerism and allograft acceptance: is it caused by microchimerism or graft antigens?
  Kimura H; Hua Y; Goto T; Kokubo T; Amemiya H; Suzuki S; M...
  Transplantation proceedings/32(7)/pp.2045-2046, 2000-11-01
  PubMed
• Cytokine requirement for the development of rat dendritic cells by in vitro culturing of bone marrow cells
  Hua Y; Miyagi T; Saito H; Gold D P; Li X K; Fujino M; Tag...
  Transplantation proceedings/32(7)/pp.2078-2079, 2000-11-01
  PubMed
• Defect of severe combined immunodeficiency (Scid) MPhi/DC in acquired tolerance induction following rat-into-scid xenogeneic bone marrow cell chimeras
  Yan H; Kimura H; Moriyama M; Goto T; Kokubo T; Amemiya H;...
  Transplantation proceedings/33(1-2)/pp.706-707
  PubMed
• Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone
  Inaoka T; Bilbe G; Ishibashi O; Tezuka K; Kumegawa M; Kok...
  Biochemical and biophysical research communications/206(1)/pp.89-96, 1995-01
  PubMed
• Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry
  Littlewood-Evans A; Kokubo T; Ishibashi O; Inaoka T; Wlod...
  Bone/20(2)/pp.81-86, 1997-02
  PubMed
• Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption
  Inui T; Ishibashi O; Inaoka T; Origane Y; Kumegawa M; Kok...
  The Journal of biological chemistry/272(13)/pp.8109-8112, 1997-03
  PubMed
• Quantification of the expression levels of lysosomal cysteine proteinases in purified human osteoclastic cells by competitive RT-PCR
  Ishibashi O; Inui T; Mori Y; Kurokawa T; Kokubo T; Kumega...
  Calcified tissue international/68(2)/pp.109-116, 2001-02
  PubMed
• Matrix metalloproteinases and lysosomal cysteine proteases in osteoclasts contribute to bone resorption through distinct modes of action
  Inui T; Ishibashi O; Origane Y; Fujimori K; Kokubo T; Nak...
  Biochemical and biophysical research communications/258(1)/pp.173-178, 1999-04
  PubMed
• Establishment of the superoxide production assay with human monocytic cell line, U937, for the evaluation of Syk kinase inhibitors
  Yamamoto Noriyuki; Shichijo Michitaka; Kokubo Toshio
  Journal of immunological methods/268(2)/pp.123-130, 2002-10
  PubMed
• Improvement of slow wave sleep continuity by mattress with better body pressure dispersal.
  Kokubo Toshio; Kayaba M.; Ogata H.; Park I.; Ishihara A.;...
  Sleep Medicine Research/10(2)/pp.75-82, 2019-12
• Subacute Ingestion of Caffeine and Oolong Tea Increases Fat Oxidation without Affecting Energy Expenditure and Sleep Architecture: A Randomized, Placebo-Controlled, Double-Blinded Cross-Over Trial
  Zhang Simeng; Takano Jiro; Murayama Norihito; Tominaga Mo...
  Nutrients/12(12), 2020-11-28
  PubMed
• DIFFERENT EFFECTS OF OREXIN RECEPTOR ANTAGONIST AND GABA(A) AGONIST ON PHYSICAL AND COGNITIVE FUNCTIONS AFTER FORCED AWAKENING
  Seol J.; Fujii Y.; Park I.; Yoko S.; Kawana F.; Yajima K....
  SLEEP MEDICINE/64(1)/pp.S343-S343, 2019-12
• Distinct effects of orexin receptor antagonist and GABA agonist on sleep and physical/cognitive functions after forced awakening
  Seol Jaehoon; Fujii Yuya; Park Insung; Suzuki Yoko; Kawan...
  Proceedings of the National Academy of Sciences of the United States of America/116(48)/pp.24353-24358, 2019-11
  PubMed
• Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey
  Oshima Tsutomu; Miyashita Hideaki; Ishimura Yoshimasa; It...
  PLOS ONE/13(5), 2018-05
  Tsukuba Repository
• Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers
  Oshima Tsutomu; Sato Shuji; Kato Junichi; Ito Yuki; Watan...
  Molecular cancer/12/p.60, 2013-06-12
  PubMed
• A novel Syk kinase-selective inhibitor blocks antigen presentation of immune complexes in dendritic cells
  Nakashima Kosuke; Kokubo Toshio; Shichijo Michitaka; Li Y...
  European journal of pharmacology/505(1-3)/pp.223-228, 2004-11-28
  PubMed
• Inhibition of syk activity and degranulation of human mast cells by flavonoids
  Shichijo Michitaka; Yamamoto Noriyuki; Tsujishita Hideki;...
  Biological & pharmaceutical bulletin/26(12)/pp.1685-1690, 2003-12-01
  PubMed
• The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents
  Yamamoto Noriyuki; Takeshita Keisuke; Shichijo Michitaka;...
  The Journal of pharmacology and experimental therapeutics/306(3)/pp.1174-1181, 2003-09-01
  PubMed

Books

• Role of proteases in osteoclastic resorption.
  Kokubo Toshio; Ishibashi O.; Kumegawa M.
  Molecular and Cellular Biology of Bone, JAI Press, pp.359-370, 1998
• Development of Some Reactions Controlled in Molecular Assemblies
  Kokubo Toshio
  1983-05

Conference, etc.

• Different effects of orexin receptor antagonist and GABAa agonist on physical and cognitive functions
  Seol J.; Fujii Y.; Park I.; Suzuki Y.; Kawana F.; Fukusum...
  The 7th Annual IIIS Symposium/2018-12

(Last updated: 2021-01-06)