YOSHINO Ryunosuke
- Affiliation
- Institute of Medicine
- Official title
- Assistant Professor
- Research keywords
Computational Chemistry, Molecular Simulation - Research projects
Development of linker design method for PROTAC based on ternary complex structure prediction 2023-04 -- 2026-03 YOSHINO Ryunosuke Japan Society for the Promotion of Science/Grant-in-Aid for Early-Career Scientists 4,680,000Yen Pharmacophore modeling using interaction analysis information by Fragment Molecular Orbital method 2018-04 -- 2020-03 YOSHINO Ryunosuke Japan Society for the Promotion of Science/Grant-in-Aid for Young Scientists 2,080,000Yen - Career history
2017-04 -- 2018-03 Tokyo Institute of TechnologyEducation Academy of Computational Life SciencesSpecially Appointed Assistant Professor - Degree
2017-03 Doctor of Agriculture Graduate School of Agricultural and Life Sciences, The University of Tokyo - Articles
- Prediction of the binding mechanism of a selective DNA methyltransferase 3A inhibitor by molecular simulation
Kudo Genki; Hirao Takumi; Harada Ryuhei; Hirokawa Tak...
Scientific reports/14(1), 2024-06-12 - Site Identification and Next Choice Protocol for Hit-to-Lead Optimization
Kudo Genki; Hirao Takumi; Yoshino Ryunosuke; Shigeta ...
JOURNAL OF CHEMICAL INFORMATION AND MODELING/64(11)/pp.4475-4484, 2024-05-20 - Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity
Saito Kenji; Sekiya Motohiro; Kainoh Kenta; Yoshino R...
J Biol Chem/299(7)/p.104890, 2023-7 - AAp-MSMD: Amino Acid Preference Mapping on Protein-Protein Interaction Surfaces Using Mixed-Solvent Molecular Dynamics
Kudo Genki; Yanagisawa Keisuke; Yoshino Ryunosuke; Hir...
JOURNAL OF CHEMICAL INFORMATION AND MODELING/63(24)/pp.7768-7777, 2023-12-25 - Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro, and X-ray Crystallography
Yoshino Ryunosuke; Yasuo Nobuaki; Hagiwara Yohsuke; Is...
ACS OMEGA/8(29)/pp.25850-25860, 2023-07-12 - Pocket to concavity: a tool for the refinement of protein-ligand binding site shape from alpha spheres
Kudo Genki; Hirao Takumi; Yoshino Ryunosuke; Shigeta ...
BIOINFORMATICS/39(4), 2023-04-03 - Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis
Tabata Junya; Nakaoku Takashi; Araki Mitsugu; Yoshino ...
CANCER RESEARCH/82(20)/pp.3751-3762, 2022-10-17 - A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin
Watanabe-Takahashi Miho; Senda Miki; Yoshino Ryunosuke...
SCIENTIFIC REPORTS/12(1), 2022-07-06 - Inverse Mixed-Solvent Molecular Dynamics for Visualization of the Residue Interaction Profile of Molecular Probes
Yanagisawa Keisuke; Yoshino Ryunosuke; Kudo Genki; Hiroka...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/23(9), 2022-04-26 - Chemosynthetic ethanolamine plasmalogen stimulates gonadotropin secretion from bovine gonadotrophs by acting as a potential GPR61 agonist
Kadokawa Hiroya; Yoshino Ryunosuke; Saito Risa; Hiroka...
ANIMAL REPRODUCTION SCIENCE/241, 2022-05-13 - Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti
Inaba Kazue; Ebihara Kana; Senda Miki; Yoshino Ryunosuke...
BMC Biology/20(1)/p.43, 2022-02 - Integrate in silico studies on the role of nicotinamide adenine dinucleotide (NADH) binding in activating C-terminal binding protein 2 (CtBP2)
Tsukasa Aoyagi; Yoshino Ryunosuke; Yuki Mitsuta; Rikuri ...
Chemistry Letters/51(1)/pp.1-4, 2021-10 - The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis
Sekiya Motohiro; Kainoh Kenta; Sugasawa Takehito; Yosh...
Nature communications/12(1)/p.6315, 2021-11 - Non-steroidal inhibitors of Drosophila melanogaster steroidogenic glutathione S-transferase Noppera-bo
Koiwai Kotaro; Morohashi Kana; Inaba Kazue; Ebihara Kana...
Journal of Pesticide Science/46(1-2)/pp.75-87, 2021-01 - Identification of key interactions between SARS-CoV-2 main protease and inhibitor drug candidates
Yoshino Ryunosuke; Yasuo Nobuaki; Sekijima Masakazu
SCIENTIFIC REPORTS/10(1), 2020-07 - An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo
Koiwai Kotaro; Inaba Kazue; Morohashi Kana; Enya Sora; Ar...
Journal of Biological Chemistry/295(20)/pp.7154-7167, 2020-05 - A prospective compound screening contest identified broader inhibitors for Sirtuin 1
Chiba Shuntaro; Ohue Masahito; Gryniukova Anastasiia; ...
Scientific reports/9, 2019-12 - Molecular Dynamics Simulation reveals the mechanism by which the Influenza Cap-dependent Endonuclease acquires resistance against Baloxavir marboxil
Yoshino Ryunosuke; Yasuo Nobuaki; Sekijima Masakazu
Scientific reports/9, 2019-11 - Parallel cascade selection molecular dynamics to screen for protein complexes generated by rigid docking
Harada Ryuhei; Yoshino Ryunosuke; Nishizawa Hiroaki; Shig...
Journal of molecular graphics & modelling/92/pp.94-99, 2019-07 - Temperature-pressure shuffling outlier flooding method enhances the conformational sampling of proteins
Harada Ryuhei; Yoshino Ryunosuke; Nishizawa Hiroaki; Shig...
Journal of computational chemistry/40(15)/pp.1530-1537, 2019-02 - Compound property enhancement by virtual compound synthesis
Arai Naoki; Yoshikawa Shunsuke; Yasuo Nobuaki; Yoshino R...
Journal of Bioinformatics and Computational Biology/16(3), 2018-6 - Exploring the selectivity of inhibitor complexes with Bcl-2 and Bcl-XL: A molecular dynamics simulation approach
Naoki Wakuia; Ryunosuke Yoshino; Yoshino Ryunosuke; Nobuaki...
Journal of Molecular Graphics and Modelling/79/pp.166-174, 2018-1 - An iterative compound screening contest method for identifying target protein inhibitors using the tyrosine-protein kinase Yes
Shuntaro Chiba; Takashi Ishida; Kazuyoshi Ikeda; Masahiro Mo...
Scientific Reports/7, 2017-9 - In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease
Yoshino Ryunosuke; Nobuaki Yasuo; Yohsuke Hagiwara; Takashi...
Scientific Reports/7, 2017-7 - Identification of potential inhibitors based on compound proposal contest: Tyrosine-protein kinase Yes as a target.
Shuntaro Chiba; Kazuyoshi Ikeda; Takashi Ishida; M. Michael ...
Scientific Reports/5, 2015-11 - more...
- Prediction of the binding mechanism of a selective DNA methyltransferase 3A inhibitor by molecular simulation
- Conference, etc.
- バーチャルスクリーニングモデル作成のためのParallel Cascade Selection Molecular Dynamicsの応用
平尾巧; 工藤玄己; 吉野龍ノ介; 広川 貴次
第51回構造活性相関シンポジウム/2023-11-20 - 拡張アンサンブル法を用いたPROTACリンカー設計のための三元複合体構造探索
吉野龍ノ介; 工藤玄己; 平尾巧; 広川 貴次
第51回構造活性相関シンポジウム/2023-11-20 - Hit-to-Leadを指向した官能基修飾始点と伸長サイトの予測手法開発
工藤玄己; 平尾巧; 吉野龍ノ介; 重田育照; 広川 貴次
第 51 回構造活性相関シンポジウム/2023-11-20 - Conformation Search of Ternary Complexes for Rational PROTAC Linker Design Using Enhanced Sampling Method
吉野龍ノ介; 工藤玄己; 平尾巧; 広川 貴次
CBI学会2023年大会/2023-10-25 - Comprehensive Structural Analysis of PROTAC Mediated Ternary Complexes using Enhanced Conformational Sampling Methods
工藤玄己; 平尾巧; 広川 貴次; 吉野龍ノ介
CBI学会2023年大会/2023-10-24 - Application of Parallel Cascade Selection Molecular Dynamics for Generating Virtual Screening Models
平尾巧; 工藤玄己; 吉野龍ノ介; 広川 貴次
CBI学会2023年大会/2023-10-24 - Hit-to-Lead最適化を目的とした立体構造に基づくリガンド伸長サイト予測
工藤玄己; 平尾巧; 吉野龍ノ介; 重田育照; 広川 貴次
第23回日本蛋白質科学会年会/2023-7-5 - Molecular Dynamics for Visualization of Amino Acid Residue Interaction Profile of Molecular Probes
Hirokawa Takatsugu; K Yanagisawa; R Yoshino; G Kudo
日本生物物理学会第60回年会/2022-09-29 - Amino acid preference mapping on protein-protein interaction surface using mixed-solvent molecular dynamics
Hirokawa Takatsugu; G Kudo; K Yanagisawa; R Yoshino
CBI学会2022年大会/2022-10-25 - 蛋白質構造情報に基づく化合物結合サイト予測の高精度化
広川 貴次; 工藤玄己; 吉野龍ノ介; 重田育照
第 22 回日本蛋白質科学会年会/2022-06-07 - インバース共溶媒分子動力学法による分子プローブ周辺残基環境の可視化
広川 貴次; 柳澤渓甫; 吉野龍ノ介; 工藤玄己
第 22 回日本蛋白質科学会年会/2022-06-08 - DNAメチル基転移酵素阻害剤のアイソフォーム選択性の解明
工藤 玄己; 重田 育照; 原田 隆平; 広川 貴次; 吉野 龍ノ介
日本コンピュータ化学会2021年 秋季年会/2021/11/02--2021/11/03 - Prediction of binding mechanism for DNA methyltransferase 3A selective inhibitor using molecular simulation approach
Kudo Genki; Shigeta Yasuteru; Harada Ryuhei; Hirokawa Ta...
CBI学会2021年大会/2021/10/26--2021/10/28 - 分子シミュレーション技術を用いたタンパク質-リガンド間の分子認識メカニズムの解析
吉野 龍ノ介
第43回日本分子生物学会年会/2020-12-02--2020-12-04 - Structure-activity relationship analysis of mosquito glutathione S-transferase Noppera-bo and its inhibitors for insecticide development
Inaba Kazue; Koiwai Kotaro; Ebihara Kana; Yoshino Ryunos...
American Crystallographic Association (ACA) 2020 Virtual Meeting/2020-08-02--2020-08-07 - 昆虫ステロイドホルモン生合成に必要なグルタチオンS -転移酵素Noppera-boの 阻害剤探索
海老原 佳奈; 稲葉 和恵; 小祝 孝太郎; 吉野 龍ノ介; 広川 貴次; 今村 理世; 小島 宏建; 岡部 隆...
日本結晶学会 令和2年(2020年)度年会/2020-11-27--2020-11-28 - 環状ペプチドにおける、溶媒の違いによる構造変化と自由エネルギー安定性の評価
柳 昂輝; 重田 育照; 西澤 宏晃; 原田 隆平; 吉野 龍ノ介; 満田 祐樹
日本コンピュータ化学会2019秋季年会/2019-10-24--2019-10-25 - Systematic trends and features in the stable structure of cyclic dipeptides
栁 昂輝; 西澤 宏晃; 吉野 龍ノ介; 原田 隆平; 重田 育照
第57回日本生物物理学会年会/2019-09-24--2019-09-26 - Combined experimental and computational approaches reveal a unique structural property of the Halloween glutathione S-transferase Noppera-bo
Koiwai Kotaro; Inaba Kazue; Morohashi Kana; Enya Sora; Im...
4th International Insect Hormone Workshop/2019-07-01--2019-07-01 - Discovery of a novel inhibitor of spermidine synthase for Chagas' disease by molecular dynamics and docking simulation
Yoshino Ryunosuke
Asia Hub for e-Drug Discovery Symposium/2018-09-26--2018-09-29 - In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease
Yoshino Ryunosuke
4th IITM – Tokyo Tech Joint Symposium titled Frontiers in Bioinformatics: Large scale data analysis, Resources and Drug design/2017-11-10--2017-11-11 - Compound Property Enhancer by Virtual Compound Synthesis
Naoki Arai; Shunsuke Yoshikawa; Nobuaki Yasuo; Yoshino Ryun...
The 28th International Conference on Genome Informatics GIW/BIOINFO 2017/2017-10-31--2017-11-3
- バーチャルスクリーニングモデル作成のためのParallel Cascade Selection Molecular Dynamicsの応用
(Last updated: 2024-10-04)