Ishikawa Kaori
- Affiliation
- Faculty of Life and Environmental Sciences
- Official title
- Assistant Professor
- URL
- Research fields
Cell biology - Research keywords
ミトコンドリア ミトコンドリアDNA - Research projects
加齢に伴う生殖系列からの変異型ミトコンドリアDNA消失機構の解明 2021 -- 2022 石川 香 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research on Innovative Areas (Research in a Proposed Research Area) 9,620,000Yen 加齢に伴う生殖系列からの変異型ミトコンドリアDNA消失機構の解明 2021-04 -- 2023-03 石川 香 日本学術振興会/新学術領域研究(研究領域提案型)公募研究 ミトコンドリア病の未知の病態形成機構の解明 2021-04 -- 2024-03 石川 香 国立研究開発法人科学技術振興機構/創発的研究支援事業 ミトコンドリアDNAのランダムな突然変異が呼吸欠損を誘導する理由 2016-09 -- 2019-03 Kaori ISHIKAWA 公益財団法人 武田科学振興財団/ライフサイエンス研究奨励 2,000,000Yen 可逆的ミトコンドリア・ダイナミクス制御による神経細胞変性メカニズムの解明 2018-04 -- 2021-03 Kaori ISHIKAWA Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research(C) 4,420,000Yen 核‐ミトコンドリア間クロストークからのミトコンドリア病発症機構へのアプローチ 2016 -- 2017 石川 香 Japan Society for the Promotion of Science/Grant-in-Aid for Young Scientists(B) 4,290,000Yen マトリョーシカ型進化原理 2014-04 -- 2016-03 野崎 智義 文部科学省/新学術領域研究(研究領域提案型) - Career history
2009-04 -- 2014-03 武田薬品工業株式会社医薬研究本部研究員 2006-04 -- 2009-03 日本学術振興会特別研究員(DC1) - Academic background
2006-04 -- 2009-03 筑波大学大学院 生命環境科学研究科 情報生物科学専攻(博士後期) 2004-04 -- 2006-03 筑波大学大学院 生命環境科学研究科 情報生物科学専攻(博士前期) 2000-04 -- 2004-03 筑波大学 第二学群 生物学類 - Degree
2009-03 博士(理学) 筑波大学 - Licenses and qualifications
2006-04 高等学校教諭理科専修 2006-04 中学校教諭理科専修 2004-03 高等学校教諭理科一種 2004-03 中学校教諭理科一種 - Academic societies
2014-04 -- (current) THE JAPANESE SOCIETY OF MITOCHONDRIAL RESEARCH AND MEDICINE 2014-04 -- (current) The Molecular Biology Society of Japan - Honors & Awards
2020/05 令和2年度筑波大学若手教員特別奨励賞 2020/04 令和2年度科学技術分野の文部科学大臣表彰 若手科学者賞 2014-12 日本ミトコンドリア学会ベストプレゼンテーション賞 2016-10 日本ミトコンドリア学会ポスター賞 2017-11 日本ミトコンドリア学会ベストプレゼンテーション賞 2008-12 日本ミトコンドリア学会学会賞 - Articles
- A high mutation load of m.14597A>G in MT-ND6 causes Leigh syndrome
Kishita Yoshihito; Ishikawa Kaori; Nakada Kazuto; Haya...
SCIENTIFIC REPORTS/11(1), 2021-05 - Attempts to understand the mechanisms of mitochondrial diseases: The reverse genetics of mouse models for mitochondrial disease
Ishikawa Kaori; Nakada Kazuto
Biochimica et biophysica acta. General subjects/1865(3), 2021-03 - Neuronal degeneration and cognitive impairment can be prevented via the normalization of mitochondrial dynamics
Ishikawa Kaori; Yamamoto Satoshi; Hattori Satoko; Nishimu...
PHARMACOLOGICAL RESEARCH/163, 2021-01 - Pharmacokinetic and pharmacodynamic modeling of the metastin/kisspeptin analog, TAK-448, for its anti-tumor efficacy in a rat xenograft model
Kogame Akifumi; Ishikawa Kaori; DeJongh Joost; Tagawa ...
BIOPHARMACEUTICS & DRUG DISPOSITION/41(7)/pp.283-294, 2020-07 - Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders
Tani Haruna; Mito Takayuki; Velagapudi Vidya; Ishikawa...
Scientific reports/9(1), 2019-11 - Concentration of mitochondrial DNA mutations by cytoplasmic transfer from platelets to cultured mouse cells
Ishikawa Kaori; Kobayashi Kohei; Yamada Akihito; Umehara ...
PloS one/14(3), 2019-04 - Acquired expression of mutant Mitofusin2 causes progressive neurodegeneration and abnormal behavior
Ishikawa Kaori; Yamamoto Satoshi; Hattori Satoko; Nishimu...
The Journal of neuroscience : the official journal of the Society for Neuroscience/39(9)/pp.1588-1604, 2019-01 - Trading mtDNA uncovers its role in metastasis
Ishikawa Kaori; Hayashi Jun-Ichi
Cell adhesion & migration/3(1)/pp.11-13, 2009-03 - An administration of TAK-683 at a minimally effective dose for luteinizing hormone stimulation under the absence of the ovary induces luteinizing hormone surge in ovary-intact goats.
Nahoko Kanai; Natsumi Endo; Satoshi Ohkura; Yoshihiro Wa...
J Reprod Dev./63(3)/pp.305-310, 2017-06 - Mito-mice∆ and mitochondrial DNA mutator mice as models of human osteoporosis caused not by aging but by hyperparathyroidism
Mito Takayuki; Tani Haruna; Suzuki Michiko; Ishikawa ...
Experimental animals/67(4)/pp.509-516, 2018-07 - Usefulness of pharmacokinetic/efficacy analysis of an investigational kisspeptin analog, TAK-448, in quantitatively evaluating anti-tumor growth effect in the rat VCaP androgen-sensitive prostate cancer model
Ishikawa Kaori; Tanaka Akira; Kogame Akifumi; Watanabe...
EUROPEAN JOURNAL OF PHARMACOLOGY/828/pp.126-134, 2018-06 - Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal
Tani Haruna; Ohnishi Sakiko; Shitara Hiroshi; Mito Ta...
Scientific reports/8(1)/p.425, 2018-01 - Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice
Shimizu Akinori; Tani Haruna; Takibuchi Gaku; Ishikawa...
Biochemical and biophysical research communications/493(1)/pp.252-257, 2017-09 - RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity
Yoshizumi Takuma; Imamura Hiromi; Taku Tomohiro; Kurok...
Scientific reports/7(1)/p.5379, 2017-07 - A novel mutation in TAZ causes mitochondrial respiratory chain disorder without cardiomyopathy
Borna Nurun N; Kishita Yoshihito; Ishikawa Kaori; Naka...
Journal of human genetics/62(5)/pp.539-547, 2017-01 - Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging
Hayashi Jun-Ichi; Hashizume Osamu; Ishikawa Kaori; Shi...
CURRENT OPINION IN GENETICS & DEVELOPMENT/38/pp.63-67, 2016-06 - Suppression of disease phenotypes of adult mito-mice carrying pathogenic mtDNA by bone marrow transplantation
Inoue Shin-Ichi; Kaori Ishikawa; Kazuto Nakada; Akitsugu Sat...
NEUROMUSCULAR DISORDERS/16(Suppl. 1)/pp.0-0, 2006-07 - Mouse somatic mutation orthologous to MELAS A3302G mutation in the mitochondrial tRNA(Leu(UUR)) gene confers respiration defects
Shimizu Akinori; Enoki Shunkei; Ishikawa Kaori; Mito ...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/467(4)/pp.1097-1102, 2015-11 - A somatic T15091C mutation in the Cytb gene of mouse mitochondrial DNA dominantly induces respiration defects
Hayashi Chisato; Takibuchi Gaku; Shimizu Akinori; Mito...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/463(4)/pp.1021-1027, 2015-08 - Transmitochondrial mito-mice Delta and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders
Mito Takayuki; Ishizaki Hikari; Suzuki Michiko; Morish...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/456(4)/pp.933-937, 2015-01 - Determination of normal ranges of mitochondrial respiratory activities by mtDNA transfer from 54 Human subjects to mtDNA-less HeLa cells for identification of the pathogenicities of mutated mtDNAs
Ishikawa Kaori
J Biochem/135/p.237, 2004 - Rare creation of recombinant mtDNA haplotypes in mammalian tissues
Ishikawa Kaori
Proc Natl Acad Sci U S A/102/p.6057, 2005 - Application of ES cells for generation of respiration-deficient mice carrying mtDNA with a large-scale deletion
Ishikawa Kaori
Biochem Biophys Res Commun/333/p.590, 2005 - Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation
Ishikawa Kaori
Proc Natl Acad Sci U S A/102/p.16765, 2005 - Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells
Ishikawa Kaori
Hum Mol Genet/15/p.871, 2006 - more...
- A high mutation load of m.14597A>G in MT-ND6 causes Leigh syndrome
- Books
- ヒト神経変性疾患の進行をモデル動物で再現する試み
石川 香
BioClinica/pp.60-62, 2021-04 - ミトコンドリア・ダイナミクスの異常による神経変性の病態比較-ヒト神経変性疾患の進行をモデル動物で再現するために-
石川 香
Medical Science Digest/pp.34-35, 2020-11 - 第2章 細胞の構造とエネルギー代謝・2-3 呼吸のしくみ, 2-4 光合成のしくみ
石川 香
現代人のための高校理科 新しい高校生物の教科書, 2006 - 第II部 実践編・2章 細胞染色のためのプローブ・②ミトコンドリア
石川 香
実験がうまくいく蛍光・発光試薬の選び方と使い方, 2007
- ヒト神経変性疾患の進行をモデル動物で再現する試み
- Conference, etc.
- mtDNA改変モデルマウス作出の試み
石川 香
第6回ゲノム編集学会/2021-06-16--2021-06-18 - 突然変異型MFN2の時期特異的発現調節による神経変性の病態比較
石川 香
第43回日本分子生物学会年会/2020-12-02--2020-12-04 - Generation and analysis of trans-mitochondrial mice carrying mtDNA with a point mutation in tRNALeu(UUR) gene.
谷 春菜; Ishikawa Kaori; 林純一; 中田和人
The 16th Conference of Asian Society for Mitochondrial Research and Medicine [ASMRM] and The 19th Conference of Japan Society for Mitochondrial Research and Medicine [J-mit]/2019-10-03--2019-10-05 - Human neurodegenerative disease-like phenotypes induced by acquired expression of mutant MFN2 in mice.
Ishikawa Kaori
The 16th Conference of Asian Society for Mitochondrial Research and Medicine [ASMRM] and The 19th Conference of Japan Society for Mitochondrial Research and Medicine [J-mit]/2019-10-03--2019-10-05 - 突然変異型MFN2の神経特異的な誘導性発現による病態の評価
Ishikawa Kaori
2019年度文部科学省新学術領域研究 学術研究支援基盤形成 先端モデル動物支援プラットフォーム成果発表会/2020-02-04--2020-02-05 - Progressive neurodegeneration and abnormal behavior were caused by acquired expression of mutant Mitofusin 2 in neurons.
Ishikawa Kaori
The Cold Spring Harbor Asia conference on Mitochondria and Metabolism in Health and Disease/2019-11-11--2019-11-15 - マウス培養細胞は組織よりも高い割合のミトコンドリアDNA突然変異を許容できる
石川 香
第18回日本ミトコンドリア学会年会/2018-12-07--2018-12-09 - Progressive neurodegeneration and abnormal behavior were caused by acquired expression of mutant Mitofusin 2 in neurons.
Ishikawa Kaori
The 41st Annual Meeting of the Molecular Biology Society of Japan/2018-11-28--2018-11-30 - The D210V mutation of Mfn2 in neurons induces different pathologies in severity depends on its expression timing
Ishikawa Kaori
Keystone Symposia -Mitochondrial Biology (Z1)-/2018-04-22--2018-04-26 - The importance of Mfn2 in neuronal function from juvenile to adult phase
Ishikawa Kaori
The 1st International Mitochondria Meeting for Young Scientists/2018-04-20--2018-04-22 - ミトコンドリア病の多様な病態発症機構の理解に向けたアプローチ~核-ミトコンドリア間クロストーク~
石川 香
第39回日本分子生物学会年会/2016-11-30--2016-12-02 - Novel function of mtDNA: its involvement in metastasis
Ishikawa Kaori
6th Conference of the Asian Society of Mitochondrial Research and Medicine/2009-10-30--2009-11-01 - Phenotypes controlled by the mutation of mammalian mtDNA~Impacts of the mutation of non-nuclear genome~
石川 香
第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会(BMB2015)/2016-12-01--2016-12-04 - 神経におけるMfn2のD210V突然変異は発現時期によって重症度の異なる病態を引き起こす
石川 香
第17回日本ミトコンドリア学会年会/2017-11-22--2017-11-23 - The importance of mitochondrial fission in preventing disease phenotypes induced by a pathogenic mtDNA mutation
石川 香
13th Conference of the Asian Society of Mitochondrial Research and Medicine/2016-10-30--2016-11-01 - mtDNAの突然変異は活性酸素産生を介してがん細胞の転移能を制御する
石川 香
第8回日本ミトコンドリア学会年会/2008 - ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis
Ishikawa Kaori
The 7th European meeting on mitochondrial pathology (EUROMIT VII)/2008 - ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.
Ishikawa Kaori
The 31st Annual Meeting of the Molecular Biology Society of Japan and The 81st Annual Meeting of the Japanese Biochemical Society Joint Meeting (BMB2008)/2008 - Novel fuction of mtDNA: its involvement in metastasis
Ishikawa Kaori
The 6th Conference of the Asian Society of Mitochondrial Research and Medicine (ASMRM)/2009
- mtDNA改変モデルマウス作出の試み
- Teaching
2021-10 -- 2021-10 Topics of Biosciences V University of Tsukuba. 2021-04 -- 2021-08 Seminar on Molecular and Cellular Biology AI University of Tsukuba. 2021-04 -- 2021-08 Methodology on Molecular and Cellular Biology BI University of Tsukuba. 2021-11 -- 2021-12 Introduction to Comparative Omics Analyses University of Tsukuba. 2021-04 -- 2021-08 Methodology on Molecular and Cellular Biology AI University of Tsukuba. 2021-10 -- 2022-02 Methodology on Molecular and Cellular Biology BII University of Tsukuba. 2021-10 -- 2022-02 Seminar on Molecular and Cellular Biology CII University of Tsukuba. 2021-10 -- 2022-02 Methodology on Molecular and Cellular Biology AII University of Tsukuba. 2021-10 -- 2022-02 Seminar on Molecular and Cellular Biology DII University of Tsukuba. 2021-10 -- 2022-02 Seminar on Molecular and Cellular Biology BII University of Tsukuba. more... - Other educational activities
2019-08 -- 2019-08 リケジョサイエンス合宿 筑波大学ダイバーシティ部門 2019-06 -- 2019-06 高校生対象模擬授業 筑波大学高大連携課・茨城県 2018-08 -- 2018-08 高校生科学体験教室 筑波大学高大連携課・茨城県 2018-08 -- 2018-08 リケジョサイエンス合宿 筑波大学ダイバーシティ部門 - University Management
2020-07 -- 2021-04 筑波大学入学試験問題出題専門委員会 委員 2015-04 -- (current) ハラスメント相談委員 - Other activities
2016-07 -- 2016-08 国際生物学オリンピックの国内代表選考会の運営
(Last updated: 2021-08-03)