現在地

関谷 元博(セキヤ モトヒロ; Sekiya, Motohiro)

研究者情報全体を表示

論文
  • Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis.
    H Okazaki; M Igarashi; M Nishi; Sekiya Motohiro; M Tajima
    J Lipid Res., 2008-08
  • Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages.
    H Okazaki; M Igarashi; M Nishi; Sekiya Motohiro; M Tajima
    J Biol Chem., 2008-11
  • Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence.
    Sekiya Motohiro
    J Lipid Res, 2010-02
  • Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.
    Sekiya Motohiro; J Osuga; S Nagashima; T Ohshiro; M Igara...
    Cell Metab., 2009-09
  • The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages.
    M Igarashi; J Osuga; H Uozaki; Sekiya Motohiro; S Nagashi...
    Circ Res., 2010-11
  • Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.
    Commun. Biochem Biophys Res; Sekiya Motohiro; H Uozaki; M...
    Biochem Biophys Res Commun., 2011-01
  • The role of neutral cholesterol ester hydrolysis in macrophage foam cells.
    Sekiya Motohiro; Osuga J; Igarashi M; Okazaki H; Ishibashi S
    J Atheroscler Thromb., 2011-04
  • Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice.
    T Karasawa; A Takahashi; R Saito; Sekiya Motohiro; M Igar...
    Arterioscler Thromb Vasc Biol, 2011-08
  • Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.
    Sekiya Motohiro
    Arterioscler Thromb Vasc Biol, 2012-8
  • Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene.
    Takase S; Osuga J; Fujita H; Hara K; Sekiya Motohiro; Iga...
    J Atheroscler Thromb., 2013-3
  • Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production.
    Sekiya Motohiro
    Cell Metab, 2013-5
  • Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.
    Sekiya Motohiro
    J Lipid Res, 2014-10
  • Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.
    Nagashima S; Yagyu H; Tozawa R; Tazoe F; Takahashi M; Kit...
    J Lipid Res., 2015-5
  • Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.
    Sekiya Motohiro; MF Burak; KE Inouye; A White; G Tuncman;...
    Sci Transl Med, 2015-12
  • Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice
    Takei Kenta; Nakagawa Yoshimi; Wang Yunong; Han Song-Iee;...
    Journal of pharmacological sciences/133(4)/pp.214-222, 2017-04