Ho Kiong

Affiliation

Faculty of Medicine

Official title

Associate Professor

URL

http://www.md.tsukuba.ac.jp/basic-med/kiongho/

Email

64:923:N]Y8/W?>@6@-,W,.W5; 

Research fields

Parasitology (including sanitary zoology)

Functional biochemistry

Molecular biology

Research keywords

Parasitology, RNA Processing, RNA ligation, Trypanosoma

Research projects

Mechanism of mRNA recapping pathway in trypanosome	2016-04 -- 2020-03	HO KIONG	日本学術振興会/科研費/Scientific Research Basic B	14,320,000Yen
Structural, Functional and Genetic Analysis of Archaea RNA Ligase	2011-04 -- 2016-03	Kiong Ho	National Science Foundation/Div Of Molecular and Cellular Bioscience	76,500,000Yen
Mechanism of mRNA cap formation in Trypanosoma brucei	2006-07 -- 2011-06	HO KIONG	American Heart Association/Scientist Development Grant	26,000,000Yen
Mechanism of Archaeal RNA ligase	2007-07 -- 2008-09	HO KIONG	University at Buffalo/UB2020 Interdisciplinary Research Development Fund	4,000,000Yen

Career history

2003-01 -- 2010-10	State University of New York at Buffalo Department of Biological Sciences Assistant Professor
2000-01 -- 2003-10	Sloan Kettering Instite for Cancer Research Program in Molecular Biology Senior Research Scientist
1997-04 -- 1999-12	Sloan Kettering Institute for Cancer Research Program in Molecular Biology Post-doctoral Fellow

Academic background

1986-09 -- 1990-01	Rutgers University, The State University of New Jersey College of Arts and Sciences B.A. Biochemistry	Graduated
1990-09 -- 1997-03	Cornell University, Weill Graduate School of Medical Sciences Ph.D. Molecular Biology Molecular Biology	Graduated

Academic societies

1997-01 -- (current)	ASM (American Society of Microbiology)
2017-04 -- (current)	THE JAPANESE SOCIETY OF PARASITOLOGY
2007-01 -- (current)	RNA Society (International)
2017-04 -- (current)	THE RNA SOCIETY OF JAPAN

Articles

• Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
  Mayers Thomas; Morikawa Kazuya; Fukuda Aya; Watanabe Yuki...
  J Med Eng Educ/19(1)/pp.40-44, 2020-02
• Crystal structures of the RNA triphosphatase from Trypanosoma cruzi provide insights into how it recognizes the 5' end of the RNA substrate
  Ho Kiong; Takagi Yuko; Kuwabara Naoyuki; Dang Truong Tat;...
  Journal of Biological Chemistry/295(27)/pp.9076-9086, 2020-05
  PubMed Tsukuba Repository
• An international exchange program for undergraduate medical science students.
  Mayers Thomas; Morikawa Kazuya; Ho Kiong; Ohneda Osamu
  J Med Eng Educ/17(1)/pp.7-13, 2018-04
• Cleavage of 3'-terminal adenosine by archaeal ATP-dependent RNA ligase
  Yoshinari Shigeo; Liu Yancheng; Gollnick Paul; Ho C Kiong
  Scientific reports/7(1), 2017-09
  PubMed Tsukuba Repository
• Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis
  Gu H; Yoshionari S; Ghosh R; Ignatochkina AV; Gollnick PD...
  Nucleic acids research/44(5)/pp.2337-2347, 2016-03
  PubMed Tsukuba Repository
• Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase
  Paul Smith; Ho Kiong; Yuko Takagi; Hakim Djaballah; Stewa...
  mBIO/7(1)/p.10.1128/mBio.00058-16 , 2016-02
  PubMed Tsukuba Repository
• Teaching science and learning English: an introduction to the Molecular Biology Course in Vietnam
  Ho Kiong
  The Journal of Medical English Education/14(3)/pp.93-98, 2015-10
• The messenger RNA decapping and recapping pathway in Trypanosoma
  Ignatochkina AV; Takagi Y; Liu Y; Negate K; Ho Kiong
  Proceedings of the National Academy of Sciences USA/112(22)/pp.6967-6972, 2015-06
  PubMed
• The messenger RNA decapping and recapping pathway in Trypanosoma
  Anna Ignatochkina; Yuko Takagi; Yancheng Liu; Kyosuke Nag...
  Proc. Natl. Acad. Sci. U. S. A./112(22)/pp.6967-6972, 2015-06
  PubMed
• Archaea RNA Ligase is a Homodimeric Protein that Catalyzes Intramolecular Ligation of Single-Stranded RNA and DNA.
  Torchea C Takagi Y and Ho CK.
  Nucleic Acid Research/36/p.6218-6227, 2008-01
• Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events.
  Dong H; Ray D; Ren S; Zhang B; Puig-Basagoiti F; Takagi Y...
  J. Virol./81/p.4412-4421, 2007-01
• Trypanosoma brucei Encodes a Bifunctional Capping Enzyme Essential for Cap 4 Formation on the Spliced Leader RNA.
  Takagi Y Sindkar S Ekonomidis D Hall MP and Ho CK.
  J. Biol. Chem/282/p.15995-16005, 2007-01
• Characterization of a Trypanosoma brucei mRNA Cap (Guanine N-7) Methyltransferase.
  Hall MP and Ho CK.
  RNA/12/p.488 -497, 2006-01
• Functional Characterization of a 48-kDa Trypanosoma brucei Cap 2 RNA Methyltransferase.
  Hall MP and Ho CK.
  Nucleic Acid Research/34/p.5594 - 5602, 2006-01
• Identification of the MicroRNAs of the Herpesvirus Family.
  Pfeffer S Sewer A Lagos-Quintana M Sheridan R Sander C Gr...
  Nature Method/2/p.269-276, 2005-01
• Structure and Mechanism of RNA Ligase.
  Ho CK Wang LK Lima CD and Shuman S.
  Structure/12/p.327-339, 2004-01
• Portability and Fidelity of RNA Repair Systems.
  Schwer B; Sawaya R; Ho CK; Shuman S.; +HO KIONG
  Proc. Natl. Acad. Sci. USA/101/p.2788-2793, 2004-01
• Characterization of Bacteriophage KVP40 and T4 RNA Ligase 2.
  Yin S Ho CK Miller ES and Shuman S.
  Virology/319/p.141-151, 2004-01
• RNA Substrate Specificity and Structure-Guided Mutational Analysis of T4 RNA Ligase 2.
  Nandakumar J Ho CK Lima CD and Shuman S.
  J. Biol. Chem./279/p.31337-31347, 2003-01
• Mutation Analysis of Bacteriophage T4 RNA Ligase 1: Differential Functional Group are Required for the Nucleotidyl Transfer and Phosphodiester Bond Formation Steps of the Ligation Reaction.
  Wang LK Ho CK Pei Y and Shuman S.
  J. Biol. Chem./278/p.17601-17608, 2003-01
• Tat Stimulates Cotranscriptional Capping of HIV-1 mRNA.
  Chiu YL; Ho CK; Saha N; Schwer B; Shuman S; and Rana TM.;...
  Molecular Cell/10/p.585-597, 2002-01
• Bacteriophage T4 RNA Ligase 2 (gp 24.1) Exemplifies a Family of RNA Ligases Found in All Phylogenic Domains.
  Ho CK and Shuman S.
  Proc. Natl. Acad. Sci. USA/99/p.12709-12714, 2002-01
• HIV-1 Tat Protein Interacts with Mammalian Capping Enzyme and Stimulates Capping of TAR RNA
  Chiu YL; Coronel E; Ho Kiong; Shuman S; Rana TM
  Journal of Biological Chemistry/276/pp.12959-12966, 2001-04
• A Yeast-like mRNA Capping Apparatus in Plasmodium falciparum
  Ho CK; Shuman S
  Proc. Natl. Acad. Sci. USA/98(6)/pp.3050-3055, 2001-03
• RNA Triphosphatase Component of the mRNA Capping Apparatus of Paramecium bursaria Chlorella Virus
  Ho CK; Gong C; Shuman S
  JOURNAL OF VIROLOGY/75/pp.1744-1750, 2001-02

more...

Books

• Detection and Identification of Uncapped RNA by Ligation-Mediated Reverse Transcription Polymerase Chain Reaction
  Ho Kiong
  Methods Molecular Biology, Humana Press, New York, NY, pp.1-9, 2017-08
  PubMed

Conference, etc.

• Regulation of Protozoa Gene Expression by mRNA Recapping Pathway
  Ho Kiong
  The 2nd Joint Young Researcher Meeting in Biomedical Sciences/2020-01-10--2020-01-11
• Crystal structure of Trypanosoma RNA triphosphatase illuminates the mechanism of triphosphate and nucleic acid recognition.
  Ho Kiong; Takagi Yuko; Kuwabara Naoyuki; Truong Dang; Fur...
  The 42nd Annual Meeting of the Molecular Biology Society of Japan/2019-12-03--2019-12-06
• Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
  Mayers Thomas David; Ho Kiong; Fukuda Aya; Watanabe Yukih...
  The 22nd JASMEE Academic Meeting/2019-08-03--2019-08-04
• Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
  Mayers Thomas David; Ho Kiong; Fukuda Aya; Watanabe Yukih...
  The 22nd JASMEE Academic Meeting/2019-08-03--2019-08-04
• Targeting of mRNA Cap Formation for Treatment of Parasitic Infections
  Ho Kiong
  The Joint Symposium in Infectious Diseases/2019-02-22--2019-02-22
• Structural and Functional Analysis of protozoan mRNA capping enzyme
  HO KIONG
  20th RNA Meeting in Japan/2018-07-09--2018-07-12
• The messenger RNA recapping pathway in Trypanosome
  Ho Kiong
  88th Japan Parasitology Meeting/2019-03-14--2019-03-16
• Structural and Functional Analysis of Trypanosoma RNA Triphosphatase
  HO KIONG
  第88回日本寄生虫学会大会/2019-03-14--2019-03-16
• RNA methylation at the 5’-end of the mRNA stimulates Trypanosoma mRNA recapping activities
  Ho Kiong
  Cold Spring Harbor Meeting, Translational Control Meeting/2018-09-04--2018-09-08
• Structure and mechanism of archaeal ATP-dependent RNA ligase
  Ho Kiong; Yoshinari Shigeo; Murakami Katsuhiko S.
  Cutting Edge Developments in RNA Biology for the Control of Gene Expression/2017-11-13--2017-11-17
• Messenger RNA recapping enzyme is regulated by hypermethylation at the 5’-end of the RNA
  Ho Kiong; Ignatochkina Anna V.; Iguchi Jesavel; Kore Anil...
  Cutting Edge Developments in RNA Biology for the Control of Gene Expression/2017-11-13--2017-11-17
• Molecular Mechanism of mRNA Recapping in Trypanosome
  HO KIONG
  2017年度生命科学系学会合同年次大会/2017-12-06--2017-12-09
• Identification and characterization of a novel 5'-monophosphate RNA kinase in Trypanosoma brucei
  Ho Kiong
  21th Annual RNA Society Meeting/2016-06-28--2016-07-02
• Recapping the Message: The mRNA Decapping and Recapping Pathway in Trypanosomes
  Ho Kiong
  21th Annual RNA Society International Meeting/2016-06-28--2016-07-02
• Inhibitor Screening Against Trypanosoma cruzi RNA Triphosphatase
  Ho Kiong; Takagi Yuko; Kuwabara Naoyuki; Tani Osamu; Saka...
  Kinetoplastid Molecular Cell Biology 2017/2017-04-22--2017-04-26
• Archaea RNA Ligase is Required for Circularizing Small Non-Coding RNA.
  Ho Kiong; Liu Yancheng; Takagi Yuko; Hirata Akira; Hori H...
  RNA Meeting 2017 in Toyama/2017-07-19--2017-07-21
• Trypanaosome mRNA recapping activity is modulated by hypermethylation derived from cap 4 structure
  Ho Kiong; Ignatochkina Anna V.; Iguchi Jesavel; Kore Anil...
  RNA Meeting 2017 in Toyama/2017-07-19--2017-07-21

Teaching

2020-10 -- 2021-02	International Medical Sciences Exchange Program II	University of Tsukuba.
2020-04 -- 2020-08	International Medical Sciences Exchange Program II	University of Tsukuba.
2020-10 -- 2021-02	International Medical Sciences Exchange Program III	University of Tsukuba.
2020-04 -- 2020-08	International Medical Sciences Exchange Program III	University of Tsukuba.
2020-10 -- 2021-02	Internship II	University of Tsukuba.
2020-04 -- 2020-08	Internship II	University of Tsukuba.
2020-10 -- 2020-10	Workshop for Medical Science Students	University of Tsukuba.
2020-10 -- 2021-02	International Medical Sciences Exchange Program I	University of Tsukuba.
2020-04 -- 2020-08	International Medical Sciences Exchange Program I	University of Tsukuba.
2020-04 -- 2020-08	Seminar on Basic Medical Sciences	University of Tsukuba.

more...

Other educational activities

2020-01 -- 2020-01	Transcriptosome Analysis, Experimental Course in Biotechnology and Medicine	University of Indonesia Medical Campus
2020-01 -- 2020-01	Transcriptosome Analysis, Experimental Course in Biotechnology and Medicine	University of Medicine and Pharmacy, Vietnam
2020-02 -- 2020-02	Undergraduate Medical Science Course in Tsukuba	筑波大学
2020-01 -- 2020-01	Biomedical Research Workshop in South East Asia	University of Indonesia Medical Campus
2019-08 -- 2019-08	Infection Diagnosis Workshop	HCM Biotechnology Center
2019-08 -- 2019-08	International Medical Science Training Course in HCMC	University of Medicine and Pharmacy HCMC
2019-02 -- 2019-02	Gene Editing Workshop, Experimental Course in Biotechnology and Medicine	HCM Biotechnology Center
2019-02 -- 2019-02	Transcriptosome Analysis, Experimental Course in Biotechnology and Medicine	University of Medicine and Pharmacy HCMC
2018-08 -- 2018-08	Infection Diagnosis Workshop	HCM Biotechnology Center
2018-08 -- 2018-08	International Medical Science Training Course in HCMC	University of Medicine and Pharmacy HCMC

more...

Talks

• Structure and Mechanism of RNA Repair Enzymes
  Ho Kiong
  生命と機能とかたち/2018-03-07--2018-03-07

University Management

2018-04 -- (current)	全学学群教育課程委員会	委員
2018-04 -- (current)	全学国際戦略委員会	委員
2018-04 -- (current)	医学医療系　国際連携委員会	副委員長
2014-04 -- (current)	医学生命システム　国際連携委員会	委員
2016-04 -- (current)	医学フロンティア 国際連携委員会	委員
2018-04 -- (current)	医療科学類　G30英語プログラム	委員長
2016-04 -- (current)	医療科学類　国際連携委員会	委員
2018-04 -- (current)	医療科学類　情報／広告委員会	委員
2018-04 -- (current)	医療科学類　カリキュラム委員会	委員
2019-04 -- (current)	ヒューマンバイオロジープログラム 学位審査委員会	委員長

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(Last updated: 2020-08-18)