SAIKI Shinji
- Affiliation
- Institute of Medicine
- Official title
- Professor
- Research keywords
臨床神経学 パーキンソン病 細胞生物学 オートファジー バイオマーカー 代謝産物 - Research projects
Elucidation of mechanism of propagation and aggregation of alpha-synuclein and development of disease-modifying therapies 2024-04 -- 2029-03 HATTORI Nobutaka Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (S) 20,000Yen New strategy for preventing colorectal cancer by targeting polyamines, which are thought to be carcinogens 2023-06 -- 2027-03 Matsumoto Mitsuharu Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Research (Pioneering) 1,600Yen パーキンソン病発症起点としてのmicrobiome-gut連関機構の解明 2022-06 -- 2024-03 SAIKI Shinji Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Research (Exploratory) 6,500,000Yen Development of anti-Parkinson's disease drugs enhancing neuronal autophagy 2022-04 -- 2025-03 SAIKI Shinji Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (B) 17,420,000Yen Elucidation of transmission and aggregation mechanisms of alpha-synuclein as a major component of Lewy body and development of disease-modifying therapies for synucleinopathies 2021-04 -- 2024-03 HATTORI Nobutaka Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (A) 42,510,000Yen Studies on the regulatory mechanism of aggresome formatiion and clearance 2021-04 -- 2024-03 MOTO Masaya Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (B) 17,290,000Yen Elucidation of the molecular mechanisms of dopaminergic neurodegenerative disorders using a large genome resource 2019-04 -- 2022-03 FUNAYAMA Manabu Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (C) 4,290,000Yen Identification of Parkinson disease-specific mitochondrial pathogenesis for disease-modifying therapy 2018-10 -- 2022-03 SAIKI Shinji Japan Society for the Promotion of Science/Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)) 17,940,000Yen Identification of Parkinson's disease progression markers based on skeletal muscle-brain axis 2018-04 -- 2022-03 SAIKI Shinji Japan Society for the Promotion of Science/Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) 17,290,000Yen Research on PD pathogenesis based on polyamine metabolism using multiomics analysis 2018-07 -- 2021-03 Saiki Shinji Japan Society for the Promotion of Science/Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) 18,590,000Yen more... - Career history
2001-04 -- 2005-06 Kanazawa Medical University 2005-07 -- 2008-03 Cambridge Institute for Medical Reseach 研究員 2008-03 -- 2011-03 Juntendo University 2011-04 -- 2021-05 Juntendo University 2021-06 -- 2022-12 Juntendo UniversityDepartment of NeurologyAssociate Professor 2023-01 -- (current) University of Tsukuba医学医療系神経内科学分野教授 - Academic background
-- 1999 Kyoto Prefectural University of Medicine 医学部 医学科 - Degree
2011-1 博士（医学） Juntendo University - Academic societies
-- (current) 日本神経学会 -- (current) 日本内科学会 -- (current) American Academy of Neurology -- (current) Movement Disorder Society -- (current) THE MOLECULAR BIOLOGY SOCIETY OF JAPAN 2015-04 -- (current) 日本神経科学学会 2017-04 -- (current) 日本脳卒中学会 2019-04 -- (current) 日本神経化学会 - Honors & Awards
2023-06-20 順天堂大学医師会賞 2005 2005 Pergolide Fellowship for Eli Lilly Japan K.K. 2005 British Council Japan Association 留学助成 2021-03 - A metabolic profile of polyamines in Parkinson disease: A promising biomarker - Articles
- 神経変性疾患病態における腸内細菌叢の役割
斉木 臣二; 片浦 哲志; 藤巻 基紀
Microbiome science : 腸内細菌をめぐる交流誌 / 「Microbiome science」編集委員会 編/3(3)/pp.155-159, 2024-07 - Comprehensive data for studying serum exosome microRNA transcriptome in Parkinson's disease patients
Yu Zhiyang; Saiki Shinji; Shiina Kenta; Iseki Tatou; ...
Scientific data/11(1)/p.1128, 2024-10-15 - Extracellular vesicles contain filamentous alpha-synuclein and facilitate the propagation of Parkinson's pathology
Ishiguro Yuta; Tsunnemi Taiji; Shimada Tomoyo; Yoroisa...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/703, 2024-04-09 - Free-water diffusion magnetic resonance imaging under selegiline treatment in Parkinson's disease
Takeshige-Amano Haruka; Hatano Taku; Kamagata Koji; An...
JOURNAL OF THE NEUROLOGICAL SCIENCES/457, 2024-02-15 - Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models
Kataura Tetsushi; Sedlackova Lucia; Sun Congxin; Kocak...
Cell death & disease/15(5)/p.382, 2024-05-31 - Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models
Kataura Tetsushi; Sedlackova Lucia; Sun Congxin; Kocak...
Cell death & disease/15(5)/p.382, 2024-05-31 - 眼で見る脳神経内科 脳動静脈奇形治療後に消失した脳動脈瘤
鍛治田倫英; 秋本 健; 相山 仁; 石川栄一; 斉木臣二
脳神経内科/99(5)/pp.702-704, 2023 - JNK-interacting protein 4 is a central molecule for lysosomal retrograde trafficking
Sasazawa Yukiko; Hattori Nobutaka; Saiki Shinji
BIOESSAYS/45(11), 2023-11 - De novo formation of twig-like middle cerebral artery: An illustrative case
Kajita Michihide; Yanaka Kiyoyuki; Hanai Sho; Aiyama ...
Surgical neurology international/14/p.192, 2023-04-01 - Propagative α-synuclein seeds as serum biomarkers for synucleinopathies
Okuzumi Ayami; Hatano Taku; Matsumoto Gen; Nojiri Shu...
NATURE MEDICINE/29(6)/pp.1448-1455, 2023-06-01 - Autophagy promotes cell survival by maintaining NAD levels.
Kataura Tetsushi; Sedlackova Lucia; Otten Elsje G.; Ku...
Developmental cell/57(22)/pp.2584-2598, 2022-11-21 - Oxidative stress-induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2.
Sasazawa Yukiko; Souma Sanae; Furuya Norihiko; Miura ...
The EMBO journal/41(22)/p.e111476, 2022-11-17 - Systemic Metabolic Alteration Dependent on the Thyroid-Liver Axis in Early PD.
Miyamoto Kengo; Saiki Shinji; Matsumoto Hirotaka; Suzu...
Annals of neurology/93/pp.303-316, 2022-09-21 - テンソル分解を用いた黒質緻密部の3次元パターン表現に関する初期的検討
伊東 隼人; 小田 昌宏; 斉木 臣二; 服部 信考; 鎌形 康司; 青木 茂樹; 森 健策
日本医用画像工学会大会予稿集/41回/pp.124-125, 2022-07 - Plasma taurine is an axonal excitability-translatable biomarker for amyotrophic lateral sclerosis.
Nakazato Tomoko; Kanai Kazuaki; Kataura Tetsushi; Noji...
Scientific reports/12(1)/pp.9155-9155, 2022-06-01 - Autophagy is Required for the Maintenance of NAD
Kataura Tetsushi; Sedlackova Lucia; Otten Elsje G.; Shapi...
SSRN Electronic Journal, 2022 - The autophagy pathway and its key regulators
Kataura Tetsushi; Hattori Nobutaka; Saiki Shinji
Autophagy Dysfunction in Alzheimer's Disease and Dementia/pp.47-69, 2022 - Enhancing Model Generalization for Substantia Nigra Segmentation Using a Test-time Normalization-Based Method.
Hu Tao; Itoh Hayato; Oda Masahiro; Hayashi Yuichiro; ...
MICCAI (8)/pp.736-744, 2022 - Investigating the efficacy and safety of elobixibat, an ileal bile acid transporter inhibitor, in patients with Parkinson's disease with chronic constipation: a multicentre, placebo-controlled, randomised, double-blind, parallel-group stud (CONST-PD).
Hatano Taku; Oyama Genko; Shimo Yasushi; Ogaki Kotaro...
BMJ open/12(2)/p.e054129, 2022-02-11 - Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson's disease: a pilot study.
Yoritaka Asako; Kobayashi Yasuko; Hayashi Tetsuo; Saik...
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology/42(11)/pp.4767-4770, 2021-11 - Non-invasive diagnostic tool for Parkinson's disease by sebum RNA profile with machine learning.
Uehara Yuya; Ueno Shin-Ichi; Amano-Takeshige Haruka; S...
Scientific reports/11(1)/pp.18550-18550, 2021-09-20 - Intrajejunal Infusion of Levodopa/Carbidopa for Advanced Parkinson's Disease: A Systematic Review.
Tsunemi Taiji; Oyama Genko; Saiki Shinji; Hatano Taku...
Movement disorders : official journal of the Movement Disorder Society/36(8)/pp.1759-1771, 2021-04-25 - Diffusion MRI Captures White Matter Microstructure Alterations in PRKN Disease.
Koinuma Takahiro; Hatano Taku; Kamagata Koji; Andica ...
Journal of Parkinson's disease/11(3)/pp.1221-1235, 2021-04-19 - Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon.
Nakamura Atsuo; Kurihara Shin; Takahashi Daisuke; Ohas...
NATURE COMMUNICATIONS/12(1), 2021-04 - Clinical manifestations of Parkinson's disease harboring VPS35 retromer complex component p.D620N with long-term follow-up.
Ishiguro Mayu; Li Yuanzhe; Yoshino Hiroyo; Daida Kens...
Parkinsonism & related disorders/84/pp.139-143, 2021-03 - more...
- 神経変性疾患病態における腸内細菌叢の役割
- Conference, etc.
- 筋特異的受容体チロシンキナーゼ（MuSK）抗体陽性重症筋無力症でのエフガルチギモド使用例
中馬越 清隆; 猪狩弘大; 鍜治田倫英; 鈴木 哲; 斉木臣二
第62回日本神経眼科学会総会/2024-11-29--2024-11-30 - 抗AQP-4抗体陽性視神経脊髄炎スペクトラム障害のサトラリズマブ導入後のステロイド減量に関する考察
中馬越 清隆; 田中真由子; 猪狩弘大; 鈴木 哲; 大内翔吾; 斉木臣二
第61回日本神経眼科学会総会/2023-12-01--2023-12-02 - Saccadic intrusions observed in amyotrophic lateral sclerosis
中馬越 清隆; 東野 望; 松元 駿弥; 舘野 育実; 平本 祐; 小金澤 禎史; 南橋 丈瑠; 林 竜一郎; 猪...
65th Annual Meeting of the Japanese Society of Neurology/2024-05-29--2024-06-01 - 脳梗塞を契機に診断に至ったアデノシンデアミナーゼ2欠損症の21歳女性例
奥根祥; 早川幹人; 穂坂 翔; 鈴木寿人; 高田英俊; 斉木臣二; 松丸祐司
第247回日本神経学会関東・甲信越地方会/2023-12-2 - サトラリズマブ導入後ステロイド減量中止しえたNMOSD症例
中馬越 清隆; 田中真由子; 猪狩弘大; 鈴木 哲; 中井 華; 南橋丈瑠; 林 竜一郎; 大内翔吾; 斉木臣二
第４１回日本神経治療学会学術集会/2023-11-3--2023-11-5 - サトラリズマブ導入後ステロイドを中止しえたNMOSD症例
中馬越 清隆; 田中真由子; 猪狩弘大; 鈴木 哲; 大内翔吾; 斉木臣二
第３５回日本神経免疫学会学術集会/2023-9-13--2023-9-15 - Definite Bickerstaff脳幹脳炎に対して血液浄化療法とIVIG両方を実施した1例
金澤 優伸; 鈴木 哲; 石井 一弘; 林 竜一郎; 南橋 丈瑠; 猪狩 弘大; 斉木 臣二
第689回日本内科学会関東地方会/2023-09-16 - 多発単神経障害で発症したABCA1遺伝子の新規複合ヘテロ遺伝子変異を伴うタンジール病 の49歳女性例
三橋 泉; 冨所 康志; 古田 泰久; 大崎 芳典; 鈴木 浩明; 石井 一弘; 玉岡 晃; 斉木 臣二
第244回 日本神経学会関東・甲信越地方会/2023-3-4
- 筋特異的受容体チロシンキナーゼ（MuSK）抗体陽性重症筋無力症でのエフガルチギモド使用例
- Intellectural property rights
- 化合物又はその塩、及びパーキンソン病治療薬又は予防薬
井本 正哉; 井岡 秀二; 服部 信孝; 斉木 臣二; 吉川(笹澤) 有紀子 - パーキンソン病の重症度判定方法
服部 信孝; 斉木 臣二; 波田野 琢; 吉川(笹澤) 有紀子; 青木 茂樹; 鎌形 康司; 三浦 芳樹; 高 ... - パーキンソン病予防治療剤
服部 信孝; 斉木 臣二; 井本 正哉; 藤巻 貴宏 - パーキンソン病診断指標
服部 信孝; 斉木 臣二; 波田野 琢; 山城 一雄; 石川 景一; 王子 悠; 森 聡生; 奥住 文美 - オートファジー誘導剤
服部 信孝; 斉木 臣二; 平野 一興; 石川 景一; 吉川(笹澤) 有紀子; 藤巻 基紀; 山口 昴大 - パーキンソン病の検出方法
上原 裕也; 井上 高良; 服部 信孝; 斉木 臣二; 上野 真一; 竹重 遥香
- 化合物又はその塩、及びパーキンソン病治療薬又は予防薬
- Teaching
2024-10 -- 2025-03 Doctoral Research in Life Science Innovation Ⅰ University of Tsukuba. 2024-10 -- 2025-03 Master's Research in Life Science Innovation Ⅲ University of Tsukuba. 2024-10 -- 2025-03 Master's Research in Life Science Innovation Ⅳ University of Tsukuba. 2024-10 -- 2025-03 Doctoral Research in Life Science Innovation Ⅴ University of Tsukuba. 2024-10 -- 2025-03 Doctoral Research in Life Science Innovation Ⅱ University of Tsukuba. 2024-04 -- 2024-09 Master's Research in Life Science InnovationⅡ University of Tsukuba. 2024-04 -- 2024-09 Doctoral Research in Life Science Innovation Ⅱ University of Tsukuba. 2024-10 -- 2025-03 Life Science Innovation Doctor's Special Research I Fall University of Tsukuba. 2024-10 -- 2025-03 Doctoral Research in Life Science Innovation Ⅳ University of Tsukuba. 2024-04 -- 2024-09 Doctoral Research in Life Science Innovation Ⅴ University of Tsukuba. more...
(Last updated: 2024-12-16)