OBARA Naoshi

Affiliation

Institute of Medicine

Official title

Professor

Research projects


造血不全における造血支持細胞異常と赤芽球島形成障害の解明	2021-04 -- 2024-03	OBARA Naoshi	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (C)	4,290,000Yen
特発性寒冷凝集素症に関連する異常クローンの解明	2019 -- 2020	OBARA Naoshi	Japan Blood Products Organization/Research Grant	300,000Yen
特発性寒冷凝集素症に関わる異常クローンの解明	2018 -- 2019	OBARA Naoshi	Japan Blood Products Organization/Research Grant	300,000Yen
Analysis of neural cell marker-expressing hematopoietic supporting cells in human bone marrow failure	2017-04 -- 2020-03	OBARA Naoshi	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (C)	4,550,000Yen
Unraveling bone marrow erythropoiesis niche	2015-04 -- 2017-03	CHIBA Shigeru	Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Exploratory Research
エリスロポエチン産生細胞および骨成型におけるNotchシグナルの解析	2015-04 -- 2016-03	OBARA Naoshi	Kidney Foundation, Japan/Research Grant	800,000Yen
エリスロポエチン産生細胞におけるNotchシグナルの解析	2014 -- 2015-03	OBARA Naoshi	Kidney Foundation, Japan/Research Grant	2,000,000Yen
エリスロポエチン産生細胞における神経系マーカーの発現・機能解析	2013 -- 2014-03	OBARA Naoshi	Kidney Foundation, Japan/Research Grant	800,000Yen
エリスロポエチン遺伝子のGATA転写因子による発現調節機構の解明	2011 -- 2012-03	OBARA Naoshi	Kidney Foundation, Japan/Research Grant
エリスロポエチン遺伝子の組織特異的遺伝子発現に関する研究	2010 -- 2011-03	OBARA Naoshi	Kidney Foundation, Japan/Research Grant
more...

Degree


2005-03	博士（医学）	筑波大学

Licenses and qualifications


	日本輸血・細胞治療学会認定医
	日本血液学会認定指導医
	日本血液学会認定専門医
	日本内科学総合内科専門医
	日本内科学会認定内科認定医
	医師免許証

Academic societies


-- (current)	日本輸血細胞治療学会
-- (current)	日本医学史
-- (current)	The Molecular Biology Society of Japan
-- (current)	日本造血幹細胞移植学会
-- (current)	THE JAPANESE SOCIETY OF HEMATOLOGY
-- (current)	THE JANPANESE SOCIETY OF INTERNAL MEDICINE

Articles

Burden of illness in Japanese patients with paroxysmal nocturnal hemoglobinuria receiving C5 inhibitors
Obara Naoshi; Usuki Kensuke; Hayashi Takeshi; Fujii M...
INTERNATIONAL JOURNAL OF HEMATOLOGY/119(3)/pp.255-264, 2024-01-19
PubMed
Impact of CD34 positive cell dose in donor graft on the outcomes after haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide - A retrospective single-center study with a Japanese cohort
Maruyama Yumiko; Nishikii Hidekazu; Kurita Naoki; Saka...
Blood cells, molecules & diseases/105, 2023-12-30
PubMed
同種造血幹細胞移植により長期寛解を得たCLEC16A::IL2融合遺伝子を有するT細胞前リンパ球性白血病
百瀬春佳; 栗田尚樹; 錦井秀和; 遊佐希; 横山和明; 清水英吾; 井元清哉; 南木...
臨床血液/65(1)/pp.35-40, 2024-01
PubMed
The phase III, randomized, multicenter commodore 2 trial: results from the study of crovalimab vs eculizumab in paroxysmal nocturnal hemoglobinuria (PNH) patients naive to complement inhibitors
Roeth A.; He G.; Brodsky A.; Chai-Adisaksopha C.; Dum...
ONCOLOGY RESEARCH AND TREATMENT/46(5)/pp.294-295, 2023-10-03
Female and preserved platelet count subgroups of myelodysplastic syndrome patients benefit from standard-dose azacitidine
Ogawa Shinichi; Sakamoto Tatsuhiro; Matsuoka Ryota; Is...
CANCER REPORTS/Epub, 2023-11-28
Crovalimab treatment in patients with paroxysmal nocturnal haemoglobinuria: Long-term results from the phase I/II COMPOSER trial
Roeth Alexander; Ichikawa Satoshi; Ito Yoshikazu; Kim ...
EUROPEAN JOURNAL OF HAEMATOLOGY/111(2)/pp.300-310, 2023-06-15
PubMed
A longitudinal analysis of paroxysmal nocturnal haemoglobinuria-type cells in patients with bone marrow failure: Results of a prospective multi-centre study in Japan
Ishiyama Ken; Yonemura Yuji; Kawaguchi Tatsuya; Hosoka...
BRITISH JOURNAL OF HAEMATOLOGY/203(3)/pp.468-476, 2023-08-31
Interim analysis of post-marketing surveillance of ravulizumab for paroxysmal nocturnal hemoglobinuria in Japan
Usuki Kensuke; Ikezoe Takayuki; Ishiyama Ken; Kanda Y...
INTERNATIONAL JOURNAL OF HEMATOLOGY/118(3)/pp.311-322, 2023-09
Safety of romiplostim administered immediately after cord-blood transplantation: a phase 1 trial
Kurita Naoki; Nishikii Hidekazu; Maruyama Yumiko; Sueh...
ANNALS OF HEMATOLOGY/102(10)/pp.2895-2902, 2023-08-17
PubMed
Repeated immunosuppressive rabbit antithymocyte globulin therapy for adult patients with relapsed or refractory aplastic anemia
Sakamoto Tatsuhiro; Obara Naoshi; Maruyama Yumiko; Kat...
EUROPEAN JOURNAL OF HAEMATOLOGY/111(5)/pp.768-776, 2023-08-07
PubMed
Real-World Treatment Patterns, Outcomes and Disease Burden of Japanese Patients with High-Risk Myelodysplastic Syndrome: A Claims Database Study
Obara Naoshi; Shioi Hirotomo; Ooi Shi Hong; Tay Hao Z...
BLOOD/140(1)/pp.12327-12328, 2022-11
Tumor Necrosis Factor from Leukemic Microenvironment Provides Non-Leukemic Hematopoietic Stem Cells with Megakaryocyte Lineage Bias
Nishikii Hidekazu; Saito Mizuki; Kimura Takaharu; Kiyo...
BLOOD/140(1)/pp.5774-5775, 2022-11
Elongation of Long-Chain Fatty Acids Is Crucial for Hematopoietic Stem Cell Engraftment and Leukemia Propagation
Kato Takayasu; Kiyoki Yusuke; Kito Sakura; Matsuzaka ...
BLOOD/140(1), 2022-11
Clinical Significance of Small PNH-Type Cell Populations in Bone Marrow Failure Syndromes - an Interim Analysis of Japanese Multicentrer Prospective Study -
Ueda Yasutaka; Hosokawa Kohei; Ishiyama Ken; Takamori ...
BLOOD/138(1), 2021-11
PNH患者におけるmRNAワクチン接種後の溶血
小原直
日本血栓止血学会誌/33(5)/pp.572-575, 2022-10
[Acute myeloid leukemia harboring NUP98::DDX10]
Kurita Naoki; Kato Takayasu; Nanmoku Toru; Maruyama Yumi...
[Rinsho ketsueki] The Japanese journal of clinical hematology/63(10)/pp.1397-1401, 2022-10
PubMed
Dysmegakaryopoiesis and Transient Mild Increase in Bone Marrow Blasts in Patients With Aplastic Anemia Treated With Eltrombopag May Be Signs of Hematologic Improvement and Not Portend Clonal Evolution
Matsuda Akira; Imada Kazunori; Obara Naoshi; Iida Hir...
AMERICAN JOURNAL OF CLINICAL PATHOLOGY/158(5)/pp.604-615, 2022-08
PubMed
Decision analysis of allogeneic bone marrow transplantation versus immunosuppressive therapy for young adult patients with aplastic anemia
Kanda Yoshinobu; Usuki Kensuke; Inagaki Mitsuhiro; Oht...
INTERNATIONAL JOURNAL OF HEMATOLOGY/117(5:SI)/pp.660-668, 2023-01-03
PubMed
The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation
Kiyoki Yusuke; Kato Takayasu; Kito Sakura; Matsuzaka ...
LEUKEMIA/37(4)/pp.910-913, 2023-03-08
PubMed
Novel translocation of POGZ/STK11 in de novo mast cell leukemia with KIT D816H mutation
Ishitsuka Kantaro; Yoshizawa Yuki; Nishikii Hidekazu; Kus...
LEUKEMIA & LYMPHOMA/63(14)/pp.3475-3479, 2022-09
PubMed
[Lymphoplasmacytic lymphoma accompanied by severe myelofibrosis]　
Takarada Ayako; Momose Haruka; Kurita Naoki; Matsuoka Ry...
[Rinsho ketsueki] The Japanese journal of clinical hematology/64(1)/pp.54-59, 2023-01
PubMed
[Hematopoietic recovery by ASXL1-mutated clones after immune suppressive therapy in a patient with severe aplastic anemia]
Shimizu Yumoe; Nishikii Hidekazu; Iitsuka Tadashi; Matsuo...
[Rinsho ketsueki] The Japanese journal of clinical hematology/64(1)/pp.49-53, 2023-01
PubMed
Waldenström macroglobulinemia complicated by peripheral neuropathy due to neural infiltration
Norioka Natsuki; Kurita Naoki; Kamura Yuya; Sakamoto Tat...
[Rinsho ketsueki] The Japanese journal of clinical hematology/64(1)/pp.18-22, 2023-01
PubMed
Hemolysis induced by SARS-CoV-2 mRNA vaccination in patients with paroxysmal nocturnal hemoglobinuria
Kamura Yuya; Sakamoto Tatsuhiro; Yokoyama Yasuhisa; Nishi...
INTERNATIONAL JOURNAL OF HEMATOLOGY/116(1:SI)/pp.55-59, 2022-06
Triple-negative Thrombocythemia and Subsequent Acute Lymphoblastic Leukemia with Additional Somatic Mutations
Tsuboi Yuri; Sakamoto Tatsuhiro; Makishima Kenichi; Su...
Internal medicine (Tokyo, Japan)/62(10)/pp.1527-1530, 2022-09-13
PubMed
more...

Books

Ⅱ赤血球の異常　1.貧血　（3）巨赤芽球性貧血　6）ホルムイミノトランスフェラーゼ欠損症
小原直
別冊血液症候群I 血液症候群(第3版)-その他の血液疾患を含めて-/日本臨床社/pp.100-102, 2023-09
Ⅱ赤血球の異常　1.貧血　（3）巨赤芽球性貧血　3）Imerslund-Graesbeck症候群
小原直
別冊血液症候群I 血液症候群(第3版)-その他の血液疾患を含めて-/日本臨床社/pp.88-90, 2023-09
Ⅱ赤血球の異常　1.貧血　（3）巨赤芽球性貧血　2）若年性悪性貧血
小原直
別冊血液症候群I 血液症候群(第3版)-その他の血液疾患を含めて-/日本臨床社/pp.85-87, 2023-09
Ⅳ赤血球系疾患　巨赤芽球性貧血
小原直
血液疾患のすべて　生涯教育シリーズ102　日本医師会雑誌　第151巻　特別号（1）/日本医師会/pp.181-183, 2022-06
Ⅲ赤血球系疾患　1貧血総論と各種貧血へのアプローチ
小原直
専門医のための血液病学/医学書院/pp.62-64, 2022-03
Ⅱ.赤血球系疾患　10.腎性貧血
小原直
EBM　血液疾患の治療　2019-2020/中外医学社/pp.69-74, 2018-10
Use of gene-manipulated mice in the study of Erythropoietin gene expression
Suzuki Norio; Obara Naoshi; Yamamoto Masayuki
OXYGEN BIOLOGY AND HYPOXIA/ELSEVIER ACADEMIC PRESS INC/pp.157-0, 2007-01

Conference, etc.

Safety proof of romiplostim immediately after cord-blood transplantation: Results of a phase 1 trial
Kurita N.; Maruyama Y.; Suehara Y.; Hattori K.; Kato ...
BONE MARROW TRANSPLANTATION/2022-11
The phase III, randomized, multicenter commodore 2 trial: results from the study of crovalimab vs eculizumab in paroxysmal nocturnal hemoglobinuria (PNH) patients naive to complement inhibitors
Roeth A.; He G.; Brodsky A.; Chai-Adisaksopha C.; Dum...
The EHA 2023 Hybrid Congress/2023-06-08--2023-06-11
再生不良性貧血患者の血清ビリルビン測定に及ぼす血中エルトロンボパグ濃度の干渉
小田　峻; 土岐浩介; 鈴木嘉治; 小原　直; 千葉　滋; 本間真人
第44回日本臨床薬理学会学術総会/2023-12-14--2023-12-16
Treatment outcomes of Tisagenlecleucel in Ibaraki prefecture
樽井裕太朗; 錦井秀和; 栗田尚樹; 丸山ゆみ子; 小川晋一; 清水誠一; 渡邉真威; ...
第46回日本造血･免疫細胞療法学会　総会/2024-03-21--2024-03-23
Cases with myelofibrosis undergoing haploidentical hematopoietic stem-cell transplantation
宮越敏宏; 栗田尚樹; 丸山ゆみ子; 小田卓也; 海江田拓実; 樽井裕太朗; 松村文明; ...
第46回日本造血･免疫細胞療法学会　総会/2024-03-21--2024-03-23
カルフィルゾミブ長期投与後に血栓性微小血管障害をきたした 1 例
小田卓弥; 横山泰久; 海江田拓実; 宮越俊宏; 樽井裕太朗; 松村文明; 清木祐介; ...
第20回日本血液学会関東甲信越地方会/2024-03-09--2024-03-09
Pegcetacoplan improves D-dimer normalization and decreases incidence of thrombosis in PNH patients
Hisakazu Nishimori; Kensuke Usuki; 小原直; Toshiki Uchi...
第85回日本血液学会学術集会/2023-10-13--2023-10-15
第 III 相 COMMODORE 2 試験：補体阻害剤未治療PNH 患者を対象としたクロバリマブとエクリズマブのランダム化比較
西村純一; Alexander Röth; Guangsheng He; Andres Brodsky; C...
第85回日本血液学会学術集会/2023-10-13--2023-10-15
The burden of illness of patients with PNH receiving complement inhibitors: PRO study in Japan
小原直; Kensuke Usuki; Takeshi Hayashi; Masato Fujii; T...
第85回日本血液学会学術集会/2023-10-13--2023-10-15
Outcome of TP53-mutated myelodysplastic syndrome: a single center experience
Yutaro Tarui; Tatsuhiro Sakamoto; Naoki Kurita; Yumiko...
第85回日本血液学会学術集会/2023-10-13--2023-10-15
Safety of romiplostim administered immediately after CBT: A phase 1 trial (PROMPT-1)
Naoki Kurita; Hidekazu Nishikii; Yumiko Maruyama; Yasu...
第85回日本血液学会学術集会/2023-10-13--2023-10-15
発作性夜間ヘモグロビン尿症(PNH)に対するクロバリマブ長期投与　COMPOSER試験非盲検継続投与の結果
植田康敬; Roeth Alexander; Egyed Miklos; 市川聡; 伊藤良和; K...
第59回日本補体学会学術集会/2023-08-25--2023-08-26
Survival of CB and haploidentical transplantation were comparable to HLA-matched transplantation
Yoshizawa Yuki; Kurita Naoki; Maruyama Yumiko; Nishiki...
The 13th JSH International Symposium 2023 in Tsukuba/2023-07-21--2023-07-22
エトポシド投与を回避し，正常分娩に至った妊娠 9 週発症血球貪食性リンパ組織球症の 1 例
樽井祐太朗; 末原泰人; 服部圭一朗; 佐々木裕哉; 丸山ゆみ子; 坂本竜弘; 加藤貴...
第19回日本血液学会関東甲信越地方会/2023-07-15--2023-07-15
ELOVL6 regulates engraftment of hematopoietic cells through the PI3K pathway
Kiyoki Yusuke; Kato Takayasu; Kito Sakura; Matsuzaka ...
2nd JCA-AACR Precision Cancer Medicine International Conference/2023-06-28--2023-06-30
脊柱管内に腫瘤を形成したリンパ形質細胞性リンパ腫に対するチラブルチニブと放射線照射の併用療法
普天間幸愛; 栗田尚樹; 坂本竜弘; 加藤貴康; 服部圭一朗; 末原泰人; 横山泰久; 錦...
第63回日本リンパ網内系学会学術集会・総会/2023-06-22--2023-06-24
The fatty acid elongase elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation
Kiyoki Yusuke; Kato Takayasu; Kito Sakura; Matsuzaka ...
The EHA 2023 Hybrid Congress/2023-06-08--2023-06-11
Elongation of long-chain fatty acids is crucial for hematopoietic stem cell engraftment and leukemia propagation
Kato Takayasu; Kiyoki Yusuke; Kito Sakura; Matsuzaka ...
The 20th Stem Cell Research Symposium/2023-05-19--2023-05-20
ATRAによる横紋筋融解症が疑われた一例
上原惇; 服部圭一朗; 末原泰人; 佐々木裕哉; 横山泰久; 小原直; 坂田（柳元）麻...
医学生・研修医・専攻医の日本内科学会ことはじめ2023東京/2023-04-15--2023-04-15
同種造血幹細胞移植後に発症した肝類洞閉塞症候群26例の後方視的検討
宝田亜矢子; 栗田尚樹; 服部圭一朗; 坂本竜弘; 加藤貴康; 横山泰久; 錦井秀和; ...
第120回日本内科学会総会/2023-04-14--2023-04-16
Real-World Treatment Patterns, Outcomes and Disease Burden of Japanese Patients with High-Risk Myelodysplastic Syndrome: A Claims Database Study
Obara Naoshi; Shioi Hirotomo; Ooi Shi Hong; Tay Hao Z...
64th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/2022-12-10--2022-12-13
Safety proof of romiplostim immediately after cord-blood transplantation: Results of a phase 1 trial
Kurita N.; Maruyama Y.; Suehara Y.; Hattori K.; Sakam...
48th Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT)/2022-03-19--2022-03-23
BTK 阻害薬が著効した脳神経障害を有する再発難治 MYD88 変異陽性 B 細胞リンパ腫
上原惇; 錦井秀和; 末原泰人; 服部圭一朗; 佐々木裕哉; 丸山ゆみ子; 坂本竜弘; 加藤貴康; 栗田尚樹; 横山泰久; 小原 ...
第18回日本血液学会関東甲信越地方会/2023-03-11--2023-03-11
Temporal changes in ABO blood groups and clinical significance after ABO-incompatible HSCT
丸山ゆみ子; 錦井秀和; 新井裕介; 栗田尚樹; 坂本竜弘; 服部圭一朗; 末原泰人; 加藤貴康; 横山泰久; 坂田(柳元)麻実子; ...
第45回日本造血・免疫細胞療法学会総会/2023-02-10--2023-02-12
Tumor Necrosis Factor from Leukemic Microenvironment Provides Non-Leukemic Hematopoietic Stem Cells with Megakaryocyte Lineage Bias
Nishikii Hidekazu; Saito Mizuki; Kimura Takaharu; Kiyo...
64th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/2022-12-10--2022-12-13
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Teaching


2024-10 -- 2024-12	Introduction of Medical Science	University of Tsukuba.
2024-04 -- 2024-08	Seminar in Internal Medicine I	University of Tsukuba.
2024-04 -- 2024-08	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2024-10 -- 2025-02	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2024-10 -- 2025-02	Seminar in Internal Medicine II	University of Tsukuba.
2024-10 -- 2025-02	Frontier of Clinical Laboratory Science	University of Tsukuba.
2024-10 -- 2024-12	Medical Quality and Safety Science: Lecture and Practice	University of Tsukuba.
2024-04 -- 2024-08	Practice in Internal Medicine I	University of Tsukuba.
2024-12 -- 2025-02	Bioethics	University of Tsukuba.
2024-04 -- 2024-04	Clinical Physiology	University of Tsukuba.
more...

Professional activities


2018 -- 2020	THE JAPANESE SOCIETY OF HEMATOLOGY	専門医委員会
2017 -- 2019	THE JAPANESE SOCIETY OF HEMATOLOGY	診療委員会

(Last updated: 2024-12-04)