YOSHIHARA Masaharu

Affiliation
Institute of Medicine
Official title
Specially Appointed Assistant Professor
ORCID
0000-0002-0212-0909
Sex
Male
KAKEN ID
60963618
Email
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Office
Department of Anatomy and Embryology
Phone
029-853-7516
Fax
029-853-6965
Research fields
Laboratory animal science
General anatomy (including histology/embryology)
Research keywords
Transgenic Mouse
Morphogenesis
Delta-Notch signaling pathway
Developmental Biology
Histology
Gross Anatomy
Research projects
Elucidation of Notch1 involvement in the left-side heart development2023-04 -- 2028-03YOSHIHARA MasaharuJapan Society for the Promotion of Science/Grant-in-Aid for Early-Career Scientists4,680,000Yen
Identification of Notch1 signaling- receiving cell lineage during acute kidney injury in a mouse sepsis model2022-10 -- 2023-03Masaharu YOSHIHARAYOKOYAMA Foundation for Clinical Pharmacology/1,000,000Yen
Elucidation of a morphogenic mechanism via Delta-Notch signaling pathway- an in vivo examination of a mathematical prediction on biliary formation2022-10 -- 2024-03Masaharu YOSHIHARAJapan Society for the Promotion of Science/Grant-in-Aid for Research Activity Start-up2,860,000Yen
Mathematical and genetical analysis on the Delta-Notch signaling dynamics in bile duct formation2021-04 -- 2022-03Masaharu YOSHIHARAJapan Society for the Promotion of Science/Grant-in-Aid for JSPS Fellows2,200,000Yen
Career history
2025-04 -- (current)University of TsukubaInstitute of MedicineSpecially Appointed Assistant Professor
2022-04 -- 2025-03University of TsukubaInstitute of MedicineAssistant Professor
2021-04 -- 2022-03Japan Society for the Promotion of ScienceYoung Scientist Fellow (DC1)
2019-04 -- 2021-03University of TsukubaResearch Assistant
2017-04 -- 2019-03Tsukuba Medical Center Foundationjunior resident physician
Academic background
2019-04 -- 2023-03University of Tsukuba School of Integrative and Global Majors PhD Program in Humanics
2011-04 -- 2017-03University of Tsukuba School of Medicine and Medical Sciences School of Medicine
Degree
2023-03Doctor of Philosophy in Medical SciencesUniversity of Tsukuba
2017-03Doctor of MedicineUniversity of Tsukuba
Licenses and qualifications
2024-01Certified Interviewer (Medical Care Act)
2025-02Junior Resident Consultant
2025-05Completion of skill training course for operations chief of specified chemical substances and tetraalkyl lead
2024-02死体解剖資格
2024-04アンガーマネジメントファシリテーター
2022-07第6回一般教養・基礎社会医学系教員のためのカリキュラムプランニングワークショップ　修了
2018-11Certified Industrial Physician
2017-11茨城県緩和ケア研修会修了
2017-03Medical license
Academic societies
2024-12 -- (current)Japan Society for Medical Education
2023-01 -- (current)日本実験動物協会
2022-02 -- (current)Japanese Association of Anatomists
Honors & Awards
2024-11Young Investigator Award
2025-04Best Teachers' Award
2024-04Best Teachers’ Award
2023-11筑波大学医学医療系大学教員業績評価優秀教員
2023-04Best Teachers' Award
Articles
Conference, etc.
  • Notch1シグナルレポーターマウスの心臓の解剖学的解析
    吉原 雅大; 高橋 智
    第112回日本解剖学会関東支部学術集会/2024-12-01--2024-12-01
  • 遺伝子組換え技術を用いたシグナル伝達解析の数理的評価
    渡部 嘉徳; 高橋 智; 吉原 雅大
    第112回日本解剖学会関東支部学術集会/2024-12-01--2024-12-01
  • 新規遺伝子組換えマウスを用いた、敗血症におけるNotch1シグナルの腎内動態解析
    吉原 雅大
    第70回日本実験動物学会総会/2023-05-24--2023-05-26
  • 地域住民における心不全バイオマーカーと循環器疾患リスクファクターの関連
    吉原 雅大; 山岸良匡; 北村明彦; 木山昌彦; 隅田武夫; 山海知子; 大平哲也; 今野弘規; 崔仁哲; 梅澤光政; 湊百合子; 井...
    第23回日本疫学会学術集会/2013-01-25--2013-01-25
  • 成獣組織の血管内皮細胞におけるVEGF受容体の発言差異
    吉原 雅大
    第119回日本解剖学会総会・全国学術集会/2014-03-28--2014-03-28
  • Delta-Notchシグナル経路を介したパターン形成機構〜肝内胆管形成から摂動による誘導現象を探る〜
    吉原 雅大
    日本解剖学会第110回関東支部学術集会/2022-10-01--2022-10-01
  • Notch1シグナル可視化マウス系の樹立
    三瓶直人; 吉原 雅大; 高橋智
    日本解剖学会第110回関東支部学術集会/2022-10-01--2022-10-01
  • 腎内におけるNotch1シグナルの可視化
    吉原 雅大; 杉浦涼介; 高橋智
    日本解剖学会第110回関東支部学術集会/2022-10-01--2022-10-01
  • 解剖学人材をいかに確保するか〜取り組みと提言〜
    吉原 雅大
    第126回日本解剖学会総会全国学術集会/2021-03-28
Works
  • からだの成り立ちを求めて（国立大学医学部長会議 若手研究者のひらめき～研究医への誘い～）
    吉原 雅大
Teaching
2025-04 -- (current)Functional Structure and Laboratory CourseMaster's Program in Medical Sciences
2024-09 -- (current)Advanced CourseCollege of Medicine
2025-04 -- (current)Clinical AnatomyCollege of Medicine
2025-04 -- (current)Initiation SeminarPhD Program in Human Biology
2025-07 -- (current)Rehabilitation MedicineSpecial Needs Education School for the Visually Impaired, University of Tsukuba
2025-10 -- (current)Human Anatomy and EmbryologyPhD Program in Human Biology
2023-10 -- (current)神経解剖学生物学類
2024-09 -- (current)機能構造と病態I（組織学）医学類
2023 -- (current)Introduction to Human AnatomyMaster's Program in Medical Science
2023 -- (current)Human Anatomy (Histology Practice)College of Medical Science
more...
Other educational activities
2024-05 -- (current)Member of Medical Education CenterUniversity of Tsukuba
2025-04 -- (current)Faculty member of Department of Planning and Coordination for Medical EducationUniversity of Tsukuba
2020-02 -- (current)Chair of Humanics Alumni Network
2025-04 -- (current)Member of student life support officeUniversity of Tsukuba
2024-04 -- 2026-032024年度医学類1年生６クラス担任筑波大学
2024-01 -- (current)医学類学生担当教員筑波大学
2022-12 -- 2022-12令和4年度修学生の集い茨城県保健医療部医療人材課
2023-03 -- 2023-03第24回解剖技術研究・研修会Japan Association of Anatomists
2019-11 -- (current)Medical RallyTsukuba Medical Center Foundation
Professional activities
2025-07 -- (current)University of TsukubaChair of the subcommittee of student affairs committee, College of Medicine
2025-04 -- (current)University of TsukubaAuditor, University of Tsukuba Traffic Safety Association
2024-04 -- (current)University of TsukubaStudent Support Team Member, Ph.D. Program in Humanics, University of Tsukuba
Other activities
2021-07 -- 2022-03非常勤医師（水戸市新型コロナワクチン大規模接種会場）
2022-04 -- (current)非常勤医師（社会福祉法人恩賜財団済生会神栖済生会病院）
2019-04 -- 2021-03非常勤医師（公益財団法人筑波メディカルセンター）
2017-04 -- 2019-03医師臨床研修（公益財団法人筑波メディカルセンター）

(Last updated: 2025-07-25)