OISHI Yo
- Affiliation
- Institute of Medicine
- Official title
- Associate Professor
- Research fields
- Neurophysiology / General neuroscience - Basic / Social brain science - Nerve anatomy/Neuropathology 
- Research keywords
- Sleep 
- Research projects
- 覚醒時の徐波生成機序解明による眠気発生原理の理解 - 2022-04 -- 2029-03 - Yo OISHI - Japan Science and Technology Agency (JST)/Fusion Oriented REsearch for disruptive Science and Tecnology (FOREST) - 65,000,000Yen - Searching for neural circuits that induce "sleepiness" - 2020-07 -- 2023-03 - OISHI Yo - Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Research (Exploratory) - 6,500,000Yen - Elucidation of sleep-regulatory mechanisms by the reward system - 2018-04 -- 2023-03 - OISHI Yo - Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (B) - 17,160,000Yen - 短眠を作る神経メカニズムの研究 - 2021-04 -- 2022-03 - Yo OISHI - Japan Foundation for Applied Enzymology/Research Grant - 500,000Yen - 短眠を作る神経メカニズムの研究 - 2020-04 -- 2021-03 - Yo OISHI - Japan Foundation for Applied Enzymology/Research Grant - 300,000Yen - 報酬⾏動が制御する睡眠神経回路の解析 - 2018-09 -- 2021-03 - Yo OISHI - Takeda Science Foundation/Research Grant - 2,000,000Yen - 短眠を作る神経メカニズムの研究 - 2019-04 -- 2020-03 - Yo OISHI - Japan Foundation for Applied Enzymology/Research Grant - 400,000Yen - 報酬系による睡眠覚醒制御 - 2018-04 -- 2019-03 - Yo OISHI - Japan Foundation for Applied Enzymology/Research Grant - 550,000Yen - 腹側被蓋野ドーパミン系による睡眠覚醒制御機構の解析 - 2017-04 -- 2018-03 - Yo OISHI - Japan Foundation for Applied Enzymology/Research Grant - 200,000Yen - Elucidation of the sleep-inducing neuronal system - 2015-04 -- 2018-03 - Yo OISHI - Japan Society for the Promotion of Science/Grant-in-Aid for Young Researcher (B) - 3,900,000Yen - more... 
- Career history
- 2023-04 -- (current) - 筑波大学医学医療系准教授 - 2018-08 -- (current) - University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS)Principal investigator - 2022-04 -- 2023-03 - 筑波大学医学医療系助教 - 2017-11 -- 2022-03 - University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS)Assistant Professor - 2013-04 -- 2017-10 - University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS)Researcher - 2010-04 -- 2013-03 - Beth Israel Deaconess Medical Center, Harvard Medical SchoolResearch Fellow - 2010-04 -- 2012-03 - JSPSPostdoctoral Fellowships for Research Abroad - 2009-04 -- 2010-03 - Osaka Bioscience InstitutePostdoctoral Associate 
- Academic background
- 2005-04 -- 2009-03 - Osaka University Graduate School of Medicine - 2003-04 -- 2005-03 - Keio University Graduate school of Science and Technology - 1999-04 -- 2003-03 - Keio University Faculty of Science and Technology 
- Degree
- 2009-03 - Ph.D. - Osaka University 
- Academic societies
- 2008-07 -- (current) - The Japanese Neuroscience Society - 2008-06 -- (current) - Japanese Society of Sleep Research 
- Honors & Awards
- 2018-11 - Young faculty encouragement award, University of Tsukuba - 2018-07 - Research award, Japanese Society of Sleep Research 
- Articles
- A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease
 Kashiwagi Mitsuaki; Beck Goichi; Kanuka Mika; Arai Yo...
 Cell/187(22), 2024-09-17
- Comprehensive mapping of histamine H1 receptor mRNA in the mouse brain
 Futagawa Asako; Tsuneoka Yousuke; Lazarus Michael; Ois...
 JOURNAL OF COMPARATIVE NEUROLOGY/532(5), 2024-05
- ARE TUBEROMAMMILLARY HISTAMINE NEURONS GABAERGIC?
 Mochizuki T.; Oishi Y.; Yamamoto M.; Vong L.; Lowell ...
 SLEEP/35/pp.A35-A35, 2012
- GABAergic modulation of sleep-wake states
 Oishi Yo; Saito Yuki C.; Sakurai Takeshi
 PHARMACOLOGY & THERAPEUTICS/249, 2023-09
- Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice
 Lin Yang; Roy Koustav; Ioka Shuji; Otani Rintaro; Ame...
 Frontiers in pharmacology/14, 2023-04-01
- Editorial: Neurobiology of sleeping behaviors
 Hasegawa Emi; Oishi Yo; Kroeger Daniel; Tsunematsu To...
 FRONTIERS IN BEHAVIORAL NEUROSCIENCE/17, 2023-04-01
- Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction
 Honda Takato; Takata Yohko; Cherasse Yoan; Mizuno Sei...
 iScience/23(6), 2020-06
- Gating and the Need for Sleep: Dissociable Effects of Adenosine A(1) and A(2A) Receptors
 Lazarus Michael; Oishi Yo; Bjorness Theresa E; Greene ...
 Frontiers in neuroscience/13/p.740, 2019-04
- L-PGDS-produced PGD(2) in premature, but not in mature, adipocytes increases obesity and insulin resistance
 Fujimori Ko; Aritake Kosuke; Oishi Yo; Nagata Nanae; ...
 SCIENTIFIC REPORTS/9/p.1931, 2019-02
- Extracellular adenosine and slow-wave sleep are increased after ablation of nucleus accumbens core astrocytes and neurons in mice
 Zhou Xuzhao; Oishi Yo; Cherasse Yoan; Korkutata Musta...
 Neurochemistry international/124/pp.256-263, 2019-01
- The Leptomeninges Produce Prostaglandin D-2 Involved in Sleep Regulation in Mice
 Cherasse Yoan; Aritake Kosuke; Oishi Yo; Kaushik Mahe...
 FRONTIERS IN CELLULAR NEUROSCIENCE/12, 2018-10
- The Leptomeninges Produce Prostaglandin D-2 Involved in Sleep Regulation in Mice
 Cherasse Yoan; Aritake Kosuke; Oishi Yo; Kaushik Mahesh ...
 FRONTIERS IN CELLULAR NEUROSCIENCE/12, 2018-10
- Sleep and wakefulness are controlled by ventral medial midbrain/pons GABAergic neurons in mice
 Takata Yohko; Oishi Yo; Zhou Xu-Zhao; Hasegawa Emi; T...
 The Journal of neuroscience/38(47)/pp.10080-10092, 2018-10
- Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice
 Oishi Yo; Xu Qi; Wang Lu; Zhang Bin-Jia; Takahashi Koji; ...
 NATURE COMMUNICATIONS/8(1)/p.734, 2017-09
- Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D2-like receptors in mice
 Oishi Yo; Suzuki Yoshiaki; Takahashi Koji; Yonezawa Tosh...
 Brain structure & function, 2017-08
- The control of sleep and wakefulness by mesolimbic dopamine systems
 Oishi Yo; Lazarus Michael
 Neuroscience research/118/pp.66-73, 2017-04
- Polygraphic Recording Procedure for Measuring Sleep in Mice
 Oishi Yo; Takata Yohko; Taguchi Yujiro; Kohtoh Sayaka; Ur...
 JOVE-JOURNAL OF VISUALIZED EXPERIMENTS/(107), 2016-01
- The roles of prostaglandin E-2 and D-2 in lipopolysaccharide-mediated changes in sleep
 Oishi Yo; Yoshida Kyoko; Scammell Thomas E.; Urade Yoshi...
 BRAIN BEHAVIOR AND IMMUNITY/47(SI)/pp.172-177, 2015-07
- Role of the medial prefrontal cortex in cataplexy
 Oishi Yo; Williams Rhiannan H; Agostinelli Lindsay; Ar...
 The Journal of neuroscience/33(23)/pp.9743-9751, 2013-06
- Amygdala lesions reduce cataplexy in orexin knock-out mice
 Burgess Christian R; Oishi Yo; Mochizuki Takatoshi; Pe...
 The Journal of Neuroscience/33(23)/pp.9734-9742, 2013-06
- Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type prostaglandin D synthase in mice
 Kaneko Kentaro; Lazarus Michael; Miyamoto Chihiro; Ois...
 Molecular nutrition & food research/56(8)/pp.1315-1323, 2012-08
- Involvement of S-nitrosylation of actin in inhibition of neurotransmitter release by nitric oxide
 Lu Jingshan; Katano Tayo; Okuda-Ashitaka Emiko; Oishi ...
 Molecular pain/5/p.58, 2009-09
- Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep
 Oishi Yo; Huang Zhi-Li; Fredholm Bertil B; Urade Yosh...
 Proceedings of the National Academy of Sciences of the United States of America/105(50)/pp.19992-19997, 2008-12
- High-throughput fluorescence labelling of full-length cDNA products based on a reconstituted translation system
 Kawahashi Yuko; Doi Nobuhide; Oishi Yo; Tsuda Chizuru...
 Journal of biochemistry/141(1)/pp.19-24, 2007-01
- Escherichia coli proteome chips for detecting protein-protein interactions
 Oishi Yo; Yunomura Shuichi; Kawahashi Yuko; Doi Nobuh...
 Proteomics/6(24)/pp.6433-6436, 2006-12
- more...
 
- A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease
- Books
- 神経活動の操作
 大石 陽
 睡眠学の百科事典/丸善出版, 2024-06
- ドパミン
 大石 陽
 睡眠学の百科事典/丸善出版, 2024-06
- 正常睡眠の特徴 リード文
 大石 陽
 睡眠学の百科事典/丸善出版, 2024-06
- Adenosinergic Control of Sleep
 Lazarus Michael; Oishi Yo; Landolt Hans-Peter
 Principles and Practice of Sleep Medicine Seventh Edition/pp.452-459, 2021-12
 
- 神経活動の操作
- Conference, etc.
- 短眠マウスとその神経メカニズム
 大石 陽
 日本睡眠学会第48回定期学術集会/2024-07-19
- Analyses of the anatomical and molecular bases of REM sleep deficits that accompany Parkinson’s disease
 Ami Kaneko; Kanae Iwase; Mitsuaki Kashiwagi; Shinnosuk...
 日本生理学会 第100回記念大会/2023-03-14--2023-03-16
- 中脳・橋神経による睡眠および関連行動の制御
 大石 陽
 日本睡眠学会第47回定期学術集会/2022-06-30
- Neural mechanisms for brain slow-wave generation in mice
 大石 陽
 AMEDムーンショット目標7技術交流会/2022-03-30
- DREADD-mediated slow-wave generation in mice
 Oishi Yo
 WPI-IIIS/Fudan University Joint Symposium/2022-02-25
- モチベーションによる睡眠制御の神経機構
 大石 陽
 日本睡眠学会第44回定期学術集会/2019-6-28
- Sleep-regulating midbrain GABAergic circuitry
 Oishi Yo
 World Sleep 2019/2019-09-24
- モチベーションと睡眠覚醒をつなぐ神経回路の解析
 大石 陽
 第11回Symphony/2018-09-01
- 報酬系による睡眠覚醒制御
 大石 陽
 日本睡眠学会第43回定期学術集会/2018-07-13
- Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice
 大石 陽
 日本睡眠学会第43回定期学術集会/2018-07-11
- The role of ventral midbrain neurons in sleep-wake regulation
 Oishi Yo
 Sleep Regulation and Function; Gordon Research Conference/2018-03-18--2018-03-23
- The role of the nucleus accumbens in sleep regulation
 Oishi Yo
 World Sleep 2017/2017-10-09
- Sleep-regulatory mechanism of  the nucleus accumbens
 Oishi Yo
 The 5th Annual IIIS Symposium/The 32nd Wako Workshop/2016-12-12
- Activation of the indirect pathway in the nucleus accumbens core produces slow-wave sleep
 Oishi Yo
 The 39th Annual Meeting of the Japan Neuroscience Society/2016-7-20--2016-7-22
- Neural mechanisms of cataplexy
 Oishi Yo
 Meeting in Shanghai Medical College of Fudan University/2015-08-25
- Neural circuitry of cataplexy in orexin knockout mice
 Oishi Yo
 日本睡眠学会第39回定期学術集会/2014-07-03--2014-07-04
- Role of the Medial Prefrontal Cortex in Cataplexy
 Oishi Yo
 Neuroscience 2013/2013-11-09--2013-11-13
- Chocolate increases cataplexy and c-Fos expression in orexin knockout mice
 Oishi Yo
 Neuroscience 2011/2011-11-12--2011-11-16
- Feeding-induced cataplexy and c-Fos expression in brain areas projecting to the brainstem in orexin knockout mice
 Oishi Yo
 Worldsleep 2011/2011-10-16--2011-10-20
- Activation of adenosine A1 receptors in the histaminergic neurons induces sleep in rats
 Oishi Yo
 Biochemistry and Molecular Biology 2008/2008-12-10
- Adenosinergic inhibition of the histaminergic system induces sleep through the adenosine A1 receptors in rodents
 Oishi Yo
 第31回日本神経科学大会/2008-07-09--2008-07-11
- Activation of adenosine A1 receptors in the tuberomammillary nucleus of rodents suppresses histaminergic systems and promotes non-REM sleep.
 大石 陽
 日本睡眠学会第33回定期学術集会/2008-06-25--2008-06-26
- Function of lipocalin-type prostaglandin synthase in leptomeninges.
 Oishi Yo
 The Molecular Biology Society of Japan Forum 2006/2006-12-06--2006-12-08
- Large analysis of protein-protein interaction using E.coli proteome chips.
 大石 陽
 第27回大会日本分子生物学会年会/2004-12-08--2004-12-11
 
- 短眠マウスとその神経メカニズム
- Teaching
- 2026-01 -- 2026-02 - Practice of Clinical Pharmacology - University of Tsukuba. - 2025-04 -- 2025-08 - Clinical Pharmacology - University of Tsukuba. - 2025-04 -- 2025-06 - Pharmacology - University of Tsukuba. - 2025-10 -- 2026-03 - Neuroscience Dissertation Research 6 - University of Tsukuba. - 2025-04 -- 2025-09 - Neuroscience Dissertation Research 5 - University of Tsukuba. - 2025-10 -- 2026-03 - Neuroscience Dissertation Research 4 - University of Tsukuba. - 2025-04 -- 2025-09 - Neuroscience Dissertation Research 3 - University of Tsukuba. - 2025-10 -- 2026-03 - Neuroscience Dissertation Research 2 - University of Tsukuba. - 2025-04 -- 2025-09 - Neuroscience Dissertation Research 1 - University of Tsukuba. - 2025-10 -- 2026-02 - Lecture and Discussion in Medical Sciences of Sleep II - University of Tsukuba. - more... 
- Professional activities
- 2022-01 -- (current) - 日本睡眠学会 - 睡眠学会教育委員会 睡眠科学研究講座 作業部会 - 2021-11 -- (current) - THE JAPANESE SOCIETY OF SLEEP RESEARCH - 評議員 
- University Management
- 2025-04 -- (current) - ヒューマニクス学位プログラム学位審査委員会 - 委員長 - 2024-04 -- (current) - ヒューマニクス学位プログラム学生支援委員会 - 委員長 - 2024-04 -- (current) - ヒューマンバイオロジー学位プログラム学生支援委員会 - 副委員長 - 2024-04 -- (current) - ヒューマンバイオロジー学位プログラム運営委員会 - 委員 - 2023-04 -- 2024-03 - ヒューマニクス学位プログラム学生支援委員会 - 副委員長 - 2023-04 -- (current) - ニューロサイエンス学位プログラム入試委員会 - 委員 - 2022-10 -- (current) - ヒューマニクス学位プログラム運営委員会 - 委員 - 2022-04 -- 2024-03 - 研究戦略室 - 室員 - 2022-04 -- 2024-03 - ニューロサイエンス学位プログラム広報・HP委員会 - 委員 - 2022-04 -- 2024-03 - 生命システム医学専攻教務委員会 - 委員 - more... 
(Last updated: 2025-08-18)