SHIRAKI Kentaro
- Affiliation
- Institute of Pure and Applied Sciences
- Official title
- Professor
- URL
- Research keywords
Solution effect Additives in protein solution Viscosity of protein solution Stabilization of protein Liquid-liquid phase separation Protein folding Control of enzyme reaction Phasing biology Protein solution Protein aggregation more... - Research projects
酵素の本来の活性を引き出す天然溶媒の設計 2024 -- 2026 Shiraki Kentaro Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B) 18,460,000Yen アミロイド形成を理解する相分離仮説の実証と共溶質の開発 2022 -- 2023 白木 賢太郎 Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Research (Exploratory) 6,500,000Yen 液-液相分離によるタンパク質安定化技術の開発 2019 -- 2020 白木 賢太郎 Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Research (Exploratory) 6,500,000Yen タンパク質液-液相分離の低分子コントロール 2018 -- 2020 白木 賢太郎 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B) 17,810,000Yen タンパク質の凝集や失活を防ぐ高分子アディティブの開発 2011 -- 2013 Japan Society of for the Promotion of Science/基盤研究(C) 3,770,000Yen タンパク質の凝集や失活をふせぐ溶液デザイン法の確立 2006 -- 2007 Japan Society of for the Promotion of Science/若手研究(B) 3,800,000Yen タンパク質凝集を抑制する小分子の探索 2005 -- (current) Japan Society of for the Promotion of Science/若手研究(B) 400,000Yen - Career history
1996-04 -- 1999-03 JSPSResearch Fellow 1999-04 -- 2001-07 CRESTPost Doctral Fellow 2001-08 -- 2004-08 Japan Advanced Institute of Science and TechnologyAssociate 2004-09 -- 2007-03 University of TsukubaInstitute of Applied PhysicsAssociate Professor 2007-04 -- 2016-11 University of TsukubaFaculty of Pure and Applied SciencesAssociate Professor 2016-12 -- (current) University of TsukubaFaculty of Pure and Applied SciencesProfessor - Academic background
-- 1994-03 Osaka University Faculty of Science Department of Biology -- 1999-03 Osaka University Graduate School of Science Department of Biochemistry - Degree
Ph. D. Osaka University - Academic societies
-- (current) Chemical Society of Japan -- (current) PROTEIN SCIENCE SOCIETY OF JAPAN - Articles
- 【再定義されるタンパク質の常識 古典的なセントラルドグマの刷新と未開拓のタンパク質の世界】液-液相分離による酵素連続反応 細胞内にある代謝の理解
浦 朋人; 白木 賢太郎
実験医学/37(18)/pp.3083-3088, 2019-11 - Activation of oxidoreductases by the formation of enzyme assembly
Ura Tomoto; Sakakibara Nanako; Hirano Yu; Tamada Taro...
SCIENTIFIC REPORTS/13(1), 2023-09-01 - Synthesis of Butterfly-Like Shaped Gold Nanomaterial: For the Regulation of Liquid-Liquid Phase-Separated Biomacromolecule Droplets
Nobeyama Tomohiro; Tataka Koji; Mori Megumi; Murakami ...
SMALL/19(49), 2023-12 - Cationic polyelectrolytes prevent the aggregation of L-lactate dehydrogenase under unstable conditions
Yoshida Toya; Sakakibara Nanako; Ura Tomoto; Minamiki ...
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES/257(1), 2024-02 - In vitro construction of enzyme assemblies that enhance enzyme activity
Ura Tomoto; Sakakibara Nanako; Yagi Hiromasa; Tochio ...
PROTEIN SCIENCE/32(12), 2023-12 - Interfacial and intrinsic molecular effects on the phase separation/ transition of heteroprotein condensates
Nobeyama Tomohiro; Yoshida Toya; Shiraki Kentaro
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES/254(3), 2024-01 - Phase-Diagram Observation of Liquid-Liquid Phase Separation in the Poly(l-lysine)/ATP System and a Proposal for Diagram-Based Application Strategy
Nobeyama Tomohiro; Furuki Tomohiro; Shiraki Kentaro
LANGMUIR/39(48)/pp.17043-17049, 2023-11-15 - Detection of Fibril Nucleation in Micrometer-Sized Protein Condensates and Suppression of Sup35NM Fibril Nucleation by Liquid-Liquid Phase Separation
Fukuyama Mao; Nishinami Suguru; Maruyama Yoko; Ozawa ...
ANALYTICAL CHEMISTRY/95(26)/pp.9855-9862, 2023-06-22 - Chromatographic purification of histidine-tagged proteins using zirconia particles modified with phosphate groups
Kanoh Shogo; Shiraki Kentaro; Wada Momoyo; Tanaka Tak...
JOURNAL OF CHROMATOGRAPHY A/1703, 2023-08-16 - Selective and high-capacity binding of immunoglobulin G to zirconia nanoparticles modified with phosphate groups
Hirano Atsushi; Kanoh Shogo; Shiraki Kentaro; Wada Mo...
COLLOIDS AND SURFACES B-BIOINTERFACES/226, 2023-06 - Heat treatment in the presence of arginine increases the emulsifying properties of soy proteins
Kano Hiroshi; Shiraki Kentaro
FOOD CHEMISTRY-X/17, 2023-03-30 - Transient formation of multi-phase droplets caused by the addition of a folded protein into complex coacervates with an oppositely charged surface relative to the protein
Sakakibara Nanako; Ura Tomoto; Mikawa Tsutomu; Sugai ...
SOFT MATTER/19(25)/pp.4642-4650, 2023-06 - Dense and Acidic Organelle-Targeted Visualization in Living Cells: Application of Viscosity-Responsive Fluorescence Utilizing Restricted Access to Minimum Energy Conical Intersection
Adachi Junya; Oda Haruka; Fukushima Toshiaki; Lestari ...
ANALYTICAL CHEMISTRY/95(12)/pp.5196-5204, 2023-03 - Activation of L-lactate oxidase by the formation of enzyme assemblies through liquid-liquid phase separation
Ura Tomoto; Kagawa Ako; Sakakibara Nanako; Yagi Hirom...
SCIENTIFIC REPORTS/13(1), 2023-01 - The pH-responsive precipitation-redissolution of the CspB fusion protein, CspB50TEV-Teriparatide, triggered by changes in secondary structure
Nagano Hayato; Mannen Teruhisa; Kikuchi Yoshimi; Shira...
BIOCHEMISTRY AND BIOPHYSICS REPORTS/33, 2023-03 - Synthesis of Butterfly-like Shape Gold Nanomaterial: For the Regulation of Liquid–Liquid Phase-Separated Biomacromolecule Droplets
延山智弘; Tanaka Koji; Mori Megumi; Murakami Tatsuya; Yama...
Small, 2023/8/18 - Proteome analysis of high affinity mouse saliva proteins to hydroxyapatite
Ohshima Keijiro; Ohshima Tomoko; Meyer Karen; Takai E...
HELIYON/8(8), 2022-08 - Affinity of phenolic compounds for transition metal ions immobilized on cation-exchange columns
Ura Tomoto; Kameda Tomoshi; Laksmi Fina A.; Ishibashi ...
JOURNAL OF CHROMATOGRAPHY A/1676, 2022-08 - Arginine and its Derivatives Suppress the Opalescence of an Antibody Solution
Oki Shogo; Nishinami Suguru; Nakauchi Yoshitaka; Ogura...
JOURNAL OF PHARMACEUTICAL SCIENCES/111(4)/pp.1126-1132, 2022-04 - Differences in interaction lead to the formation of different types of insulin amyloid
Mori Wakako; Kawakami Ryosuke; Niko Yosuke; Haruta To...
SCIENTIFIC REPORTS/12(1), 2022-05 - Solution design to extend the pH range of the pH-responsive precipitation of a CspB fusion protein
Nagano Hayato; Mannen Teruhisa; Kikuchi Yoshimi; Shira...
PROTEIN EXPRESSION AND PURIFICATION/195, 2022-08 - Damage-free evaluation of cultured cells based on multivariate analysis with a single-polymer probe
Sugai Hiroka; Tomita Shunsuke; Ishihara Sayaka; Shiraki ...
Chemical Communications/58(79)/pp.11083-11086, 2022-10 - Opalescence Arising from Network Assembly in Antibody Solution
Nakauchi Yoshitaka; Nishinami Suguru; Murakami Yusuke; ...
MOLECULAR PHARMACEUTICS/19(4)/pp.1160-1167, 2022-04 - Lowering the viscosity of a high-concentration antibody solution by protein-polyelectrolyte complex
Tsumura Keisuke; Hsu WeiLin; Mimura Masahiro; Horiuchi...
JOURNAL OF BIOSCIENCE AND BIOENGINEERING/133(1)/pp.17-24, 2022-01 - Classification of protein solubilizing solutes by fluorescence assay
Nishinami Suguru; Arakawa Tsutomu; Shiraki Kentaro
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES/203/pp.695-702, 2022-04 - more...
- 【再定義されるタンパク質の常識 古典的なセントラルドグマの刷新と未開拓のタンパク質の世界】液-液相分離による酵素連続反応 細胞内にある代謝の理解
- Books
- 酵素反応と液-液相分離
浦 朋人 ; 白木 賢太郎 *
相分離生物学の全貌/白木 賢太郎編, 東京化学同人, 2020-11 - 相分離生物学
白木 賢太郎
東京化学同人, 2019-08 - Terahertz Spectroscopic Study of Ion Effects on Protein Hydration
Hattori Toshiaki; Aoki Katsuyoshi; Shiraki Kentaro
2015 40TH INTERNATIONAL CONFERENCE ON INFRARED, MILLIMETER AND TERAHERTZ WAVES (IRMMW-THZ)/IEEE, 2015 - 生物科学入門
白木賢太郎
東京化学同人, 2009-12 - Synergistic effect of polyethylene glycol with arginine on the prevention of heat-induced aggregation of lysozyme - art. no. 012022
Tomita Shunsuke; Hamada Hiroyuki; Nagasaki Yukio; Shiraki...
SECOND INTERNATIONAL SYMPOSIUM ON ATOMIC TECHNOLOGY/IOP PUBLISHING LTD/pp.12022-12022, 2008-01
- 酵素反応と液-液相分離
- Conference, etc.
- 液滴内で活性化される酵素の反応機構
浦 朋人; 白木 賢太郎
日本細胞生物学会大会(Web)/2019 - Activation of oxidoreductase by Polyelectrolytes
榊原 菜々子; 浦 朋人; 白木 賢太郎; 美川 務
日本分子生物学会年会プログラム・要旨集(Web)/2022 - カチオン性高分子電解質の添加によるL-乳酸脱水素酵素の凝集抑制と活性維持
吉田 桃也; 榊原 菜々子; 浦 朋人; 白木 賢太郎
日本蛋白質科学会年会プログラム・要旨集/2023 - In vitro construction of enzyme assemblies by liquid-liquid phase separation
URA Tomoto; TOMITA Shunsuke; SAKAKIBARA Nanako; YAGI ...
日本蛋白質科学会年会プログラム・要旨集/2023 - 液-液相分離と酵素連続反応
浦 朋人; 白木 賢太郎
第1回LLPS研究会/2018-08-31 - 酵素連続反応と液–液相分離
浦 朋人; 白木 賢太郎
第6回蛋白質工学研究会ワークショップ 蛋白質医薬における相分離現象の理解と産業利用可能性/2020-09-04 - Enzyme activation of L-lactate oxidase by liquid droplets
浦 朋人; 香川 亜子; 八木 宏昌; 栃尾 尚哉; 木川 隆則; 美川 務; 白木 賢太郎
第21回日本蛋白質科学会年会 ワークショップ タンパク質の液液相分離―計測、制御、応用/2021-06-17 - 酵素反応と連動した液滴の動的挙動
浦 朋人; 冨田 峻介; 白木 賢太郎
第94回日本生化学大会 シンポジウム 相分離メガネを通して見た酵素の機能/2021-11-05 - 酵素連続反応と連動した液滴の動的挙動
浦 朋人; 冨田 峻介; 白木 賢太郎
第44回日本分子生物学会年会 ワークショップ 液-液相分離の酵素連続反応に対する効果/2021-12-01 - In vitro construction of enzyme assemblies that enhance enzyme activity
Ura Tomoto; Sakakibara Nanako; Yagi Hiromasa; Tochio ...
37th Annual Meeting of The-Protein-Society (TPS)/2023-07-13--2023-07-16 - Ultrafast Vibrational Energy Transfer from Photoexcited Carbon Nanotubes to Proteins
Nakayama Tomohito; Yoshizawa Shunsuke; Hirano Atsushi; ...
21st International Conference on Ultrafast Phenomena (UP)/2018-07-15--2018-07-20 - Fractal dimension, persistent homology dimension, and fractal dynamics in the terahertz region: the case of protein lysozyme
Mori Tatsuya; Fujii Yasuhiro; Kitani Suguru; Yamamoto Yo...
Materials Research Meeting 2019 (MRM 2019)/2019-12-10--2019-12-14 - Terahertz Spectroscopy on Myoglobin: Boson Peak and Fracton
Mori Tatsuya; Motoji Leona; Fujii Yasuhiro; Kitani Sugur...
IRMMW-THz 2019 (44th International Conference on Infrared, Millimeter and Terahertz Waves)/2019-09-01--2019-09-06 - Terahertz Spectroscopic Study on Protein Myoglobin: Polymer-Like Behavior of Vibrational Density of States
Motoji Leona; Mori Tatsuya; Fujii Yasuhiro; Koreeda Akit...
APS March Meeting 2019/2019-03-04--2019-03-08 - Terahertz time-domain spectroscopy of lyophilized protein lysozyme
Mori Tatsuya; Fujii Yasuhiro; Jiang Yue; Motoji Leona; Ki...
TGSW2018 (Tsukuba Global Science Week 2018)/2018-09-20--2018-09-22 - Detection of fractal dynamics of protein by terahertz spectroscopy
Mori Tatsuya; Fujii Yasuhiro; Jiang Yue; Motoji Leona; Te...
EUCMOS 2018 (XXXIV EUROPEAN CONGRESS ON MOLECULAR SPECTROSCOPY)/2018-08-19--2018-08-24 - Ultrafast Vibrational Energy Transfer from Photoexcited Carbon Nanotubes to Proteins
Nakayama Tomohito; Yoshizawa Shunsuke; Hirano Atsushi; Ta...
XXI International Conference on Ultrafast Phenomena 2018 (UP 2018)/2018-07-15--2018-07-20 - Terahertz Time-Domain Spectroscopy of Protein Myoglobin: Detection of Boson Peak and Fracton
Motoji Leona; Mori Tatsuya; Fujii Yasuhiro; Koreeda A...
43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)/2018-09-09--2018-09-14 - Detection of Boson Peak and Fractal Dynamics of Protein by Terahertz Time-Domain Spectroscopy
Mori Tatsuya; Jiang Yue; Fujii Yasuhiro; Kitani Sugur...
43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)/2018-09-09--2018-09-14 - Hydration of aqueous polymers investigated by terahertz spectroscopy and principal component analysis
Aoki Katsuyoshi; Hata Ryusuke; Kaneyasu Junya F.; Schwaab...
2018 43rd International Conference on Infrared, Millimeter and Terahertz Waves/2018-09-09--2018-09-14 - カーボンナノチューブ - 蛋白質複合体内の超高速振動エネルギー移動
中山 智仁; 吉澤俊祐; 平野 篤; 田中 丈士; 白木 賢太郎; 長谷 宗明
2018年第65回応用物理学会春季学術講演会/2018-03-17--2018-03-20 - テラヘルツ帯赤外・ラマン分光によるリゾチームのボゾンピークおよびフラクトンダイナミクス
姜 越; 森 龍也; 藤井 康裕; 是枝 聡肇; 山本 洋平; 白木 賢太郎; 小島 誠治
日本セラミックス協会 第30回秋季シンポジウム/2017-09-19--2017-09-21 - Boson peak and fractal dynamics study of protein keratin
Motoji Leona; Mori Tatsuya; Jiang Yue; Yoshizawa Shunsuk...
TGSW-IWP2017 (TGSW-Interdisciplinary Workshop on Science and Patents 2017)/2017-09-26--2017-09-26 - Boson peak and facton behavior of lysozyme
Jiang Yue; Mori Tatsuya; Fujii Yasuhiro; Motoji Leona; Yo...
TGSW-IWP2017 (TGSW-Interdisciplinary Workshop on Science and Patents 2017)/2017-09-26--2017-09-26 - A Study of Boson Peak and Fracton in Protein Lysozyme by Terahertz Time-domain Spectroscopy
Jiang Yue; Mori Tatsuya; Fujii Yasuhiro; Kitani Suguru; Y...
APS March Meeting 2018/2018-03-05--2018-03-09 - more...
- 液滴内で活性化される酵素の反応機構
- Intellectural property rights
- 蛋白質を含む液状組成物中における蛋白質の安定化方法
Shiraki Kentaro - 水系溶媒中へのカーボンナノチューブの分散方法
Shiraki Kentaro
- 蛋白質を含む液状組成物中における蛋白質の安定化方法
- Teaching
2024-04 -- 2024-08 Research in MI VA University of Tsukuba. 2024-04 -- 2024-08 Joint Seminar IIIA University of Tsukuba. 2024-10 -- 2025-02 Research in IMI VB University of Tsukuba. 2024-10 -- 2025-02 Joint Seminar VA University of Tsukuba. 2024-12 -- 2025-02 Linear Algebra 3 University of Tsukuba. 2024-10 -- 2025-02 Research in MI IVA University of Tsukuba. 2024-04 -- 2024-09 Research Paper Presentation Workshop in IDE II University of Tsukuba. 2024-10 -- 2025-03 Internship III University of Tsukuba. 2024-10 -- 2025-02 Joint Seminar IIIA University of Tsukuba. 2024-10 -- 2025-02 Research in MI IIIA University of Tsukuba. more... - Talks
- Protein Aggregation Technology
Shiraki Kentaro
企業現場のニーズと先端蛋白質科学との接点を探るシンポジウム/2016-11-16--2016-11-16
- Protein Aggregation Technology
(Last updated: 2024-08-08)