FUJIMAKI Motoki
- Affiliation
- Institute of Medicine
- Official title
- Assistant Professor
- ORCID
- 0009-0007-6766-5145
- Sex
- Male
- Birth date
- 1983-07
- KAKEN ID
- 10961708
- 58?1@548,N]Y8/W?>@6@-,W,.W5;
- Research fields
Experimental pathology Neurology - Research keywords
Neuronal degenerative diseases Neurodegeneration with Brain Iron Accumulation (NBIA) Autophagy Novel drug seeds Ferroptosis - Research projects
Development of novel curative seeds for pantothenate kinase–associated neurodegeneration based on inhibition of alpha-synuclein–polyunsaturated fatty acid binding 2025-04 -- 2028-03 Motoki Fujimaki The Japan Agency for Medical Research and Development (AMED)/Research grant on rare and intractable diseases Program 39,000,000Yen Are brain iron accumulation and neuronal death in β-propeller–associated neurodegeneration caused by ferroptosis? 2023-04 -- 2028-03 Motoki Fujimaki Japan Society for the Promotion of Science/Grant-in-Aid for Early-Career Scientists 4,550,000Yen Exploratory study for curative therapeutic strategies in β-propeller protein–associated neurodegeneration 2024-12 -- 2026-03 Motoki Fujimaki Mochida Memorial Foundation for Medical and Pharmaceutical Research/Research Grant 3,000,000Yen Is dopaminergic neuronal death in Parkinson’s disease caused by iron-related cell death ferroptosis? 2024-09 -- 2029-03 Motoki Fujimaki Takeda Science Foundation/Research Grant 2,000,000Yen Overseas Research Fellowship Grant (University of Cambridge) 2019-04 -- 2022-03 Motoki Fujimaki Takeda Science Foundation/Overseas Research Fellowship Grant 15,000,000Yen - Career history
2024-04 -- (current) Faculty of Medicine, University of TsukubaDepartment of NeurologyAssistant Professor 2023-12 -- 2024-03 University of Tsukuba HospitalAssistant Professor 2022-03 -- 2023-11 Shizuoka Hospital, Faculty of Medicine, Juntendo UniversityAssistant Professor 2019-04 -- 2022-03 ケンブリッジ大学 ケンブリッジ医学生物学研究所Cambridge Institute for Medical Research, University of CambridgeResearch Associate 2012-04 -- 2015-03 Faculty of Medicine, Juntendo UniversityDepartment of NeurologyStaff Physician 2010-04 -- 2012-03 Juntendo University Hospital, Faculty of Medicine, Juntendo UniversityJunior Resident - Academic background
2015-04 -- 2019-03 Graduate School of Medicine, Juntendo University Doctoral Program Completed (Ph.D. in Medicine) 2004-04 -- 2010-03 Faculty of Medicine, University of Yamanashi Graduated (M.D.) - Degree
2019-03 Ph.D. in Medicine Juntendo University - Licenses and qualifications
2023-04 medical instructor (The Japanese Society of Neurology) 2016-07 Specialty of Clinical Neuurology (The Japanese Society of Neurology) 2010-04 medical license - Academic societies
2012-04 -- (current) THE JANPANESE SOCIETY OF INTERNAL MEDICINE 2012-04 -- (current) The Japanese Society of Neurology - Honors & Awards
2024-09 2024 Japan Medical Association Medical Research Encouragement Award Exploration of curative therapies for β-propeller protein–associated neurodegeneration (BPAN) through regulation of autophagy-independent ferroptosis 2024-05 Best Oral Presentation Award (Basic Section) Best oral presentation in the basic section at the 65th Annual Meeting of the Japanese Society of Neurology/AOCN2024 2017-09 Excellent Presentation Award Excellent presentation at the 59th Annual Meeting of the Japanese Society of Neurology 2014-10 Excellence Award Excellent presentation at the 8th Congress of the Japanese Society of Parkinson’s Disease and Movement Disorders - Articles
- Subacute Progressive Hearing Loss and Lower Body Parkinsonism in Primary Sjögren's Syndrome
Shimizu Mai; Fujimaki Motoki; Igami Eriko; Ishiguro Y...
Internal medicine (Tokyo, Japan)/63(6)/pp.853-856, 2024-03-15 - Cerebrospinal fluid dissemination of anaplastic intraventricular meningioma: report of a case presenting with progressive brainstem dysfunction and multiple cranial nerve palsies
Fujimaki Motoki; Takanashi Masashi; Kobayashi Manami; ...
BMC neurology/16/p.82, 2016-05-31 - Acute psychosis as an initial manifestation of hypothyroidism: a case report
Ueno Shinichi; Tsuboi Satoko; Fujimaki Motoki; Eguchi ...
Journal of medical case reports/9/p.264, 2015-11-17 - Lymphomatoid Granulomatosis with Central Nervous System Involvement Successfully Treated with Cyclophosphamide, High-dose Cytarabine, Dexamethasone, Etoposide, and Rituximab (CHASER therapy) Followed by Brain Irradiation: A Case Study
Fujimaki Motoki; Kawajiri Sumihiro; Ichikawa Kunimoto; ...
CNS neuroscience & therapeutics/21(7)/pp.610-612, 2015-07-01 - Eosinophilic meningitis caused by primary angiitis of the central nervous system
Hirano Kazuoki; Fukae Jiro; Hieda Sotaro; Fujimaki Mo...
Internal medicine (Tokyo, Japan)/52(12)/pp.1393-1396, 2013-04-01 - Demyelinating Peripheral Neuropathy Due to Renal Cell Carcinoma
Nishioka Kenya; Fujimaki Motoki; Kanai Kazuaki; Ishigu...
Internal medicine (Tokyo, Japan)/56(1)/pp.101-104, 2017-04-01 - Parkinsonism in a patient with valosin-containing protein gene mutation showing: a case report
Fujimaki Motoki; Kanai Kazuaki; Funabe Sayaka; Takanas...
Journal of neurology/264(6)/pp.1284-1286, 2017-06-01 - Mendelian neurodegenerative disease genes involved in autophagy
Stamatakou Eleanna; Wróbel Lidia; Hill Sandra Malmgren...
Cell discovery/6/p.24, 2020-04-01 - Huntingtin-lowering strategies for Huntington's disease
Barker Roger A; Fujimaki Motoki; Rogers Priya; Rubinsz...
Expert opinion on investigational drugs/29(10)/pp.1125-1132, 2020-10-01 - The different autophagy degradation pathways and neurodegeneration
Fleming Angeleen; Bourdenx Mathieu; Fujimaki Motoki; K...
Neuron/110(6)/pp.935-966, 2022-03-16 - Reversible Pisa syndrome caused by chronic subdural hematoma in a patient with Parkinson's disease: a case report
Igami Eriko; Fujimaki Motoki; Shimizu Mai; Ishiguro Y...
BMC neurology/22(1)/p.432, 2022-11-15 - Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis
Zhu Ye; Fujimaki Motoki; Snape Louisa; Lopez Ana; Fleming...
Nature cell biology/26(4)/pp.542-551, 2024-04-01 - Autophagy-dependent versus autophagy-independent ferroptosis
Zhu Ye; Fujimaki Motoki; Rubinsztein David C
Trends in cell biology, 2025-03-05 - Differences in gait apraxia due to reduced regional cerebral blood flow in the supplementary motor area in corticobasal syndrome: a report of two cases
Igari Kota; Fujimaki Motoki; Mai Mera; Sakuma Moe; Sa...
BMC neurology/25(1)/p.304, 2025-07-29 - Hypertrophic olivary degeneration in a patient with lung cancer
Igari Kota; Fujimaki Motoki; Saiki Shinji
PRACTICAL NEUROLOGY, 2025-06-12 - Antiproliferative activities through accelerating autophagic flux by basidalin and its analogs in human cancer cells
Matagawa Tomoe; Sasazawa Yukiko; Agui Koki; Fujimaki ...
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS/104, 2024-05-15 - Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson's Disease.
Ueno S. I.; Saiki S.; Fujimaki M.; Takeshige-Amano H....
Cells/8(1), 2018-12-29 - Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson's disease.
Saiki S.; Hatano T.; Fujimaki M.; Ishikawa K. I.; Mor...
Scientific reports/7(1)/pp.7328-7328, 2017-08-04 - Immunocytochemical Monitoring of PINK1/Parkin-Mediated Mitophagy in Cultured Cells.
Fujimaki Motoki; Saiki Shinji; Sasazawa Yukiko; Ishika...
Methods in molecular biology (Clifton, N.J.)/1759/pp.19-27, 2018 - Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease.
Fujimaki Motoki; Saiki Shinji; Li Yuanzhe; Kaga Naoko...
Neurology/90(5)/pp.e404-e411-e411, 2018-01-30 - Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy.
Mori Akio; Ishikawa Kei-Ichi; Saiki Shinji; Hatano Ta...
PloS one/14(9)/p.e0223113, 2019 - Metabolomics-based identification of metabolic alterations in PARK2.
Okuzumi Ayami; Hatano Taku; Ueno Shin-Ichi; Ogawa Tak...
Annals of clinical and translational neurology/6(3)/pp.525-536, 2019-03 - Iron Supply via NCOA4-Mediated Ferritin Degradation Maintains Mitochondrial Functions.
Fujimaki Motoki; Furuya Norihiko; Saiki Shinji; Amo T...
Molecular and cellular biology/39(14), 2019-07-15 - A metabolic profile of polyamines in parkinson disease: A promising biomarker.
Saiki Shinji; Sasazawa Yukiko; Fujimaki Motoki; Kamaga...
Annals of neurology/86(2)/pp.251-263, 2019-08 - Neuroprotective effects of memantine via enhancement of autophagy.
Hirano Kazuoki; Fujimaki Motoki; Sasazawa Yukiko; Yama...
Biochemical and biophysical research communications/518(1)/pp.161-170, 2019-10-08 - more...
- Subacute Progressive Hearing Loss and Lower Body Parkinsonism in Primary Sjögren's Syndrome
- Books
- Alterations in Caffeine Metabolism in Parkinson’s Disease and Their Diagnostic Implications
藤巻 基紀
CMC Publishing Co., Ltd., 2018-09 - Protein degradation systems and Parkinson’s disease
藤巻 基紀
The Japanese Journal of Clinical Medicine, August 2023 Special Issue: Parkinson’s Disease 2023 — Recent Advances in Basic and Clinical Research —/Nippon Rinsho Co., Ltd./pp.1329-1335, 2023-08 - From Metabolomics to Drug Discovery in Parkinson’s Disease
藤巻 基紀
Neurology, Vol. 100, No. 4/Kagaku Hyoronsha Co., Ltd./pp.1-6, 2024-04
- Alterations in Caffeine Metabolism in Parkinson’s Disease and Their Diagnostic Implications
- Conference, etc.
- Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis
FUJIMAKI Motoki
The 65th Annual Meeting of the Japanese Society of Neurology / Asian and Oceanian Congress of Neurology 2024/2024-05-29--2024-06-01
- Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis
- Teaching
2024-09 -- (current) Peripheral Nerve and Muscle Disorders Faculty of Medicine, University of Tsukuba 2024-09 -- (current) Disorders with Cerebellar Ataxia as the Main Symptom Faculty of Medicine, University of Tsukuba 2024-09 -- (current) Motor Neuron Diseases and Spinocerebellar Degeneration Faculty of Medicine, University of Tsukuba 2024-09 -- (current) Central Nervous System Pharmacology Faculty of Medicine, University of Tsukuba 2024-09 -- (current) Understanding Neuroimmunological Disorders from a Therapeutic Perspective Faculty of Medicine, University of Tsukuba
(Last updated: 2025-08-09)