YOSHIHARA Masaharu

Affiliation

Institute of Medicine

Official title

Assistant Professor

ORCID

0000-0002-0212-0909

Sex

Male

KAKEN ID

60963618

Email

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Office

Department of Anatomy and Embryology

Phone

029-853-7516

Fax

029-853-6965

Research fields

Laboratory animal science
General anatomy (including histology/embryology)

Research keywords

Transgenic Mouse
Morphogenesis
Delta-Notch signaling pathway
Developmental Biology
Histology
Gross Anatomy

Research projects

Elucidation of Notch1 involvement in the left-side heart development	2023-04 -- 2028-03	YOSHIHARA Masaharu	Japan Society for the Promotion of Science/Grant-in-Aid for Early-Career Scientists	4,680,000Yen
Identification of Notch1 signaling- receiving cell lineage during acute kidney injury in a mouse sepsis model	2022-10 -- 2023-03	Masaharu YOSHIHARA	YOKOYAMA Foundation for Clinical Pharmacology/	1,000,000Yen
Elucidation of a morphogenic mechanism via Delta-Notch signaling pathway- an in vivo examination of a mathematical prediction on biliary formation	2022-10 -- 2024-03	Masaharu YOSHIHARA	Japan Society for the Promotion of Science/Grant-in-Aid for Research Activity Start-up	2,860,000Yen
Mathematical and genetical analysis on the Delta-Notch signaling dynamics in bile duct formation	2021-04 -- 2022-03	Masaharu YOSHIHARA	Japan Society for the Promotion of Science/Grant-in-Aid for JSPS Fellows	2,200,000Yen

Career history

2022-04 -- (current)	University of TsukubaInstitute of MedicineAssistant Professor
2021-04 -- 2022-03	Japan Society for the Promotion of ScienceYoung Scientist Fellow (DC1)
2019-04 -- 2021-03	University of TsukubaResearch Assistant
2017-04 -- 2019-03	Tsukuba Medical Center Foundationjunior resident physician

Academic background

2019-04 -- 2023-03	University of Tsukuba School of Integrative and Global Majors PhD Program in Humanics
2011-04 -- 2017-03	University of Tsukuba School of Medicine and Medical Sciences School of Medicine

Degree

2023-03	Doctor of Philosophy in Medical Sciences	University of Tsukuba
2017-03	Doctor of Medicine	University of Tsukuba

Licenses and qualifications

2024-02	死体解剖資格
2024-04	アンガーマネジメントファシリテーター
2022-07	第6回一般教養・基礎社会医学系教員のためのカリキュラムプランニングワークショップ　修了
2018-11	Certified Industrial Physician
2017-11	茨城県緩和ケア研修会修了
2017-03	Medical license

Academic societies

2023-01 -- (current)	日本実験動物協会
2022-02 -- (current)	Japanese Association of Anatomists

Honors & Awards

2024-04	Best Teachers’ Award
2023-11	筑波大学医学医療系大学教員業績評価優秀教員
2023-04	Best Teachers' Award

Articles

• A case report of an Adachi-Williams type CG plus H aortic arch anomaly and implications for the development of the cervicothoracic circulation
  Yoshihara Masaharu; Watabe Yoshitoku; Morikawa Momo; I...
  Folia Morphologica, 2024-10
• Landscape of driver mutations and their clinical effects on Down syndrome-related myeloid neoplasms
  Sato Tomohiko; Yoshida Kenichi; Toki Tsutomu; Kanezaki...
  Blood/143(25)/pp.2627-2643, 2024-03-21
  
  PubMed
• Chromatin accessibility analysis suggested vascular induction of the biliary epithelium via the Notch signaling pathway in the human liver
  Yoshihara Masaharu; Nakayama Takahiro; Takahashi Satoru
  BMC RESEARCH NOTES/16(1)/p.379, 2023-12-21
  
  PubMed Tsukuba Repository
• Recent advances in in situ Notch signaling measurement
  Yoshihara Masaharu; Takahashi Satoru
  FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY/11, 2023-07-28
  
  PubMed Tsukuba Repository
• Analysis of Notch1 signaling in mammalian sperm development
  Sambe Naoto; Yoshihara Masaharu; Nishino Teppei; Sugiu...
  BMC RESEARCH NOTES/16(1)/p.108, 2023-06-19
  
  PubMed Tsukuba Repository
• Notch1 signaling is limited in healthy mature kidneys in vivo
  Sugiura Ryosuke; Nakayama Takahiro; Nishino Teppei; Sa...
  BMC RESEARCH NOTES/16(1)/p.54, 2023-04-17
  
  PubMed Tsukuba Repository
• A gain-of-function mutation in micro-RNA-142 is sufficient to cause the development of T-cell leukemia in mice
  Kawano Shingo; Araki Kimi; Bai Jie; Furukawa Imari; T...
  CANCER SCIENCE/114(7)/pp.2821-2834, 2023-03-21
  
  PubMed
• Deciphering the pattern formation mechanism via Delta-Notch signaling pathway - Evidence from mathematical analysis of liver development
  西野哲平; 吉原 雅大
  Journal of Clinical and Experimental Medicine/280(11)/pp.1167-1168, 2022-03
• Generation of a Gal4-dependent gene recombination and illuminating mouse
  Yoshihara Masaharu; Nishino Teppei; Sambe Naoto; Nayakama...
  EXPERIMENTAL ANIMALS/71(3)/pp.385-390, 2022-04-21
  
  PubMed Tsukuba Repository
• The Molecular Motor KIF21B Mediates Synaptic Plasticity and Fear Extinction by Terminating Rac1 Activation
  Morikawa Momo; Tanaka Yosuke; Cho Hyun-Soo; Yoshihara ...
  Cell reports/23(13)/pp.3864-3877, 2018-06-26
  
  PubMed
• Identifying potential regulators of JAGGED1 expression in portal mesenchymal cells
  Nishino Teppei; Yoshihara Masaharu; Nakayama Takahiro; Ts...
  BMC Rearch Notes/15(1), 2022-05-13
  
  PubMed Tsukuba Repository
• Mathematical analysis of the effect of portal vein cells on biliary epithelial cell differentiation through the Delta-Notch signaling pathway
  Yoshihara Masaharu; Nishino Teppei; Yadav Manoj Kumar; Ku...
  BMC Research Notes/14, 2021-06
  
  PubMed Tsukuba Repository

Conference, etc.

• 新規遺伝子組換えマウスを用いた、敗血症におけるNotch1シグナルの腎内動態解析
  吉原 雅大
  第70回日本実験動物学会総会/2023-05-24--2023-05-26
• 地域住民における心不全バイオマーカーと循環器疾患リスクファクターの関連
  吉原 雅大; 山岸良匡; 北村明彦; 木山昌彦; 隅田武夫; 山海知子; 大平哲也; 今野弘規; 崔仁哲; 梅澤光政; 湊百合子; 井...
  第23回日本疫学会学術集会/2013-01-25--2013-01-25
• 成獣組織の血管内皮細胞におけるVEGF受容体の発言差異
  吉原 雅大
  第119回日本解剖学会総会・全国学術集会/2014-03-28--2014-03-28
• Delta-Notchシグナル経路を介したパターン形成機構〜肝内胆管形成から摂動による誘導現象を探る〜
  吉原 雅大
  日本解剖学会第110回関東支部学術集会/2022-10-01--2022-10-01
• Notch1シグナル可視化マウス系の樹立
  三瓶直人; 吉原 雅大; 高橋智
  日本解剖学会第110回関東支部学術集会/2022-10-01--2022-10-01
• 腎内におけるNotch1シグナルの可視化
  吉原 雅大; 杉浦涼介; 高橋智
  日本解剖学会第110回関東支部学術集会/2022-10-01--2022-10-01
• 解剖学人材をいかに確保するか〜取り組みと提言〜
  吉原 雅大
  第126回日本解剖学会総会全国学術集会/2021-03-28

Works

• からだの成り立ちを求めて（国立大学医学部長会議 若手研究者のひらめき～研究医への誘い～）
  吉原 雅大

Teaching

2023-10 -- (current)	神経解剖学	生物学類
2024-09 -- (current)	機能構造と病態I（組織学）	医学類
2023 -- (current)	Introduction to Human Anatomy	Master's Program in Medical Science
2023 -- (current)	Human Anatomy (Histology Practice)	College of Medical Science
2023 -- (current)	Human Anatomy	College of Nursing
2022-07 -- (current)	Neuroanatomy	Special Needs Education School for the Visually Impaired
2020-11 -- (current)	Neuroanatomy	School of Medicine
2019-05 -- (current)	Gross Anatomy, Osteology and Embryology	School of Medicine
2022-09 -- 2022-09	Anatomy and Physiology II	Hakujuuji Nursing School
2022-06 -- 2022-06	First Year Seminar	School of Medicine
more...

Other educational activities

2024-04 -- 2026-03	2024年度筑波大学医学類1年生６クラス担任
2024-01 -- (current)	筑波大学医学類学生担当教員
2022-12 -- 2022-12	令和4年度修学生の集い	茨城県保健医療部医療人材課
2023-03 -- 2023-03	第24回解剖技術研究・研修会	Japan Association of Anatomists
2019-11 -- (current)	Medical Rally	Tsukuba Medical Center Foundation

Other activities

2021-07 -- 2022-03	非常勤医師（水戸市新型コロナワクチン大規模接種会場）
2022-04 -- (current)	非常勤医師（社会福祉法人恩賜財団済生会神栖済生会病院）
2019-04 -- 2021-03	非常勤医師（公益財団法人筑波メディカルセンター）
2017-04 -- 2019-03	医師臨床研修（公益財団法人筑波メディカルセンター）

(Last updated: 2024-09-30)