FUJIYAMA Tomoyuki
- Affiliation
- International Institute for Integrative Sleep Medicine
- Official title
- Specially Appointed Assistant Professor
- ORCID
- 0000-0001-6420-2283
- KAKEN ID
- 00635089
- URL
- I{,! 0v$vC+&$&0," C|{:IE,C+*,",wvCvxC!'
- Office
- Yanagisawa/Funato Lab
- Other affiliation
Dept of Cell Biol, Grad Sch of Med, Duke University National Institute of Neuroscience, NCNP - Research keywords
neural development, hypothalamus, sexual differentiation. Ptf1a, REM sleep, NALCN, BioID - Research projects
Grant-in-Aid for Scientific Research (B) 2026-04 -- 2030-03 Takeo Yoshikawa, Fumito Naganuma, Tomoyuki Fujiyama JSPS/Grant-in-Aid for Scientific Research (B) 18,330,000Yen Grant-in-Aid for Scientific Research (C)/26K09510 2026-04 -- 2029-03 Tomoyuki Fujiyama JSPS/基盤研究(C) 4,550,000Yen NALCNチャネルの機能変化を介した吸入麻酔薬耐性メカニズムの検討 2022 -- 2024 藤山 知之 Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Research (Exploratory) 6,500,000Yen 革新的インタラクトーム解析法in vivo BiolDを主軸とする国際共同研究網の構築 2022 -- 2023 柳沢 正史 国立研究開発法人科学技術振興機構/戦路的国際共同研究プログラム(SICORP) 3,380,000Yen 非選択的陽イオンチャネルNALCNによるレム睡眠制御の分子基盤の解明 2020 -- 2022 藤山 知之 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B) 17,550,000Yen ポストゲノム編集時代のマウス発生工学技術基盤の構築 2019 -- 2021 水野 聖哉 日本学術振興会/基盤研究(B) 17,420,000Yen Nalcn遺伝子改変マウスを用いたレム睡眠制御の神経回路基盤の解明 2018 -- 2019 藤山 知之 日本学術振興会/若手研究 4,160,000Yen 新規Dreamless遺伝子に基づくレム睡眠制御機構の解明 2015 -- 2017 藤山 知之 日本学術振興会/特別研究員奨励費 (PD) 4,030,000Yen 新規睡眠関連遺伝子に基づくレム睡眠制御機構の解明 2015 -- 2016 藤山 知之 日本学術振興会/若手研究(B) 4,030,000Yen 新規Dreamless遺伝子に基づくレム睡眠制御機構の解明 2014 -- 2014 藤山 知之 筑波大学/研究基盤支援プログラム(Aタイプ) 373,000Yen more... - Career history
2012-04 -- 2013-08 National Institute of Neuroscience, NCNPResearcher 2013-09 -- 2018-09 WPI-IIIS, University of TsukubaResearcher 2015-04 -- 2018-03 JSPSResearch Fellowship (PD) 2009-04 -- 2012-03 JSPSResearch Fellowship (DC1) 2018-10 -- (current) WPI-IIIS, University of TsukubaAssistant Professor - Academic background
2002-04 -- 2006-03 Kyushu University School of Science 2006-04 -- 2008-03 Kyoto University Graduate School of Biostudies 2008-04 -- 2012-03 Kyoto University Graduate School of Medicine - Degree
2012-03 博士(医学) 京都大学 - Licenses and qualifications
2023-07 JSBi Bioinformatics technician - Academic societies
-- (current) The Japanese Pharmacological Society -- (current) The Molecular Biology Society of Japan -- (current) The Japan Neuroscience Society -- (current) Society for Neuroscience - Articles
- Deep Learning-coupled Proximity Proteomics to Deconvolve Kinase Signaling In Vivo
FUJIYAMA Tomoyuki
bioRxiv, 2025-04-27 - Partial activation of SIK3 delays the onset of wakefulness and alleviates hypersomnia due to the lack of protein kinase A-phosphorylation site
Nakata Shinya; Fujiyama Tomoyuki; Asano Fuyuki; Komiya...
Sleep, 2024-12-04 - Exocyst complex component 1 (Exoc1) loss in dormant oocyte disrupts c-KIT and growth differentiation factor (GDF9) subcellular localization and causes female infertility in mice
Nguyen Chi Lieu Kim; Kuba Yumeno; Le Hoai Thu; Shawki ...
Cell death discovery/11(1), 2025-01-20 - Evaluation of ET-2 physiology in the lung via the generation of a novel Edn-2 luminescent reporter mice
Ryanto Gusty RIzky Tegu; Fujiyama Tomoyuki; Suzuki Yok...
CLINICAL SCIENCE/138(1), 2024-05 - Kinase signalling in excitatory neurons regulates sleep quantity and depth
Kim Staci J; Hotta-Hirashima Noriko; Asano Fuyuki; Kit...
NATURE/612(7940)/pp.512-518, 2022-12-01 - Crucial role of TFAP2B in the nervous system for regulating NREM sleep
Nakai Ayaka; Kashiwagi Mitsuaki; Fujiyama Tomoyuki; Iw...
MOLECULAR BRAIN/17(1)/p.13, 2024-02-27 - Crucial role of TFAP2B in the nervous system for regulating NREM sleep
Nakai Ayaka; Kashiwagi Mitsuaki; Fujiyama Tomoyuki; Iw...
Molecular brain/17(1)/p.13, 2024-02-27 - SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice
Asano Fuyuki; Kim Staci J; Fujiyama Tomoyuki; Miyoshi ...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA/120(11), 2023-03-14 - Kinase signalling in excitatory neurons regulates sleep quantity and depth
Kim Staci J; Hotta-Hirashima Noriko; Asano Fuyuki; Kit...
NATURE/612(7940)/pp.512-518, 2022-12-01 - The Role of Reproductive Hormones in Sex Differences in Sleep Homeostasis and Arousal Response in Mice
Choi Jinhwan; Kim Staci J.; Fujiyama Tomoyuki; Miyoshi...
FRONTIERS IN NEUROSCIENCE/15, 2021-09 - An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension
Ryanto Gusty R. T.; Ikeda Koji; Miyagawa Kazuya; Tu L...
NATURE COMMUNICATIONS/12(1), 2021-03 - Efficient induction of proximity-dependent labeling by biotin feeding in BMAL1-BioID knock-in mice
Murata Kazuya; Mimura Asuka; Suzuki Hayate; Mikami Na...
Journal of biochemistry/170(4)/pp.453-461, 2021-05 - Induction of Mutant Sik3(Sleepy) Allele in Neurons in Late Infancy Increases Sleep Need
Iwasaki Kanako; Fujiyama Tomoyuki; Nakata Shinya; Park M...
The Journal of neuroscience : the official journal of the Society for Neuroscience/41(12)/pp.2733-2746, 2021-02 - Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β
Nakai Ayaka; Fujiyama Tomoyuki; Nagata Nanae; Kashiwag...
Genetics/216(3)/pp.753-764, 2020-09 - Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need
Park Minjeong; Miyoshi Chika; Fujiyama Tomoyuki; Kakiz...
SCIENTIFIC REPORTS/10(1), 2020-05 - Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1
Fujiyama Tomoyuki; Yamada Mayumi; Terao Mami; Terashim...
Development (Cambridge, England)/136(12)/pp.2049-2058, 2009-06-01 - Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain
Fujiyama Tomoyuki; Miyashita Satoshi; Tsuneoka Yousuke...
Cell reports/24(1)/pp.79-94, 2018-07 - Quantitative phosphoproteomic analysis of the molecular substrates of sleep need
Wang Zhiqiang; Ma Jing; Miyoshi Chika; Li Yuxin; Sato...
Nature/558(7710)/pp.435-439, 2018-06 - Forward-genetics analysis of sleep in randomly mutagenized mice
Funato Hiromasa; Miyoshi Chika; Fujiyama Tomoyuki; Kan...
NATURE/539(7629)/pp.378-383, 2016-11 - Mice lacking cerebellar cortex and related structures show a decrease in slow-wave activity with normal non-REM sleep amount and sleep homeostasis.
Fujiyama Tomoyuki; Takenaka Henri; Asano Fuyuki; Miyan...
FRONTIERS IN BEHAVIORAL NEUROSCIENCE/16/pp.910461-910461, 2022/5 - Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway
Sakikubo Morito; Furuyama Kenichiro; Horiguchi Masashi...
SCIENTIFIC REPORTS/8, 2018-10 - A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice
Honda Takato; Fujiyama Tomoyuki; Miyoshi Chika; Ikkyu ...
Proceedings of the National Academy of Sciences of the United States of America/115(41)/pp.10458-10463, 2018-09
- Deep Learning-coupled Proximity Proteomics to Deconvolve Kinase Signaling In Vivo
- Books
- 「眠気」の生化学的な実体に迫るー睡眠要求を規定するリン酸化タンパク質群の同定
藤山 知之; 柳沢 正史
実験医学 2019年1月号 Vol.37 No.1, 2019-01 - 「膵臓転写因子1A」藤山知之, 星野幹雄 (担当:分担執筆)
藤山 知之; 星野 幹雄
脳科学辞典, 2025-10
- 「眠気」の生化学的な実体に迫るー睡眠要求を規定するリン酸化タンパク質群の同定
- Conference, etc.
- ムーンショット:睡眠基礎研究の最前線
柳沢 正史; 藤山知之; 史蕭逸; 安垣進之助; Roy Koustav
日本睡眠学会第48回定期学術集会/2024/07/18--2024/07/19
- ムーンショット:睡眠基礎研究の最前線
- Teaching
2026-01 -- 2026-01 令和7年度 サマーリサーチプログラムSRP2025受入担当 筑波大学HBP 2024-11 -- 2024-11 令和6年度 第283回つくばブレインサイエンス・セミナー 筑波大学大学院修士課程フロンティア医科学学位プログラム 2022-07 -- 2022-07 SRP2022 HBP, Univ of Tsukuba 2022-07 -- 2022-08 令和4年度 バイオサイエンストピック -EC32041- 筑波大学生物資源
(Last updated: 2026-09-03)