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Kokubo Toshio

International Institute for Integrative Sleep Medicine
Official title
Research fields
Medical pharmacy
Drug development chemistry
Cell biology
Molecular biology
Career history
2013-06 -- (current)筑波大学 国際統合睡眠医科学研究機構 教授/事務部門長
2013-02 -- 2013-05筑波大学 国際統合睡眠医科学研究機構 教授/副事務部門長
2011-04 -- 2013-01武田薬品工業(株) 医薬研究本部アライアンス室 主席部員
2010-04 -- 2011-03武田薬品工業(株) 医薬研究本部筑波研究推進グループ グループマネジャー
2005-12 -- 2010-03武田薬品工業(株) 医薬研究本部バイオ医薬研究室 室長
2004-08 -- 2005-11武田薬品工業(株) 医薬研究本部バイオ医薬研究室 リサーチマネジャー
2003-04 -- 2004-07武田薬品工業(株) 医薬研究本部医薬探索センター リサーチマネジャー
2002-08 -- 2003-03武田薬品工業(株) 医薬研究本部医薬探索センター 主席研究員
1997-10 -- 2002-07バイエル薬品(株) 中央研究所 部長(主席研究員)
1988-07 -- 1997-09日本チバガイギー(株) 国際科学研究所 プロジェクトリーダー/グループリーダー
Academic background
1980-04 -- 1983-03京都大学大学院 工学研究科 合成化学専攻Accomplished credits for doctoral program
1978-04 -- 1980-03京都大学大学院 工学研究科 合成化学専攻Completed
1974-04 -- 1978-03京都大学 工学部 合成化学Graduated
1983-05工学博士(京都大学)Kyoto University
  • Sequential analysis of gene expression after an osteogenic stimulus: c-fos expression is induced in osteocytes
    Inaoka T; Lean J M; Bessho T; Chow J W; Mackay A; Kokubo ...
    Biochemical and biophysical research communications/217(1)/pp.264-270, 1995-12
  • Conversion of L-lactate oxidase to a long chain alpha-hydroxyacid oxidase by site-directed mutagenesis of alanine 95 to glycine
    Yorita K; Aki K; Ohkuma-Soyejima T; Kokubo T; Misaki H; M...
    The Journal of biological chemistry/271(45)/pp.28300-28305, 1996-11
  • The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma
    Littlewood-Evans A J; Bilbe G; Bowler W B; Farley D; Wlod...
    Cancer research/57(23)/pp.5386-5390, 1997-12
  • Conformational studies on the specific cleavage site of Type I collagen (alpha-1) fragment (157-192) by cathepsins K and L by proton NMR spectroscopy
    Nosaka A Y; Kanaori K; Teno N; Togame H; Inaoka T; Takai ...
    Bioorganic & medicinal chemistry/7(2)/pp.375-379, 1999-02
  • Analysis of a local fitness landscape with a model of the rough Mt. Fuji-type landscape: application to prolyl endopeptidase and thermolysin
    Aita T; Uchiyama H; Inaoka T; Nakajima M; Kokubo T; Husimi Y
    Biopolymers/54(1)/pp.64-79, 2000-07
  • Directed evolution to improve the thermostability of prolyl endopeptidase
    Uchiyama H; Inaoka T; Ohkuma-Soyejima T; Togame H; Shiban...
    Journal of biochemistry/128(3)/pp.441-447, 2000-09
  • New immunosuppressive reagent, FTY 720, spares immunologic memory
    Lei G; Amemiya H; Suzuki S; Goto T; Kokubo T; Miyamoto M;...
    Transplantation proceedings/32(7)/p.1628, 2000-11-01
  • Microchimerism and allograft acceptance: is it caused by microchimerism or graft antigens?
    Kimura H; Hua Y; Goto T; Kokubo T; Amemiya H; Suzuki S; M...
    Transplantation proceedings/32(7)/pp.2045-2046, 2000-11-01
  • Cytokine requirement for the development of rat dendritic cells by in vitro culturing of bone marrow cells
    Hua Y; Miyagi T; Saito H; Gold D P; Li X K; Fujino M; Tag...
    Transplantation proceedings/32(7)/pp.2078-2079, 2000-11-01
  • Defect of severe combined immunodeficiency (Scid) MPhi/DC in acquired tolerance induction following rat-into-scid xenogeneic bone marrow cell chimeras
    Yan H; Kimura H; Moriyama M; Goto T; Kokubo T; Amemiya H;...
    Transplantation proceedings/33(1-2)/pp.706-707
  • Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone
    Inaoka T; Bilbe G; Ishibashi O; Tezuka K; Kumegawa M; Kok...
    Biochemical and biophysical research communications/206(1)/pp.89-96, 1995-01
  • Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry
    Littlewood-Evans A; Kokubo T; Ishibashi O; Inaoka T; Wlod...
    Bone/20(2)/pp.81-86, 1997-02
  • Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption
    Inui T; Ishibashi O; Inaoka T; Origane Y; Kumegawa M; Kok...
    The Journal of biological chemistry/272(13)/pp.8109-8112, 1997-03
  • Quantification of the expression levels of lysosomal cysteine proteinases in purified human osteoclastic cells by competitive RT-PCR
    Ishibashi O; Inui T; Mori Y; Kurokawa T; Kokubo T; Kumega...
    Calcified tissue international/68(2)/pp.109-116, 2001-02
  • Matrix metalloproteinases and lysosomal cysteine proteases in osteoclasts contribute to bone resorption through distinct modes of action
    Inui T; Ishibashi O; Origane Y; Fujimori K; Kokubo T; Nak...
    Biochemical and biophysical research communications/258(1)/pp.173-178, 1999-04
  • Establishment of the superoxide production assay with human monocytic cell line, U937, for the evaluation of Syk kinase inhibitors
    Yamamoto Noriyuki; Shichijo Michitaka; Kokubo Toshio
    Journal of immunological methods/268(2)/pp.123-130, 2002-10
  • Improvement of slow wave sleep continuity by mattress with better body pressure dispersal.
    Kokubo Toshio; Kayaba M.; Ogata H.; Park I.; Ishihara A.;...
    Sleep Medicine Research/10(2)/pp.75-82, 2019-12
  • Subacute Ingestion of Caffeine and Oolong Tea Increases Fat Oxidation without Affecting Energy Expenditure and Sleep Architecture: A Randomized, Placebo-Controlled, Double-Blinded Cross-Over Trial
    Zhang Simeng; Takano Jiro; Murayama Norihito; Tominaga Mo...
    Nutrients/12(12), 2020-11-28
    Seol J.; Fujii Y.; Park I.; Yoko S.; Kawana F.; Yajima K....
    SLEEP MEDICINE/64(1)/pp.S343-S343, 2019-12
  • Distinct effects of orexin receptor antagonist and GABA agonist on sleep and physical/cognitive functions after forced awakening
    Seol Jaehoon; Fujii Yuya; Park Insung; Suzuki Yoko; Kawan...
    Proceedings of the National Academy of Sciences of the United States of America/116(48)/pp.24353-24358, 2019-11
  • Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey
    Oshima Tsutomu; Miyashita Hideaki; Ishimura Yoshimasa; It...
    PLOS ONE/13(5), 2018-05
  • Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers
    Oshima Tsutomu; Sato Shuji; Kato Junichi; Ito Yuki; Watan...
    Molecular cancer/12/p.60, 2013-06-12
  • A novel Syk kinase-selective inhibitor blocks antigen presentation of immune complexes in dendritic cells
    Nakashima Kosuke; Kokubo Toshio; Shichijo Michitaka; Li Y...
    European journal of pharmacology/505(1-3)/pp.223-228, 2004-11-28
  • Inhibition of syk activity and degranulation of human mast cells by flavonoids
    Shichijo Michitaka; Yamamoto Noriyuki; Tsujishita Hideki;...
    Biological & pharmaceutical bulletin/26(12)/pp.1685-1690, 2003-12-01
  • The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents
    Yamamoto Noriyuki; Takeshita Keisuke; Shichijo Michitaka;...
    The Journal of pharmacology and experimental therapeutics/306(3)/pp.1174-1181, 2003-09-01
  • Role of proteases in osteoclastic resorption.
    Kokubo Toshio; Ishibashi O.; Kumegawa M.
    Molecular and Cellular Biology of Bone, JAI Press, pp.359-370, 1998
  • Development of Some Reactions Controlled in Molecular Assemblies
    Kokubo Toshio
Conference, etc.
  • Different effects of orexin receptor antagonist and GABAa agonist on physical and cognitive functions
    Seol J.; Fujii Y.; Park I.; Suzuki Y.; Kawana F.; Fukusum...
    The 7th Annual IIIS Symposium/2018-12

(Last updated: 2021-01-06)