OBARA Naoshi

Affiliation

Institute of Medicine

Official title

Professor

Research projects


造血不全における造血支持細胞異常と赤芽球島形成障害の解明	2021-04 -- 2024-03	OBARA Naoshi	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (C)	4,290,000Yen
特発性寒冷凝集素症に関連する異常クローンの解明	2019 -- 2020	OBARA Naoshi	Japan Blood Products Organization/Research Grant	300,000Yen
特発性寒冷凝集素症に関わる異常クローンの解明	2018 -- 2019	OBARA Naoshi	Japan Blood Products Organization/Research Grant	300,000Yen
Analysis of neural cell marker-expressing hematopoietic supporting cells in human bone marrow failure	2017-04 -- 2020-03	OBARA Naoshi	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (C)	4,550,000Yen
Unraveling bone marrow erythropoiesis niche	2015-04 -- 2017-03	CHIBA Shigeru	Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Exploratory Research
エリスロポエチン産生細胞および骨成型におけるNotchシグナルの解析	2015-04 -- 2016-03	OBARA Naoshi	Kidney Foundation, Japan/Research Grant	800,000Yen
エリスロポエチン産生細胞におけるNotchシグナルの解析	2014 -- 2015-03	OBARA Naoshi	Kidney Foundation, Japan/Research Grant	2,000,000Yen
エリスロポエチン産生細胞における神経系マーカーの発現・機能解析	2013 -- 2014-03	OBARA Naoshi	Kidney Foundation, Japan/Research Grant	800,000Yen
エリスロポエチン遺伝子のGATA転写因子による発現調節機構の解明	2011 -- 2012-03	OBARA Naoshi	Kidney Foundation, Japan/Research Grant
エリスロポエチン遺伝子の組織特異的遺伝子発現に関する研究	2010 -- 2011-03	OBARA Naoshi	Kidney Foundation, Japan/Research Grant
more...

Degree


2005-03	博士（医学）	筑波大学

Licenses and qualifications


	日本輸血・細胞治療学会認定医
	日本血液学会認定指導医
	日本血液学会認定専門医
	日本内科学総合内科専門医
	日本内科学会認定内科認定医
	医師免許証

Academic societies


-- (current)	日本輸血細胞治療学会
-- (current)	日本医学史
-- (current)	The Molecular Biology Society of Japan
-- (current)	日本造血幹細胞移植学会
-- (current)	THE JAPANESE SOCIETY OF HEMATOLOGY
-- (current)	THE JANPANESE SOCIETY OF INTERNAL MEDICINE

Articles

【進歩する貧血の治療法】発作性夜間ヘモグロビン尿症(PNH)
小原直
Pharma Medica/42(2)/pp.103-107, 2025-07
Tracking of Donor Erythropoiesis following ABO-Incompatible Allogeneic Hematopoietic Stem Cell Transplantation
Kiyoki Yusuke; Maruyama Yumiko; Maruyama Yuzuki; Arai ...
Transplantation and cellular therapy/32(4)/p.431.e1-431.e4, 2026-04-01
PubMed
Eltrombopag-induced clinically negligible negative bias in creatinine measurements using enzymatic assays
Oda Shun; Doki Kosuke; Obara Naoshi; Sakata-Yanagimoto...
Clinical chemistry and laboratory medicine, 2026-04-07
PubMed
Safety of Post-transplant Cyclophosphamide as a Single Agent for Graft-Versus-Host Disease Prophylaxis After Human Leukocyte Antigen (HLA)-Matched Transplantation With the Japanese Population: A Single-Center Phase Ⅰ/Ⅱ Study
Joyce Miki; Kurita Naoki; Mathis Bryan J; Makishima K...
Cureus/17(12), 2025-12-01
PubMed
Disease burden and treatment patterns of paroxysmal nocturnal hemoglobinuria in Japan: a real-world survey
Sakurai Masatoshi; Ueda Yasutaka; Obara Naoshi; Kroes ...
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2026-02-11
Long-term follow-up of patients with aplastic anemia enrolled in two phase 2/3 trials of immunosuppressive therapy plus romiplostim as a first-line treatment: Final report for up to 5 years
Lee Jong Wook; Hosokawa Kohei; Jang Jun Ho; Obara Nao...
BLOOD/146(1)/pp.3197-3198, 2025-11-03
Tumor necrosis factor from leukemic environment stimulates hematopoietic stem/progenitor cells toward megakaryocyte/myeloid lineage bias
Nishikii Hidekazu; Kikuchi Riko; Kimura Takaharu; Sait...
EXPERIMENTAL HEMATOLOGY/155, 2026-03
A retrospective analysis of autologous stem cell transplantation conditioning with reduced-dose busulfan/thiotepa for patients with central nervous system lymphomas at a single institution
Hattori Keiichiro; Kurita Naoki; Matsumura Fumiaki; Ma...
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2025-12-16
PubMed
Case report: Spontaneous remission of severe aplastic anemia mediated by mutant hematopoietic stem cells evading T-cell attack
Shiroshita Kohei; Zaimoku Yoshitaka; Kudo Himari; Obar...
FRONTIERS IN IMMUNOLOGY/16, 2025-10-01
COMMODORE 2: Crovalimab 2-year efficacy and safety in complement inhibitor-naïve patients with paroxysmal nocturnal haemoglobinuria
Kelly Richard; He Guangsheng; Brodsky Andres; Chai-Adi...
BRITISH JOURNAL OF HAEMATOLOGY/206, 2025-04
Evaluation of Delayed Initiation of Lenalidomide Maintenance Therapy After Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma
Kawamura Koji; Tsukada Nobuhiro; Kimura Shun-ichi; Kak...
HEMATOLOGICAL ONCOLOGY/43(5), 2025-08-17
Treatment burden in patients with paroxysmal nocturnal hemoglobinuria: an in-depth interview survey
Ueda Yasutaka; Obara Naoshi; Ueno Shikiko; Sakurai Ma...
ANNALS OF HEMATOLOGY, 2025-07-18
Dynamics of Red Blood Cell Hematopoiesis Following ABO-Incompatible Allogeneic Hematopoietic Stem Cell Transplantation
Kiyoki Yusuke; Maruyama Yumiko; Maruyama Yuzuki; Arai ...
BLOOD/144(1)/pp.7102-7103, 2024-11-05
Real-World Data on the p.Gly17Val RHOA Mutation in Diagnosing T Follicular Helper Cell Lymphomas
Tsuboi Yuri; Hattori Keiichiro; Kurita Naoki; Suehara ...
Cancer medicine/14(9), 2025-05-01
PubMed
血中タクロリムス濃度の個体内変動が造血幹細胞移植後の移植片対宿主病発症に及ぼす影響（会議録）
森山侑太; 鈴木嘉治; 坂本竜弘; 末原泰人; 栗田尚樹; 錦井秀和; 小原　直; 坂田 ...
Organ Biology/31(3)/p.105, 2024-10
[Current trends in the treatment of aplastic anemia]
Obara Naoshi
[Rinsho ketsueki] The Japanese journal of clinical hematology/65(6)/pp.514-520, 2024-04-01
PubMed
Eltrombopag-Induced Falsely Elevated Bilirubin Concentrations in Enzymatic and Vanadate Oxidation Assays: Involvement of High Serum Eltrombopag Concentrations
Oda Shun; Doki Kosuke; Obara Naoshi; Suzuki Yoshiharu...
Therapeutic drug monitoring/47(5)/pp.635-640, 2025-02-05
PubMed
[Successful BTK inhibitor therapy for refractory transformed B-cell lymphoma originating from an MYD88 mutant clone]
Uehara Atsushi; Nishikii Hidekazu; Suehara Yasuhito; M...
[Rinsho ketsueki] The Japanese journal of clinical hematology/65(11)/pp.1368-1374, 2024-11
PubMed
環状鉄芽球と血小板増加を伴う骨髄異形成/骨髄増殖性腫瘍の形態学的および臨床的特徴と新規SF3B1変異解析法の樹立
小山諒太; 加藤貴康; 南木融; 井上真由; 国井拓弥; 山崎慎介; 神田智之; 大木...
日本検査血液学会雑誌/25(2)/pp.242-250, 2024-07
A Case of Multiple Myeloma in a Patient with Birt-Hogg-Dube Syndrome
Matsumura Fumiaki; Sakamoto Tatsuhiro; Kai Hirayasu; U...
INTERNAL MEDICINE, 2025-03-15
PubMed
Phase III Randomized COMMODORE 2 Trial: 2-Year Efficacy and Safety of Crovalimab in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Naive to Complement Inhibition
Roeth Alexander; He Guangsheng; Brodsky Andres; Chai-A...
BLOOD/144(1)/pp.2687-2689, 2024-11-05
Long-Term Follow-up of Patients with Aplastic Anemia Enrolled in Phase 2/3 Trials of Immunosuppressive Therapy Plus Romiplostim As a First-Line Treatment: Two-Year Interim Analysis
Hosokawa Kohei; Lee Jong Wook; Jang Jun Ho; Obara Nao...
BLOOD/144(1)/pp.1310-1311, 2024-11-05
Beyond Recycling Antibodies: Crovalimab's Molecular Design Enables Four-Weekly Subcutaneous Injections for PNH Treatment
Sampei Zenjiro; Haraya Kenta; Gan Siok Wan; Muraoka M...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/25(21), 2024-11
Long-term safety and effectiveness of romiplostim for chronic idiopathic thrombocytopenic purpura in real-world settings
Obara Naoshi; Hatanaka Shigeki; Tsuji Yukie; Higashi ...
INTERNATIONAL JOURNAL OF HEMATOLOGY/120(6)/pp.665-974, 2024-09-29
Phase 3 randomized COMMODORE 2 trial: Crovalimab versus eculizumab in patients with paroxysmal nocturnal hemoglobinuria naive to complement inhibition
Roeth Alexander; He Guangsheng; Tong Hongyan; Lin Zen...
AMERICAN JOURNAL OF HEMATOLOGY/99(9)/pp.1768-1777, 2024-06
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Books

第２章症例で理解するPNH診療　症例16 抗C5療法が効果不十分と考えられ、イプタコパンへの変更が有効であった症例
小原直; 坂本竜弘
発作性夜間ヘモグロビン尿症症例集　20症例で読み解くPNH診断・治療アプローチ/診断と治療社/pp.103-107, 2026-03
第２章症例で理解するPNH診療　症例3 再生不良性貧血の経過中にPNHクローン拡大と脳静脈洞血栓症をきたし、C5阻害薬とCFD阻害薬併用による抗補体療法が奏功した一例
坂本竜弘; 小原直
発作性夜間ヘモグロビン尿症症例集　20症例で読み解くPNH診断・治療アプローチ/診断と治療社/pp.31-36, 2026-03
Ⅱ赤血球の異常　1.貧血　（3）巨赤芽球性貧血　6）ホルムイミノトランスフェラーゼ欠損症
小原直
別冊血液症候群I 血液症候群(第3版)-その他の血液疾患を含めて-/日本臨床社/pp.100-102, 2023-09
Ⅱ赤血球の異常　1.貧血　（3）巨赤芽球性貧血　3）Imerslund-Graesbeck症候群
小原直
別冊血液症候群I 血液症候群(第3版)-その他の血液疾患を含めて-/日本臨床社/pp.88-90, 2023-09
Ⅱ赤血球の異常　1.貧血　（3）巨赤芽球性貧血　2）若年性悪性貧血
小原直
別冊血液症候群I 血液症候群(第3版)-その他の血液疾患を含めて-/日本臨床社/pp.85-87, 2023-09
Ⅳ赤血球系疾患　巨赤芽球性貧血
小原直
血液疾患のすべて　生涯教育シリーズ102　日本医師会雑誌　第151巻　特別号（1）/日本医師会/pp.181-183, 2022-06
Ⅲ赤血球系疾患　1貧血総論と各種貧血へのアプローチ
小原直
専門医のための血液病学/医学書院/pp.62-64, 2022-03
Ⅱ.赤血球系疾患　10.腎性貧血
小原直
EBM　血液疾患の治療　2019-2020/中外医学社/pp.69-74, 2018-10
Use of gene-manipulated mice in the study of Erythropoietin gene expression
Suzuki Norio; Obara Naoshi; Yamamoto Masayuki
OXYGEN BIOLOGY AND HYPOXIA/ELSEVIER ACADEMIC PRESS INC/pp.157-0, 2007-01

Conference, etc.

2-y efficacy and safety of crovalimab (crova) for patients (pts) with PNH in the COMMODORE 2 trial
Jun-ichi Nishimura; Alexander Roth; Guangsheng He; Andres...
第87回日本血液学会学術集会/2025-10-10--2025-10-12
Long-term safety of romiplostim in refractory aplastic anemia: A specified drug-use survey
Mitsuhiro Itagaki; Moe Matsuura; Masaki Fujita; Tomoharu ...
第87回日本血液学会学術集会/2025-10-10--2025-10-12
ヘムサイトが診断に寄与したPMBL様の組織像を呈するDLBCLの1例
宮越歩; 槇島健一; 末原泰人; 佐々木裕哉; 松岡亮太; 松村文明; 須摩桜子; 服部圭一朗; ...
第24回日本血液学会関東甲信越地方会/2026-03-21--2026-03-21
Timing of graft infection and the outcome of allogeneic hematopoietic stem cell transplantation
原浩ノ輔; 坂本竜弘; 栗田尚樹; 松村文明; 槇島健一; 須摩桜子; 佐々木裕哉; 末原泰人; ...
第48回日本造血・免疫細胞療法学会総会/2026-02-27--2026-03-01
A single-center retrospective analysis of allogeneic HSCT in elderly patients
鳥居優希; 栗田尚樹; 松村文明; 槇島健一; 須摩桜子; 佐々木裕哉; 末原泰人; 服部圭一朗...
第48回日本造血・免疫細胞療法学会総会/2026-02-27--2026-03-01
Impact of donor source on efficacy of letermovir after allogeneic HSCT: A single-center experience
樽井裕太朗; 栗田尚樹; 松村文明; 須摩桜子; 槇島健一; 佐々木裕哉; 末原泰人; 服部圭一朗; ...
第48回日本造血・免疫細胞療法学会総会/2026-02-27--2026-03-01
2-year efficacy and safety of crovalimab (crova) self administration (SA) in the COMMODORE 2 trial
小原直; Alexander Roeth; Guangsheng He; Andres Brodsky; Cha...
第87回日本血液学会学術集会/2025-10-10--2025-10-12
Two cases developing cutaneous squamous cell carcinoma during long-term voriconazole use
Fumiaki Matsumura; Naoki Kurita; Tatsuhiro Sakamoto; Yuka...
第87回日本血液学会学術集会/2025-10-10--2025-10-12
Horse anti-thymocyte globulin for aplastic anemia patients: a single institute experience
Shingo Tsuji; Tatsuhiro Sakamoto; Naoshi Obara; Kenichi ...
第87回日本血液学会学術集会/2025-10-10--2025-10-12
Monomorphic epitheliotropic intestinal T-cell lymphoma: a single institution case series
Ayumi Miyakoshi; Yasuhito Suehara; Fumiaki Matsumura; Sak...
第87回日本血液学会学術集会/2025-10-10--2025-10-12
Effect of prophylactic dexamethasone on severe CRS and ICANS after Axi-cel infusion
Toshihiro Miyakoshi; Kenichi Makishima; Fumiaki Matsumur...
第87回日本血液学会学術集会/2025-10-10--2025-10-12
Management of transient immune complex reaction during the switching of anti-C5 therapy in PNH
小原直; Shingo Tsuji; Tatsuhiro Sakamoto; Fumiaki Matsumur...
第87回日本血液学会学術集会/2025-10-10--2025-10-12
Real-world use of immunoglobulin replacement therapy in multiple myeloma: a single-center study
Shingo Tsuji; Takayasu Kato; Fumiaki Matsumura; Kenichi ...
第87回日本血液学会学術集会/2025-10-10--2025-10-12
Retrospective Analysis of Medical Costs and Length of Initial Hospitalization Following Allogeneic Hematopoietic Stem Cell Transplantation
Takarada Ayako; Kurita Naoki; Ishii Ryota; Matsumura Fum...
The 9th Annual International Congress of Blood and Marrow Transplantation (ICBMT 2025)/2025-09-11--2025-09-13
骨髄塗抹標本の形態診断を補助するLBC法の有用性　がんの骨髄転移2症例の検討
井上真由; 加藤貴康; 中川智貴; 小山諒太; 佐々木裕哉; 錦井秀和; 小原直; 南木融; 坂田（...
第26回日本検査血液学会学術集会/2025-07-26--2025-07-27
自然消退した原発性皮膚B細胞性リンパ腫の1例
橋川諒; 槇島健一; 松岡亮太; 須摩桜子; 佐々木裕哉; 末原泰人; 丸山ゆみ子; ...
第23回日本血液学会関東甲信越地方会/2025-07-19--2025-07-19
A retrospective analysis of ASCT conditioning with BUTT regimen for patients with CNS lymphomas in a single institute
服部圭一朗; 坂田（柳元）麻実子; 栗田尚樹; 松村文明; 槇島健一; 須摩桜子; 佐々木...
第65回日本リンパ腫学会学術集会・総会/2025-07-03--2025-07-05
Treatment burden in patients with paroxysmal nocturnal hemoglobinuria (PNH) treated with intravenous C5 inhibitors: an in-depth interview survey study
OBARA Naoshi; Ueda Yasutaka; Ueno Shikiko; Sakurai Ma...
The EHA 2025 Congress/2025-06-12--2025-06-15
ABO-Flow法を用いたABO不適合造血幹細胞移植後の赤血球造血動態の解明
清木祐介; 丸山ゆみ子; 丸山柚; 新井裕介; 荻野靖子; 末原泰人; 佐々木裕哉; ...
第73回日本輸血・細胞治療学会学術総会/2025-05-31--2025-06-01
筑波大学附属病院における同種末梢血幹細胞採取時間における最適化の検討
丸山ゆみ子; 錦井秀; 新井裕介; 末原泰人; 服部圭一朗; 坂本竜弘; 佐々木裕哉; ...
第73回日本輸血・細胞治療学会学術総会/2025-05-31--2025-06-01
Cyclophosphamide monotherapy against graft-versus-host disease in BMT: A Phase I/II study
Joyce Miki; Kurita Naoki; Mathis Bryan J.; Makishima ...
The 15th JSH International Symposium 2025 in Saga/2025-05-16--2025-05-17
同種造血幹細胞移植における医療費および入院期間の後方視的解析
宝田亜矢子; 栗田尚樹; 石井亮太; 服部圭一朗; 坂本竜弘; 加藤貴康; 小原直; ...
第122回日本内科学会総会/2025-04-18--2025-04-20
Long-term follow-up of patients with aplastic anemia enrolled in two phase 2/3 trials of immunosuppressive therapy plus romiplostim as a first-line treatment: Final report for up to 5 years
Lee Jong Wook; Hosokawa Kohei; Jang Jun Ho; Obara Nao...
67th Annual Meeting of the American-Society-of-Hematology (ASH)/2025-12-06--2025-12-09
COMMODORE 2: Crovalimab 2-year efficacy and safety in complement inhibitor-naïve patients with paroxysmal nocturnal haemoglobinuria
Kelly Richard; He Guangsheng; Brodsky Andres; Chai-Adi...
65th Annual Scientific Meeting of the British-Society-for-Haematology/2025-04-27--2025-04-29
Dynamics of Red Blood Cell Hematopoiesis Following ABO-Incompatible Allogeneic Hematopoietic Stem Cell Transplantation
Kiyoki Yusuke; Maruyama Yumiko; Maruyama Yuzuki; Arai ...
66th Annual Meeting of the American-Society-of-Hematology (ASH)/2024-12-7--2024-12-10
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Teaching


2025-10 -- 2025-11	Clinical Pathophysiology	University of Tsukuba.
2025-10 -- 2026-02	Lecture and Discussion in Internal Medicine II	University of Tsukuba.
2025-04 -- 2025-08	Lecture and Discussion in Internal Medicine I	University of Tsukuba.
2025-10 -- 2026-02	Practice in Internal Medicine II	University of Tsukuba.
2025-04 -- 2025-08	Practice in Internal Medicine I	University of Tsukuba.
2025-10 -- 2026-02	Seminar in Internal Medicine II	University of Tsukuba.
2025-04 -- 2025-08	Seminar in Internal Medicine I	University of Tsukuba.
2025-10 -- 2026-02	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2025-04 -- 2025-08	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2025-10 -- 2025-11	Clinical Practice in Laboratories	University of Tsukuba.
more...

Professional activities


2018 -- 2020	THE JAPANESE SOCIETY OF HEMATOLOGY	専門医委員会
2017 -- 2019	THE JAPANESE SOCIETY OF HEMATOLOGY	診療委員会

(Last updated: 2026-05-18)