KITAZONO Tomohiro

Affiliation

International Institute for Integrative Sleep Medicine

Official title

Assistant Professor

ORCID

0000-0003-4868-7385

Sex

Male

Birth date

1988-12

URL

https://sleepymouse.jp/

Office

Yanagisawa Funato laboratory

Phone

029-853-5857

Research fields


Molecular biology
Neurophysiology / General neuroscience

Research keywords


Sleep
kinase
Signaling pathway

Research projects


Memory dynamism elucidated by studying on the mechanisms of forgetting in C. elegans	2013-06 -- 2018-03	Takeshi Ishihara	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)	74,360,000Yen
線虫Ｃ．ｅｌｅｇａｎｓを用いた神経回路における忘却促進の分子メカニズム	2014-04 -- 2017-03	Tomohiro Kitazono	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research-KAKENHI	2,800,000Yen
Identification of intracellular signal transduction pathways in the regulation of sleep/wakefulness states	2017-04 -- 2019-03	Taeko Matsuoka	Japan Society for the Promotion of Science/Grant-in-Aid for Young Scientists (B)	4,160,000Yen
Exploration and analysis of novel components of intracellular molecular cascade for sleep	2018-08 -- 2020-03	Tomohiro Kitazono	Japan Society for the Promotion of Science/Grant-in-Aid for Research Activity Start-up	2,990,000Yen
Elucidating the molecular basis and neural circuit of "sleepiness"	2021-04 -- 2024-03	Tomohiro Kitazono	Japan Society for the Promotion of Science/Grants-in-Aid for Scientific Research-KAKENHI	3,640,000Yen
Analysis of the novel intracellular signaling pathways for sleep/wake regulation	2021-04 -- 2024-03	Tomohiro Kitazono	Japan Society for the Promotion of Science/Grant-in-Aid for Early-Career Scientists	4,550,000Yen
低分子量Gタンパク質RhoAを起点とした眠気の制御メカニズムの解明	2024-04 -- 2027-03	Tomohiro Kitazono	Japan Society for the Promotion of Science/Grant-in-Aid for Early-Career Scientists	4,680,000Yen
眠気を制御する細胞内分子機構の解明	2024-05 -- 2025-04	Tomohiro Kitazono	Japan Foundation for Applied Enzymology/The Medical Frontier Conferenceに関する研究助成（TMFC)

Career history


2014-04 -- 2017-03	Japan Society for the Promotion of ScienceResearch Fellowship for Young Scientists (DC1)
2017-12 -- 2017-12	Kyushu UniversityFaculty of SciencesPostdoc
2018-01 -- 2018-03	University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS)technical staff
2018-04 -- 2021-03	University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS)Postdoc
2021-04 -- 2024-03	Japan Society for the Promotion of ScienceResearch Fellowship for Young Scientists (PD)
2024-04 -- (current)	University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS)Assistant professor

Academic background


2008-04 -- 2012-03	Kyushu University School of Science Department of Biology
2012-04 -- 2017-11	Kyushu University Graduate School of Systems Life Sciences Department of Systems Life Sciences

Degree


2017-11	Doctor of Science	Kyushu University

Academic societies


2012 -- (current)	The Molecular Biology Society of Japan
2013 -- (current)	The Japan Neuroscience Society
2021-04 -- (current)	The Japanese Biochemical Society

Articles

Forgetting in C. elegans is accelerated by neuronal communication via the TIR-1/JNK-1 pathway
Inoue Akitoshi; Sawatari Etsuko; Hisamoto Naoki; Kitaz...
Cell reports/3(3)/pp.808-819, 2013-03-28
PubMed
Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans
Kitazono Tomohiro; Hara-Kuge Sayuri; Matsuda Osamu; In...
The Journal of neuroscience : the official journal of the Society for Neuroscience/37(42)/pp.10240-10251, 2017-10-18
PubMed
An improved inverse-type Ca2+ indicator can detect putative neuronal inhibition in Caenorhabditis elegans by increasing signal intensity upon Ca2+ decrease
Hara-Kuge Sayuri; Nishihara Tomonobu; Matsuda Tomoki; ...
PloS one/13(4), 2018-04-01
PubMed
Behavioral Forgetting of Olfactory Learning Is Mediated by Interneuron-Regulated Network Plasticity in Caenorhabditis elegans
Teo Jamine Hooi-Min; Kurokawa Itsuki; Onishi Yuuki; Sa...
eNeuro/9(4), 2022-04-01
PubMed
Regulation of Diacylglycerol Content in Olfactory Neurons Determines Forgetting or Retrieval of Olfactory Memory in Caenorhabditis elegans
Arai Mary; Kurokawa Itsuki; Arakane Hoshinosuke; Kitaz...
The Journal of neuroscience : the official journal of the Society for Neuroscience/42(43)/pp.8039-8053, 2022-10-26
PubMed
Kinase signalling in excitatory neurons regulates sleep quantity and depth
Kim Staci J; Hotta-Hirashima Noriko; Asano Fuyuki; Kit...
NATURE/612(7940)/pp.512-518, 2022-12-01
PubMed
Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway
Hirose Yuki; Kitazono Tomohiro; Sezaki Maiko; Abe Man...
Proceedings of the National Academy of Sciences of the United States of America/117(37)/pp.23106-23112, 2020-08
PubMed

Books

生化学96巻4号「睡眠の質と量をつかさどる、興奮性ニューロン内LKB1-SIK3-HDAC4シグナル経路」
北園智弘
公益社団法人日本生化学会, 2024-08
新規睡眠制御因子SIK3キナーゼによる睡眠覚醒制御機構
北園智弘
Obe-lisk Vol.29 No,1/ハムリー株式会社広報室/pp.3-10, 2024-01
睡眠恒常性の制御機構
北園智弘
Experimental Medicine December 2022/Yodosha/pp.3091-3096, 2022-12

Conference, etc.

The SIK3-RhoA-ROCK pathway regulates sleep quantity and sleep need
KITAZONO Tomohiro
NEURO2024/2024-07-24--2024-07-27
眠気を制御する細胞内分子機構の解明
北園智弘
2024年度The Medical Frontier Conferenceに関する研究助成（TMFC）第30回研究発表会/2024-06-29--2024-06-30
低分子量Gタンパク質RhoAはSIK3の下流で睡眠圧を制御している
北園智弘
The 48th Annual Meeting of Japanese Society of Sleep Research/2024-07-18--2024-07-19
Isolation of mutants for forgetting signals of olfactory adaptation
KITAZONO Tomohiro
EMBO Conference Series C.elegans Neurobiology/2012-06-14--2012-06-17
線虫C. elegansを用いた忘却シグナルの探索
北園智弘
包括型脳科学研究推進支援ネットワーク夏のワークショップ/2012-07-24--2012-07-27
線虫C.elegansを用いた忘却シグナルの探索
北園智弘
日本遺伝学会第84回大会/2012-09-24--2012-09-26
線虫C.elegansを用いた忘却シグナルの探索
北園智弘
第35回日本分子生物学会年会/2012-12-11--2012-12-14
線虫C. elegansにおいて、記憶の忘却を制御するTIR-1/JNK-1経路の下流の因子の探索
KITAZONO Tomohiro
第36回日本神経科学大会/2013-06-20--2013-06-23
Identification of regulatory factors for forgetting in C. elegans
KITAZONO Tomohiro
19th International C. elegans Meeting/2013-06-26--2013-06-30
線虫C. elegansにおける忘却を制御するTIR-1/JNK-1経路の下流因子の探索
北園智弘
第36回日本分子生物学会年会/2013-12-03--2013-12-06
Downstream regulatory components of the TIR-1/JNK-1 pathway for forgetting in C. elegans
KITAZONO Tomohiro
C. elegans Topic Meeting: Neuronal Development, Synaptic Function and Behavior/2013-06-23--2013-06-26
線虫C. elegansにおいて、忘却を制御するTIR-1/JNK-1経路の下流因子の解析
KITAZONO Tomohiro
第37回日本神経科学大会/2014-09-11--2014-09-13
線虫C. elegansにおいて、嗅覚順応の忘却を制御するTIR-1/JNK-1経路の下流制御因子
KITAZONO Tomohiro
第３８回日本神経科学大会/2015-07-28--2015-07-31
線虫C. elegansにおける嗅覚順応の記憶と忘却を制御する新規因子の解析
北園智弘
第３８回日本分子生物学会年会/2015-12-01--2015-12-04
The novel components regulating forgetting of the olfactory adaptation at the downstream of the TIR-1/JNK-1 pathway
KITAZONO Tomohiro
２０１６年線虫神経生物学国際集会/2016-07-27--2016-07-30
線虫C. elegansにおいて、嗅覚順応の忘却は複数のシグナル伝達経路による感覚応答の調節により、協調的・時間的に制御される
KITAZONO Tomohiro
第４０回日本神経科学大会/2017-07-20--2017-07-23
恒常的睡眠・覚醒制御の細胞内分子メカニズムの解析
北園智弘
第41回日本分子生物学会年会/2018-11-28--2018-11-30
Exploration of the intracellular molecular mechanisms for homeostatic sleep-wake regulation
KITAZONO Tomohiro
The 7th Annual IIIS Symposium ~Solving the mystery of sleep~/2018-12-20--2018-12-20
SIK3の基質スクリーニングによる眠気の分子基盤の解析
北園智弘
第42回日本分子生物学会年会/2019-12-03--2019-12-06
SIK3シグナル伝達経路を介した恒常的睡眠要求の分子基盤の同定
北園智弘
第43回日本分子生物学会年会/2020-12-02--2020-12-04
恒常的睡眠要求を制御する新規シグナル伝達経路の探索
北園智弘
第44回日本神経科学大会/2021-07-28--2021-07-31
「眠気」を制御する新規シグナル伝達経路の探索と解析
北園智弘
第94回日本生化学大会/2021-11-03--2021-11-05
恒常的睡眠要求を制御する神経細胞内新規シグナル伝達経路
北園智弘
第45回日本神経科学大会 (NEURO2022)/2022-06-30--2022-07-03
Upstream and downstream pathways of SIK3 in the regulation of sleep and wakefulness
KITAZONO Tomohiro
The 11th Annual WPI-IIIS Symposium ～Deciphering the Mysteries of Instinctive Behaviors～/2023-02-22--2023-02-22
The LKB1-SIK3-RhoA pathway regulates sleep and wakefulness
北園智弘
The 46th Annual Meeting of the Japan Neuroscience Society/2023-08-01--2023-08-04

(Last updated: 2024-09-18)