YAMASHITA Yasunobu

Affiliation

Institute of Medicine

Official title

Specially Appointed Assistant Professor

Career history


2026 -- (current)	筑波大学医学医療系特任助教
2020 -- (current)	大阪大学産業科学研究所助教
2017 -- 2019	Bielefeld UniversityDepartment of chemistry博士研究員

Academic background


2014 -- 2017	慶應義塾大学大学院薬学研究科薬科学専攻後期博士課程
2012 -- 2014	慶應義塾大学大学院薬学研究科薬科学専攻前期博士課程
2008 -- 2012	慶應義塾大学薬学部薬科学科

Degree


2017-03	博士（薬科学）	慶應義塾大学大学院薬学研究科

Articles

Identification of non-hydroxamate histone deacetylase 8 inhibitors using deep learning-based screening of two-dimensional molecular images
Yamashita Yasunobu; Yun Juhyun; Asai Ayumu; Kato Hiro...
Bioorganic & medicinal chemistry/139, 2026-05-06
PubMed
Dual Catalysis in Organic Synthesis
Yamashita Yasunobu; Groeger Harald
Science of Synthesis/pp.339-3, 2019
Recent progress on small molecules targeting epigenetic complexes
Itoh Yukihiro; Takada Yuri; Yamashita Yasunobu; Suzuki...
Current opinion in chemical biology/67, 2022-04-01
PubMed
Medicinal Chemistry Research on Targeting Epigenetic Complexes.
Yasunobu Yamashita; Yuri Takada; Yukihiro Itoh; Takayos...
Journal of Synthetic Organic Chemistry Japan/80/pp.664-675, 2022
Epigenetic Inhibitors as Alzheimer's Disease Therapeutic Agents
Yamashita Yasunobu; Itoh Yukihiro; Takada Yuri; Suzuki...
Chemical & pharmaceutical bulletin/72(7)/pp.630-637, 2024-04-01
PubMed
Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease
Tanaka Ken-Ichiro; Ishihara Tomoaki; Sugizaki Toshifum...
Nature communications/4/p.2686, 2013-04-01
PubMed
Prostaglandin E1 -containing nanoparticles improve walking activity in an experimental rat model of intermittent claudication
Ishihara Tomoaki; Yamashita Yasunobu; Takasaki Naoko; ...
The Journal of pharmacy and pharmacology/65(8)/pp.1187-1194, 2013-08-01
PubMed
Chemo-enzymatic Enantioconvergent Approach toward Ethyl Shikimate from Ethyl 5-Hydroxy-3,4-Isopropylidenedioxycyclohex-1-Enecarboxylate.
Yasunobu Yamashita; Kengo Hanaya; Takeshi Sugai; Tohru...
Tetrahedron/69/pp.6527-6532, 2013
Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity
Yamakawa Naoki; Suzuki Koichiro; Yamashita Yasunobu; K...
Bioorganic & medicinal chemistry/22(8)/pp.2529-2534, 2014-04-15
PubMed
Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities
Yamashita Yasunobu; Tanaka Ken-Ichiro; Asano Teita; Ya...
Bioorganic & medicinal chemistry/22(13)/pp.3488-3497, 2014-07-01
PubMed
Superiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease
Tanaka Ken-Ichiro; Kurotsu Shota; Asano Teita; Yamakaw...
Scientific reports/4/p.4510, 2014-03-28
PubMed
Ex situ Enantioconvergent Approaches for Effective Use of Undesired Isomers: Stereochemical Convergence of Substrates with Multiple Chiral Centers and Recycling of Decarboxylated Byproduct.
Yasunobu Yamashita; Kurihara Tohru; Horiguchi Takanobu...
Synthesis/48/pp.2191-2200, 2016
Simple Synthesis of Sakuranetin and Selinone via a Common Intermediate, Utilizing Complementary Regioselectivity in the Deacetylation of Naringenin Triacetate
Yamashita Yasunobu; Hanaya Kengo; Shoji Mitsuru; Sugai...
Chemical & pharmaceutical bulletin/64(7)/pp.961-965, 2016-04-01
PubMed
Preparation of (R)-3-Hydroxy-N-methylpiperidine, a Synthetic Key Intermediate of (R)-Mepenzolate, Based on the Lipase-Catalyzed Resolution of the Racemic Form.
Yamashita Yasunobu; Hanaya Kengo; Shoji Mitsuru; Sugai...
Heterocycles (Special Issue)/95/pp.370-379, 2017
Short-step syntheses of naturally occurring polyoxygenated aromatics based on site-selective transformation
Yamashita Yasunobu; Biard Alan; Hanaya Kengo; Shoji M...
Bioscience, biotechnology, and biochemistry/81(7)/pp.1279-1284, 2017-07-01
PubMed
Prediction of Protein-compound Binding Energies from Known Activity Data: Docking-score-based Method and its Applications
Fukunishi Yoshifumi; Yamashita Yasunobu; Mashimo Tadaa...
Molecular informatics/37(6-7), 2018-07-01
PubMed
Identification of Mepenzolate Derivatives With Long-Acting Bronchodilatory Activity
Tanaka Ken-Ichiro; Yamakawa Naoki; Yamashita Yasunobu; ...
Frontiers in pharmacology/9/p.344, 2018-04-01
PubMed
An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode
Yamashita Yasunobu; Schober Lukas; Ratnam Shahilan; Ad...
Synthesis/51/pp.1178-1184, 2019
Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity
Yamashita Yasunobu; Tanaka Ken-Ichiro; Yamakawa Naoki; ...
Bioorganic & medicinal chemistry/27(15)/pp.3339-3346, 2019-08-01
PubMed
Metalloprotein-Catalyzed Click Reaction for In situ Generation of a Potent Inhibitor.
Yamashita Yasunobu; Miyake Yuka; Itoh Yukihiro; Suzuma...
ACS Catalyst/10/pp.5383-5392, 2020
Learning About Enzyme Stability Against Organic Co-Solvents from Structural Insight by Ion Mobility Mass Spectrometry.
Yamashita Yasunobu; Sproß Jens; Gröger Harald
ChemBioChem/21/pp.1968-1971, 2020
Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders
Iida Tetsuya; Itoh Yukihiro; Takahashi Yukari; Yamashi...
ChemMedChem/16(10)/pp.1609-1618, 2021-05-18
PubMed
Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach
Prakash Muthuraj; Itoh Yukihiro; Fujiwara Yoshie; Taka...
Journal of medicinal chemistry/64(21)/pp.15810-15824, 2021-11-11
PubMed
Identification of Novel Histone Deacetylase 6-Selective Inhibitors Bearing 3,3,3-Trifluorolactic Amide (TFLAM) Motif as a Zinc Binding Group
Kurohara Takashi; Tanaka Keita; Takahashi Daisuke; Ued...
Chembiochem : a European journal of chemical biology/22(22)/pp.3158-3163, 2021-11-16
PubMed
Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC)
Chotitumnavee Jiranan; Yamashita Yasunobu; Takahashi Y...
Chemical communications (Cambridge, England)/58(29)/pp.4635-4638, 2022-04-07
PubMed
more...

(Last updated: 2026-05-19)