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Villareal Myra Orlina

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Affiliation
Faculty of Life and Environmental Sciences
Official title
Associate Professor
KAKEN ID
30619515
Email
 
Office
Alliance for Research on North Africa (ARENA), Cooperative Research Bldg. A, Room 310
Phone
029-853-5793
Research fields
Molecular biology
Applied molecular and cellular biology
Cell biology
Research keywords
Cell Biology, Food Functionality, Cell differentiation, Pigment cell research, Natural products research
Research projects
Induction of melanocyte stem cells differentiation ...2019-07 -- 2020-06Myra O. VillarealMishima Kaiun Memorial Foundation/1,000,000Yen
Valorization of Bio-resources based on Scientific Evidence in Semi- and Arid Land for Creation of New Industry2015 -- 2021Isoda HirokoJST/SATREPS/
Valorization of Bio-resources in Semi Arid and Arid Land for Regional Development2009 -- 2013Isoda Hiroko/
Career history
2018-11 -- (current)University of Tsukuba Faculty of Life and Environmental Sciences, Associate Professor
2018-04 -- 2018-10AIST, Tsukuba, Researcher
2014-02 -- 2018-03University of Tsukuba Faculty of Life and Environmental Sciences, Assistant Professor
2011-04 -- 2014-01University of Tsukuba, Alliance for Research on North Africa, Postdoc Researcher
2004 -- 2007Ateneo de Manila University, Biology Department, Instructor
2000 -- 2004Peter Paul Philippine Corporation, Quality Control Department, Quality Control Manager
1995-06 -- 1996-05National Institute of Molecular Biology and Biotechnology (BIOTECH-UPLB),University of the Philippines Los Baños University Research Assoc.
Academic background
2008-04 -- 2011-03University of Tsukuba/Graduate School of Life and Environmental Sciences Biosphere Resource Science and Technology Ph.D.Graduated
1996-06 -- 2000-11Graduate School, University of the Philippines Los Baños Dept. of Microbiology Master of Science in MicrobiologyGraduated
1991-06 -- 1995-03University of the Philippines Los Baños College of Agriculture Bachelor of Science in Agriculture (Soil Microbiology)Graduated
Degree
2011-03Ph.D. (Agri)University of Tsukuba
2000-11Master of Science in Microbiology (Microbial Genetics)University of the Philippines Los Baños
1995-03Bachelor of Science in Agriculture (Soil Microbiology)University of the Philippines Los Baños
Academic societies
-- (current)Japan Society for Cell Biology
-- (current)Society for Medicinal Plants and Natural Products Research
-- (current)Japanese Society for Pigment Cell Research (JSPCR)
-- (current)Philippine Society for Microbiology, Inc.
Honors & Awards
2018-11Best Presentation Award, The 31st Annual and International Meeting of JAACT2018 Tsukuba
2016-06-17Teaching Mobility Program Scholarship (Erasmus Mundus)For research activities at the University of Montpellier
2007-04-02MEXT Ph.D. Fellowship at University of Tsukuba
2011-05-15Top 15 Poster Award, European Society for Animal Cell Culture Technology (ESACT) 2011Poster Award
2013Excellent Poster Award, Tsukuba Global Science Week 2013Excellent Poster Award
Refereed academic journal/Refereed international conference paper
  • Melanogenesis Promoting Effect, Antioxidant Activity, and UPLC-ESI-HRMS Characterization of Phenolic Compounds of Argan Leaves Extract
    Bourhim Thouria; Villareal Myra Orlina; Couderc François;...
    Molecules/26(2), 2021-01
  • Effect of saponin-rich fractions of extracts of argan oil by-products and argan leaves on melanogenesis
    Villareal Myra O.; Chaochaiphat Thanyanan; Makbal Rachida...
    TJASSST Proceedings, 2019-11
  • 3,4,5-tri-O-caffeoylquinic acid (TCQA) as a potential candidate to promote hair growth and melanogenesis
    Bejaoui Meriem; Villareal Myra O.; Isoda Hiroko
    TJASSST Proceedings, 2019-09
  • The Wnt/ β-catenin signaling pathway mediated hair growth and pigmentation promotion effect of 3,4,5-tri-O-caffeoylquinic acid
    Bejaoui Meriem; Villareal Myra Orlina; Isoda Hiroko
    Pigment Cell and Melanoma Research, 2019-09
  • Lupenone from Erica multiflora leaf extract stimulates melanogenesis in B16 murine melanoma cells through the inhibition of ERK1/2 activation
    Villareal Myra Orlina; Han Junkyu; Matsuyama Kyoko; Sekii...
    Planta Medica, 2013-03
  • Caffeoylquinic Acid-Rich Purple Sweet Potato Extract, with or without Anthocyanin, Imparts Neuroprotection and Contributes to the Improvement of Spatial Learning and Memory of SAMP8 Mouse
    Sasaki Kazunori; Han Junkyu; Hidetoshi Shimozono; Villare...
    Journal of agricultural and food chemistry, 2013-05
  • Acteoside inhibits type Ι allergy through the down-regulation of Ca/NFAT and JNK MAPK signaling pathways in basophilic cells
    Motojima Hideko; Villareal Myra O; Iijima Rieko; Han Junk...
    Journal of natural medicines, 2013-10
  • Effect of Olive Leaf Components on the Expansion of Human Hematopoietic Stem and Progenitor Cells
    Samet Imen; Villareal Myra O; Junkyu Han; Sayadi Sami; Is...
    Asian Journal Biomed. Pharm. Sci., 2014-04
  • Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells
    Isoda Hiroko; Motojima Hideko; Onaga Shoko; Samet Imen; V...
    Chemico-biological interactions, 2014-09
  • The Type 2 diabetes-preventive effect of cyanidin-3-glucoside on adipocytes
    Matsukawa Toshiya; Villareal Myra O; Isoda Hiroko
    Journal of Developments in Sustainable Agriculture, 2016-11
  • Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer
    Iwasaki Kenichi; Zheng Yun-Wen; Murata Soichiro; Ito Hiro...
    World journal of gastroenterology, 2016-11
  • Increasing cAMP levels of preadipocytes by cyanidin-3-glucoside treatment induces the formation of beige phenotypes in 3T3-L1 adipocytes
    Matsukawa Toshiya; Villareal Myra O; Motojima Hideko; Iso...
    The Journal of nutritional biochemistry, 2017-02
  • Anti-stress and neuronal cell differentiation induction effects of Rosmarinus officinalis L. essential oil
    Villareal Myra Orlina; Ikeya Ayumi; Sasaki Kazunori; Arfa...
    BMC complementary and alternative medicine, 2017-12
  • Daphnane diterpenes inhibit the metastatic potential of B16F10 murine melanoma cells in vitro and in vivo
    Villareal Myra Orlina; Sato Yuki; Matsuyama Kyoko; Isoda ...
    BMC Cancer, 2018-08
  • Depigmenting effect of argan press-cake extract through the down-regulation of Mitf and melanogenic enzymes expression in B16 murine melanoma cells
    Bourhim Thouria; Villareal Myra Orlina; Gadhi Chemseddoha...
    Cytotechnology, 2018-10
  • β-catenin-mediated hair growth induction effect of 3, 4, 5-tri-O-caffeoylquinic acid
    Bejaoui Meriem; Villareal Myra Orlina; Isoda Hiroko
    Aging, 2019-06
  • 3, 4, 5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes
    Bejaoui Meriem; Villareal Myra Orlina; Isoda Hiroko
    Frontiers in Cell and Developmental Biology, 2020-03
  • Argania Spinosa Fruit Shell Extract-Induced Melanogenesis via cAMP Signaling Pathway Activation
    Makbal Rachida; Villareal Myra; Gadhi Chemseddoha; Abdell...
    International Journal of Molecular Sciences, 2020-01
  • Elucidation of the effect of plumbagin on the metastatic potential of B16F10 murine melanoma cells via MAPK signalling pathway
    Alem Fatima‐Zahra; Bejaoui Meriem; Villareal Myra Orlina;...
    Experimental Dermatology, 2020-04
  • Tara Tannin Regulates Pigmentation by Modulating Melanogenesis Enzymes and Melanosome Transport Proteins Expression
    Villareal Myra Orlina; Chaochaiphat Thanyanan; Bejaoui Me...
    Planta Medica International Open, 2020-04
  • Varietal effect on the concentration and anti-inflammatory activity of hydroxytyrosol in French olive oils
    Almaksour Ziad; Boudard Frederic; Kelly Mary; Puljate Igo...
    Journal of Medicinal Food/Epub, 2020-05
  • L-Citrulline Supplementation-Increased Skeletal Muscle PGC-1α Expression is Associated With Exercise Performance and Increased Skeletal Muscle Weight
    Villareal Myra O; Matsukawa Toshiya; Isoda Hiroko
    Molecular nutrition & food research/62(14), 2018-05
  • Anti-inflammatory and antioxidant activities of different extra virgin olive oil varieties extracts
    Almaksour Z. Boudard F. Grosmaire L. Guzman C. Larroque M...
    Arabian Journal of Medicinal & Aromatic Plants/(2017 V3 N(2) 183), 2017-06
  • Terpinen-4-ol inhibits colorectal cancer growth via reactive oxygen species
    Nakayama K; Murata Soichiro; Ito Hiromu; Iwasaki Kenichi;...
    Oncology Letters./14(2)/pp.2015-2024, 2017-06
  • Hirseins inhibit melanogenesis by regulating the gene expressions of Mitf and melanogenesis enzymes
    Villareal Myra Orlina; Han Junkyu; Yamada Parida; Shigemo...
    Experimental Dermatology, 2010-05
Other articles
Books
  • Comparative genome plasticity of tomato and banana strains of Ralstonia solanacearum in the Philippines
    VILLAREAL MYRA ORLINA; Auncion K. Raymundo Myra Orlina-Vi...
    Bacterial wilt disease and the Ralstonia solanacearum species complex, 2005
  • Harnessing the Potential of North African and Mediterranean Bioresources for the Regulation of Signal Transduction in Melanogenesis and Cancer Cell Differentiation
    Villareal Myra Orlina
    Sustainable North African Society: Exploring Seeds and Resources for Innovation, 2014
  • Caffeic Acid and its Biological Effects on Brain Function.
    Villareal Myra Orlina; Sato Yuki; Isoda Hiroko
    Health Benefits Of Green Coffee Bean In Human, Taylor and Francis, 2016
Conference, etc.
  • Effect of Argania spinosa L. leaves and its saponin-rich fraction on melanogenesis in vitro
    Villareal Myra Orlina; Chaochaiphat Thanyanan; Bourhim Th...
    JAACT 2020 Fuchu
  • Natural products regulate melanogenesis by targetting MITF
    Villareal Myra Orlina; Isoda Hiroko
    2020 APAMS Annual Scientific Meeting/2020-07-20--2020-08-14
  • Regulation of Melanogenesis using Natural Compounds
    Villareal Myra Orlina
    DAILAB PIKNIH Series XXXVII. October 7, 2019/2019-10-05--2019-10-07
  • Melanogenesis regulatory effects of Mediterranean and North African plants and their bioactive components.
    Villareal Myra Orlina; Isoda Hiroko
    The 31st Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT)/2018-11-05--2018-11-08
  • Elucidation of the hair growth promoting effects of 3,4,5-tri-O-caffeoylquinic acid (TCQA)
    Bejaoui Meriem; Villareal Myra O.; Isoda Hiroko
    The 31st Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT)/2018-11-05--2018-11-08
  • Natural Products Regulate Melanogenesis By Targeting MITF
    Villareal Myra Orlina; Isoda Hiroko
    40th PAASE Anniversary and 2020 APAMS/2020-07-20--2020-08-14
  • Effect of saponin-rich fractions of extracts of argan oil by-products and argan leaves on melanogenesis
    Villareal Myra O.; Chaochaiphat Thanyanan; Makbal Rachida...
    Tunisia-Japan Symposium on Science , Society and Technology (TJASSST)/2019-11-29--2019-12-02
  • 3,4,5-tri-O-caffeoylquinic acid (TCQA) as a potential candidate to promote hair growth and melanogenesi
    Bejaoui Meriem; Villareal Myra Orlina; Isoda Hiroko
    Tunisia-Japan Symposium on Science , Society and Technology (TJASSST)/2019-11-29--2019-12-02
  • The Wnt/ β-catenin signaling pathway mediated hair growth and pigmentation promotion effect of 3,4,5-tri-O-caffeoylquinic acid
    Bejaoui Meriem; Villareal Myra Orlina; Isoda Hiroko
    European Society for Pigment Cell Research (ESPCR)/2019-09-12--2019-09-14
  • Experiences, ideas, and networking: Life Science solutions to global challenges in the context of Society 5.0 and SDGs
    Villareal Myra Orlina
    Tsukuba Conference 2019/2019-10-02--2019-10-04
  • 3,4,5-tri-O-caffeoylquinic acid as a potential candidate to induce hair growth and hair pigmentation
    Bejaoui Meriem; Orlina VILLAREAL Myra; Isoda Hiroko
    Tunisia-Japan Symposium on Science, Society and Technology (TJASSST 2017)/2017-11-24--2017-11-26
  • Melanogenesis Regulatory effect of argan (Argan spinosa) oil and by-products from argan fruit on melanogenesis in B16 murine melanoma cells
    Orlina VILLAREAL Myra; Isoda Hiroko
    Tunisia-Japan Symposium on Science, Society and Technology (TJASSST 2017, Gammarth, Tunisia),/2017-11-24--2017-11-26
  • Effect of certain byproducts of the Argan tree on hyper pigmentation of the skin
    Bourhim T. Makbal R. Hafidi A. Gadhi C.; Orlina VILLAREA...
    4th edition of the Argan International Congress/2017-11-20--2017-11-22
  • Molecular basis of the lightening effect on the skin of Argan oil and some by-products of the Argan
    Bourhim T. Makbal R. Hafidi A. Gadhi C.; VILLAREAL Myra O...
    1st International Symposium on the beneficial effects of Argan oil on human health/2017-05-04--2017-05-06
  • In vitro and in vivo Anti-Melanoma Effect of T. hirsuta Extract and Its Bioactive Component Daphnane Diterpenoid Gnidilatidin
    Orlina VILLAREAL Myra; Sato; Isoda Hiroko
    International Pigment Cell Conference/2017-08-26--2017-08-30
  • Anti-melanoma effects of natural products from olives (Olea europaea) in vitro
    Villareal Myra Orlina; Isoda Hiroko
    TJASSST 2015/2016-02
  • Oxidative-stress targeted anti-melanoma effects of Cymbopogon schoenanthus
    Myra O. Villareal; Sakura Maezono; Mai Maeda; Mohamed Nef...
    The 27th Annual Meeting of Japanese Association for Animal Cell Technology (JAACT2014 Kitakyushu)/2014-11-11--2014-11-14
  • Essential oil of Mediterranean Rosmarinus officinalis L. shows anti-stress effect by inducing neuronal differentiation
    Ayumi Ikeya; Junkyu Han; Myra O. Villareal; Mohamed Neffa...
    The 27th Annual Meeting of Japanese Association for Animal Cell Technology (JAACT2014 Kitakyushu)/2014-11-11--2014-11-14
  • Anti-allergy and melanogenesis regulatory effects of semi-arid and arid land plants
    Huichia CHAO; Konomi MURAKAMI; Hanen NAJJA; Hideko MOTOJI...
    Second International Conference on Arid Land Studies (ICAL2)/2014-09-10--2014-09-14
  • Diterpenoid Hirsein-A Activate Nuclear P38 Through GADD45b Upregulation: Possible Route For Induction Of Melanoma Cell
    M. Villareal; Isoda Hiroko
    XXII International Pigment Cell Conference (IPCC2014)/2014-09-04--2014-09-07
  • Suppressive effect of Caffeic acid and Caffeic Acid Phenethyl Ester on Oxidative Stress in B16 Mouse Melanoma and Human Epidermal Melanocytes
    Sakura Eri B. Maezono; Myra O. Villareal; Junkyu Han; Iso...
    The XXVIIth International Conference on Polyphenols & The 8th Tannin Conference (ICP2014 Nagoya)/2014-09-02--2014-09-06
  • The metabolism-enhancement effect of cyanidin-3-glucoside derived from black soybean in C2C12 myotubes
    Toshiya Matsukawa; Myra O. Villareal; Junkyu Han; Masaya ...
    The XXVIIth International Conference on Polyphenols & The 8th Tannin Conference (ICP2014 Nagoya)/2014-09-02--2014-09-06
  • Apigenin inhibits type I allergic reaction in RBL-2H3 cells through the mitogen-activated protein kinase pathway
    Hideko Motojima; Myra O. Villareal; Junkyu Han; Isoda Hiroko
    The XXVIIth International Conference on Polyphenols & The 8th Tannin Conference (ICP2014 Nagoya)/2014-09-02--2014-09-06
  • Inhibitory effect of caffeic acid and its derivative, caffeic acid phenethyl ester on oxidative stress in human epidermal melanocytes
    Maezono S.; Villareal M.O.; Han J.; Isoda Hiroko
    先導的研究者体験者プログラム(ARE)第3回リサーチフェスタ
  • Regulatory effect of terpene compounds on melanogenesis signal transduction pathways in B16 murine melanoma cells
    Villareal M.O.; Han J.; Shigemori H.; H. Isoda
    Annual meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry 2014/2014-03-28--2014-03-30
Teaching
2020-04 -- 2020-08Thesis Seminar in Environmental Sciences 1S [Japanese]University of Tsukuba.
2020-04 -- 2020-08Seminar in Environmental Sciences 1S [Japanese]University of Tsukuba.
2020-10 -- 2021-02Thesis Seminar in Environmental Sciences 1F [Japanese]University of Tsukuba.
2020-10 -- 2021-02Seminar in Environmental Sciences 1F [Japanese]University of Tsukuba.
2020-11 -- 2020-11Forum on Environmental Studies IIUniversity of Tsukuba.
2020-04 -- 2020-08Internship in Environmental Studies IIIUniversity of Tsukuba.
2020-10 -- 2021-02Internship in Environmental Studies IIIUniversity of Tsukuba.
2020-10 -- 2021-03Life Science Innovation Doctor's Special Seminar III FallUniversity of Tsukuba.
2020-10 -- 2021-02Seminar in Environmental Sciences 1FUniversity of Tsukuba.
2020-10 -- 2021-02Environmental Studies Practicum IIUniversity of Tsukuba.
Talks
  • Report on TLSI Session: Experiences, ideas, and networking: Life Science solutions to global challenges in the context of Society 5.0 and SDGs
    Villareal Myra Orlina
    Tsukuba Global Science Week 2020 (Session 3: Tsukuba Conference Session – Perspectives on global challenges in attaining Society 5.0 and SDGs)/2020-09-28--2020-09-30
  • Determination of the effect of argan oil and its by-products on melanogenesis in vitro
    Villareal Myra Orlina; Isoda Hiroko
    International symposium on Medicinal and Aromatic Plants (SIPAM),/2017-03-16--2017-03-18
University Management
2018-11 -- (current)TLSI Steering CommitteeMember
2018-11 -- (current)TLSI International Liaison Comm.Member
2018-11 -- (current)Student Support CommitteeChairperson
2018-11 -- (current)Sustainability Science, Technology, and Policy (SUSTEP) certificate programMember
Other activities
2018-11 -- (current)Alliance for Research on Mediterranean and North Africa (ARENA), Member

(Last updated: 2021-06-25)