KITAZONO Tomohiro
- Affiliation
- International Institute for Integrative Sleep Medicine
- Official title
- Specially Appointed Assistant Professor
- ORCID
- 0000-0003-4868-7385
- Sex
- Male
- Birth date
- 1988-12
- KAKEN ID
- 40826517
- URL
- Office
- Yanagisawa Funato laboratory
- Phone
- 029-853-5857
- Research fields
- Molecular biology - Neurophysiology / General neuroscience 
- Research keywords
- Sleep - kinase - Signaling pathway 
- Research projects
- Memory dynamism elucidated by studying on the mechanisms of forgetting in C. elegans - 2013-06 -- 2018-03 - Takeshi Ishihara - Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area) - 74,360,000Yen - 線虫C. elegansを用いた神経回路における忘却促進の分子メカニズム - 2014-04 -- 2017-03 - Tomohiro Kitazono - Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research-KAKENHI - 2,800,000Yen - Identification of intracellular signal transduction pathways in the regulation of sleep/wakefulness states - 2017-04 -- 2019-03 - Taeko Matsuoka - Japan Society for the Promotion of Science/Grant-in-Aid for Young Scientists (B) - 4,160,000Yen - Exploration and analysis of novel components of intracellular molecular cascade for sleep - 2018-08 -- 2020-03 - Tomohiro Kitazono - Japan Society for the Promotion of Science/Grant-in-Aid for Research Activity Start-up - 2,990,000Yen - Elucidating the molecular basis and neural circuit of "sleepiness" - 2021-04 -- 2024-03 - Tomohiro Kitazono - Japan Society for the Promotion of Science/Grants-in-Aid for Scientific Research-KAKENHI - 3,640,000Yen - Analysis of the novel intracellular signaling pathways for sleep/wake regulation - 2021-04 -- 2024-03 - Tomohiro Kitazono - Japan Society for the Promotion of Science/Grant-in-Aid for Early-Career Scientists - 4,550,000Yen - 低分子量Gタンパク質RhoAを起点とした眠気の制御メカニズムの解明 - 2024-04 -- 2027-03 - Tomohiro Kitazono - Japan Society for the Promotion of Science/Grant-in-Aid for Early-Career Scientists - 4,680,000Yen - 眠気を制御する細胞内分子機構の解明 - 2024-05 -- 2025-04 - Tomohiro Kitazono - Japan Foundation for Applied Enzymology/The Medical Frontier Conferenceに関する研究助成(TMFC) 
- Career history
- 2014-04 -- 2017-03 - Japan Society for the Promotion of ScienceResearch Fellowship for Young Scientists (DC1) - 2017-12 -- 2017-12 - Kyushu UniversityFaculty of SciencesPostdoc - 2018-01 -- 2018-03 - University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS)technical staff - 2018-04 -- 2021-03 - University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS)Postdoc - 2021-04 -- 2024-03 - Japan Society for the Promotion of ScienceResearch Fellowship for Young Scientists (PD) - 2024-04 -- 2025-03 - University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS)Assistant professor - 2025-04 -- (current) - University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS)Assistant professor 
- Academic background
- 2008-04 -- 2012-03 - Kyushu University School of Science Department of Biology - 2012-04 -- 2017-11 - Kyushu University Graduate School of Systems Life Sciences Department of Systems Life Sciences 
- Degree
- 2017-11 - Doctor of Science - Kyushu University 
- Academic societies
- 2012 -- (current) - The Molecular Biology Society of Japan - 2013 -- (current) - The Japan Neuroscience Society - 2021-04 -- (current) - The Japanese Biochemical Society 
- Articles
- Forgetting in C. elegans is accelerated by neuronal communication via the TIR-1/JNK-1 pathway
 Inoue Akitoshi; Sawatari Etsuko; Hisamoto Naoki; Kitaz...
 Cell reports/3(3)/pp.808-819, 2013-03-28
- Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans
 Kitazono Tomohiro; Hara-Kuge Sayuri; Matsuda Osamu; In...
 The Journal of neuroscience : the official journal of the Society for Neuroscience/37(42)/pp.10240-10251, 2017-10-18
- An improved inverse-type Ca2+ indicator can detect putative neuronal inhibition in Caenorhabditis elegans by increasing signal intensity upon Ca2+ decrease
 Hara-Kuge Sayuri; Nishihara Tomonobu; Matsuda Tomoki; ...
 PloS one/13(4), 2018-04-01
- Behavioral Forgetting of Olfactory Learning Is Mediated by Interneuron-Regulated Network Plasticity in Caenorhabditis elegans
 Teo Jamine Hooi-Min; Kurokawa Itsuki; Onishi Yuuki; Sa...
 eNeuro/9(4), 2022-04-01
- Regulation of Diacylglycerol Content in Olfactory Neurons Determines Forgetting or Retrieval of Olfactory Memory in Caenorhabditis elegans
 Arai Mary; Kurokawa Itsuki; Arakane Hoshinosuke; Kitaz...
 The Journal of neuroscience : the official journal of the Society for Neuroscience/42(43)/pp.8039-8053, 2022-10-26
- Kinase signalling in excitatory neurons regulates sleep quantity and depth
 Kim Staci J; Hotta-Hirashima Noriko; Asano Fuyuki; Kit...
 NATURE/612(7940)/pp.512-518, 2022-12-01
- Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway
 Hirose Yuki; Kitazono Tomohiro; Sezaki Maiko; Abe Man...
 Proceedings of the National Academy of Sciences of the United States of America/117(37)/pp.23106-23112, 2020-08
 
- Forgetting in C. elegans is accelerated by neuronal communication via the TIR-1/JNK-1 pathway
- Books
- 生化学96巻4号「睡眠の質と量をつかさどる、興奮性ニューロン内LKB1-SIK3-HDAC4シグナル経路」
 北園 智弘
 公益社団法人日本生化学会, 2024-08
- 新規睡眠制御因子SIK3キナーゼによる睡眠覚醒制御機構
 北園 智弘
 Obe-lisk Vol.29 No,1/ハムリー株式会社広報室/pp.3-10, 2024-01
- 睡眠恒常性の制御機構
 北園 智弘
 Experimental Medicine December 2022/Yodosha/pp.3091-3096, 2022-12
 
- 生化学96巻4号「睡眠の質と量をつかさどる、興奮性ニューロン内LKB1-SIK3-HDAC4シグナル経路」
- Conference, etc.
- The SIK3-ARHGEF2-RhoA-ROCK pathway regulates sleep quantity and quality.
 KITAZONO Tomohiro
 The 48th Annual Meeting of Japanese Society of Sleep Research/2025-07-24--2025-07-27
- 睡眠圧は複数のキナーゼからなる独立したシグナル伝達経路によって制御されている
 北園 智弘
 日本睡眠学会第49回定期学術集会/2025-6-28--2025-6-29
- The RhoA signaling pathway regulates sleep quantity and sleep need downstream of SIK3
 KITAZONO Tomohiro
 The 13th Annual WPI-IIIS Symposium -Science of Behaving and Sleeping Brains-/2024-11-25--2025-11-25
- The SIK3-RhoA-ROCK pathway regulates sleep quantity and sleep need
 KITAZONO Tomohiro
 NEURO2024/2024-07-24--2024-07-27
- 眠気を制御する細胞内分子機構の解明
 北園 智弘
 2024年度The Medical Frontier Conferenceに関する研究助成(TMFC)第30回研究発表会/2024-06-29--2024-06-30
- 低分子量Gタンパク質RhoAはSIK3の下流で睡眠圧を制御している
 北園 智弘
 The 48th Annual Meeting of Japanese Society of Sleep Research/2024-07-18--2024-07-19
- Isolation of mutants for forgetting signals of olfactory adaptation
 KITAZONO Tomohiro
 EMBO Conference Series C.elegans Neurobiology/2012-06-14--2012-06-17
- 線虫C. elegansを用いた忘却シグナルの探索
 北園 智弘
 包括型脳科学研究推進支援ネットワーク 夏のワークショップ/2012-07-24--2012-07-27
- 線虫C.elegansを用いた忘却シグナルの探索
 北園 智弘
 日本遺伝学会 第84回大会/2012-09-24--2012-09-26
- 線虫C.elegansを用いた忘却シグナルの探索
 北園 智弘
 第35回日本分子生物学会年会/2012-12-11--2012-12-14
- 線虫C. elegansにおいて、記憶の忘却を制御するTIR-1/JNK-1経路の下流の因子の探索
 KITAZONO Tomohiro
 第36回日本神経科学大会/2013-06-20--2013-06-23
- Identification of regulatory factors for forgetting in C. elegans
 KITAZONO Tomohiro
 19th International C. elegans Meeting/2013-06-26--2013-06-30
- 線虫C. elegansにおける忘却を制御するTIR-1/JNK-1経路の下流因子の探索
 北園 智弘
 第36回日本分子生物学会年会/2013-12-03--2013-12-06
- Downstream regulatory components of the TIR-1/JNK-1 pathway for forgetting in C. elegans
 KITAZONO Tomohiro
 C. elegans Topic Meeting: Neuronal Development, Synaptic Function and Behavior/2013-06-23--2013-06-26
- 線虫C. elegansにおいて、忘却を制御するTIR-1/JNK-1経路の下流因子の解析
 KITAZONO Tomohiro
 第37回日本神経科学大会/2014-09-11--2014-09-13
- 線虫C. elegansにおいて、嗅覚順応の忘却を制御するTIR-1/JNK-1経路の下流制御因子
 KITAZONO Tomohiro
 第38回 日本神経科学大会/2015-07-28--2015-07-31
- 線虫C. elegansにおける嗅覚順応の記憶と忘却を制御する新規因子の解析
 北園 智弘
 第38回 日本分子生物学会年会/2015-12-01--2015-12-04
- The novel components regulating forgetting of the olfactory adaptation at the downstream of the TIR-1/JNK-1 pathway
 KITAZONO Tomohiro
 2016年 線虫神経生物学国際集会/2016-07-27--2016-07-30
- 線虫C. elegansにおいて、嗅覚順応の忘却は複数のシグナル伝達経路による感覚応答の調節により、協調的・時間的に制御される
 KITAZONO Tomohiro
 第40回 日本神経科学大会/2017-07-20--2017-07-23
- 恒常的睡眠・覚醒制御の細胞内分子メカニズムの解析
 北園 智弘
 第41回日本分子生物学会年会/2018-11-28--2018-11-30
- Exploration of the intracellular molecular mechanisms for homeostatic sleep-wake regulation
 KITAZONO Tomohiro
 The 7th Annual IIIS Symposium ~Solving the mystery of sleep~/2018-12-20--2018-12-20
- SIK3の基質スクリーニングによる眠気の分子基盤の解析
 北園 智弘
 第42回 日本分子生物学会年会/2019-12-03--2019-12-06
- SIK3シグナル伝達経路を介した恒常的睡眠要求の分子基盤の同定
 北園 智弘
 第43回日本分子生物学会年会/2020-12-02--2020-12-04
- 恒常的睡眠要求を制御する新規シグナル伝達経路の探索
 北園 智弘
 第44回日本神経科学大会/2021-07-28--2021-07-31
- 「眠気」を制御する新規シグナル伝達経路の探索と解析
 北園 智弘
 第94回日本生化学大会/2021-11-03--2021-11-05
- more...
 
- The SIK3-ARHGEF2-RhoA-ROCK pathway regulates sleep quantity and quality.
(Last updated: 2025-09-04)