Asano Keiichi

Affiliation

Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA)

Official title

Assistant Professor

ORCID

0009-0000-1065-6386

URL

https://scholar.google.com/citations?user=sSOGv5QAAAAJ&hl=en&authuser=1
https://www.saggymousehkytsukuba.com

Research fields

Pathological medical chemistry

Research keywords

Marfan syndrome
Single Cell Analyses
Extracellular matrix
Vascular biology
Aortic aneurysm and dissection

Research projects

平滑筋細胞の形質転換は大動脈瘤の新規治療標的となりうるか？	2024-04 -- 2028-03		文部科学省 科研費/科研費若手研究

Career history

2023-04 -- (current)	University of TsukubaLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA)Assistant Professor
2018-04 -- 2023-03	Icahn School of Medicine at Mount SinaiDepartment of Pharmacological SciencesPostdoctoral Researcher
2018-04 -- 2019-03	Okayama UniversityMedical SchoolGuest Investigator

Academic background

-- 2018-03	Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Degree

2018-03	PhD in Medical Science	Okayama University

Academic societies

2015 -- (current)	Jananese Society for Matirx Biology and Medicine
2014 -- (current)	American Society for Matrix Biology
2022 -- (current)	North American Vascular Biology Organization

Honors & Awards

2014-06	Young Investigator Award
2021-09	Marfan Foundation Travel Award

Articles

• A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta
  Kimura Kenichi; Motoyama Eri; Kanki Sachiko; Asano Ke...
  Biorxiv, 2024-05-07
• Dissecting aortic aneurysm in Marfan syndrome is associated with losartan-sensitive transcriptomic modulation of aortic cells
  Sun Yifei; Asano Keiichi; Sedes Lauriane; Cantalupo A...
  JCI insight, 2023-04-06
  
  PubMed
• The Multiple Functions of Fibrillin-1 Microfibrils in Organismal Physiology
  Asano Keiichi; Cantalupo Anna; Sedes Lauriane; Ramirez...
  International journal of molecular sciences/23(3), 2022-02-08
  
  PubMed
• Pathophysiology and Therapeutics of Thoracic Aortic Aneurysm in Marfan Syndrome
  Asano Keiichi; Cantalupo Anna; Sedes Lauriane; Ramirez...
  Biomolecules/12(1), 2022-01-14
  
  PubMed
• Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1
  Ohtsuki Takashi; Shinaoka Akira; Kumagishi-Shinaoka Ka...
  Experimental cell research/383(2), 2019-10-15
  
  PubMed
• High molecular weight hyaluronan protects cartilage from degradation by inhibiting aggrecanase expression
  Ohtsuki Takashi; Asano Keiichi; Inagaki Junko; Shinaok...
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society/36(12)/pp.3247-3255, 2018-12-01
  
  PubMed
• Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth
  Asano Keiichi; Edamatsu Midori; Hatipoglu Omer F; Inag...
  Acta medica Okayama/72(3)/pp.257-266, 2018-06-01
  
  PubMed
• Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis
  Asano Keiichi; Nelson Courtney M; Nandadasa Sumeda; Ar...
  Scientific reports/7(1), 2017-12-08
  
  PubMed
• ADAMTS1 inhibits lymphangiogenesis by attenuating phosphorylation of the lymphatic endothelial cell-specific VEGF receptor
  Inagaki Junko; Takahashi Katsuyuki; Ogawa Hiroko; Asan...
  Experimental cell research/323(2)/pp.263-275, 2014-05-01
  
  PubMed
• Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis
  Ohtsuki Takashi; Hatipoglu Omer F; Asano Keiichi; Inag...
  International journal of molecular sciences/21(9), 2020-04-29
  
  PubMed
• Fibrillin-1 deficiency in the outer perichondrium causes longitudinal bone overgrowth in mice with Marfan syndrome.
  Asano Keiichi
  Human Molecular Genetics, 2022
  
  PubMed

Books

• 座談会　エキスパートが語るシングルセル研究のリアル
  浅野 恵一
  実験医学別冊 実験デザインからわかる　シングルセル研究実践テキスト/羊土社, 2024-03-11

Conference, etc.

• Phenotypic changes of endothelial cells in the pathogenesis of aortic dissection.
  Kimura Kenichi; Motoyama Eri; Kanki Sachiko; Asano Ke...
  International Vascular Biology Meeting 2024/2024-07-02--2024-07-02
• Investigation of the molecular pathogenesis of aortic dissection in Fibrillin-1 mutant mice by synchrotron imaging and transcriptomics analysis
  Sheikh Md Al Amin; Kimura Kenichi; Motoyama Eri; Delee...
  第7回日本循環器学会　基礎研究フォーラム（BCVR）/2023-12-09--2023-12-10
• A Novel Mutation in the Hybrid1 Domain of the Fibrillin 1 Gene Causes Tight Skin Phenotype
  ASM Sakhawat Hossain; Maria Thea Rane Dela Cruz; Koichi...
  第7回エラスチン・関連分子研究会学術集会/2023-11-23--2023-11-24
• Investigation of the molecular pathogenesis of aortic dissection in Fibrillin-1 mutant mice by synchrotron imaging and transcriptomics analysis
  Sheikh Md Al Amin; Kimura Kenichi; Motoyama Eri; Delee...
  the annual Tsukuba Global Science Week (TGSW) 2023/2023-09-27--2023-09-28
• A Novel Mutation in the Hybrid1 Domain of the Fibrillin 1 Gene Causes an Abnormal Skin Phenotype
  ASM Sakhawat Hossain; Yuki Taga; Maria Thea Rane Dela ...
  Tissue, Matrix, and Pathobiology: Joint Meeting of ASMB, HCS, and ASIP/2023-10-23--2023-10-26

Teaching

2023 -- (current)	Research Presentation and Discussion	University of Tsukuba
2023 -- (current)	Topics in Vascular Biology	University of Tsukuba

(Last updated: 2024-05-09)