Mochizuki Takatoshi

Affiliation

International Institute for Integrative Sleep Medicine

Official title

Professor

Research keywords


Neuroscience
Pharmacology
Sleep-Wake
Orexin
Histamine

Research projects


Physiological roles of neuronal histamine release in the brain	1992-01 -- 1994-03	Takatoshi Mochizuki	Japan Society for the Promotion of Science/Young Scientists Award (DC1)	0Yen
New development of pharmacological research for histamine: using mast cell deficient rat (Co-Investigator)	1995-04 -- 1997-03	Kazutaka Maeyama	Ministry of Education, Culture, and Science of Japan/Grant-in-Aid for Scientific Research (A)	0Yen
Electrophysiological detection of presynaptic receptors using a novel preparation of nerve terminals, Fusasome	1997-04 -- 1999-03	Takatoshi Mochizuki	Ministry of Education, Culture, and Science of Japan/Grant-in-Aid for Encouragement of Scientists (A)	0Yen
Characterization of prostaglandin D2-induced adenosine increase in the subarachnoid space of rats	1999-04 -- 2001-03	Takatoshi Mochizuki	Ministry of Education, Culture, and Science of Japan/Grant-in-Aid for Encouragement of Scientists (A)	0Yen
Novel function of prostaglandin D2 and its metabolites in pathogenesis of immune and allergic diseases as examined by prostaglandin D synthase gene-manipulated mice (Co-Investigator)	1999-04 -- 2001-03	Yoshihiro Urade	Ministry of Education, Culture, and Science of Japan/Grant-in-Aid for Scientific Research (C)	0Yen
Studies on the arousal mechanism of prostaglandin E2 and histamine	2000-04 -- 2002-03	Takatoshi Mochizuki	Sankyo Foundation of Life Science/Faculty Career Advancement Award	0Yen
Designing of inhibitors for prostaglandin D synthases based on crystallographic analyses (Co-Investigator)	2000-04 -- 2002-03	Yoshihiro Urade	Ministry of Education, Culture, and Science of Japan/Grant-in-Aid for Scientific Research (B)	0Yen
The molecular mechanism of gamma-hydroxybutyrate	2004-06 -- 2006-05	Takatoshi Mochizuki	The American Sleep Medicine Foundation/Faculty Career Advancement Award	0Yen
Mechanisms of State Switching in Sleep and Sleep Apnea	2010-03 -- 2018-05	Clifford Saper	NIH/NHLBI/P01 HL095491 (Core Leader)	0Yen
Production of a bipolar model mice and clarification of the neuronal mechanism of the manic switch	2021-04 -- 2024-03	新田淳美; 國井泰人; 有岡祐子; 望月貴年; 高雄啓三; 浅野昂志; 泉尾直孝	Japan Society for the Promotion of Science/Grants-in-Aid for Scientific Research	17,420,000Yen
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Career history


1992-01 -- 1994-03	Japan Society for the Promotion of ScienceResearch Fellow (DC1)
1994-04 -- 1998-06	Ehime UniversitySchool of MedicineAssistant Professor
1998-07 -- 2001-03	Osaka Bioscience InstituteDepartment of Molecular Behavioral BiologyResearch Associate
2001-04 -- 2015-08	Harvard Medical School / Beth Israel Deaconess Medical CenterDepartment of NeurologyAssistant Professor
2015-09 -- 2019-06	Kyushu UniversityAcademic Research and Industrial Collaboration Management OfficeSenior URA
2019-07 -- 2023-12	University of ToyamaFaculty of ScienceProfessor
2024-01 -- (current)	University of TsukubaInternational Institute for Integrative Sleep Medicine教授

Academic background


1984-04 -- 1988-03	Osaka University School of Human Sciences Behavioral Sciences
1988-04 -- 1990-03	Osaka University Graduate School of Medicine Medical Sciences
1990-04 -- 1994-03	Osaka University Graduate School of Medicine Physiology

Honors & Awards


2004-06	Faculty Career Advancement Award	The molecular mechanism of gamma-hydroxybutyrate

Articles

VESTIBULAR MODULATION OF THE SEPTOHIPPOCAMPAL CHOLINERGIC SYSTEM OF RATS
HORII A; TAKEDA N; MOCHIZUKI T; OKAKURAMOCHIZUKI K; Y...
ACTA OTO-LARYNGOLOGICA/Suppl 520/pp.395-398, 1995
RELATIONSHIP BETWEEN IN-VIVO OCCUPANCY OF CENTRAL HISTAMINE H3-RECEPTORS AND HISTAMINERGIC ACTIVITY ESTIMATED WITH A NOVEL H3-ANTAGONIST, CLOBENPROPIT
MOCHIZUKI T; JANSEN FP; LEURS R; TIMMERMAN H; MAEYAMA K
JOURNAL OF NEUROCHEMISTRY/65/pp.S27-S27, 1995
TURNOVER OF BRAIN HISTAMINE EVALUATED WITH MAST-CELL DEFICIENT RATS (WS/WS)
ALAM MK; SUGIMOTO K; MOCHIZUKI T; WATANABE T; MAEYAMA K
JOURNAL OF NEUROCHEMISTRY/65/pp.S179-S179, 1995
Arousal effect of orexin A depends on activation of the histaminergic system (vol 98, pg 9965, 2001)
Huang ZL; Qu WM; Li WD; Mochizuki T; Eguchi N; Watan...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA/99(2)/pp.1098-1098, 2002-01
Core body temperature and locomotor activity in orexin knockout mice
Klerman EB; Mochizuki T; Crocker A; Yanagisawa M; Sak...
SLEEP/26/pp.A17-A17, 2003-05
Maintenance of wakefulness in orexin knockout mice
Mochizuki T; Crocker A; McCormack S; Yanagisawa M; Sa...
SLEEP/26/pp.A13-A13, 2003-05
Region-restricted knockout of T-type calcium channel Cav3.1: Subcortical neuron bursts stabilize NREM sleep
Anderson MP; Mochizuki T; Scammell TE; Tonegawa S
SLEEP/27/pp.383-383, 2004
Alterations of sleep-wake behavioral characteristics in histamine H-1 receptor knockout mice
Huang Zhi-Li; Mochizuki Takatoshi; Qu Wei-Min; Hong Z...
NEUROSCIENCE RESEARCH/55/pp.S163-S163, 2006
Sodium oxybate consolidates wakefulness in orexin knockout mice
Mochizuki T.; Clark E. L.; Scammell T. E.
SLEEP/29/pp.A1-A1, 2006
Chronic EEG recordings in a mouse model of human autosomal dominant lateral temporal lobe epilepsy
Atefy Ramin; Lee Sanghoon; Mochizuki Takatoshi; Scamme...
EPILEPSIA/47/pp.297-298, 2006
Gene expression in the rat brain during prostaglandin D2-and adenosinergically-induced sleep
Terao A.; Huang Z.; Wisor J. P.; Mochizuki T.; Gerash...
SLEEP/31/pp.A361-A361, 2008
DIFFERENTIAL EFFECTS OF OREXIN AND DYNORPHIN ON CORTICALLY-PROJECTING NEURONS OF THE BASAL FOREBRAIN: AN IN VITRO STUDY
Arrigoni E.; Mochizuki T.; Clark E. L.; Saper C. B.; ...
SLEEP/32/pp.A16-A16, 2009
ARE TUBEROMAMMILLARY HISTAMINE NEURONS GABAERGIC?
Mochizuki T.; Oishi Y.; Yamamoto M.; Vong L.; Lowell ...
SLEEP/35/pp.A35-A35, 2012
Histamine N-methyltransferaseの欠損はマウスにおいて睡眠覚醒サイクルの異常を引き起こす
長沼史登; 吉川雄朗; 中村正帆; 堀米愛; 三浦大和; 矢内敦; 望月貴年; 谷内一彦
日本ヒスタミン学会プログラム・講演要旨集/19th, 2015
Interactions between histaminergic neuronal system and isoflurane anesthesia in mice
Nakamura Tadaho; Yoshikawa Takeo; Naganuma Fumito; Iid...
JOURNAL OF PHARMACOLOGICAL SCIENCES/130(3)/pp.S98-S98, 2016-03
Histamine N-methyltransferase deficiency causes abnormal sleep-wake cycles and aggressive behaviors
Naganuma Fumito; Yoshikawa Takeo; Nakamura Tadaho; Hor...
JOURNAL OF PHARMACOLOGICAL SCIENCES/130(3)/pp.S112-S112, 2016-03
EFFECTS OF INTRACEREBROVENTRICULAR HISTAMINE INJECTION ON CIRCADIAN ACTIVITY PHASE ENTRAINMENT DURING RAPID ILLUMINATION CHANGES
ITOWI N; YAMATODANI A; MOCHIZUKI T; WADA H
NEUROSCIENCE LETTERS/123(1)/pp.53-56, 1991-02
INVIVO RELEASE OF NEURONAL HISTAMINE IN THE HYPOTHALAMUS OF RATS MEASURED BY MICRODIALYSIS
MOCHIZUKI T; YAMATODANI A; OKAKURA K; TAKEMURA M; INA...
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY/343(2)/pp.190-195, 1991-02
Effect of caloric stimulation of histaminergic neuron system of rats
Horii Arata; Takeda Noriaki; Matsunaga T; Yamatodani ...
Proceedings of XVII Barany Society Meeting/pp.167-168, 1992
CIRCADIAN-RHYTHM OF HISTAMINE-RELEASE FROM THE HYPOTHALAMUS OF FREELY MOVING RATS
MOCHIZUKI T; YAMATODANI A; OKAKURA K; HORII A; INAGAK...
PHYSIOLOGY & BEHAVIOR/51(2)/pp.391-394, 1992-02
GLUTAMATERGIC REGULATION OF HISTAMINE-RELEASE FROM RAT HYPOTHALAMUS
OKAKURA K; YAMATODANI A; MOCHIZUKI T; HORII A; WADA H
EUROPEAN JOURNAL OF PHARMACOLOGY/213(2)/pp.189-192, 1992-03
SUPERNORMAL HISTAMINE-RELEASE AND NORMAL CYTOTOXIC ACTIVITY OF BEIGE (CHEDIAK-HIGASHI-SYNDROME) RAT MAST-CELLS WITH GIANT GRANULES
T Jippo-Kanemoto; T Kasugai; A Yamatodani; H Ushio; T...
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY/100(2)/pp.99-106, 1993
INCREASE OF HISTIDINE-DECARBOXYLASE ACTIVITY IN MICE HYPOTHALAMUS AFTER INTRACEREBROVENTRICULAR ADMINISTRATION OF LIPOPOLYSACCHARIDE
NIIMI M; MOCHIZUKI T; CACABELOS R; YAMATODANI A
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY/15(8)/pp.509-514, 1993-10
EFFECT OF UNILATERAL VESTIBULAR STIMULATION ON HISTAMINE-RELEASE FROM THE HYPOTHALAMUS OF RATS IN-VIVO
HORII A; TAKEDA N; MATSUNAGA T; YAMATODANI A; MOCHIZU...
JOURNAL OF NEUROPHYSIOLOGY/70(5)/pp.1822-1826, 1993-11
HISTAMINERGIC MODULATION OF HIPPOCAMPAL ACETYLCHOLINE-RELEASE IN-VIVO
MOCHIZUKI T; OKAKURAMOCHIZUKI K; HORII A; YAMAMOTO Y; ...
JOURNAL OF NEUROCHEMISTRY/62(6)/pp.2275-2282, 1994-06
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Books

Sleep and clock gene
望月貴年; 裏出良博
中外医学社: Annual Review 神経, 1999
Input and output systems of orexin neurons
Mochizuki Takatoshi; Yoshida-Court Kyoko
Springer International Publishing AG: Orexins and Sleep: molecular, functional, and clinical aspects., 2015
Clock gene and sleep-wake behavior
望月貴年; 池田真行
ライフ・サイエンス社: 睡眠医療 Vol 14(1), 2020-03
Histamine as an alert signal in the brain
Mochizuki Takatoshi
Springer Nature Switzerland AG: Current topics in behavioral neurosciences, 2021-08
Hypothalamic flip-flop仮説
望月貴年
ライフ・サイエンス社: 睡眠医療 Vol 16(2), 2022-06

Conference, etc.

Sleep-wake regulation in mice devoid of histamine H1 receptors
望月貴年
International Histamine Symposium (Sendai)/2000-11
Elevated body temperature during sleep in orexin knockout mice
望月貴年
Associated Professional Sleep Societies 20th Annual Meeting (Salt Lake City)/2006-06
Rescue of narcolepsy phenotypes in orexin receptor disrupted mice – an application of Cre-loxP system
望月貴年
Associated Professional Sleep Societies 22nd Annual Meeting (Baltimore)/2008-06
Unraveling the pathways that cause sleepiness in narcoleptic mice
望月貴年
Associated Professional Sleep Societies 24th Annual Meeting (San Antonio)/2010-06
Functional mapping of orexin receptors to regulate sleep/wake behavior in a mouse model of narcolepsy
望月貴年
The 37th Annual Meeting of Japanese Society of Sleep Research (Yokohama)/2012-06
Orexin and histamine as arousal signals in the brain
望月貴年
The 8th International Symposium on Respiratory Disease & ATS (Shanghai)/2012-11
Significance of co-localized GABA in histamine neurons
望月貴年
The 38th Annual Meeting of Japanese Society of Sleep Research (Akita)/2013-06
Histamine N-methyltransferaseの欠損はマウスにおいて攻撃性を高め、睡眠サイクルの異常を引き起こす
長沼史登; 吉川雄朗; 堀米愛; 三浦大和; 中村正帆; 矢内敦; 望月貴年; 谷内一彦
日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集/2015-09--2015-09
Roles of histamine neurons in narcolepsy
望月貴年
The 19 th Annual Meeting of Japanese Histamine Research Society (Sendai)/2015-11
Orexin receptor antagonists and behavioral changes in mice
望月貴年
2019 Oriental International Sleep Medicine Summit Forum (Shanghai)/2019-10-18

(Last updated: 2024-02-19)