KANEKO Shin

Affiliation

Institute of Medicine

Official title

Professor

Research fields

General internal medicine (including psychosomatic medicine)
Cell biology

Research keywords

Gene Therapy
Cell Therapy
Clinical Hematology
Stem cell biology

Research projects

Clinical gene therapy of hematological malignancies	1998 -- (current)		/

Academic background

1989 -- 1995	University of Tsukuba Faculty of Medicine
1998 -- 2002	University of Tsukuba Graduate School, Division of Medicine Homatology, Immunology

Degree

	Doctor(Medicine)	University of Tsukuba

Academic societies

-- (current)	The Japanese Cancer Association
-- (current)	日本がん免疫学会
-- (current)	THE JAPANESE SOCIETY OF HEMATOLOGY
-- (current)	JAPANESE SOCIETY FOR IMMUNOLOGY
-- (current)	THE JANPANESE SOCIETY OF INTERNAL MEDICINE
-- (current)	日本免疫治療学会
-- (current)	THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE

Honors & Awards

2001	The Young Investigater's award of Japanese Society of Hematology
2001	日本血液学会奨励賞

Articles

• Human iPSC-derived CD4+ Treg-like cells engineered with chimeric antigen receptors control GvHD in a xenograft model
  KANEKO Shin
  Cell Stem Cell, 2024-06
• A culture method with berbamine, a plant alkaloid, enhances CAR-T cell efficacy through modulating cellular metabolism
  金子 新
  Communications biology, 2024-06
• ex vivo gene editing―HLA editing for regenerative immunotherapy
  金子 新; 蟹江慶太郎
  実験医学/42(6), 2024-04
• Development of B-cell maturation antigen (BCMA)-specific CD8+ cytotoxic T lymphocytes using induced pluripotent stem cell technology for multiple myeloma.
  金子 新
  JOURNAL OF CLINICAL ONCOLOGY/pp.2542-2542, 2022-06
• BCR-ABL-specific CD4+ T-helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells
  Ueda Norihiro; Zhang Rong; Tatsumi Minako; Liu Tian-Y...
  Cellular & molecular immunology/15(1)/pp.15-26, 2018-01-01
  
  PubMed
• Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors
  Oshima Koichi; Saiki Norikazu; Tanaka Michihiro; Imamu...
  Biochemical and biophysical research communications/497(2)/pp.719-725, 2018-03-04
  
  PubMed
• Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response
  Ueda Norihiro; Uemura Yasushi; Zhang Rong; Kitayama S...
  Stem cell reports/10(6)/pp.1935-1946, 2018-06-05
  
  PubMed
• Generation of HIV-Resistant Macrophages from IPSCs by Using Transcriptional Gene Silencing and Promoter-Targeted RNA
  Higaki Kei; Hirao Masako; Kawana-Tachikawa Ai; Iriguch...
  Molecular therapy. Nucleic acids/12/pp.793-804, 2018-09-07
  
  PubMed
• Repurposing the Cord Blood Bank for Haplobanking of HLA-Homozygous iPSCs and Their Usefulness to Multiple Populations
  Lee Suji; Huh Ji Young; Turner David M; Lee Soohyeon; ...
  Stem cells (Dayton, Ohio)/36(10)/pp.1552-1566, 2018-10-01
  
  PubMed
• Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy
  Minagawa Atsutaka; Yoshikawa Toshiaki; Yasukawa Masaki...
  Cell stem cell/23(6)/p.850-858.e4, 2018-12-06
  
  PubMed
• Toward the development of true "off-the-shelf" synthetic T-cell immunotherapy
  Iriguchi Shoichi; Kaneko Shin
  Cancer science/110(1)/pp.16-22, 2019-01-01
  
  PubMed
• Redifferentiation of Adaptive Naïve-Like CTL from T-Cell-Derived iPSC
  Kawai Yohei; Kaneko Shin
  Methods in molecular biology (Clifton, N.J.)/2048/pp.71-75, 2019-04-01
  
  PubMed
• In Vitro Differentiation of T Cell: From CAR-Modified T-iPSC
  Ueda Tatsuki; Kaneko Shin
  Methods in molecular biology (Clifton, N.J.)/2048/pp.85-91, 2019-04-01
  
  PubMed
• In Vitro Differentiation of T Cells: From Nonhuman Primate-Induced Pluripotent Stem Cells
  Iriguchi Shoichi; Kaneko Shin
  Methods in molecular biology (Clifton, N.J.)/2048/pp.93-106, 2019-04-01
  
  PubMed
• Differentiating CD8αβ T Cells from TCR-Transduced iPSCs for Cancer Immunotherapy
  Minagawa Atsutaka; Kaneko Shin
  Methods in molecular biology (Clifton, N.J.)/2048/pp.81-84, 2019-04-01
  
  PubMed
• In Vitro Differentiation of T Cells: From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
  Iriguchi Shoichi; Kaneko Shin
  Methods in molecular biology (Clifton, N.J.)/2048/pp.59-70, 2019-04-01
  
  PubMed
• In Vitro Detection of Cellular Adjuvant Properties of Human Invariant Natural Killer T Cells
  Zhang Rong; Kitayama Shuichi; Liu Tianyi; Ueda Norihi...
  Methods in molecular biology (Clifton, N.J.)/2048/pp.121-130, 2019-04-01
  
  PubMed
• Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility
  Xu Huaigeng; Wang Bo; Ono Miyuki; Kagita Akihiro; Fuj...
  Cell stem cell/24(4)/p.566-578.e7, 2019-04-04
  
  PubMed
• Junctional Adhesion Molecule 2 Represents a Subset of Hematopoietic Stem Cells with Enhanced Potential for T Lymphopoiesis
  Radulovic Visnja; van der Garde Mark; Koide Shuhei; Si...
  Cell reports/27(10)/p.2826-2836.e5, 2019-06-04
  
  PubMed
• Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1⁺ Dendritic Cells
  Tsuchiya Nobuhiro; Zhang Rong; Iwama Tatsuaki; Ueda N...
  Cell reports/29(1)/p.162-175.e9, 2019-10-01
  
  PubMed
• Non-clinical efficacy, safety and stable clinical cell processing of induced pluripotent stem cell-derived anti-glypican-3 chimeric antigen receptor-expressing natural killer/innate lymphoid cells
  Ueda Tatsuki; Kumagai Ayako; Iriguchi Shoichi; Yasui ...
  Cancer science/111(5)/pp.1478-1490, 2020-05-01
  
  PubMed
• Podoplanin as an Attractive Target of CAR T Cell Therapy
  Waseda Masazumi; Kaneko Shin
  Cells/9(9), 2020-08-26
  
  PubMed
• Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling
  Kazuki Yasuhiro; Uno Narumi; Abe Satoshi; Kajitani Na...
  Molecular therapy. Nucleic acids/23/pp.629-639, 2021-03-05
  
  PubMed
• Capturing human trophoblast development with naive pluripotent stem cells in vitro
  Io Shingo; Kabata Mio; Iemura Yoshiki; Semi Katsunori...
  Cell stem cell/28(6)/p.1023-1039.e13, 2021-06-03
  
  PubMed
• Improved safety of induced pluripotent stem cell-derived antigen-presenting cell-based cancer immunotherapy
  Mashima Hiroaki; Zhang Rong; Kobayashi Tsuyoshi; Tsuka...
  Molecular therapy. Methods & clinical development/21/pp.171-179, 2021-06-11
  
  PubMed
• more...

Teaching

2024-04 -- 2024-08	Seminar in Internal Medicine I	University of Tsukuba.
2024-10 -- 2025-02	Seminar in Internal Medicine II	University of Tsukuba.
2024-04 -- 2024-08	Practice in Internal Medicine I	University of Tsukuba.
2024-10 -- 2025-02	Lecture and Discussion in Internal Medicine II	University of Tsukuba.
2024-04 -- 2024-08	Lecture and Discussion in Internal Medicine I	University of Tsukuba.
2024-10 -- 2025-02	Practice in Internal Medicine II	University of Tsukuba.
2023-04 -- 2023-08	Seminar in Internal Medicine I	University of Tsukuba.
2023-10 -- 2024-02	Practice in Internal Medicine II	University of Tsukuba.
2023-04 -- 2023-08	Lecture and Discussion in Internal Medicine I	University of Tsukuba.
2023-10 -- 2024-02	Lecture and Discussion in Internal Medicine II	University of Tsukuba.
more...

Talks

• 遺伝子改変による高機能型iPS由来CAR-T（予定）
  金子 新
  第22回日本再生医療学会総会/2023-03-25
• がん治療のための iPS 細胞由来免疫細胞の製造と臨床試験
  金子 新
  再生医療実現拠点ネットワークプログラム　iPS細胞研究中核拠点　第5回情報交換会/2023-02-15
• アロジェニックCAR-T
  金子 新
  第7回再生医療産官学連携シンポジウム/2023-01-26
• 免疫再生研究と産業化への取り組み
  金子 新
  再生医療を推進する議員の会/2022-12-15
• DEVELOPMENT OF IPSC-DERIVED FUNCTIONAL LYMPHOCYTES FOR IMMUNE CELL THERAPY
  Kaneko Shin
  2022 Symposium on Cell Manufacturing and Commercialization/2022-11-19
• iPS細胞からのT細胞再生と同種CAR-T療法、TCR-T療法の開発
  金子 新
  第84回日本血液学会学術集会/2022-10-15
• iPS細胞を用いたがん免疫再生療法の研究
  金子 新
  メディア勉強会/2022-09-15
• CD8 killer T cells and NK cells from iPSC for cancer immunotherapy
  金子 新
  第28回日本遺伝子細胞治療学会学術集会/2022-07-16
• iPS cell-based technologies for allogeneic cancer immunotherapy
  Kaneko Shin
  The 1st Catholic International Symposium for Advenced Regenerative Medicine/2022-07-08
• iPS由来T細胞、NK細胞を用いた新たながん治療～基礎から最前線まで
  金子 新
  SBI証券講演会/2022-06-24
• Development of CAR-T cell therapy using allogeneic induced pluripotent stem cells
  Kaneko Shin
  ISSCR: Workshop Clinical Translation/2022-06-15
• Induced pluripotent stem cell derived killer cell for CAR-based cancer immunotherapy
  Kaneko Shin
  Mayo Clinic Honorarium Lecture/2022-06-11
• iPS細胞から誘導したCD8キラーT細胞とNK細胞の特性
  金子 新
  第19回日本免疫治療学会学術集会/2022-05-22
• iPS細胞を用いた免疫再生治療の開発
  金子 新
  第1回EPU先端医療セミナー/2022-05-20
• iPS細胞からのキラーT細胞、NK細胞の再生と臨床応用
  金子 新
  第44回日本造血・免疫細胞療法学会総会/2022-05-13
• Development of iPSC-derived Immune Cells For Cancer Immunotherapy
  Kaneko Shin
  ISCT 2022/2022-05-05

(Last updated: 2024-10-30)