KIMURA Kenichi
- Affiliation
- Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA)
- Official title
- Assistant Professor
- ORCID
- 0000-0002-0363-8865
- URL
- %FFDHPM<^kp<O^kpO<M<gONPFP=<g<>gEK
- Phone
- 029-853-7323
- Research fields
Cell biology Pathological medical chemistry - Research keywords
組織幹細胞 血管生物学 微小環境 疾患モデル 細胞外マトリクス 変形性関節症 骨疾患 大動脈解離 - Research projects
ミクロフィブリルを介した造血制御機構の解明 2025-07 -- 2026-07 木村健一 リディアオリリー記念ピアス皮膚科学振興財団/2025年度 エラスチン・関連分子研究会 ・研究奨励金 1,000,000Yen ミクロフィブリル変異による骨髄ニッチ恒常性異常と大動脈疾患へ及ぼす影響の解明 2025-04 -- 2029-03 木村健一 日本学術振興会//科学研究費助成事業（学術研究助成基金助成金）基盤研究(B) 14,400,000Yen 腸内細菌叢が織りなす大動脈疾患の新たな制御機構の解明 2025-04 -- 2026-03 木村健一 公益財団法人ヤクルト・バイオサイエンス研究財団/一般研究助成 1,000,000Yen 内在性間葉系幹細胞を用いた変形性関節症治療のための再生医療基盤の開発 2023-07 -- 2026-03 木村健一 AMED/「再生・細胞医療・遺伝子治療実現加速化プログラム（再生・細胞医療・遺伝子治療研究開発課題（基礎応用研究課題））」 39,000,000Yen 変形関節症における軟骨変性メカニズムの解明 2023-07 -- 2028-03 木村健一 Takeda Science Foundation/2023年度 医学系研究助成（基礎） 2,000,000Yen CD73陽性細胞による骨髄造血微小環境形成メカニズムの解明 2023-04 -- 2025-03 木村健一 稲盛財団/稲盛研究助成 1,000,000Yen 細胞外マトリクスを基軸とした胸部大動脈疾患の発生機序の解明と新規治療法の開発 2023-04 -- 2027-03 柳沢裕美 日本学術振興会/科学研究費補助金 基盤研究（A） 46,800,000Yen 細胞系譜解析を用いたCD73発現細胞による骨髄ニッチ形成および骨修復機構の解明 2022-04 -- 2025-03 木村健一 日本学術振興会/基盤研究(C) 4,290,000Yen CD73発現細胞による骨髄微小環境の細胞ダイナミクスの解明 2022-04 -- 2023-03 木村健一 ノバルティス科学振興財団/第35回 ノバルティス研究奨励金 1,000,000Yen ミクロフィブリル変異による大動脈解離の病態解明 2021-10 -- 2025-03 柳沢裕美 /国際共同研究加速基金(国際共同研究強化(B)) 19,110,000Yen more... - Career history
2020-04 -- (current) 筑波大学 生存ダイナミクス研究センターAssistant Professor 2012-09 -- 2020-03 University of Bonn, Institute of Physiology IPostdoctoral Reseacher 2012-04 -- 2012-08 筑波大学 医学医療系Postdoctoral Reseacher - Academic background
-- 2012-03 筑波大学大学院人間総合科学研究科 生命システム医学専攻 - Degree
2012-03 博士（医学） 筑波大学 - Academic societies
2022 -- (current) 日本結合組織学会 2021 -- (current) The Molecular Biology Society of Japan 2006 -- (current) 日本再生医療学会 2011 -- (current) 国際幹細胞学会 2021 -- (current) The Japanese Vascular Biology and Medicine Organization 2021 -- (current) THE JAPANESE CIRCULATION SOCIETY - Honors & Awards
2022-12 The Excellent Abstract Award ( 日本循環器学会基礎研究フォーラム2022) 2021-12 若手奨励賞(日本血管生物医学会) 2009-11 The Excellent Poster Award (The 2nd Leading Graduate Schools International Conference) 2009-09 The Young Scientist Award (日本生化学会関東支部例会） - Articles
- Novel Aortic Dissection Model Links Endothelial Dysfunction and Immune Infiltration
Kimura Kenichi; Motoyama Eri; Kanki Sachiko; Asano Ke...
Circulation research/137(1)/pp.26-42, 2025-05-14 - Spatiotemporal dynamics of CD73 in mouse retina under physiological conditions
ISHII Ryutaro; Sakurai Keisuke; Hosomi Nao; Fleischman...
bioRxiv, 2025-05 - Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice
Hossain ASM Sakhawat; Clarin Maria Thea Rane Dela Cruz; ...
MATRIX BIOLOGY/135/pp.24-38, 2025-02 - descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques
Otomo Kohei; Omura Takaki; Nozawa Yuki; Edwards Steve...
Nature communications/15(1)/p.4941, 2024-06-12 - A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta
Kimura Kenichi; Motoyama Eri; Kanki Sachiko; Asano Ke...
Biorxiv, 2024-05-07 - Bone marrow CD73+ mesenchymal stem cells display increased stemness in vitro and promote fracture healing in vivo
Kimura Kenichi; Breitbach Martin; Schildberg Frank A.; He...
Bone Reports/15, 2021-12 - Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy.
Kenichi Kimura; Astrid Ooms; Kathrin Graf-Riesen; Maithre...
Nature Communications/12(1), 2021-06 - Contribution of PDGFRα-positive cells in maintenance and injury responses in mouse large vessels
Kimura Kenichi; Ramirez Karina; Nguyen Tram Anh Vu; Yamas...
Scientific Reports/11, 2021-04 - Tetrahydroimidazo[1,2-a]pyrazine Derivatives: Synthesis and Evaluation As Gαq-Protein Ligands
Gütschow Michael; Küppers Jim; Benkel Tobias; Annala ...
Chemistry (Weinheim an der Bergstrasse, Germany), 2020-05 - Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling
Roell Wilhelm; Klein Alexandra M; Breitbach Martin; Be...
Scientific reports/8(1)/p.7145, 2018-04 - Midbody Positioning and Distance Between Daughter Nuclei Enable Unequivocal Identification of Cardiomyocyte Cell Division in Mice
Hesse Michael; Doengi Michael; Becker Alexandra; Kimur...
Circulation research/123(9)/pp.1039-1052, 2018-04 - PECAM/eGFP transgenic mice for monitoring of angiogenesis in health and disease
Winkler Florian; Herz Katia; Rieck Sarah; Kimura Keni...
Scientific reports/8(1), 2018-04 - In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche
Breitbach Martin; Kimura Kenichi; Luis Tiago C.; Fuegeman...
CELL STEM CELL/22(2)/pp.262-+, 2018-02 - Elevated Expression of Dkk-1 by Glucocorticoid Treatment Impairs Bone Regenerative Capacity of Adipose Tissue-Derived Mesenchymal Stem Cells.
Vuong Cat Khanh; Kimura Kenichi; Kato Toshiki; Sato Kazu...
Stem Cells and Development, 2018-01 - Increased Expression of EGR-1 in Diabetic Human Adipose Tissue-Derived Mesenchymal Stem Cells Reduces Their Wound Healing Capacity
Nhu Thuy Trinh; Toshiharu Yamashita; Kinuko Ohneda; Kenic...
Stem Cells and Development/25(10)/pp.760-773, 2016-03 - A chemokine receptor, CXCR4, which is regulated by hypoxia inducible factor 2α, iscrucial for functional EPC migration to ischemic tissue and wound repair.
Tu Tran Cam; Nagano Masumi; Yamashita Toshiharu; Hamada ...
Stem Cells Dev./25/pp.266-276, 2016-02 - Impaired Expression of HIF-2 alpha Induces Compensatory Expression of HIF-1 alpha for the Recovery From Anemia
Tsuboi Ikki; Yamashita Toshiharu; Nagano Masumi; Kimura ...
JOURNAL OF CELLULAR PHYSIOLOGY/230(7)/pp.1534-1548, 2015-07 - Hypoxia-inducible factor-3 alpha promotes angiogenic activity of pulmonary endothelial cells by repressing the expression of the VE-cadherin gene
Kobayashi Satomi; Yamashita Toshiharu; Ohneda Kinuko; Nag...
GENES TO CELLS/20(3)/pp.224-241, 2015-03 - Dual Functions of Hypoxia-Inducible Factor 1 Alpha for the Commitment of Mouse Embryonic Stem Cells Toward a Neural Lineage
Zhao Yang; Takasaki Mami; Tsuboi Ikki; Kimura Kenichi; Sa...
Stem Cells Dev., 2014 - The role of CCL5 in the ability of adipose tissue-derived mesenchymal stem cells to support repair of ischemic regions.
Kimura Kenichi; Nagano M; Salazar G; 山下 年晴; Tsuboi I; Mis...
STEM CELLS AND DEVELOPMENT/23(5)/pp.488-501, 2014-03 - Functional endothelial progenitor cells selectively recruit neurovascular protective monocyte-derived F4/80+/Ly6c+ macrophages in a mouse model of retinal degeneration
Shinichi Fukuda; Nagano Masumi; Toshiharu Yamashita; Kimu...
Stem Cells/31(10)/pp.2149-2161, 2013-10 - Umbilical cord blood-derived mesenchymal stem cells inhibit, but adipose tissue-derived mesenchymal ste cells promote, glioblastoma multiforme proliferation
Keiko Akimoto; Kenichi Kimura; 長野 真澄; Shingo Takano; Geor...
Stem Cell and Development/22(9)/pp.1370-1386, 2013-05 - Identification of Human Placenta-Derived Mesenchymal Stem Cells Involved in Re-Endothelialization
Tran Tu Cam; Kimura Kenichi; Nagano Masumi; Yamashita To...
JOURNAL OF CELLULAR PHYSIOLOGY/226(1)/pp.224-235, 2011-01 - Hypoxia Responsive Mesenchymal Stem Cells Derived from Human Umbilical Cord Blood Are Effective for Bone Repair
Nagano Masumi; Kimura Kenichi; Yamashita Toshiharu; Ohned...
STEM CELLS AND DEVELOPMENT/19(8)/pp.1195-1210, 2010-08 - Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood
Nagano Masumi; Yamashita Toshiharu; Hamada Hiromi; Ohneda...
BLOOD/110(1)/pp.151-160, 2007-07
- Novel Aortic Dissection Model Links Endothelial Dysfunction and Immune Infiltration
- Books
- 大動脈瘤への分子生物学的アプローチ
木村 健一; 柳沢裕美
心臓/日本医学出版, 2022-06
- 大動脈瘤への分子生物学的アプローチ
- Conference, etc.
- A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta
KIMURA Kenichi
The 2nd internatinal symposium for Research Unit "Peripheral Central Interaction in Stress"/2025-03-14 - A Smart Nanofiber-based Therapeutic Approach for Aortic Dissection by Targeting Sympathetic Innervation
Kai LI; Kenichi Kimura; Eri Motoyama; Nanami Fujisawa...
第57回日本結合組織学会学術大会/2025-06-07--2025-06-08 - 骨髄ニッチにおけるミクロフィブリルを介した造血制御機構の解明
木村 健一; 細見奈生; 本山絵理; 神吉佐智子; 柳沢裕美
第57回日本結合組織学会学術大会/2025-06-07--2025-06-08 - 大動脈瘤・解離における免疫細胞のダイナミクス： 新規マルファン症候群マウスモデルからの知見
浅野 恵一; 本山絵理; 神吉佐智子; 木村健一; 柳沢 裕美
第57回日本結合組織学会学術大会/2025-06-07--2025-06-08 - Elucidating the Role of Anti-aging Matrix Fibulin 7 in Skin Inflammatory Disease Psoriasis
ERNA Raja; Watanabe Yukihide; Kimura Kenichi; Yanagisa...
The 49th Annual Meeting of the Japanese Society for Investigative Dermatology/2024-12-6--2024-12-08 - Transformation of enteroendocrine cell identity by the stress-inducible transcription factor Xrp1
Qian Qingyin; Hayashi Makoto; Nagai Hiroki; Sanaki Yu...
66th Annual Drosophila Research Conference/2025-03-19--2025-03-23 - Anti-inflammatory Nanoparticles as Potential Treatment for Aortic Dissection
Clarin M.T.R.D.C.; Motoyama Eri; A. Nabil; Kanki Sach...
つくば医工連携フォーラム2025/2025-01-25--2025-01-25 - Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.
Kimura Kenichi; Motoyama Eri; Kanki Sachiko; Asano Ke...
CVMW 2024/2024-12-07--2024-12-08 - 遺伝性胸部大動脈疾患におけるメカノトランスダクション異常
柳沢裕美; 木村健一; 本山絵理; 浅野恵一; 神吉佐知子
CVMW 2024/2024-12-07--2024-12-08 - フィブリリン１遺伝子変異による大動脈解離病態に関わる血管内皮細胞の機能解析
本山 絵理; 木村 健一; 浅野 恵一; 神吉 佐知子; 中邨 智之; 柳沢 裕美
第8回エラスチン・関連分子研究会/2024-11-30--2024-12-01 - 骨髄ニッチにおけるミクロフィブリルを介した造血制御機構の解明
木村 健一; 本山 絵理; 神吉 佐知子; 柳沢 裕美
第8回エラスチン・関連分子研究会/2024-11-30--2024-12-01 - 軟骨組織におけるCD73陽性細胞の細胞系譜解析
Sanaki-Matsumiya Marina; Hosomi Nao; Yanagisawa Hiromi...
第47回日本分子生物学会年会/2024-11-27--2024-11-29 - Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.
Kimura Kenichi; Motoyama Eri; Kanki Sachiko; Asano Ke...
第47回日本分子生物学会年会/2024-11-27--2024-11-29 - A stress-responsive transcriptional factor drives fate conversion of enteroendocrine cells in Drosophila melanogaster
Qian Qingyin; Hayashi Makoto; Nagai Hiroki; Kimura Ke...
第47回日本分子生物学会年会/2024-11-27--2024-11-29 - Role of CD73-lineage cells in articular cartilage degeneration and remodeling in osteoarthritis
Hosomi Nao; Matsumiya Marina; Yanagisawa Hiromi; Kimur...
Tsukuba Global Science Week 2024/2024-10-03--2024-10-04 - Investigation of the molecular pathogenesis of aortic dissection in new Fibrillin 1 mutant mice by synchrotron imaging and transcriptomics analysis
Sheikh Md Al Amin; Kimura Kenichi; Motoyama Eri; Delee...
Tsukuba Global Science Week 2024/2024-10-03--2024-10-04 - Anti-inflammatory Nanoparticles as Potential Treatment for Aortic Dissection
Clarin M.T.R.D.C.; Motoyama Eri; A. Nabil; Kanki Sach...
NIMS Award Symposium/2024-11-06--2024-11-07 - Nanoparticles as a potential therapeutic tool for targeting M1 macrophages in Aortic Dissection
Clarin M.T.R.D.C.; Motoyama Eri; A. Nabil; Kanki Sach...
Tsukuba Global Science Week 2024/2024-10-03--2024-10-04 - Converting one differentiated cell identity into another: Insights from Drosophila enteroendocrine cells
Qian Qingyin; Hayashi Makoto; Nagai Hiroki; Kimura Ke...
The 16th Japanese Drosophila Research Conference (JDRC16)/2024-09-17--2024-09-19 - 新規Fibrillin-1点変異マウスモデルを⽤いた⼤動脈解離発症機序の解明
木村 健一
第10回MatriCellフォーラム/2024-9-7--2024-9-8 - A Smart Nanofiber-based Therapeutic Approach for Aortic Dissection by Targeting Sympathetic Innervation
LI Kai; Chen Lili; Fujisawa Nanami; Kimura Kenichi; M...
The 40th annual meeting of JSDDS/2024-07-09--2024-07-11 - CELL LINEAGE ANALYSIS OF CD73-POSITIVE CELLS IN OSTEOCHONDRAL TISSUE
Kimura Kenichi; Ishi Ryutaro; Yanagisawa Hiromi
The International Society for Stem Cell Research 2024/2024-07-09--2024-07-13 - Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.
Kimura Kenichi; Motoyama Eri; Kanki Sachiko; Asano Ke...
International Vascular Biology Meeting 2024/2024-07-02--2024-07-02 - Development of nanoparticles to induce M1-to-M2 switch as a treatment for aortic dissection in Fbn1 mutant mice.
Clarin M.T.R.D.C.; E. Motoyama; A. Nabil; S. Kanki; U...
International Vascular Biology Meeting 2024/2024-07-02--2024-07-05 - A Smart Nanofiber-based Therapeutic Approach for Aortic Dissection by Targeting Sympathetic Innervation
LI Kai; Kimura Kenichi; Motoyama Eri; Fujisawa Nanami...
第56回日本結合組織学会学術大会/2024-06-15--2024-06-16 - more...
- A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta
- Teaching
2024-10 -- 2025-02 Practice in Diagnostic Pathology I University of Tsukuba. 2024-04 -- 2024-08 Practice in Diagnostic Pathology I University of Tsukuba. 2024-04 -- 2024-08 Lecture and Discussion in Human Medical Biology I University of Tsukuba. 2024-10 -- 2025-02 Lecture and Discussion in Human Medical Biology II University of Tsukuba. 2024-10 -- 2025-02 Practice in Human Medical Biology II University of Tsukuba. 2024-10 -- 2025-02 Practice in Diagnostic Pathology II University of Tsukuba. 2024-04 -- 2024-08 Practice in Diagnostic Pathology II University of Tsukuba. 2024-10 -- 2025-02 Seminar in Human Medical Biology II University of Tsukuba. 2024-04 -- 2024-08 Medical Science Seminar V: Career Path University of Tsukuba. 2024-10 -- 2025-02 Medical Science Seminar V: Career Path University of Tsukuba. more... - Professional activities
2025-06 -- (current) Jananese Society for Matirx Biology and Medicine 評議員 2022-11 -- (current) Jananese Society for Matirx Biology and Medicine 若手の会/代表 2024-11 -- (current) THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE 代議員 2022-08 -- (current) 日本再生医療学会 チームU45/サブメンバー - University Management
2023-04 -- 2024-03 TARAセンター仕様策定委員会 委員 2021-04 -- (current) フロンティア医科学専攻キャリア支援担当委員会 委員
(Last updated: 2025-07-24)