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Yanagisawa Masashi
- Affiliation
- International Institute for Integrative Sleep Medicine
- Official title
- Professor
- Research projects
睡眠脳波を指標とする睡眠と運動の自己管理による健康寿命延伸 2019 -- 2021 柳沢 正史 科学技術振興機構/未来社会創造事業 5,000,000Yen 健康寿命の延伸を図る「食」を通じた新たな健康システムの確立 2018 -- (current) 柳沢 正史 農業・食品産業技術総合研究機構/SIP 戦略的イノベーション創造プログラム 11,150,000Yen フォワード・ジェネティクスによる睡眠覚醒制御機構の解明 2017 -- 2022 柳沢 正史 Japan Society for the Promotion of Science/特別推進研究 549,900,000Yen 脳機能改善作用を有する機能性食品開発 2017 -- 2020 柳沢 正史 農業・食品産業技術総合研究機構/「知」の集積と活用の場 研究開発モデル事業 83,950,000Yen 光を用いた睡眠の機能と制御機構の統合的解析 2016 -- 2021 柳沢 正史 科学技術振興機構/CREST 130,000,000Yen 「つくばイノベーション・エコシステムの構築（医療・先進技術シーズを用いた張スマート社会の創生事業）」における「世界中の眠りに悩む人々への睡眠計測検査サービス事業」 2016 -- 2020 柳沢 正史 つくばグローバル・イノベーション推進機構（TGI)/補助事業地域イノベーション・エコシステム形成プログラム 160,860,248Yen フォワードジェネティクスで同定した新規睡眠制御遺伝子による睡眠覚醒制御機構の解明 2014 -- 2018 柳沢 正史 Japan Society for the Promotion of Science/基盤研究(S) 195,130,000Yen フォワードジェネティクスで同定した新規睡眠制御遺伝子による睡眠覚醒制御機構の解明 2014 -- 2016 柳沢 正史 Japan Society for the Promotion of Science/基盤研究(A) 40,690,000Yen - Career history
2014 -- (current) UTSW Molecular Genetics Adjunct Professor 2012 -- (current) University of Tsukuba International Institute for Integrative Sleep Medicine (WPI-IIIS) Director and Professor 2010 -- 2014 University of Tsukuba FIRST program Professor and Director 2001 -- 2007 Yanagisawa Orphan Receptor Project (JST/ERATO) Director 1998 -- 2014 UTSW Basic Biomedical Science The Patrick E. Haggerty Distinguished Chair 1996 -- 2014 UTSW / HHMI Professor of Molecular Genetics / Investigator 1991 -- 1996 University of Texas Southwestern Medical Center at Dallas (UTSW) / Howard Hughes Medical Institute Associate Professor of Molecular Genetics / Associate Investigator 1991 -- 1991 Kyoto University School of Medicine Pharmacology Assistant Professor 1989 -- 1991 University of Tsukuba Department of Pharmacology Postdoctoral fellow - Academic background
-- 1988 University of Tsukuba Ph.D. in Medical Sciences - Academic societies
-- (current) 日本心血管内分泌代謝学会 -- (current) 日本睡眠学会 - Honors & Awards
2019 Ibaraki Honor Award 2019 Person of Cultural Merits 2019 Takamine Memorial Daiichi Sankyo Prize 2018 The Keio Medical Science Prize 2018 The Asashi Prize 2017 Erwin Von Bälz Prieis 2016 Matsuo Award 2016 Medal with Purple Ribbon 2015 Walter B. Canon Award 2013 Jokichi Takamine Memorial Award 2006 Outstanding Scientific Achievement Award 2003 Bristol-Myers Squibb Achievement Award in Cardiovascular Research 2000 Gold Medal Award 1998 The Tsukahara Memorial Award 1998 The Amgen Award 1998 The Novartis Award 1998 The J. J. Abel Award 1998 The Kilby Award 1997 The Donald Seldin Award 1997 Jokichi Takamine Young Investigator Award 1997 Medical Research Award 1990 Tsukuba Award - Articles
- Improvement of slow wave sleep continuity by mattress with better body pressure dispersal.
Kokubo Toshio; Kayaba M.; Ogata H.; Park I.; Ishihara A.;...
Sleep Medicine Research/10(2)/pp.75-82, 2019-12 - Subacute Ingestion of Caffeine and Oolong Tea Increases Fat Oxidation without Affecting Energy Expenditure and Sleep Architecture: A Randomized, Placebo-Controlled, Double-Blinded Cross-Over Trial
Zhang Simeng; Takano Jiro; Murayama Norihito; Tominaga Mo...
Nutrients/12(12), 2020-11-28 - Gut microbiota depletion by chronic antibiotic treatment alters the sleep/wake architecture and sleep EEG power spectra in mice
柳沢 正史
Scientific Reports/10(1)/p.19554, 2020-11 - ASSOCIATION OF SELF-RATED SLEEP APNEA WITH HYPERTENSION, DYSLIPIDEMIA AND DIABETES MELLITUS: SLEPT STUDY
Suzuki C.; Morita E.; Matsumoto S.; Ishihara A.; Ikeda Y....
SLEEP MEDICINE/64(1)/pp.S368-S368, 2019-12 - DIFFERENT EFFECTS OF OREXIN RECEPTOR ANTAGONIST AND GABA(A) AGONIST ON PHYSICAL AND COGNITIVE FUNCTIONS AFTER FORCED AWAKENING
Seol J.; Fujii Y.; Park I.; Yoko S.; Kawana F.; Yajima K....
SLEEP MEDICINE/64(1)/pp.S343-S343, 2019-12 - Loss of Arc attenuates the behavioral and molecular responses for sleep homeostasis in mice
Suzuki Ayako; Yanagisawa Masashi; Greene Robert W.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA/117(19)/pp.10547-10553, 2020-04 - GABAergic VMP Neurons Ablation Induces Mania-like Behaviors with Hyperactivity, Elevated Mood, and Dopamine D2R-mediated Sleep Reduction in Mice.
柳沢 正史
iScience/23(6)/pp.101240-101240, 2020-06 - Hypnotic effect of thalidomide is independent of teratigenic ubiquitin/proteasome pathway
Yanagisawa Masashi
PNAS, 2020-08 - Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice
Liu Chih-Yao; Tsai Chia-Jung; Yasugaki Shinnosuke; Nagata...
Neuroscience research/in press, 2020-04 - Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway
Hirose Yuki; Kitazono Tomohiro; Sezaki Maiko; Abe Manabu;...
Proceedings of the National Academy of Sciences of the United States of America/117(37)/pp.23106-23112, 2020-08 - The role of endothelin B receptor in bone modelling during orthodontic tooth movement: a study on ET knockout rats
Ibrahimi Disha S; Furlani B; Drevensek G; Plut A; Yanagis...
Scientific reports/10(1), 2020-08 - Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β
Nakai Ayaka; Fujiyama Tomoyuki; Nagata Nanae; Kashiwagi M...
Genetics/Epub, 2020-09 - Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need
Park Minjeong; Miyoshi Chika; Fujiyama Tomoyuki; Kakizaki...
SCIENTIFIC REPORTS/10(1), 2020-05 - IIIS 発 ナルコレプシー治療薬開発に向けた取り組み
⻫藤 毅; 入鹿山 容子; 柳沢 正史; ⻑瀬 博
なるこ/(34)/pp.8-10, 2017-05 - A small molecule orexin receptor agonist promotes recovery from inflammation-induced immobility
Uchida Shuntaro; Irukayama Yoko; Ogawa Yasuhiro; Tominaga...
JOURNAL OF PHARMACOLOGICAL SCIENCES/133(3)/p.S163, 2017-03 - Histological and electrophysiological analysis of a small-molecule OX2R-slective agonist YNT-185
Ogawa Yasuhiro; Irukayama Yoko; Tominaga Hiromu; Hosokawa...
JOURNAL OF PHARMACOLOGICAL SCIENCES/133(3)/p.S163, 2017-03 - Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine
Nagumo Yasuyuki; Katoh Koki; Iio Keita; Saitoh Tsuyoshi; ...
Bioorganic & medicinal chemistry letters/30(17), 2020-06 - Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine
Nagumo Yasuyuki; Katoh Koki; Iio Keita; Saitoh Tsuyoshi; ...
Bioorganic & Ｍedicinal Chemistry Letters/30(17), 2020-09 - Loss of Arc attenuates the behavioral and molecular responses for sleep homeostasis in mice
Suzuki Ayako; Yanagisawa Masashi; Greene Robert W.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA/117(19)/pp.10547-10553, 2020-05 - Enhanced cortical responsiveness during natural sleep in freely behaving mice
Matsumoto Sumire; Ohyama Kaoru; Díaz Javier; Yanagisawa M...
Scientific reports/10(1)/p.2278, 2020-02 - Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation
Kumar Deependra; Koyanagi Iyo; Carrier-Ruiz Alvaro; Verga...
Neuron/107(3)/pp.552-+, 2020-05 - Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction
Honda Takato; Takata Yohko; Cherasse Yoan; Mizuno Seiya; ...
iScience/23(6), 2020-06 - A discrete neuronal circuit induces a hibernation-like state in rodents
Takahashi Tohru M; Sunagawa Genshiro A; Soya Shingo; Abe ...
Nature, 2020-06-11 - A discrete neuronal circuit induces a hibernation-like state in rodents
Takahashi Tohru M; Sunagawa Genshiro A; Soya Shingo; Abe ...
Nature, 2020-06 - Widely Distributed Neurotensinergic Neurons in the Brainstem Regulate NREM Sleep in Mice
Kashiwagi Mitsuaki; Kanuka Mika; Tatsuzawa Chika; Suzuki ...
CURRENT BIOLOGY/30(6)/pp.1002-1014, 2020-03
- Improvement of slow wave sleep continuity by mattress with better body pressure dispersal.
- Books
- Distribution of orexin-containing neurons and glucose-sensitive neurons in the lateral hypothalamic area.
T. Moriguchi; T. Sakurai; T. Nambu; M. Yanagisawa; K. Goto.
1998-12
- Distribution of orexin-containing neurons and glucose-sensitive neurons in the lateral hypothalamic area.
- Conference, etc.
- 勤労者における生きがいの有無と睡眠状態との関連：SLEPT Study
森田 えみ; 柳沢正史; 池田有; 松本すみ礼; 石原あすか; 鈴木...
第60回日本心身医学会総会ならびに学術講演会,第2回日本心身医学関連学会合同集会/2019-11-15--2019-11-17 - 一般集団における短時間睡眠家系・長時間睡眠家系の頻度の推計
石原あすか; 森田 えみ; 萱場桃子; 佐藤誠; 平井康仁; 大井雄...
日本睡眠学会第42回定期学術集会/2017-06-29--2017-06-30 - 勤労世代の睡眠計測データを用いた睡眠効率に影響する要因の解明
松本すみ礼; 森田 えみ; 石原あすか; 堀大介; 平井康仁; 大井...
日本睡眠学会第43回定期学術集会/2018-07-11--2018-07-13 - 客観指標を用いた睡眠効率と生活習慣との関連 -勤労者を対象とした研究-
池田有; 森田 えみ; 池田朝彦; 高橋司; 白木渚; Christina-Sy...
第28回体力・栄養・免疫学会大会/2018-09-01--2018-09-02 - 勤労者における心的ストレスと眠気・睡眠との関連
池田有; 森田 えみ; 池田朝彦; 高橋司; 堀大介; 道喜将太郎; ...
第92回日本産業衛生学会/2019-05-22--2019-05-25 - 勤労者における主観による睡眠時無呼吸有病率と関連因子
鈴木稚寛; 森田 えみ; 松本すみ礼; 石原あすか; 樋江井哲郎; ...
日本睡眠学会第44回定期学術集会/2019-06-27--2019-06-28 - 若年労働者と中高年労働者における不眠傾向者の実態 ～睡眠の客観的指標を用いての検討～
石塚真美; 森田 えみ; 松本 すみ礼; 石原 あすか; 鈴木 稚寛;...
第26回日本産業精神保健学会/2019-08-30--2019-08-31 - 就寝前の光照射と勤労者の睡眠との関連性
石原あすか; 森田 えみ; 松本 すみ礼; 鈴木 稚寛; 樋江井 哲...
日本睡眠学会第44回定期学術集会/2019-06-27--2019-06-28 - 勤労者における必要な睡眠時間の体質と日常の心理的ストレスとの関連：SLEPT Study
森田 えみ; 柳沢 正史; 池田 有; 石原 あすか; 松本 すみ礼; ...
第30回日本疫学会/2020-02-20--2020-02-22 - 冬季の寝室室温が睡眠効率に及ぼす影響に関するマルチレベル分析
浅倉弘尭、伊香賀俊治、中島侑江; 森田 えみ; 堀大介; 笹原信...
2018年度（第89回）日本建築学会関東支部研究発表会/2019-03-06--2019-03-07 - Different effects of orexin receptor antagonist and GABAa agonist on physical and cognitive functions
Seol J.; Fujii Y.; Park I.; Suzuki Y.; Kawana F.; Fukusum...
The 7th Annual IIIS Symposium/2018-12 - Association of self-rated sleep apnea with hypertension, dyslipidemia and diabetes mellitus: SLEPT study
Suzuki Chihiro; Morita Emi; Matsumoto Sumire; Ishihara As...
World Sleep/2019-09-20--2019-09-25 - Sleep State Analysis Using Calcium Imaging Data by Non-negative Matrix Factorization
Nagayama Mizuo; Aritake Toshimitsu; Hino Hideitsu; Kanda ...
28th International Conference on Artificial Neural Networks (ICANN)/2019-09-17--2019-09-19 - 長時間労働と睡眠時間・睡眠効率の関係：活動量計を用いた疫学研究
室井 慧; 森田えみ; 鈴木雅寛; 石原あすか; 松本すみ礼; 新...
第93回日本産業衛生学会/2020-6-12--2020-6-28 - 労働者を対象としたクロノタイプ(朝型・昼型）と心理的ストレスの関連
新井 陽; 森田えみ; 鈴木雅寛; 石原あすか; 松本すみ礼; 室...
第93回日本産業衛生学会/2020-6-12--2020-6-28 - Orexin System In Fear Memory Formation
Soya Shingo; Shoji Hirotaka; Hasegawa Emi; Hondo Mari; Mi...
FENS forum/2014-08 - Orexin Receptor-1 in the Locus Coeruleus Plays an Important Role in Cue-Dependent Fear Memory Consolidation
Shingo Soya; Shoji hirotaka; Emi Hasegawa; Mari Hondo; Ts...
SfN meeting/2013-11 - 若年労働者と中高年労働者における不眠傾向者の実態～睡眠の客観的指標を用いての検討～
石塚恵美; 森田えみ; 松本すみ礼; 石原あすか; 鈴木 稚寛; ...
第26回日本産業精神保健学会/2019-08-31--2019-08-31 - Search for neural circuits of narcolepsy-cataplexy.
E Hagesawa; T Maejima; T Yoshida; M Yoshioka; M Yanagisaw...
SfN meeting 2018/2018-11-03--2018-11-07 - A synthetic orexin agonist improves inflamemation-induced immobility through activating the medullary raphe nucleus.
Uchida S; Irukayama-Tomobe Y; Ogawa Y; Yamaguchi T; Ishik...
SfN meeting 2018/2018-11-03--2018-11-07 - Association between the evening use of electronic media, sleep, and chronotypes of employees in Japan
ishihara Asuka; Morita Emi; matsumoto Suimire; Chihiro Su...
Society for Light Treatment and Biological Rhythms (SLTBR) 31st Annual Meeting/2019-06-22--2019-06-22 - 就寝前の光照射と勤労者の睡眠との関連性
石原あすか; 森田えみ; 松本すみ礼; 鈴木 稚寛; 樋江井哲郎;...
日本睡眠学会第44回定期学術集会/2019-06-27--2019-06-28 - 勤労者における主観による睡眠時無呼吸有病率と関連因子
鈴木 稚寛; 森田えみ; 松本すみ礼; 石原あすか; 樋江井哲郎;...
日本睡眠学会第44回定期学術集会/2019-06-27--2019-06-28 - 勤労者における心的ストレスと睡眠時間・眠気との関連
池田 有; 森田えみ; 池田朝彦; 高橋 司; 白木 渚; 大滝 ...
第92回日本産業衛生学会/2019-05-22--2019-05-25 - 大規模マウス睡眠ステージ解析のための深層学習モデルの開発
山部 剛士; 堀江 和正; 塩川 浩昭; 柳沢 正史; 北川 博之
第11回データ工学と情報マネジメントに関するフォーラム (DEIM 2019)/2019-03-04--2019-03-06
- 勤労者における生きがいの有無と睡眠状態との関連：SLEPT Study
- Teaching
2020-04 -- 2020-08 Special Practice in Human Biology II University of Tsukuba. 2020-10 -- 2021-02 Special Practice in Human Biology II University of Tsukuba. 2020-10 -- 2021-02 Special Seminars in Human Biology II University of Tsukuba. 2020-04 -- 2020-08 Special Lectures in Human Biology II University of Tsukuba. 2020-10 -- 2021-02 Special Research in Human Biology II University of Tsukuba. 2020-04 -- 2020-08 Seminar in Medical Science of Sleep I University of Tsukuba. 2020-04 -- 2020-08 Special Seminars in Human Biology I University of Tsukuba. 2020-10 -- 2021-03 Life Science Innovation Doctor's Special Seminar III Fall University of Tsukuba. 2020-04 -- 2020-08 Special Seminars in Human Biology II University of Tsukuba. 2020-04 -- 2020-08 Laboratory Training in Human Biology I University of Tsukuba.
(Last updated: 2020-11-17)