SAITO Tsuyoshi
- Articles
- Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice
Lin Yang; Roy Koustav; Ioka Shuji; Otani Rintaro; Ame...
Frontiers in pharmacology/14, 2023-04-01 - Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5-trioxazatriquinane skeleton
Amezawa Mao; Yamamoto Naoshi; Nagumo Yasuyuki; Kutsumu...
Bioorganic & Medicinal Chemistry Letters/82(15)/p.129151, 2023-02-15 - Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library
Saitoh Tsuyoshi; Amezawa Mao; Horiuchi Jumpei; Nagumo Ya...
European Journal of Medicinal Chemistry/240/p.114505, 2022-06 - Design and synthesis of orexin 1 receptor-selective agonists
Saito Tsuyoshi; Iio Keita; Hashimoto Kao; Nagumo Yasu...
ChemRxiv, 2022-04-12 - OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy
Yamamoto Hikari; Nagumo Yasuyuki; Ishikawa Yukiko; Iru...
PLOS ONE/17(7)/p.e0271901, 2022-04-01 - Electro-conversion of cumene into acetophenone using boron-doped diamond electrodes
Kitano Mana; Saitoh Tsuyoshi; Nishiyama Shigeru; Einag...
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY/18/pp.1154-1158, 2022-04-01 - Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton
Hino Tsubasa; Saitoh Tsuyoshi; Nagumo Yasuyuki; Yamamo...
Bioorganic & Medicinal Chemistry Letters/59(1)/pp.128530-128530, 2022-03 - Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives
Katoh Koki; Kutsumura Noriki; Yamamoto Naoshi; Nagumo ...
Bioorganic & Medicinal Chemistry Letters/59(1)/pp.128550-128550, 2022-03 - Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors
Katoh Koki; Yamamoto Naoshi; Ishikawa Yukiko; Irukayam...
Bioorganic & Medicinal Chemistry Letters/59(1)/pp.128527-128527, 2022-03 - Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring
Iio Keita; Saitoh Tsuyoshi; Ohshita Ryuichiro; Hino Tsub...
Bioorganic & Medicinal Chemistry Letters/60(15)/pp.128555-128555, 2022-03 - Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands
Iio Keita; Kutsumura Noriki; Nagumo Yasuyuki; Saitoh ...
Bioorganic & Medicinal Chemistry Letters/56(15)/pp.128485-128485, 2022-01 - Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors
Tsai Chia-Jung; Nagata Takeshi; Liu Chih-Yao; Suganuma...
Cell reports/36(7)/p.109558, 2021-08 - Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation
Shokirova Hurramhon; Inomata Takenori; Saitoh Tsuyoshi...
SCIENTIFIC REPORTS/11(1), 2021-04 - Anodic Oxidation of Phenols: A Key Step for the Synthesis of Natural Products
Yamamoto Takashi; Saitoh Tsuyoshi; Einaga Yasuaki; Nis...
CHEMICAL RECORD/Epub, 2021-03 - Novel Baeyer–Villiger-type oxidation of 4,5-epoxymorphinan derivatives
Hino Tsubasa; Kutsumura Noriki; Saitoh Tsuyoshi; Yamamoto...
Tetrahedron Letters/63(19)/pp.152714-152714, 2021-01 - Novel Baeyer-Villiger-type oxidation of 4,5-epoxymorphinan derivatives
Hino Tsubasa; Kutsumura Noriki; Saitoh Tsuyoshi; Yamam...
TETRAHEDRON LETTERS/63, 2021-01 - Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine
Nagumo Yasuyuki; Katoh Koki; Iio Keita; Saitoh Tsuyoshi; ...
Bioorganic & Ｍedicinal Chemistry Letters/30(17), 2020-09 - Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities
Kutsumura N.; Koyama Y.; Saitoh T.; Yamamoto N.; Nagumo ...
Molecules/25(5)/pp.1112-1112, 2020-03 - Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group
Saito Tsuyoshi; Seki Kazunori; Nakajima Ryo; Yamamoto Na...
Bioorg. Med. Chem. Lett./30(3), 2019-12 - Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity
Saitoh Tsuyoshi; Seki Kazunori; Nakajima Ryo; Yamamoto N...
Bioorganic & medicinal chemistry letters/29(18)/pp.2655-2658, 2019-09 - Oxidative Cleavage of the Acyl-Carbon Bond in Phenylacetone with Electrogenerated Superoxide Anions
Zhang Yan; Sugai Tomoya; Yamamoto Takashi; Yamamoto Naos...
CHEMELECTROCHEM/6(16:::SI)/pp.4194-4198, 2019-08 - Electrochemical Pinacol Coupling of Acetophenone Using Boron-Doped Diamond Electrode
Nakahara Kenshin; Naba Keisuke; Saitoh Tsuyoshi; Sugai T...
CHEMELECTROCHEM/6(16:::SI)/pp.4153-4157, 2019-08 - A NOVEL REARRANGEMENT REACTION OF MORPHINAN TO ARYLMORPHAN SKELETONS AND THE PHARMACOLOGIES OF ARYLMORPHAN DERIVATIVES
Yata Masahiro; Kutsumura Noriki; Nagumo Yasuyuki; Yamamot...
HETEROCYCLES/99(1)/pp.134-144, 2019-04 - Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring
Yamamoto Naoshi; Ohrui Sayaka; Okada Takahiro; Saitoh Ts...
Bioorganic & medicinal chemistry/27(8)/pp.1747-1758, 2019-04 - Electrochemical Tryptophan-Selective Bioconjugation
Toyama Eisho; Maruyama Katsuya; Sugai Tomoya; Kondo Mio; ...
<i>ChemRxiv<i/>, 2019-03 - more...
- Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice