FUJITA Ryo

Affiliation

Institute of Medicine

Official title

Associate Professor

ORCID

0000-0002-8392-0122

KAKEN ID

60770435

URL

http://www.md.tsukuba.ac.jp/tmrc/members/fujita/

Email

;+:/.7>4HUU&9HUU2)Q98:0:'&Q&(Q/5

Office

Division of Regenerative Medicine

Research keywords

Sarcopenia
muscle stem cell
skeletal muscle
muscular dystrophy
Exercise
regenerative medicine
tissue specific stem cell

Research projects

Ryo Fujita	2025-08 -- 2026-03	Ryo Fujita	University of Tsukuba/令和7年度熊本大学発生医学研究所共同研究 導入支援	175,000Yen
骨格筋線維制御機構の解明とデザイン法の開発	2025-04 -- 2028-03	Satoru Takahashi	Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research (A)
Genetic Insights from Tsukuba Athletes: Toward Enhancing Human Skeletal Muscle Function and Developing Anti-Aging Strategies	2025-04 -- 2026-03	Ryo Fujita	University of Tsukuba/R&D Project with Inter-Faculty Team	1,200,000Yen
骨格筋幹細胞の運命多様性操作による筋可塑性最大化と筋疾患の克服	2024-10 -- 2028-03	Ryo Fujita	Japan Science and Technology Agency (JST)/FOREST	20,000,000Yen
骨格筋幹細胞の新 (心) 機能	2024-06 -- 2027-03	Ryo FUJITA	Japan Society of for the Promotion of Science/Grant-in-Aid for Challenging Research (Exploratory)	6,370,000Yen
筋疾患に対する幹細胞個別化医療の実現に向けた骨格筋幹細胞の運命制御機構の解明	2024-04 -- 2029-03	Ryo FUJITA	Japan Society of for the Promotion of Science/Grant-in-Aid for Scientific Research(B)	18,590,000Yen
Anti-aging strategy based on skeletal muscle quality control	2023-10 -- 2029-03	Satoru Takahashi	Japan Agency for Medical Research and Development (AMED)/ユニットタイプ「根本的な老化メカニズムの理解と破綻に伴う疾患機序解明」研究開発領域　戦略的創造研究推進事業
骨格筋幹細胞ダイナミクスの理解に基づいた幹細胞個別化医療の実現	2023-12 -- 2024-12	Ryo Fujita	Mochida Memorial Foundation for Medical and Pharmaceutical Research/令和5年度研究助成：(1) バイオ技術を基盤とする先端医療に関する研究	3,000,000Yen
骨格筋組織幹細胞が秘めた新しい可能性の探索	2023-07 -- 2028-03	Ryo Fujita	Takeda Science Foundation/医学系研究継続助成	3,000,000Yen
筋疾患領域における治療薬の創出 (学術指導)	2022-01 -- 2022-12	藤田諒	帝人ファーマ株式会社/学術指導契約	360,000Yen
more...

Career history

2025-06 -- (current)	University of TsukubaDivision of Regenerative Medicine, Transborder Medical Research Center, Institute of MedicineAssociate Professor
2025-02 -- 2025-05	University of TsukubaDivision of Regenerative Medicine, Transborder Medical Research Center, Institute of MedicineAssistant Professor
2020-02 -- 2025-01	Unuversity of TsukubaDivision of Regenerative Medicine, Transborder Medical Research Center, Institute of MedicineAssistant Professor

Degree

2015-3-25	Ph.D.	Osaka University

Academic societies

2023-10 -- (current)	Japanese Association on Sarcopenia and Frailty
2022-10 -- (current)	JAPAN SOCIETY FOR BIOMEDICAL GERONTOLOGY
2015-04 -- (current)	Japan Muscle Society
2009-03 -- (current)	THE JAPANESE SOCIETY OF PHYSICAL FITNESS AND SPORTS MEDICINE

Honors & Awards

2023-11	令和5年度筑波大学医学医療系優秀教員表彰
2023-11	令和５年度若手教員奨励賞
2023-08	12th Annual International Space Station Research and Development Conference (ISSRDC), Compelling Results Award-Biology and Medicine
2023-08	Young Investigator’s Award. The 9th Annual Meeting of Japan Muscle Society
2020-12	The 6th Annual Meeting of Japan Muscle Society, Young Investigator's Award
2019-12	Travel grants to early career researchers in overseas
2019-09	Trainee Travel Award for the Frontiers in Myogenesis Conference
2019-09	SCN International Travel Award
2018-11	Best Trainee Talks for the MRM Seminars Series 2018-2019
2018-10	Lucie Besner Award in Stem Cell and Regenerative Medicine Research
2018-03	CDB symposium 2018 Travel Fellowship (Dynamic Homeostasis from Development to Aging)
2014-08	The Young Investigator Award for the 20th Annual Meeting of JSGT2014

Articles

• Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle
  Sadaki Shunya; Tsuji Ryosuke; Hayashi Takuto; Watanabe...
  Skeletal Muscle/15(19), 2025-07
  
  PubMed
• The Multifaceted Role of MyoD in Adult Skeletal Muscle: Homeostasis, Regeneration, and Diseases
  Tsuji Ryosuke; Hayashi Takuto; Takahashi Satoru; Asaku...
  American journal of physiology. Cell physiology/329(1)/pp.C200-C212, 2025-06-05
  
  PubMed
• Cardiac Reprogramming and Gata4 Overexpression Reduce Fibrosis and Improve Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction
  Yamada Yu; Sadahiro Taketaro; Nakano Koji; Honda Seii...
  Circulation/151(6)/pp.379-395, 2024-12-14
  
  PubMed
• Development of adeno-associated viral vectors targeting cardiac fibroblasts for efficient in vivo cardiac reprogramming
  Nakano Koji; Sadahiro Taketaro; Fujita Ryo; Isomi Mar...
  Stem cell reports/19(10)/pp.1389-1398, 2024-08-21
  
  PubMed
• Dual-specificity phosphatases 13 and 27 as key switches in muscle stem cell transition from proliferation to differentiation
  Takuto Hayashi; Shunya Sadaki; Ryosuke Tsuji; Risa Ok...
  Stem Cells/42(9)/pp.830-847, 2024-09
  
  PubMed
• Flk1 Deficiency and Hypoxia Synergistically Promote Endothelial Dysfunction, Vascular Remodeling, and Pulmonary Hypertension
  Akiyama Tatsuya; Sadahiro Taketaro; Yamada Yu; Fujita ...
  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY/43(9)/pp.1668-1683, 2023-08-03
  
  PubMed
• MEF2C/p300-mediated epigenetic remodeling promotes the maturation of induced cardiomyocytes
  Kojima Hidenori; Sadahiro Taketaro; Muraoka Naoto; Yam...
  STEM CELL REPORTS/18(6)/pp.1274-1283, 2023-06
  
  PubMed
• Lunar gravity prevents skeletal muscle atrophy but not myofiber type shift in mice
  Hayashi Takuto; Fujita Ryo; Okada Risa; Hamada Michit...
  COMMUNICATIONS BIOLOGY/6(1)/p.424, 2023-04-21
  
  PubMed
• Generation of a MyoD knock-in reporter mouse line to study muscle stem cell dynamics and heterogeneity
  Fujita Ryo; Mizuno Seiya; Sadahiro Taketaro; Hayashi ...
  ISCIENCE/26(5)/p.106592, 2023-05
  
  PubMed
• High Throughput Screening of Mitochondrial Bioenergetics in Myoblasts and Differentiated Myotubes
  Takeda Kohei; Takemasa Tohru; Fujita Ryo
  Methods in molecular biology (Clifton, N.J.)/2640/pp.89-98, 2023-04-01
  
  PubMed
• Large Maf transcription factor family is a major regulator of fast type IIb myofiber determination
  Sadaki Shunya; Fujita Ryo; Hayashi Takuto; Nakamura A...
  CELL REPORTS/42(4), 2023-03
  
  PubMed
• Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction
  Hidenori Tani; Taketaro Sadahiro; Yu Yamada; Mari Iso...
  CIRCULATION/147(3)/pp.223-238, 2022-12
  
  PubMed
• The adhesion G-protein-coupled receptor Gpr116 is essential to maintain the skeletal muscle stem cell pool
  Senechal Charlotte; Fujita Ryo; Jamet Solene; Maiga Arha...
  Cell Reports/41(7)/p.111645, 2022-11
• The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells
  Baker Nicole; Wade Steven; Triolo Matthew; Girgis John; C...
  CELL STEM CELL/29(9)/pp.1315-1332, 2022-09
  
  PubMed
• Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight
  Hayashi Takuto; Kudo Takashi; Fujita Ryo; Fujita Shin...
  Communications biology/4(1), 2021-06
  
  PubMed
• Overexpression of Gata4, Mef2c, and Tbx5 Generates Induced Cardiomyocytes Via Direct Reprogramming and Rare Fusion in the Heart
  Mari Isomi; Taketaro Sadahiro; Hiroyuki Yamakawa; Ryo ...
  Circulation/143(21)/pp.2123-2125, 2021-05
• Direct reprogramming with Sendai virus vectors repaired infarct hearts at the chronic stage
  Isomi Mari; Sadahiro Taketaro; Fujita Ryo; Abe Yuto; ...
  Biochemical and Biophysical Research Communications/560(30)/pp.87-92, 2021-06
• Direct Reprogramming as a Novel Approach for Cardiovascular Regeneration
  藤田 諒; 貞廣威太郎; 家田真樹
  Pediatric Cardiology and Cardiac Surgery/37(1)/pp.10-17, 2021-04
• Satellite cell expansion is mediated by P-eIF2α dependent translation
  Fujita Ryo; Jamet Solène; Lean Graham; Cheng Harry Ch...
  Development (Cambridge, England)/148(2), 2020-12
  
  PubMed
• Estrogen Receptor β Controls Muscle Growth and Regeneration in Young Female Mice
  Seko Daiki; Fujita Ryo; Kitajima Yuriko; Nakamura Kod...
  Stem cell reports/15(3)/pp.577-586, 2020-08
  
  PubMed
• Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures
  Kurotsu Shota; Sadahiro Taketaro; Fujita Ryo; Tani Hi...
  Stem cell reports/15(3)/pp.612-628, 2020-08
  
  PubMed
• Scribble dictates orderly stem cell fate
  Fujita Ryo; Seko Daiki; Ono Yusuke
  Oncotarget/6(22)/pp.18738-18739, 2015-08-07
  
  PubMed
• eIF2α, a potential target for stem cell-based therapies
  Fujita Ryo; Ono Yusuke
  Stem cell investigation/3/p.30, 2016-04-01
  
  PubMed
• Translational Control of the Myogenic Program in Developing, Regenerating, and Diseased Skeletal Muscle
  Fujita Ryo; Crist Colin
  Current topics in developmental biology/126/pp.67-98, 2018-04
  
  PubMed
• Slow Your Roll: Inhibiting SETD7 Activity Permits Ex Vivo Expansion of Muscle Stem Cells
  Fujita Ryo; Crist Colin
  Cell stem cell/22(2)/pp.146-147, 2018-04-01
  
  PubMed
• more...

Books

• 宇宙から解明する骨格筋線維タイプの制御機構─抗老化戦略への応用を見据えて
  藤田 諒; 高橋智
  実験医学増刊 Vol.43 No.5 骨格筋の老化によるサルコペニア その理解と戦略〜筋生物学を超えた総合知で、運動・栄養・創薬による介入をめざす/羊土社, 2025-03
• 骨格筋線維タイプの決定機構─速筋タイプIIB筋線維決定因子の同定を中心に
  定木駿弥; 高橋智; 藤田 諒
  医学のあゆみ/医歯薬出版株式会社/pp.555-556, 2024-11-16
• 幹細胞ニッシェを中心とした骨格筋幹細胞の制御機構
  辻諒介; 藤田 諒
  医学のあゆみ―特集 骨格筋の再生・維持・適応メカニズムの新知見 ―最先端研究がもたらしたパラダイムシフト/医歯薬出版株式会社/pp.726-730, 2024-06-08
• 骨格筋幹細胞の幹細胞性維持機構-休止期維持メカニズムを中心に-
  藤田 諒
  医学のあゆみ/医歯薬出版株式会社/pp.913-914, 2023-09
• Skeletal Muscle Stem Cells: Methods and Protocols （Methods in Molecular Biology Book 2640）
  Takeda Kohei; Tohru Takemasa; Fujita Ryo
  Humana Press, 2023-03
• Role of muscle stem cells in sarcopenia
  Fujita Ryo
  Sarcopenia: Molecular Mechanism and Treatment Strategies/Elsevier/pp.109-138, 2021-07
• Direct reprogrammingによる心筋再生
  藤田 諒; 貞廣 威太郎; 家田 真樹
  Journal of JCS Cardiologists/The Japanese Circulation Society/pp.63-69, 2020-11
  
  CiNii
• 海外留学情報:カナダにあるフランス！？McGill University,Montreal,Canada
  藤田 諒
  再生医療, 2020-02
• 1章 運動と筋肉, 2章 運動と神経
  藤田 諒
  運動生理学―生理学の基礎から疾病予防まで/三共出版, 2013-05

Conference, etc.

• Insights into Muscle Fiber Regulation from Space: Toward Strategies for Healthy Aging
  FUJITA Ryo
  TSUKUBA CONFERENCE/2025-10-01--2025-10-03
• 筋線維タイプスイッチングの新規モデル:誘導型大Maf群転写因子欠損マウスモデルの解析
  定木駿弥; 林卓杜; 辻諒介; 岩井遼澄; 菅澤威仁; 工藤崇; 高橋智; 藤田 諒
  第11回日本筋学会学術集会/2025-08-22--2025-08-23
• 骨格筋線維タイプ制御機構の発見と 骨格筋の進化・機能革新への展望
  藤田 諒
  第11回日本筋学会学術集会/2025-08-22--2025-08-23
• 骨格筋線維タイプ制御機構の解明とその応用
  藤田 諒
  順天堂大学 第32回スポーツ健康医科学研究所セミナー/2025-05-09
• 筋疾患治療に向けた骨格筋幹細胞の運命制御機構の解明
  藤田 諒
  第24回日本再生医療学会総会/2025-03-20--2025-03-22
• Large Maf Transcription Factor family as a Principal Regulator of Fast Type IIb Myofiber Determination in Mice and Humans
  FUJITA Ryo
  Symposium on “Skeletal muscle Development, Maintenance, and Adaptation”/2025-03-04
• Regulating Muscle Stem Cell Fate and Myofiber Type Determination: A Path to Sustaining and Reviving Muscle Function
  藤田 諒
  第74回TARA Biweekly Mixer/2025-02-28
• Skeletal Muscle Development to Aging - Unraveling Muscle Stem Cell Regulation and Myofiber Diversity
  藤田 諒
  第26回 Top Runners in TRS/2025-02-17
• Large Maf Transcription Factors Govern the Specification of Fast Type IIb Myofibers
  Sadaki Shunya; Hayashi Takuto; Akhmetov Ildus; Sakurai...
  EMBO Workshop-SkeletalMuscle Development, Metabolism & Repair during Homeostasis and Disease/2024-10-12--2024-10-17
• Development of MyoD Knock-in Mice and Discovery of New Regulators of Muscle Stem Cell Fate Determination
  FUJITA Ryo; Hayashi Takuto; Takahashi Satoru
  EMBO Workshop-SkeletalMuscle Development, Metabolism & Repair during Homeostasis and Disease/2024-10-12--2024-10-17
• Analysis of the plastic changes induced in the soleus muscle under microgravity conditions
  諒介 辻; 林 卓杜; 工藤 崇; 藤田 諒; 濱田 理人; 岡田 理沙; 村谷 匡史; 芝 大; ...
  74th International Astronautical Congress/2023-10
• 微小重力環境を利用した新規骨格筋制御遺伝子の探索
  林 卓杜; 藤田 諒; 岡田 理沙; 濱田 理人; 布施谷 清香; 金井 真帆; 井上 由理; 定木 駿弥; 村谷...
  第9回(2023年度)日本筋学会学術集会/2023-08
• 月重力1/6 gは微小重力による筋萎縮を抑制するが、筋線維タイプの変化は抑制しない
  林 卓杜; 藤田 諒; 岡田 理沙; 濱田 理人; 布施谷 清香; 金井 真帆; 井上 由理; 定木...
  第70回(2023年度)日本実験動物学会総会/2023-05-24--2023-05-26
• Large Maf transcription factor family is a major regulator of fast type IIb myofiber determination
  定木 駿弥; 藤田 諒; 林 卓杜; 中村 綾乃; 岡村 結; 布施谷 清香; 濱田 理人; 蕨 ...
  50TH EUROPEAN MUSCLE CONFERENCE/2023-09
• 速筋線維を制御する大Maf群転写因子の解析
  定木 駿弥; 藤田 諒; 林 卓杜; 中村 綾乃; 岡村 結; 布施谷 清香; 濱田 理人; 蕨 ...
  第10回サルコペニア・フレイル学会大会/2023-11
• Large Maf transcription factor family is a major regulator of fast type IIb myofiber determination
  定木 駿弥; 藤田 諒; 林 卓杜; 中村 綾乃; 岡村 結; 布施谷 清香; 濱田 理人; 蕨 ...
  第31回(2023年度)日本運動生理学会大会/2023-08
• 大Maf群転写因子はtype IIb筋線維を制御する主要な因子である
  定木 駿弥; 藤田 諒; 林 卓杜; 中村 綾乃; 岡村 結; 布施谷 清香; 濱田 理人; 蕨 ...
  第70回(2023年度)日本実験動物学会総会/2023-05-24--2023-05-26
• Cardiac Reprogramming Reduces Fibrosis and Improves Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction
  山田 優; 貞廣 威太郎; 仲野 晃司; 本田 誠一郎; 安部 悠人; 藤田 諒; 家田 真樹
  American Heart Association Scientific Sessions 2023/2023-11-11--2023-11-13
• Cardiac reprogramming reduces fibrosis and improves diastolic dysfunction in heart failure with preserved ejection fraction
  山田 優; 貞廣 威太郎; 藤田 諒; 安部 悠人; 仲野 晃司; 本田 誠一郎; 家田 真樹
  第7回日本循環器学会基礎研究フォーラム (BCVR)/2023-12-09--2023-12-10
• 骨格筋線維タイプ制御機構の解明とその応用
  藤田 諒
  第14回分子骨格筋代謝研究会/2024-09-21--2024-09-21
• 骨格筋線維タイプ制御機構の解明とサルコペニア
  藤田 諒
  筋・骨・リウマチ3学会合同若手研究会/2024-05-11--2024-05-12
• サルコペニア克服に向けた骨格筋線維タイプ制御機構の解明
  藤田 諒; 定木 駿弥; 林 卓杜; 辻 諒介; 工藤 崇; 高橋 智
  第10回 日本サルコペニア・フレイル学会大会/2023-11-04--2023-11-05
• MyoD ノックインマウスによる骨格筋幹細胞の運命制御機構の解明
  藤田 諒
  第9回日本筋学会学術集会/2023-08-19--2023-08-20
• これであなたもネズミのように走れる!? 肉質制御機構の解明
  藤田 諒
  The 153rd Scienc-ome/2023-07-26
• Large Maf transcription factor family is a major regulator of fast type IIb myofiber determination
  Fujita Ryo; Sadaki Shunya; Takahashi Satoru
  1st Symposium on "Skeletal muscle cells in Growth and Disease"/2023-05-01--2023-05-02
• more...

Teaching

2025-09 -- 2026-03	Research Presentation and Discussion	Doctoral Program in Medical Sciences
2025-09 -- 2025-09	医学概論IV アドヴァンストコース「人体再生に挑む!発生・再生研究の最前線」	筑波大学　医学医療系
2025-04 -- 2025-06	実験動物科学特論・同実習	筑波大学
2023-04 -- 2023-07	First Year Seminar	University of Tsukuba.
2023-05 -- 2023-06	Advances in Cellular Regulation	University of Tsukuba.
2023-04 -- 2023-05	Invitation to Arts and Sciences	University of Tsukuba.
2022-05 -- 2022-06	Advances in Cellular Regulation	University of Tsukuba.
2022-06 -- 2022-07	M1 医療概論I 「人間性教育」テュートリアル	筑波大学医学医療系
2022-06 -- 2022-07	Advances in Cellular Regulation	Master's/Doctoral Program in Life Science Innovation
2021-09 -- 2021-09	M1「生化学」テュートリアル	筑波大学医学医療系
more...

Other educational activities

2024-04 -- 2025-03	M2クラス担任	医学類
2023-04 -- 2024-03	筑波大学大学院　人間総合科学学術院　人間総合科学研究群　博士後期課程　体育科学学位プログラム　専攻外副査	University of Tsukuba
2023-04 -- 2024-03	M1クラス担任	医学類

Professional activities

2024-11 -- (current)	Japanese Association on Sarcopenia and Frailty	評議員
2023-11 -- 2024-05	筋・骨・リウマチ3学会合同若手研究会	運営委員
2022-09 -- 2023-08	Japan Muscle Society	運営委員
2022-09 -- 2023-08	Japan Society of Exercise and Sports Physiology	運営委員
2021-09 -- (current)	THE JAPANESE SOCIETY OF PHYSICAL FITNESS AND SPORTS MEDICINE	Councilor

(Last updated: 2025-10-03)