NISHIKII Hidekazu

Affiliation

Institute of Medicine

Official title

Associate Professor

Research projects


ヒト造血幹細胞の不均一性の解明と機能制御	2022-04 -- 2025-03	NISHIKII Hidekazu	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,160,000Yen
Analyses of hematopoietic niche in hematologic malignancy	2018-04 -- 2021-03	NISHIKII Hidekazu	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,550,000Yen
Analyses of immune tolerance mechanism in allogeneic transplantation	2015-04 -- 2018-03	NISHIKII Hidekazu	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,810,000Yen
巨核球・血小板分化における転写因子ＨＥＳ１が担う制御機構の解明	2012-04 -- 2013-03	NISHIKII Hidekazu	Japan Society for the Promotion of Science (JSPS)/Grant-in-Aid for Young Scientists(B)	4,290,000Yen
The role of Notch signaling in megakaryocytopoiesis	2010 -- 2011	NISHIKII Hidekazu	Japan Society for the Promotion of Science (JSPS)/Grant-in-Aid for Young Scientists(B)	4,030,000Yen

Degree


2008-03	博士(医学)	University of Tokyo

Articles

血中タクロリムス濃度の個体内変動が造血幹細胞移植後の移植片対宿主病発症に及ぼす影響（会議録）
森山侑太; 鈴木嘉治; 坂本竜弘; 末原泰人; 栗田尚樹; 錦井秀和; 小原　直; 坂田 ...
Organ Biology/31(3)/p.105, 2024-10
[Successful BTK inhibitor therapy for refractory transformed B-cell lymphoma originating from an MYD88 mutant clone]
Uehara Atsushi; Nishikii Hidekazu; Suehara Yasuhito; M...
[Rinsho ketsueki] The Japanese journal of clinical hematology/65(11)/pp.1368-1374, 2024-11
PubMed
環状鉄芽球と血小板増加を伴う骨髄異形成/骨髄増殖性腫瘍の形態学的および臨床的特徴と新規SF3B1変異解析法の樹立
小山諒太; 加藤貴康; 南木融; 井上真由; 国井拓弥; 山崎慎介; 神田智之; 大木...
日本検査血液学会雑誌/25(2)/pp.242-250, 2024-07
Spatially Resolved Single-Cell Transcriptomics of T Cells in Follicular Lymphoma Reveals Distinct Immune Ecosystems
Abe Yoshiaki; Zenkoh Junko; Kanai Akinori; Ikeda Dais...
BLOOD/144(1)/pp.741-742, 2024-11-05
The novel protein C variant p.C101F results in early intracellular degradation that drives type I protein C deficiency
Yui Rikuto; Nagaya Satomi; Yasuda Ibuki; Togashi Tomo...
INTERNATIONAL JOURNAL OF HEMATOLOGY/Epub, 2025-02-10
Final Analysis Results from the AGEHA Study: Emicizumab Prophylaxis for Acquired Hemophilia A with or without Immunosuppressive Therapy
Shima Midori; Suzuki Nobuaki; Nishikii Hidekazu; Amano...
THROMBOSIS AND HAEMOSTASIS/125(5)/pp.449-459, 2024-09-12
High-throughput mechanical phenotyping and transcriptomics of single cells
Shiomi Akifumi; Kaneko Taikopaul; Nishikawa Kaori; Tsu...
Nature communications/15(1), 2024-05-17
Activated mesenchymal stem/stromal cells promote myeloid cell differentiation via CCL2/CCR2 signaling
Yamazaki Satoshi; Mabuchi Yo; Kimura Takaharu; Suto E...
STEM CELL REPORTS/19(3)/pp.414-425, 2024-02-29
PubMed
Impact of CD34 positive cell dose in donor graft on the outcomes after haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide - A retrospective single-center study with a Japanese cohort
Maruyama Yumiko; Nishikii Hidekazu; Kurita Naoki; Saka...
Blood cells, molecules & diseases/105, 2023-12-30
PubMed
Purging myeloma cell contaminants and simultaneous expansion of peripheral blood-mobilized stem cells
Ishitsuka Kantaro; Nishikii Hidekazu; Kimura Takaharu; ...
EXPERIMENTAL HEMATOLOGY/131, 2023-12-25
PubMed
Risk factors for CAR-T cell manufacturing failure among DLBCL patients: A nationwide survey in Japan
Jo Tomoyasu; Yoshihara Satoshi; Okuyama Yoshiki; Fujii...
British journal of haematology/202(2)/pp.256-266, 2023-04-25
PubMed
同種造血幹細胞移植により長期寛解を得たCLEC16A::IL2融合遺伝子を有するT細胞前リンパ球性白血病
百瀬春佳; 栗田尚樹; 錦井秀和; 遊佐希; 横山和明; 清水英吾; 井元清哉; 南木...
臨床血液/65(1)/pp.35-40, 2024-01
PubMed
Safety of romiplostim administered immediately after cord-blood transplantation: a phase 1 trial
Kurita Naoki; Nishikii Hidekazu; Maruyama Yumiko; Sueh...
ANNALS OF HEMATOLOGY/102(10)/pp.2895-2902, 2023-08-17
PubMed
Repeated immunosuppressive rabbit antithymocyte globulin therapy for adult patients with relapsed or refractory aplastic anemia
Sakamoto Tatsuhiro; Obara Naoshi; Maruyama Yumiko; Kat...
EUROPEAN JOURNAL OF HAEMATOLOGY/111(5)/pp.768-776, 2023-08-07
PubMed
Tumor Necrosis Factor from Leukemic Microenvironment Provides Non-Leukemic Hematopoietic Stem Cells with Megakaryocyte Lineage Bias
Nishikii Hidekazu; Saito Mizuki; Kimura Takaharu; Kiyo...
BLOOD/140(1)/pp.5774-5775, 2022-11
Efficacy and Safety of Emicizumab Prophylaxis in Patients with Acquired Hemophilia a Who Were Deemed Ineligible for Immunosuppressive Therapy: Additional Data from the Ageha Study
Nishikii Hidekazu; Suzuki Nobuaki; Kobayashi Ryota; Mi...
BLOOD/140(1)/pp.2724-2725, 2022-11
Elongation of Long-Chain Fatty Acids Is Crucial for Hematopoietic Stem Cell Engraftment and Leukemia Propagation
Kato Takayasu; Kiyoki Yusuke; Kito Sakura; Matsuzaka ...
BLOOD/140(1), 2022-11
A Single-Cell Atlas of Nonhematopoietic Cells in Human Lymph Node and Lymphoma Reveals Landscape of Stromal Remodeling
Abe Yoshiaki; Sakata-Yanagimoto Mamiko; Fujisawa Manabu; ...
BLOOD/138(1), 2021-11
[Acute myeloid leukemia harboring NUP98::DDX10]
Kurita Naoki; Kato Takayasu; Nanmoku Toru; Maruyama Yumi...
[Rinsho ketsueki] The Japanese journal of clinical hematology/63(10)/pp.1397-1401, 2022-10
PubMed
The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation
Kiyoki Yusuke; Kato Takayasu; Kito Sakura; Matsuzaka ...
LEUKEMIA/37(4)/pp.910-913, 2023-03-08
PubMed
Chemically defined cytokine-free expansion of human haematopoietic stem cells
Sakurai Masatoshi; Ishitsuka Kantaro; Ito Ryoji; Wilki...
NATURE/615(7950)/pp.127-133, 2023-02
PubMed
Novel translocation of POGZ/STK11 in de novo mast cell leukemia with KIT D816H mutation
Ishitsuka Kantaro; Yoshizawa Yuki; Nishikii Hidekazu; Kus...
LEUKEMIA & LYMPHOMA/63(14)/pp.3475-3479, 2022-09
PubMed
[Lymphoplasmacytic lymphoma accompanied by severe myelofibrosis]　
Takarada Ayako; Momose Haruka; Kurita Naoki; Matsuoka Ry...
[Rinsho ketsueki] The Japanese journal of clinical hematology/64(1)/pp.54-59, 2023-01
PubMed
[Hematopoietic recovery by ASXL1-mutated clones after immune suppressive therapy in a patient with severe aplastic anemia]
Shimizu Yumoe; Nishikii Hidekazu; Iitsuka Tadashi; Matsuo...
[Rinsho ketsueki] The Japanese journal of clinical hematology/64(1)/pp.49-53, 2023-01
PubMed
Waldenström macroglobulinemia complicated by peripheral neuropathy due to neural infiltration
Norioka Natsuki; Kurita Naoki; Kamura Yuya; Sakamoto Tat...
[Rinsho ketsueki] The Japanese journal of clinical hematology/64(1)/pp.18-22, 2023-01
PubMed
more...

Books

制御性T細胞による骨髄環境制御
錦井秀和
医学のあゆみ/医歯薬出版/pp.1177-1182, 2019-03
Chapter 14 Hematopoietic differentiation from Embryonic Stem Cells
Yokoyama Y; Nishikii H; Chiba S
Embryonic Stem Cells - Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine/InTech/pp.251-272, 2011-03

Conference, etc.

Efficacy of lusutrombopag while self-renewal of hematopoietic stem cells in ex-vivo expansion system
Riko Kikuchi; Takao Yogo; 錦井秀和; Takaharu Kimura; Tom...
第86回日本血液学会学術集会/2024-10-11--2024-10-13
遺伝性プロテインC欠乏症患者に同定された新規バリアントp.Cys101Pheの細胞内動態解析
油井陸斗; 長屋聡美; 安田芽生; 今井湧太; 松本陽斗; 菊池結香; 森屋羽瑠雅; 桑島大和; 竹川清太郎; 築...
第46回日本血栓止血学会学術集会/2024-06-13--2024-06-15
茨城県におけるエミシズマブ世代の後天性血友病診療状況
錦井秀和; 堤育代; 吉田近思; 萩原將太郎; 小原直; 藤尾高行; 千葉滋; 長谷川雄一
第46回日本血栓止血学会学術集会/2024-06-13--2024-06-15
Spatially Resolved Single-Cell Transcriptomics of T Cells in Follicular Lymphoma Reveals Distinct Immune Ecosystems
Abe Yoshiaki; Zenkoh Junko; Kanai Akinori; Ikeda Dais...
66th ASH Annual Meeting and Exposition/2024-12-07--2024-12-10
Dynamics of erythropoiesis after ABO mismatched allogeneic hematopoietic stem cell transplantation
Yusuke Kiyoki; Hidekazu Nishikii; Yuzuki Maruyama; Yus...
第86回日本血液学会学術集会/2024-10-11--2024-10-13
Clinical usefulness and validity of WAVE system for p.Gly17Val RHOA mutations
Yuri Tsuboi; Keiichiro Hattori; Naoki Kurita; Toru Na...
第86回日本血液学会学術集会/2024-10-11--2024-10-13
Single-center study: Discontinuation of cyclosporine tapering in patients with aplastic anemia
Takayasu Kato; Naoshi Obara; Tatsuhiro Sakamoto; Sakur...
第86回日本血液学会学術集会/2024-10-11--2024-10-13
Sperm cryopreservation in patients with hematological malignancies: A single-center experience
Shinichiro Honda; Naoki Kurita; Kosuke Kojo; Ayako Ik...
第86回日本血液学会学術集会/2024-10-11--2024-10-13
A retrospective analysis of ASCT with BUTT regimen for CNS lymphomas in a single institute
Keiichiro Hattori; Naoki Kurita; Kenichi Makishima; Sa...
第86回日本血液学会学術集会/2024-10-11--2024-10-13
Spatially resolved single-cell dissection reveals distinct immune ecosystems in follicular lymphoma
Abe Yoshiaki; Zenkoh Junko; Kanai Akinori; Ikeda Dais...
第86回日本血液学会学術集会/2024-10-11--2024-10-13
Translational research targeting intractable lymphomas with T follicular helper cell phenotype
Suma Sakurako; SAKATA-YANAGIMOTO Mamiko; Suehara Yasuh...
第86回日本血液学会学術集会/2024-10-11--2024-10-13
当院で経験した NPM1::HAUS1 融合遺伝子を伴う急性骨髄性白血病の1例
松村文明; 横山泰久; 坂本竜弘; 南木融; 南谷泰仁; 大木圭子; 国井拓弥; 樽井裕太朗; 清木祐介; 末...
第21回日本血液学会関東甲信越地方会/2024-07-27--2024-07-27
Translational Research Targeting Intractable Lymphomas with T Follicular Helper Cell Phenotype
Suma Sakurako; SAKATA-YANAGIMOTO Mamiko; Suehara Yasuh...
第14回　JSH国際シンポジウム/2024-07-13--2024-07-14
Genomic analysis of discordant lymphoma consisting of splenic marginal zone lymphoma and diffuse large B-cell lymphoma.
海江田拓実; 槇島健一; 須摩桜子; 清木祐介; 安部佳亮; 末原泰人; 佐々木裕哉; 丸山ゆみ子; 服部圭一朗; ...
第64回日本リンパ網内系学会学術集会・総会/2024-06-27--2024-06-29
血中タクロリムス濃度の個体内変動が造血幹細胞移植後の移植片対宿主病発症に及ぼす影響
森山侑太; 鈴木嘉治; 坂本竜弘; 末原泰人; 栗田尚樹; 錦井秀和; 小原　直; 坂田 ...
第50回日本臓器保存生物医学会学術集会/2024-11-08--2024-11-09
Translational research targeting intractable lymphomas with T follicular helper cell phenotype
Suma Sakurako; Suehara Yasuhito; Goto Hideki; Usuki K...
The EHA 2024 Hybrid Congress/2024-06-13--2024-06-16
Spatially resolved single-cell profiling identifies distinct follicular T-cell subsets and ecosystems that regulate biological and clinical fate of follicular lymphoma
Abe Yoshiaki; Zenkoh Junko; Kanai Akinori; Ikeda Dais...
The EHA 2024 Hybrid Congress/2024-06-13--2024-06-16
急性前骨髄性白血病（APL）に対する亜ヒ酸療法における帯状疱疹予防の検討
佐野友宥; 加藤貴康; 末原泰人; 坂本竜弘; 栗田尚樹; 横山泰久; 錦井秀和; 小原直; 坂田（柳元） ...
第121回日本内科学　医学生・研修医・専攻医の日本内科学会ことはじめ 2024東京/2024-04-13--2024-04-13
治療を要する慢性好酸球性白血病と多発性骨髄腫を合併した1例
小田卓弥; 佐々木裕哉; 須摩桜子; 末原泰人; 槇島健一; 服部圭一朗; 坂本竜弘; 栗田尚樹; 加藤貴康; 丸...
第22回日本血液学会関東甲信越地方会情報/2025-03-22--2025-03-22
化学療法前に卵子凍結を行った急性骨髄性白血病の1例
服部聡; 須摩桜子; 佐々木裕哉; 槇島健一; 末原泰人; 服部圭一朗; 坂本竜弘; 加藤貴康; 丸山ゆみ子; ...
第22回日本血液学会関東甲信越地方会情報/2025-03-22--2025-03-22
抗NMDA受容体抗体脳炎発症から8ヶ月後に診断した中枢神経原発悪性リンパ腫の1例
辻真伍; 末原泰人; 佐々木裕哉; 服部圭一朗; 坂本竜弘; 加藤貴康; 丸山ゆみ子; 栗田尚樹; 錦井秀和; ...
第22回日本血液学会関東甲信越地方会情報/2025-03-22--2025-03-22
Phase I/II study of BMT from HLA-matched donor using PTCy as a single agent for GVHD prophylaxis
ジョイス美紀; 栗田尚樹; Bryan J. Mathis; 槇島健一; 須摩桜子; 佐々木裕哉; 末原泰人; ...
第47回日本造血･免疫細胞療法学会　総会/2025-02-27--2025-03-01
Analysis of costs and length of hospital stay in allogeneic hematopoietic stem cell transplantation
宝田亜矢子; 栗田尚樹; 石井亮太; 槇島健一; 須摩桜子; 佐々木裕哉; 末原泰人; 服部圭一朗; 坂本竜弘; ...
第47回日本造血･免疫細胞療法学会　総会/2025-02-27--2025-03-01
A retrospective study on lymphocyte and PBSCH in University of Tsukuba hospital
丸山ゆみ子; 錦井秀和; 新井裕介; 末原泰人; 服部圭一朗; 坂本竜弘; 佐々木裕哉; 加藤貴康; 小原直; ...
第47回日本造血･免疫細胞療法学会　総会/2025-02-27--2025-03-01
Safety proof of romiplostim immediately after cord-blood transplantation: Results of a phase 1 trial
Kurita N.; Maruyama Y.; Suehara Y.; Hattori K.; Kato ...
BONE MARROW TRANSPLANTATION/2022-11
more...

Teaching


2024-04 -- 2024-08	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2024-10 -- 2025-02	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2024-12 -- 2025-02	Hematology for Beginners	University of Tsukuba.
2024-10 -- 2024-12	Outline of Internal Medicine	University of Tsukuba.
2023-10 -- 2024-02	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2023-04 -- 2023-08	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2023-04 -- 2023-08	Advanced Seminar in Medical Sciences	University of Tsukuba.
2023-10 -- 2024-02	Advanced Seminar in Medical Sciences	University of Tsukuba.
2023-10 -- 2023-12	Outline of Internal Medicine	University of Tsukuba.
2024-01 -- 2024-02	Hematology for Beginners	University of Tsukuba.
more...

Talks

造血幹細胞増幅技術の臨床応用への展望と課題
錦井秀和
第30回日本輸血・細胞治療学会秋季シンポジウム/2023-10-26--2023-10-27

(Last updated: 2025-05-14)