Matsuzaki Hitomi
- Affiliation
- Institute of Life and Environmental Sciences
- Official title
- Assistant Professor
- Research projects
ゲノム刷り込みの階層性制御におけるシス配列トポロジーの役割 2023 -- 2025 松_ 仁美 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C) 4,680,000Yen 哺乳類の正常発生を支える非対称性DNAメチル化維持機構の解明 2020 -- 2021 松﨑 仁美 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research on Innovative Areas (Research in a Proposed Research Area) 8,320,000Yen 哺乳類の世代間エピジェネティックマーク変換機構の解明 2020 -- 2022 松﨑 仁美 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C) 4,420,000Yen 受精後刷り込みメチル化を誘導する生殖細胞エピゲノム情報の解明 2017 -- 2019 松﨑 仁美 Japan Society for the Promotion of Science/Grant-in-Aid for Young Scientists(A) 16,770,000Yen マウスゲノム刷り込み遺伝子座におけるエピジェネティック修飾制御の分子メカニズム 2014 -- 2016 松﨑 仁美 Japan Society for the Promotion of Science/若手研究(B) 4,030,000Yen - Degree
博士（学術） 筑波大学 - Academic societies
2002-08 -- (current) The Molecular Biology Society of Japan 2003 -- (current) THE JAPANESE BIOCHEMICAL SOCIETY 2007-06 -- (current) The Japanese Society for Epigenetics - Articles
- Five nucleotides found in RCTG motifs are essential for post-fertilization methylation imprinting of the H19 ICR in YAC transgenic mice
Matsuzaki Hitomi; Takahashi Takuya; Kuramochi Daichi; ...
NUCLEIC ACIDS RESEARCH/51(14)/pp.7236-7253, 2023-08 - The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization period
Matsuzaki Hitomi; Sugihara Shokichi; Tanimoto Keiji
Epigenetics & Chromatin/16(1)/p.7, 2023-02-17 - Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms
Matsuzaki Hitomi; Miyajima Yu; Fukamizu Akiyoshi; Tani...
Communications biology/4(1)/p.1410, 2021-04 - Transient establishment of imprinted DNA methylation of transgenic human IC1 sequence in mouse during the preimplantation period
Hirakawa Katsuhiko; Matsuzaki Hitomi; Tanimoto Keiji
Human molecular genetics/29(22)/pp.3646-3661, 2021-01 - Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus
Matsuzaki Hitomi; Kuramochi Daichi; Okamura Eiichi; Hi...
Epigenetics & chromatin/13(1), 2020-01 - Transvection-like interchromosomal interaction is not observed at the transcriptional level when tested in the Rosa26 locus in mouse
Tanimoto Keiji; Matsuzaki Hitomi; Okamura Eiichi; Ushi...
PLoS ONE/14(2)/p.e0203099, 2019-04 - Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic mice
Matsuzaki Hitomi; Okamura Eiichi; Kuramochi Daichi; Us...
Epigenetics & Chromatin/11(1)/p.36, 2018-06 - Homeostatic response of mouse renin gene transcription in a hypertensive environment is mediated by a novel 5' enhancer
Ushiki Aki; Matsuzaki Hitomi; Fukamizu Akiyoshi; Tanim...
Molecular and Cellular Biology/38(7)/p. e00566-17, 2018-01 - Long-Range Control of Renin Gene Expression in Tsukuba Hypertensive Mice
Ushiki Aki; Matsuzaki Hitomi; Ishida Junji; Fukamizu ...
PLOS ONE/11(11), 2016-11 - De novo DNA methylation through the 5 '-segment of the H19 ICR maintains its imprint during early embryogenesis
Matsuzaki Hitomi; Okamura Eiichi; Takahashi Takuya; Us...
DEVELOPMENT/142(22)/pp.3833-3844, 2015-11 - A mouse renin distal enhancer is essential for blood pressure homeostasis in BAC-rescued renin-null mutant mice
Tanimoto Keiji; Kanafusa Sumiyo; Ushiki Aki; Matsuzaki Hitom...
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION/34(5)/pp.401-409, 2014-10 - Sox-Oct motifs contribute to maintenance of the unmethylated H19 ICR in YAC transgenic mice.
Sakaguchi R; Okamura E; Matsuzaki H; Fukamizu A; Tanimoto K
HUMAN MOLECULAR GENETICS/22(22)/pp.4627-4637, 2013-11 - The chicken HS4 insulator element does not protect the H19 ICR from differential DNA methylation in yeast artificial chromosome transgenic mouse.
Eiichi Okamura; Hitomi Matsuzaki ; Fukamizu Akiyoshi; Keiji ...
PLoS One./8(9), 2013-09 - The H19 imprinting control region mediates preimplantation imprinted methylation of nearby sequences in yeast artificial chromosome transgenic mice.
Okamura Eiichi; Matsuzaki Hitomi; Sakaguchi Ryuuta; Takahash...
MOLECULAR AND CELLULAR BIOLOGY/33(4)/pp.858-871, 2013-02 - Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice
Takahashi Takuya; Matsuzaki Hitomi; Tomizawa Shin-ichi; O...
GENE/508(1)/pp.26-34, 2012-10 - DNase I Hypersensitivity and epsilon-Globin Transcriptional Enhancement Are Separable in Locus Control Region (LCR) HS1 Mutant Human beta-Globin YAC Transgenic Mice
Shimotsuma Motoshi; Okamura Eiichi; Matsuzaki Hitomi; Fuk...
JOURNAL OF BIOLOGICAL CHEMISTRY/285(19)/pp.14495-14503, 2010-05 - CTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the transgenic H19 ICR
Matsuzaki Hitomi; Okamura Eiichi; Fukamizu Akiyoshi; Tani...
HUMAN MOLECULAR GENETICS/19(7)/pp.1190-1198, 2010-04 - All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice
Okamura Eiichi; Matsuzaki Hitomi; Campbell Andrew D.; En...
FASEB JOURNAL/23(12)/pp.4335-4343, 2009-12 - A Randomly Integrated Transgenic H19 Imprinting Control Region Acquires Methylation Imprinting Independently of Its Establishment in Germ Cells
Matsuzaki Hitomi; Okamura Eiichi; Shimotsuma Motoshi; Fukami...
MOLECULAR AND CELLULAR BIOLOGY/29(17)/pp.4595-4603, 2009-09 - Linear distance from the locus control region determines epsilon-globin transcriptional activity
Shimotsuma Motoshi; Matsuzaki Hitomi; Tanabe Osamu; Campb...
MOLECULAR AND CELLULAR BIOLOGY/27(16)/pp.5664-5672, 2007-08 - Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1
Asada Sachie; Daitoku Hiroaki; Matsuzaki Hitomi; Saito T...
CELLULAR SIGNALLING/19(3)/pp.519-527, 2007-03 - Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation
Matsuzaki H; Daitoku H; Hatta M; Aoyama H; Yoshimochi K; ...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA/102(32)/pp.11278-11283, 2005-08 - Genomic imprinting recapitulated in the human beta-globin locus
Tanimoto K; Shimotsuma M; Matsuzaki H; Omori A; Bungert ...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA/102(29)/pp.10250-10255, 2005-07 - Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
Daitoku H; Hatta M; Matsuzaki H; Aratani S; Ohshima T; Mi...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA/101(27)/pp.10042-10047, 2004-07 - Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo
Ishida J; Hashimoto T; Hashimoto Y; Nishiwaki S; Iguchi ...
JOURNAL OF BIOLOGICAL CHEMISTRY/279(25)/pp.26274-26279, 2004-06 - more...
- Five nucleotides found in RCTG motifs are essential for post-fertilization methylation imprinting of the H19 ICR in YAC transgenic mice
- Conference, etc.
- トランスジェニックマウスにおけるDlk1-Dio3遺伝子領域IG-DMRの刷り込みメチル化の検証
谷本 啓司; 松﨑 仁美
第95回日本生化学会大会/2022-11-09--2022-11-11 - Search for cis regulatory sequences and trans factor candidates involved in post-fertilization imprinted methylation of mouse H19-ICR
谷本 啓司; 松﨑 仁美; 高橋 拓也; 倉持 大地; 平川 勝彦
第45回日本分子生物学会年会/2022-11-30--2022-12-02 - In vivo test for the involvement of a candidate trans factor in post-fertilization imprinted methylation of the H19-ICR
木村 美南; 松﨑 仁美; 谷本 啓司
第45回日本分子生物学会年会/2022-11-30--2022-12-02 - Post-fertilization allele-specific DNA methylation of the H19-ICR as a maintenance mechanism of genomic imprinting at the Igf2/H19 locus
松﨑 仁美; 谷本 啓司
第45回日本分子生物学会年会/2022-11-30--2022-12-02 - トランスジェニックマウスにおけるラットH19-ICRのDMR形性能の検討
杉原 翔吉; 松﨑 仁美; 谷本 啓司
第94回日本生化学会大会/2021-11-03--2021-11-05 - マウスH19-ICR配列のin vivo反転によるインプリント遺伝子発現機構の解明
松﨑 仁美; 宮嶋 優; 谷本 啓司
第43回日本分子生物学会年会/2020-12-02--2020-12-04 - ヒトH19-ICR YACトランスジェニック・マウスを用いた受精後刷り込みメチル化活性の検証
松﨑 仁美; 平川 勝彦; 谷本 啓司
第93回日本生化学会年会/2020-9-14--2020-9-16 - YACトランスジェニック・マウスを用いたヒトH19-ICR刷り込みメチル化メカニズムの検証
平川 勝彦; 松﨑 仁美; 谷本 啓司
第42回日本分子生物学会年会/2019-12-03--2019-12-06 - マウスのゲノム刷り込み制御におけるH19-ICR配列反転の効果
宮嶋 優; 谷本 啓司; 松﨑 仁美
第42回日本分子生物学会年会/2019-12-03--2019-12-06 - A genetic test for transvection-like interchromosomal functional interaction at the mouse Rosa26 locus
Tanimoto Keiji; Matsuzaki Hitomi; Engel James Douglas
第42回日本分子生物学会年会/2019-12-03--2019-12-06 - Reconstituted H19 ICR sequence with identified cis elements is capable of maintaining genomic imprinting in knock-in mouse
Matsuzaki Hitomi; Daichi Kuramochi; katsuhiko Hirakawa; T...
33rd International Mammalian Genome Conference/2019-9-25--2019-9-28 - Test for imprinted DNA methylation activity of the human H19-ICR in YAC transgenic mice by adopting a transgene co-placement strategy
Hirakawa Katsuhiko; Matsuzaki Hitomi; Tanimoto Keiji
The 15th Transgenic Technology Meeting (TT2019)/2019-04-07--2019-04-10 - H19-ICR 反転マウスを用いたゲノム刷り込み制御機構の解析
松﨑 仁美; 宮嶋 優; 谷本 啓司
第41回日本分子生物学会年会/2018-11-28--2018-11-30 - In vivo analysis of H19 gene transcriptional mechanism by inversion of the H19 imprinting control region
Matsuzaki Hitomi; Miyajima Yu; Tanimoto Keiji
32nd International Mammalian Genome Conference/2018-11-11--2018-11-14 - ヒトβグロビン遺伝子座におけるH19-ICR断片挿入の効果とクロマチン立体構造解析
平川 勝彦; 松﨑 仁美; 谷本 啓司
第12回日本エピジェネティクス研究会年会/2018-5-24--2018-5-24 - H19-ICR反転によるH19遺伝子転写制御機構のin vivo解析
宮嶋 優; 谷本 啓司; 松﨑 仁美
第12回日本エピジェネティクス研究会年会/2018-05-24--2018-05-25 - Homeostatic response of renin gene transcription to hypertension is mediated by its novel 5’ enhancer
Tanimoto Keiji; Ushiki Aki; Matsuzaki Hitomi; Fukamizu A...
Keystone Symposia (Gene Control in Development and Disease)/2018-03-23--2018-03-27 - Imprinted gene expression can be reconstituted by synthetic DNA fragment composed of specified cis regulatory elements from the H19 ICR
Matsuzaki Hitomi; Kuramochi Daichi; Hirakawa Katsuhiko; T...
Keystone Symposia (Gene Control in Development and Disease)/2018-03-23--2018-03-27 - レニン遺伝子の高血圧応答性を制御するエンハンサーの同定
牛木亜季; 松﨑仁美; 谷本啓司; 深水昭吉
2017年度遺伝研研究会/2017-12-14 - Enhancer-mediated regulatory mechanism of mouse renin gene transcription in hypertensive-environment
Tanimoto Keiji; Ushiki Aki; Matsuzaki Hitomi; Fukamizu A...
Mammalian Genetics and Genomics/2017-10-24--2017-10-27 - Conserved regulatory mechanisms of human and mouse renin genes expression in the hypertensive-environment
Ushiki Aki; Matsuzaki Hitomi; Fukamizu Akiyoshi; Keiji T...
CDB Symposium 2017 -Towards Understanding Human Development, Heredity, and Evolution-/2017-03-27--2017-03-29 - 高血圧応答性エンハンサーによるレニン遺伝子の転写制御
牛木亜季; 松﨑仁美; 谷本啓司; Fukamizu Akiyoshi
第39回日本分子生物学会年会/2016-12 - マウスH19 ICRにおけるアリル特異的DNAメチル化制御配列の同定
Matsuzaki Hitomi; 倉持 大地; 牛木 亜季; 谷本 啓司
第39回日本分子生物学会年会/2016-11-30--2016-12-02 - アリル特異的DNAメチル化（刷り込みメチル化）配列の in vivo 再構築
谷本 啓司; Matsuzaki Hitomi; 牛木 亜季; 倉持 大地
第89回日本生化学会大会/2016-09-25--2016-09-27 - Imprinted DNA methylation status can be reconstituted by combining activity of distinct H19 ICR elements in mice
Matsuzaki Hitomi; Tanimoto Keiji
Mouse Genetics 2016 at The Allied Genetics Conference 2016/2016-07-13--2016-07-17 - more...
- トランスジェニックマウスにおけるDlk1-Dio3遺伝子領域IG-DMRの刷り込みメチル化の検証
- Teaching
2023-10 -- 2023-12 Essential Biology University of Tsukuba. 2023-10 -- 2024-02 Dissertation in Animal Life Science III University of Tsukuba. 2023-04 -- 2023-08 Dissertation in Animal Life Science III University of Tsukuba. 2023-10 -- 2024-02 Dissertation in Animal Life Science II University of Tsukuba. 2023-04 -- 2023-08 Dissertation in Animal Life Science II University of Tsukuba. 2023-10 -- 2024-02 Seminar in Life and Agricultural Sciences University of Tsukuba. 2023-04 -- 2023-08 Seminar in Life and Agricultural Sciences University of Tsukuba. 2024-01 -- 2024-02 Fundamental Biology, Laboratory III University of Tsukuba. 2023-04 -- 2023-08 Seminar in Applied Biochemistry IS University of Tsukuba. 2023-10 -- 2023-12 Fundamental Biology, Laboratory II University of Tsukuba. more...
(Last updated: 2024-02-02)