NISHIKII Hidekazu

Affiliation

Institute of Medicine

Official title

Associate Professor

Research projects

ヒト造血幹細胞の不均一性の解明と機能制御	2022-04 -- 2025-03	NISHIKII Hidekazu	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,160,000Yen
Analyses of hematopoietic niche in hematologic malignancy	2018-04 -- 2021-03	NISHIKII Hidekazu	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,550,000Yen
Analyses of immune tolerance mechanism in allogeneic transplantation	2015-04 -- 2018-03	NISHIKII Hidekazu	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,810,000Yen
巨核球・血小板分化における転写因子ＨＥＳ１が担う制御機構の解明	2012-04 -- 2013-03	NISHIKII Hidekazu	Japan Society for the Promotion of Science (JSPS)/Grant-in-Aid for Young Scientists(B)	4,290,000Yen
The role of Notch signaling in megakaryocytopoiesis	2010 -- 2011	NISHIKII Hidekazu	Japan Society for the Promotion of Science (JSPS)/Grant-in-Aid for Young Scientists(B)	4,030,000Yen

Degree

2008-03	博士(医学)	University of Tokyo

Articles

• 【造血幹細胞研究の革新と臨床応用への挑戦】造血幹細胞増幅がもたらす臨床応用と基礎研究の発展
  菊地理子; 錦井 秀和
  医学のあゆみ/295(8)/pp.644-648, 2025-11
• Tracking of Donor Erythropoiesis following ABO-Incompatible Allogeneic Hematopoietic Stem Cell Transplantation
  Kiyoki Yusuke; Maruyama Yumiko; Maruyama Yuzuki; Arai ...
  Transplantation and cellular therapy/32(4)/p.431.e1-431.e4, 2026-04-01
  
  PubMed
• Safety of Post-transplant Cyclophosphamide as a Single Agent for Graft-Versus-Host Disease Prophylaxis After Human Leukocyte Antigen (HLA)-Matched Transplantation With the Japanese Population: A Single-Center Phase Ⅰ/Ⅱ Study
  Joyce Miki; Kurita Naoki; Mathis Bryan J; Makishima K...
  Cureus/17(12), 2025-12-01
  
  PubMed
• Discordant lymphoma consisting of splenic marginal zone lymphoma and diffuse large B-cell lymphoma in a hepatitis B virus carrier suggests virus-associated lymphomagenesis
  Kaieda Takumi; Makishima Kenichi; Suma Sakurako; Sasak...
  JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 2026-01-28
  
  PubMed
• Prospective isolation of mouse and human hematopoietic stem cells using PLXDC2
  Tanaka Yosuke; Kubota Yasushi; Kikuchi Riko; Yabushita...
  COMMUNICATIONS BIOLOGY/9(1), 2025-12-10
• Tumor necrosis factor from leukemic environment stimulates hematopoietic stem/progenitor cells toward megakaryocyte/myeloid lineage bias
  Nishikii Hidekazu; Kikuchi Riko; Kimura Takaharu; Sait...
  EXPERIMENTAL HEMATOLOGY/155, 2026-03
• FINE TUNING OF MPL SIGNALING DURING SELF-RENEWAL OF HSCS USING THROMBOPOIETIN RECEPTOR AGONISTS
  Kikuchi Riko; Yogo Takao; Nishikii Hidekazu; Kimura T...
  EXPERIMENTAL HEMATOLOGY/151(S), 2025-11
• A retrospective analysis of autologous stem cell transplantation conditioning with reduced-dose busulfan/thiotepa for patients with central nervous system lymphomas at a single institution
  Hattori Keiichiro; Kurita Naoki; Matsumura Fumiaki; Ma...
  INTERNATIONAL JOURNAL OF HEMATOLOGY, 2025-12-16
  
  PubMed
• Distinct follicular T cell subsets regulate lymphoma progression and outcomes
  Abe Yoshiaki; Zenkoh Junko; Kanai Akinori; Ikeda Dais...
  Cancer cell/43(10), 2025-07-01
  
  PubMed
• Dynamics of Red Blood Cell Hematopoiesis Following ABO-Incompatible Allogeneic Hematopoietic Stem Cell Transplantation
  Kiyoki Yusuke; Maruyama Yumiko; Maruyama Yuzuki; Arai ...
  BLOOD/144(1)/pp.7102-7103, 2024-11-05
• Safety of hematopoietic stem cell donation from young related donors following the lowering of the age of legal adulthood in Japan
  Hirakawa Tsuneaki; Yabe Hiromasa; Hino Masayuki; Doki ...
  INTERNATIONAL JOURNAL OF HEMATOLOGY, 2025-05-20
• Real-World Data on the p.Gly17Val RHOA Mutation in Diagnosing T Follicular Helper Cell Lymphomas
  Tsuboi Yuri; Hattori Keiichiro; Kurita Naoki; Suehara ...
  Cancer medicine/14(9), 2025-05-01
  
  PubMed
• 血中タクロリムス濃度の個体内変動が造血幹細胞移植後の移植片対宿主病発症に及ぼす影響（会議録）
  森山 侑太; 鈴木 嘉治; 坂本 竜弘; 末原 泰人; 栗田 尚樹; 錦井 秀和; 小原　直; 坂田 ...
  Organ Biology/31(3)/p.105, 2024-10
• [Successful BTK inhibitor therapy for refractory transformed B-cell lymphoma originating from an MYD88 mutant clone]
  Uehara Atsushi; Nishikii Hidekazu; Suehara Yasuhito; M...
  [Rinsho ketsueki] The Japanese journal of clinical hematology/65(11)/pp.1368-1374, 2024-11
  
  PubMed
• 環状鉄芽球と血小板増加を伴う骨髄異形成/骨髄増殖性腫瘍の形態学的および臨床的特徴と新規SF3B1変異解析法の樹立
  小山 諒太; 加藤 貴康; 南木 融; 井上 真由; 国井 拓弥; 山崎 慎介; 神田 智之; 大木...
  日本検査血液学会雑誌/25(2)/pp.242-250, 2024-07
• A Case of Multiple Myeloma in a Patient with Birt-Hogg-Dube Syndrome
  Matsumura Fumiaki; Sakamoto Tatsuhiro; Kai Hirayasu; U...
  INTERNAL MEDICINE, 2025-03-15
  
  PubMed
• Spatially Resolved Single-Cell Transcriptomics of T Cells in Follicular Lymphoma Reveals Distinct Immune Ecosystems
  Abe Yoshiaki; Zenkoh Junko; Kanai Akinori; Ikeda Dais...
  BLOOD/144(1)/pp.741-742, 2024-11-05
• The novel protein C variant p.C101F results in early intracellular degradation that drives type I protein C deficiency
  Yui Rikuto; Nagaya Satomi; Yasuda Ibuki; Togashi Tomo...
  INTERNATIONAL JOURNAL OF HEMATOLOGY/Epub, 2025-02-10
• Final Analysis Results from the AGEHA Study: Emicizumab Prophylaxis for Acquired Hemophilia A with or without Immunosuppressive Therapy
  Shima Midori; Suzuki Nobuaki; Nishikii Hidekazu; Amano...
  THROMBOSIS AND HAEMOSTASIS/125(5)/pp.449-459, 2024-09-12
• High-throughput mechanical phenotyping and transcriptomics of single cells
  Shiomi Akifumi; Kaneko Taikopaul; Nishikawa Kaori; Tsu...
  Nature communications/15(1), 2024-05-17
• Activated mesenchymal stem/stromal cells promote myeloid cell differentiation via CCL2/CCR2 signaling
  Yamazaki Satoshi; Mabuchi Yo; Kimura Takaharu; Suto E...
  STEM CELL REPORTS/19(3)/pp.414-425, 2024-02-29
  
  PubMed
• Impact of CD34 positive cell dose in donor graft on the outcomes after haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide - A retrospective single-center study with a Japanese cohort
  Maruyama Yumiko; Nishikii Hidekazu; Kurita Naoki; Saka...
  Blood cells, molecules & diseases/105, 2023-12-30
  
  PubMed
• Purging myeloma cell contaminants and simultaneous expansion of peripheral blood-mobilized stem cells
  Ishitsuka Kantaro; Nishikii Hidekazu; Kimura Takaharu; ...
  EXPERIMENTAL HEMATOLOGY/131, 2023-12-25
  
  PubMed
• Risk factors for CAR-T cell manufacturing failure among DLBCL patients: A nationwide survey in Japan
  Jo Tomoyasu; Yoshihara Satoshi; Okuyama Yoshiki; Fujii...
  British journal of haematology/202(2)/pp.256-266, 2023-04-25
  
  PubMed
• 同種造血幹細胞移植により長期寛解を得たCLEC16A::IL2融合遺伝子を有するT細胞前リンパ球性白血病
  百瀬 春佳; 栗田 尚樹; 錦井 秀和; 遊佐 希; 横山 和明; 清水 英吾; 井元 清哉; 南木...
  臨床血液/65(1)/pp.35-40, 2024-01
  
  PubMed
• more...

Books

• 制御性T細胞による骨髄環境制御
  錦井 秀和
  医学のあゆみ/医歯薬出版/pp.1177-1182, 2019-03
• Chapter 14 Hematopoietic differentiation from Embryonic Stem Cells
  Yokoyama Y; Nishikii H; Chiba S
  Embryonic Stem Cells - Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine/InTech/pp.251-272, 2011-03

Conference, etc.

• Fine tuning of MPL signaling during self-renewal of HSCs using thrombopoietin receptor agonists
  Riko Kikuchi; Takao Yogo; 錦井 秀和; Takaharu Kimura; Tomomas...
  第87回日本血液学会学術集会/2025-10-10--2025-10-12
• 臍帯血由来造血幹細胞増幅技術の臨床応用への展望と課題
  錦井 秀和
  第49回日本血液事業学会総会/2025-10-28--2025-10-30
• ヘムサイトが診断に寄与したPMBL様の組織像を呈するDLBCLの1例
  宮越 歩; 槇島 健一; 末原 泰人; 佐々木 裕哉; 松岡 亮太; 松村 文明; 須摩 桜子; 服部 圭一朗; ...
  第24回 日本血液学会関東甲信越地方会/2026-03-21--2026-03-21
• 臍帯血移植後のBKウイルス（BKV）による難治性出血性膀胱炎に対してシドフォビルが著効した1例
  樽井 裕太朗; 佐々木 裕哉; 栗田 尚樹; 和田 迪子; 末原 泰人; 槇島 健一; 海江田 拓実; 風間 奈...
  第24回 日本血液学会関東甲信越地方会/2026-03-21--2026-03-21
• Timing of graft infection and the outcome of allogeneic hematopoietic stem cell transplantation
  原 浩ノ輔; 坂本 竜弘; 栗田 尚樹; 松村 文明; 槇島 健一; 須摩 桜子; 佐々木 裕哉; 末原 泰人; ...
  第48回 日本造血・免疫細胞療法学会総会/2026-02-27--2026-03-01
• A single-center retrospective analysis of allogeneic HSCT in elderly patients
  鳥居 優希; 栗田 尚樹; 松村 文明; 槇島 健一; 須摩 桜子; 佐々木 裕哉; 末原 泰人; 服部 圭一朗...
  第48回 日本造血・免疫細胞療法学会総会/2026-02-27--2026-03-01
• Impact of donor source on efficacy of letermovir after allogeneic HSCT: A single-center experience
  樽井裕太朗; 栗田 尚樹; 松村 文明; 須摩 桜子; 槇島 健一; 佐々木 裕哉; 末原 泰人; 服部 圭一朗; ...
  第48回 日本造血・免疫細胞療法学会総会/2026-02-27--2026-03-01
• Targeting T-cell receptor signaling in T cell lymphomas shaped by clonal hematopoiesis
  Suma Sakurako; SAKATA-YANAGIMOTO Mamiko; Yasuhito Suehara...
  The 2025 Cold Spring Harbor Asia Conference/2025-11-11--2025-11-14
• Two cases developing cutaneous squamous cell carcinoma during long-term voriconazole use
  Fumiaki Matsumura; Naoki Kurita; Tatsuhiro Sakamoto; Yuka...
  第87回日本血液学会学術集会/2025-10-10--2025-10-12
• Horse anti-thymocyte globulin for aplastic anemia patients: a single institute experience
  Shingo Tsuji; Tatsuhiro Sakamoto; Naoshi Obara; Kenichi ...
  第87回日本血液学会学術集会/2025-10-10--2025-10-12
• Monomorphic epitheliotropic intestinal T-cell lymphoma: a single institution case series
  Ayumi Miyakoshi; Yasuhito Suehara; Fumiaki Matsumura; Sak...
  第87回日本血液学会学術集会/2025-10-10--2025-10-12
• Effect of prophylactic dexamethasone on severe CRS and ICANS after Axi-cel infusion
  Toshihiro Miyakoshi; Kenichi Makishima; Fumiaki Matsumur...
  第87回日本血液学会学術集会/2025-10-10--2025-10-12
• Management of transient immune complex reaction during the switching of anti-C5 therapy in PNH
  小原 直; Shingo Tsuji; Tatsuhiro Sakamoto; Fumiaki Matsumur...
  第87回日本血液学会学術集会/2025-10-10--2025-10-12
• Clonal hematopoietic-derived microenvironment in T cell lymphoma treated with dasatinib
  Sakurako Suma; 坂田（柳元） 麻実子; Yasuhito Suehara; Takahide Ar...
  第87回日本血液学会学術集会/2025-10-10--2025-10-12
• Real-world use of immunoglobulin replacement therapy in multiple myeloma: a single-center study
  Shingo Tsuji; Takayasu Kato; Fumiaki Matsumura; Kenichi ...
  第87回日本血液学会学術集会/2025-10-10--2025-10-12
• Fine tuning of MPL signaling during self-renewal of HSCs using thrombopoietin receptor agonists
  Riko Kikuchi; Takao Yogo; 錦井 秀和; Takaharu Kimura; Tomomas...
  ISEH 54th Annual Scientific Meeting/2025-09-24--2025-09-27
• Retrospective Analysis of Medical Costs and Length of Initial Hospitalization Following Allogeneic Hematopoietic Stem Cell Transplantation
  Takarada Ayako; Kurita Naoki; Ishii Ryota; Matsumura Fum...
  The 9th Annual International Congress of Blood and Marrow Transplantation (ICBMT 2025)/2025-09-11--2025-09-13
• 骨髄塗抹標本の形態診断を補助するLBC法の有用性　がんの骨髄転移2症例の検討
  井上 真由; 加藤 貴康; 中川 智貴; 小山 諒太; 佐々木 裕哉; 錦井 秀和; 小原 直; 南木 融; 坂田（...
  第26回日本検査血液学会学術集会/2025-07-26--2025-07-27
• Impact of clonal hematopoietic-derived microenvironment in T-cell lymphomas on dasatinib treatment as an immunostimulatory agent
  Suma Sakurako; SAKATA-YANAGIMOTO Mamiko; Suehara Yasuhit...
  第29回日本がん免疫学会総会/2025-07-24--2025-07-26
• 自然消退した原発性皮膚B細胞性リンパ腫の1例
  橋川 諒; 槇島 健一; 松岡 亮太; 須摩 桜子; 佐々木 裕哉; 末原 泰人; 丸山 ゆみ子; ...
  第23回 日本血液学会関東甲信越地方会/2025-07-19--2025-07-19
• A retrospective analysis of ASCT conditioning with BUTT regimen for patients with CNS lymphomas in a single institute
  服部 圭一朗; 坂田（柳元） 麻実子; 栗田 尚樹; 松村 文明; 槇島 健一; 須摩 桜子; 佐々木...
  第65回日本リンパ腫学会学術集会・総会/2025-07-03--2025-07-05
• Identification of the heterogeneity of CAR-T cell infiltration by multi-region sampling
  Makishima Kenichi; Tarui Yutaro; Suma Sakurako; Abe Y...
  The 3rd JCA-AACR Precision Cancer Medicine International Conference/2025-06-28--2025-06-30
• ABO-Flow法を用いたABO不適合造血幹細胞移植後の赤血球造血動態の解明
  清木 祐介; 丸山 ゆみ子; 丸山 柚; 新井 裕介; 荻野 靖子; 末原 泰人; 佐々木 裕哉; ...
  第73回日本輸血・細胞治療学会学術総会/2025-05-31--2025-06-01
• 筑波大学附属病院における同種末梢血幹細胞採取時間における最適化の検討
  丸山 ゆみ子; 錦井 秀; 新井 裕介; 末原 泰人; 服部 圭一朗; 坂本 竜弘; 佐々木 裕哉; ...
  第73回日本輸血・細胞治療学会学術総会/2025-05-31--2025-06-01
• Cyclophosphamide monotherapy against graft-versus-host disease in BMT: A Phase I/II study
  Joyce Miki; Kurita Naoki; Mathis Bryan J.; Makishima ...
  The 15th JSH International Symposium 2025 in Saga/2025-05-16--2025-05-17
• more...

Teaching

2025-10 -- 2026-02	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2025-04 -- 2025-08	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2025-10 -- 2025-12	Outline of Internal Medicine	University of Tsukuba.
2026-01 -- 2026-02	Hematology for Beginners	University of Tsukuba.
2024-04 -- 2024-08	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2024-10 -- 2025-02	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2024-12 -- 2025-02	Hematology for Beginners	University of Tsukuba.
2024-10 -- 2024-12	Outline of Internal Medicine	University of Tsukuba.
2023-10 -- 2024-02	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2023-04 -- 2023-08	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
more...

Talks

• 造血幹細胞増幅技術の臨床応用への展望と課題
  錦井 秀和
  第30回日本輸血・細胞治療学会秋季シンポジウム/2023-10-26--2023-10-27

(Last updated: 2026-05-18)