OSAKI Yoshinori

Affiliation

Institute of Medicine

Official title

Assistant Professor

ORCID

Research fields


Endocrinology
Metabolomics

Research keywords


HMG-CoA reductase
Rhabdomyolysis
statin
Skeletal muscle

Research projects


スタチンによる骨格筋障害発症機序とコレステロール代謝の骨格筋形成特有な役割の解明	2020 -- 2022	Yoshinori Osaki	日本学術振興会/若手研究	3,640,000Yen

Academic background


2012-04 -- 2016-03	筑波大学大学院人間総合科学研究科疾患制御医学
2000-04 -- 2006-03	筑波大学医学専門学群

Degree


2016-03	博士（医学）	筑波大学

Licenses and qualifications


	日本内科学会総合内科専門医
	日本糖尿病学会専門医・研修指導医
	日本内分泌学会内分泌代謝科（内科）専門医・指導医
	日本甲状腺学会専門医

Academic societies


-- (current)	THE JANPANESE SOCIETY OF INTERNAL MEDICINE
-- (current)	JAPAN DIABETES SOCIETY
-- (current)	THE JAPAN ENDOCRINE SOCIETY
-- (current)	JAPAN THYROID ASSOCIATION

Articles

Variability of urinary albumin to creatinine ratio and eGFR are independently associated with eGFR slope in Japanese with type 2 diabetes: a three-year, single-center, retrospective cohort study
Matsuda Takaaki; Osaki Yoshinori; Maruo Kazushi; Matsu...
BMC nephrology/25(1)/p.264, 2024-08-16
PubMed
Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia.
Y Furuta; Y Osaki; Y Nakagawa; SI Han; M Araki; A S...
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS/Epub, 2024-03-28
PubMed
Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia
Furuta Yasuhisa; Osaki Yoshinori; Nakagawa Yoshimi; Ha...
Journal of atherosclerosis and thrombosis, 2024-03-28
PubMed
Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids
Han Song-Iee; Nakakuki Masanori; Nakagawa Yoshimi; Wan...
PNAS NEXUS/2(11), 2023-11-01
PubMed
Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity
Saito Kenji; Sekiya Motohiro; Kainoh Kenta; Yoshino R...
J Biol Chem/299(7)/p.104890, 2023-7
Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity
Sekiya Motohiro; Kainoh Kenta; Yoshino Ryunosuke; Haya...
The Journal of biological chemistry/299(7), 2023-07-01
PubMed
Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function
Sekiya Motohiro; Ma Yang; Kainoh Kenta; Yamazaki Daic...
CELL REPORTS/42(8), 2023-08-29
PubMed
Effects of Branched-Chain Amino Acids on Skeletal Muscle, Glycemic Control, and Neuropsychological Performance in Elderly Persons with Type 2 Diabetes Mellitus: An Exploratory Randomized Controlled Trial
Matsuda Takaaki; Suzuki Hiroaki; Sugano Yoko; Suzuki ...
NUTRIENTS/14(19), 2022-10
A case of early-onset diabetes with impaired insulin secretion carrying a PAX6 gene Gln135* mutation
Sekiya Motohiro; Yuhara Mikiko; Murayama Yuki; Ohyama Osa...
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS/2022, 2022-08
A case of NASH with genetic predisposition successfully treated with an SGLT2 inhibitor: a possible involvement of mitochondrial dysfunction
Nakajima Rikako; Sekiya Motohiro; Furuta Yasuhisa; Miy...
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS/2022, 2022-12-01
PubMed
Takotsubo cardiomyopathy with left ventricle thrombus caused by subacute thyroiditis
Yamazaki Daichi; Osaki Yoshinori; Suzuki Hiroaki; Shim...
BMJ CASE REPORTS/16(3), 2023-03-14
PubMed
Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis
Istiqamah Nurani; Takashi Matsuzaka; Shimizu Momo; Mot...
BBA Advances/3, 2023-01
Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice
Okajima Yuka; Matsuzaka Takashi; Miyazaki Shun; Motomura ...
Biochimica et biophysica acta. Molecular basis of disease/1868(4), 2022-04-01
PubMed
Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1
Ma Yang; Sekiya Motohiro; Kainoh Kenta; Matsuda Takaaki; ...
Biochemical and biophysical research communications, 2020-03
CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2
Kainoh Kenta; Takano Ryo; Sekiya Motohiro; Saito Kenji; S...
Biochemical and biophysical research communications/562/pp.146-153, 2021-07-12
PubMed
Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion
Sekiya Motohiro; Matsuda Takaaki; Yamamoto Yuki; Furuta ...
BMC MEDICAL GENETICS/21(1), 2020-05
PubMed
Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice
Matsuzaka Takashi; Kuba Motoko; Koyasu Saori; Yamamoto Y...
Hepatology (Baltimore, Md.)/71(5)/pp.1609-1625, 2020-5
PubMed
CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms
Satoh Aoi; Han Song-Iee; Araki Masaya; Nakagawa Yoshimi; ...
iScience/23(3)/pp.100930-100930, 2020-03
PubMed Tsukuba Repository
Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1
Ma Yang; Sekiya Motohiro; Kainoh Kenta; Matsuda Takaaki; ...
Biochemical and biophysical research communications/523(2)/pp.354-360, 2020-03
PubMed
The selective PPARα modulator K-877 efficiently activates the PPARα pathway and improves lipid metabolism in mice
Takei Kenta; Han Song-Iee; Murayama Yuki; Satoh Aoi; Oika...
Journal of diabetes investigation/8(4)/pp.446-452, 2017-07
PubMed
Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression.
Kikuchi Takuya; Orihara Kana; Oikawa Fusaka; Han Song-ie...
Mol Metab./5(11)/pp.1092-1102, 2016-09
PubMed Tsukuba Repository
Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system.
Yoshimi Nakagawa; Fusaka Oikawa; Seiya Mizuno; Ohno Hiro...
SCIENTIFIC REPORTS/6(e-pub)/p.27857, 2016-06
PubMed Tsukuba Repository
Familial Dysalbuminemic Hyperthyroxinemia in a Japanese Man Caused by a Point Albumin Gene Mutation (R218P)
Osaki Yoshinori; Hayashi Yoshitaka; Nakagawa Yoshinori...
Japanese clinical medicine/7/pp.9-13, 2016-04
PubMed
Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy
Osaki Yoshinori; Nakagawa Yoshimi; Miyahara Shoko; Iwasak...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/466(3)/pp.536-540, 2015-10
PubMed
Prediction of late (24-hour) radioactive iodine uptake using early (3-hour) uptake values in Japanese patients with Graves' disease
Osaki Yoshinori; Sakurai Kanako; Arihara Zenei; Hata ...
Endocrine journal/59(2)/pp.173-177, 2012-04
PubMed
more...

Books

【脂質異常症治療の最新動向-スタチンを軸とした展開】スタチンの薬理・薬効
大﨑芳典
カレントテラピー/ライフメディコム/pp.937-942, 2019-10
I正常な脂質代謝を理解しよう-3コレステロールの代謝を理解しよう
大﨑芳典
そうだったんだ！脂質異常症/文光堂/pp.14-20, 2016-09
【脂質異常症-基礎・臨床研究の最新知見】リポ蛋白代謝　リポ蛋白代謝にかかわる核内受容体およびリポ蛋白受容体
大﨑芳典
日本臨牀/日本臨牀社/pp.70-74, 2013-06
第1部-8章 URAT1
大﨑芳典
糖尿病の分子標的と治療薬事典/羊土社/pp.230-231, 2013-05
【実地医家のための　臨床検査のすすめかた・評価のしかた】脂質代謝異常-疑いから確定診断までの検査項目の選択と総合評価
大﨑芳典
メディカルプラクティス/文光堂/pp.227-238, 2012-05

Conference, etc.

患側と考えられた副腎摘出後も改善が無く治療に苦慮した副腎髄質過形成の一例
古田泰久; 大崎芳典; 山本由季; 大山真理子; 村山友樹; 菅野洋子; 岩崎仁; 関谷元博; 矢...
第93回日本内分泌学会学術集会/2020-07-20--2020-08-31
亜急性甲状腺炎発症後バセドウ病が明らかになった2症例
菅野洋子; 中島里佳子; 大山真理子; 村山友樹; 大崎芳典; 岩崎仁; 関谷元博; 矢作直也; ...
第93回日本内分泌学会学術集会/2020-07-20--2020-08-31
亜急性甲状腺炎に甲状腺クリーゼとたこつぼ型心筋症を伴った一例
山崎大地; 松本なこ; 大崎芳典; 大内奈美; 山本由季; 大山真理子; 村山友樹; 菅野洋子; ...
第29回臨床内分泌代謝 Update/2019-11-29--2019-11-30

Teaching


2024-10 -- 2024-12	Innovative Clinical Biochemistry in Life Science	University of Tsukuba.
2024-04 -- 2024-07	Human Endocrinology and Metabolism	University of Tsukuba.
2024-10 -- 2024-11	Endocrinology and Metabolism for Beginners	University of Tsukuba.
2023-10 -- 2023-11	Endocrinology and Metabolism for Beginners	University of Tsukuba.
2023-10 -- 2024-02	Special Practice in Human Biology I	University of Tsukuba.
2023-04 -- 2023-06	Human Endocrinology and Metabolism	University of Tsukuba.
2023-10 -- 2023-12	Innovative Clinical Biochemistry in Life Science	University of Tsukuba.
2022-04 -- 2022-07	Human Endocrinology and Metabolism	University of Tsukuba.
2022-10 -- 2022-12	Innovative Clinical Biochemistry in Life Science	University of Tsukuba.

Professional activities


2021-04 -- (current)	THE JAPAN ENDOCRINE SOCIETY	評議員

(Last updated: 2024-04-10)