HIRANO Arisa
- Affiliation
- Institute of Medicine
- Official title
- Assistant Professor
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- Research fields
Animal physiology/Animal behavior - Research keywords
概日時計、概日リズム、睡眠、視交叉上核 - Research projects
低温状態での脳機能動態 2023-04 -- 2028-03 田中和正 日本学術振興会/学術変革領域研究（A）計画研究 睡眠の謎に挑む:睡眠神 経科学者のグローバル ネットワーク構築 2022-12 -- 2029-03 柳沢正史 日本学術振興会/科研費国際先導研究 8,330,000Yen クロノプロテオスタシス：タンパク質分解の破綻による概日リズム睡眠障害の病態解明と治療の試み 2022-10 -- 2026-03 平野有沙 日本医療研究開発機構（AMED）/革新的先端研究開発支援事業 (AMED-PRIME) 57,850,000Yen 冬眠様状態における時の流れの研究 2021-10 -- 2023-03 平野有沙 Japan Society of for the Promotion of Science/新学術領域研究（研究領域提案型） 5,200,000Yen 概日時計による体温リズム形成メカニズムの解明 2021-04 -- 2022-03 平野有沙 中島記念国際交流財団/2021年度日本人若手研究者研究助成金 5,000,000Yen 炎症誘発細胞除去による100歳を目指した健康寿命延伸医療の実現 2021-04 -- 2026-03 中西真 日本医療研究開発機構（AMED）/ムーンショット型研究開発事業 143,000,000Yen 新規低体温誘導ニューロンの体温の概日リズム形成における役割 2020-12 -- 2023-12 平野有沙 内藤記念科学振興財団/女性研究者研究助成金 6,000,000Yen 脳内時計細胞を起点とした神経ネットワークの分子・機能的理解 2020-04 -- 2022-03 平野有沙 Japan Society of for the Promotion of Science/若手研究 4,290,000Yen 哺乳類の非オプシン型青色光受容体CRYの機能の再検証とその光遺伝学的応用 2019-04 -- 2022-09 平野有沙 独立行政法人科学技術振興機構/JST PRESTO 52,000,000Yen 時刻依存的な睡眠パターンを形成する神経基盤の解明 2019 -- 2020 平野有沙 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research on Innovative Areas 6,110,000Yen more... - Career history
2019-04 -- (current) 筑波大学医学医療系/国際統合睡眠医科学研究機構助教/主任研究員 2017-04 -- 2019-03 筑波大学国際統合睡眠医科学研究機構助教 2014-04 -- 2017-03 University of California, San FranciscoFaculty of Medicine, Department of Neurology博士研究員 2013-04 -- 2014-03 東京大学大学院理学系研究科生物化学専攻特任助教 - Academic background
2010-04 -- 2013-03 東京大学大学院 理学系研究科 生物化学専攻 2008-04 -- 2010-03 東京大学大学院 理学系研究科 生物化学専攻 2004-04 -- 2008-03 東京大学 理学部 生物化学科 - Degree
2013-03 博士（理学） 東京大学 - Honors & Awards
2022-12 The 20th Award of the Japanese Society for Chronobiology 2021-04 科学技術分野の文部科学大臣表彰若手科学者賞 概日時計の中枢タンパク質CRYの制御機構に関する研究 2018-02 第10回 井上リサーチアウォード 時計中枢から時刻情報を伝達する神経ネットワークの同定と機能解析 2014-02 第30回井上研究奨励賞 時計タンパク質CRYの翻訳後修飾によるマウス体内時計の24時間形成 2013-03 東京大学理学系研究科 研究奨励賞 睡眠覚醒サイクルを支配する体内時計のF-boxタンパク質による制御メカニズムの解明 2013-03 東京大学総長賞 睡眠覚醒サイクルを支配する体内時計のF-boxタンパク質による制御メカニズムの解明 2012-05 Trainee Research Awards Research on biological rhythms - Articles
- A coupled model between circadian, cell-cycle, and redox rhythms reveals their regulation of oxidative stress
Masuda Kosaku; Sakurai Takeshi; Hirano Arisa
Scientific reports/14(1), 2024-07-05 - Structure and Function of Neuronal Circuits linking Ventrolateral Preoptic Nucleus and Lateral Hypothalamic Area
Prokofeva Kseniia; Saito Yuki C; Niwa Yasutaka; Mizuno...
JOURNAL OF NEUROSCIENCE/43(22)/pp.4075-4092, 2023-04-27 - Crucial role of TFAP2B in the nervous system for regulating NREM sleep
Nakai Ayaka; Kashiwagi Mitsuaki; Fujiyama Tomoyuki; Iw...
MOLECULAR BRAIN/17(1)/p.13, 2024-02-27 - Aripiprazole disrupts cellular synchrony in the suprachiasmatic nucleus and enhances entrainment to environmental light-dark cycles in mice
Li Ruoshi; Masuda Kosaku; Ono Daisuke; Kanbayashi Tak...
FRONTIERS IN NEUROSCIENCE/17, 2023-04-01 - Analysis of circadian rhythm components in EEG/EMG data of aged mice
Masuda Kosaku; Katsuda Yoko; Niwa Yasutaka; Sakurai T...
FRONTIERS IN NEUROSCIENCE/17, 2023-04-01 - Measuring body temperature of freely moving mice under an optogenetics-induced long-term hypothermic state
Takahashi Tohru M; Sakurai Takeshi; Hirano Arisa
STAR PROTOCOLS/4(2), 2023-05-31 - Structure and Function of Neuronal Circuits linking Ventrolateral Preoptic Nucleus and Lateral Hypothalamic Area
Prokofeva Kseniia; Saito Yuki C; Niwa Yasutaka; Mizuno...
JOURNAL OF NEUROSCIENCE/43(22)/pp.4075-4092, 2023-04-27 - Singularity response reveals entrainment properties in mammalian circadian clock
Masuda Kosaku; Kon Naohiro; Iizuka Kosuke; Fukada Yos...
NATURE COMMUNICATIONS/14(1)/p.2819, 2023-05-17 - SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice
Asano Fuyuki; Kim Staci J; Fujiyama Tomoyuki; Miyoshi ...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA/120(11), 2023-03-14 - Optogenetic induction of hibernation-like state with modified human Opsin4 in mice
Takahashi Tohru M; Hirano Arisa; Kanda Takeshi; Saito ...
CELL REPORTS METHODS/2(11), 2022-11-21 - Editorial: The Role of Neuropeptides in Sleep/Wakefulness States and the Circadian Clock
N Tsujino; M Ikeda; Hirano Arisa; T Sakurai
Front. Neurosci./16/p.913371, 2022-05-09 - A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice
Uchida Shuntaro; Soya Shingo; Saito Yuki C; Hirano Arisa...
The Journal of neuroscience : the official journal of the Society for Neuroscience/41(7)/pp.1582-1596, 2021-02 - DEC2 modulates orexin expression and regulates sleep
Hirano Arisa; Hsu Pei-Ken; Zhang Luoying; Xing Lijuan; Mc...
Proceedings of the National Academy of Sciences of the United States of America, 2018-3 - Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein
Hayasaka Naoto; Hirano Arisa; Miyoshi Yuka; Tokuda Is...
eLife/6, 2017-04 - FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice
Hirano Arisa; Braas Daniel; Fu Ying-Hui; Ptáček Louis J
Cell reports/19(2)/pp.255-266, 2017-04 - The intricate dance of post-translational modifications in the rhythm of life
Hirano Arisa; Fu Ying-Hui; Ptáček Louis J
Nature structural & molecular biology/23(12)/pp.1053-1060, 2016-12 - A Cryptochrome 2 mutation yields advanced sleep phase in humans
Hirano Arisa; Shi Guangsen; Jones Christopher R; Lipze...
eLife/5, 2016-04 - A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait
Zhang Luoying; Hirano Arisa; Hsu Pei-Ken; Jones Chris...
Proceedings of the National Academy of Sciences of the United States of America/113(11)/p.E1536-44, 2016-03 - Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis
Shen Yiguo; Ge Woo-Ping; Li Yulong; Hirano Arisa; Lee...
Proceedings of the National Academy of Sciences of the United States of America/112(10)/pp.2935-2941, 2015-03 - USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock
Hirano Arisa; Nakagawa Tomoki; Yoshitane Hikari; Oyama...
PloS one/11(4), 2016-04 - In vivo role of phosphorylation of cryptochrome 2 in the mouse circadian clock
Hirano Arisa; Kurabayashi Nobuhiro; Nakagawa Tomoki; S...
Molecular and cellular biology/34(24)/pp.4464-4473, 2014-12 - FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes
Hirano Arisa; Yumimoto Kanae; Tsunematsu Ryosuke; Mats...
Cell/152(5)/pp.1106-1118, 2013-02 - [Regulation of the circadian rhythm by phosphorylation and ubiquitination]
Hirano Arisa; Fukada Yoshitaka
Seikagaku. The Journal of Japanese Biochemical Society/86(4)/pp.528-531, 2014-08
- A coupled model between circadian, cell-cycle, and redox rhythms reveals their regulation of oxidative stress
- Teaching
2024-07 -- 2024-09 Neuroscience Laboratories B University of Tsukuba. 2024-10 -- 2025-03 Neuroscience Thesis Research 2 University of Tsukuba. 2024-04 -- 2024-08 Basic Medical Sciences University of Tsukuba. 2024-10 -- 2025-02 Basic Medical Sciences University of Tsukuba. 2024-04 -- 2024-09 Neuroscience Thesis Research 3 University of Tsukuba. 2024-04 -- 2024-09 Neuroscience Thesis Research 1 University of Tsukuba. 2024-10 -- 2025-03 Neuroscience Dissertation Research 6 University of Tsukuba. 2024-10 -- 2025-02 Neuroscience Professional Career Development University of Tsukuba. 2024-04 -- 2024-08 Neuroscience Professional Career Development University of Tsukuba. 2024-12 -- 2025-02 Basics in Neuroscience University of Tsukuba. more... - Other educational activities
2021-06 -- 2021-06 医学の基礎B（生理学コース） 筑波大学 2020-02 -- 2021-02 医学の基礎（生理学コース） 筑波大学 - University Management
2021-04 -- 2023-03 ニューロサイエンス学位プログラム 学生支援委員
(Last updated: 2024-09-03)