You are here

Ho Kiong

Affiliation
Faculty of Medicine
Official title
Associate Professor
URL
Email
 
Research fields
Functional biochemistry
Parasitology (including sanitary zoology)
Molecular biology
Research keywords
Parasitology, RNA Processing, RNA ligation, Trypanosoma
Research projects
Mechanism of mRNA recapping pathway in trypanosome2016-04 -- 2020-03HO KIONG日本学術振興会/科研費/Scientific Research Basic B14,320,000Yen
Structural, Functional and Genetic Analysis of Archaea RNA Ligase2011-04 -- 2016-03Kiong HoNational Science Foundation/Div Of Molecular and Cellular Bioscience76,500,000Yen
Mechanism of mRNA cap formation in Trypanosoma brucei2006-07 -- 2011-06HO KIONGAmerican Heart Association/Scientist Development Grant26,000,000Yen
Mechanism of Archaeal RNA ligase2007-07 -- 2008-09HO KIONGUniversity at Buffalo/UB2020 Interdisciplinary Research Development Fund4,000,000Yen
Career history
2003-01 -- 2010-10State University of New York at Buffalo Department of Biological Sciences Assistant Professor
2000-01 -- 2003-10Sloan Kettering Instite for Cancer Research Program in Molecular Biology Senior Research Scientist
1997-04 -- 1999-12Sloan Kettering Institute for Cancer Research Program in Molecular Biology Post-doctoral Fellow
Academic background
1986-09 -- 1990-01Rutgers University, The State University of New Jersey College of Arts and Sciences B.A. BiochemistryGraduated
1990-09 -- 1997-03Cornell University, Weill Graduate School of Medical Sciences Ph.D. Molecular Biology Molecular BiologyGraduated
Academic societies
1997-01 -- (current)ASM (American Society of Microbiology)
2017-04 -- (current)THE JAPANESE SOCIETY OF PARASITOLOGY
2007-01 -- (current)RNA Society (International)
2017-04 -- (current)THE RNA SOCIETY OF JAPAN
Articles
  • An international exchange program for undergraduate medical science students.
    Mayers Thomas; Morikawa Kazuya; Ho Kiong; Ohneda Osamu
    J Med Eng Educ/17(1)/pp.7-13, 2018-04
  • Cleavage of 3'-terminal adenosine by archaeal ATP-dependent RNA ligase
    Yoshinari Shigeo; Liu Yancheng; Gollnick Paul; Ho C Kiong
    Scientific reports/7(1), 2017-09
  • Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis
    Gu H; Yoshionari S; Ghosh R; Ignatochkina AV; Gollnick PD...
    Nucleic acids research/44(5)/pp.2337-2347, 2016-03
  • Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase
    Paul Smith; Ho Kiong; Yuko Takagi; Hakim Djaballah; Stewa...
    mBIO/7(1)/p.10.1128/mBio.00058-16 , 2016-02
  • Teaching science and learning English: an introduction to the Molecular Biology Course in Vietnam
    Ho Kiong
    The Journal of Medical English Education/14(3)/pp.93-98, 2015-10
  • The messenger RNA decapping and recapping pathway in Trypanosoma
    Ignatochkina AV; Takagi Y; Liu Y; Negate K; Ho Kiong
    Proceedings of the National Academy of Sciences USA/112(22)/pp.6967-6972, 2015-06
  • The messenger RNA decapping and recapping pathway in Trypanosoma
    Anna Ignatochkina; Yuko Takagi; Yancheng Liu; Kyosuke Nag...
    Proc. Natl. Acad. Sci. U. S. A./112(22)/pp.6967-6972, 2015-06
  • Archaea RNA Ligase is a Homodimeric Protein that Catalyzes Intramolecular Ligation of Single-Stranded RNA and DNA.
    Torchea C Takagi Y and Ho CK.
    Nucleic Acid Research/36/p.6218-6227, 2008-01
  • Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events.
    Dong H; Ray D; Ren S; Zhang B; Puig-Basagoiti F; Takagi Y...
    J. Virol./81/p.4412-4421, 2007-01
  • Trypanosoma brucei Encodes a Bifunctional Capping Enzyme Essential for Cap 4 Formation on the Spliced Leader RNA.
    Takagi Y Sindkar S Ekonomidis D Hall MP and Ho CK.
    J. Biol. Chem/282/p.15995-16005, 2007-01
  • Characterization of a Trypanosoma brucei mRNA Cap (Guanine N-7) Methyltransferase.
    Hall MP and Ho CK.
    RNA/12/p.488 -497, 2006-01
  • Functional Characterization of a 48-kDa Trypanosoma brucei Cap 2 RNA Methyltransferase.
    Hall MP and Ho CK.
    Nucleic Acid Research/34/p.5594 - 5602, 2006-01
  • Identification of the MicroRNAs of the Herpesvirus Family.
    Pfeffer S Sewer A Lagos-Quintana M Sheridan R Sander C Gr...
    Nature Method/2/p.269-276, 2005-01
  • Structure and Mechanism of RNA Ligase.
    Ho CK Wang LK Lima CD and Shuman S.
    Structure/12/p.327-339, 2004-01
  • Portability and Fidelity of RNA Repair Systems.
    Schwer B; Sawaya R; Ho CK; Shuman S.; +HO KIONG
    Proc. Natl. Acad. Sci. USA/101/p.2788-2793, 2004-01
  • Characterization of Bacteriophage KVP40 and T4 RNA Ligase 2.
    Yin S Ho CK Miller ES and Shuman S.
    Virology/319/p.141-151, 2004-01
  • RNA Substrate Specificity and Structure-Guided Mutational Analysis of T4 RNA Ligase 2.
    Nandakumar J Ho CK Lima CD and Shuman S.
    J. Biol. Chem./279/p.31337-31347, 2003-01
  • Mutation Analysis of Bacteriophage T4 RNA Ligase 1: Differential Functional Group are Required for the Nucleotidyl Transfer and Phosphodiester Bond Formation Steps of the Ligation Reaction.
    Wang LK Ho CK Pei Y and Shuman S.
    J. Biol. Chem./278/p.17601-17608, 2003-01
  • Tat Stimulates Cotranscriptional Capping of HIV-1 mRNA.
    Chiu YL; Ho CK; Saha N; Schwer B; Shuman S; and Rana TM.;...
    Molecular Cell/10/p.585-597, 2002-01
  • Bacteriophage T4 RNA Ligase 2 (gp 24.1) Exemplifies a Family of RNA Ligases Found in All Phylogenic Domains.
    Ho CK and Shuman S.
    Proc. Natl. Acad. Sci. USA/99/p.12709-12714, 2002-01
  • HIV-1 Tat Protein Interacts with Mammalian Capping Enzyme and Stimulates Capping of TAR RNA
    Chiu YL; Coronel E; Ho Kiong; Shuman S; Rana TM
    Journal of Biological Chemistry/276/pp.12959-12966, 2001-04
  • A Yeast-like mRNA Capping Apparatus in Plasmodium falciparum
    Ho CK; Shuman S
    Proc. Natl. Acad. Sci. USA/98(6)/pp.3050-3055, 2001-03
  • RNA Triphosphatase Component of the mRNA Capping Apparatus of Paramecium bursaria Chlorella Virus
    Ho CK; Gong C; Shuman S
    JOURNAL OF VIROLOGY/75/pp.1744-1750, 2001-02
  • Trypanosoma brucei RNA Triphosphatase: Anti-Protozoal Drug Target and Guide to Eukaryotic Phylogeny.
    Ho CK; Shuman S.; HO KIONG
    J. Biol. Chem./276/p.46182-46186, 2001-01
  • An Essential Function of Saccharomyces cerevicieae RNA Triphosphatase Cet1 is to Stabilize RNA Guanylyltransferase Ceg1 Against Thermal Inactivation.
    Hausmann S Ho CK Schwer B and Shuman S.
    J. Biol. Chem./276/p.36116-36124, 2001-01
Books
Conference, etc.
  • Targeting of mRNA Cap Formation for Treatment of Parasitic Infections
    Ho Kiong
    The Joint Symposium in Infectious Diseases/2019-02-22--2019-02-22
  • Structural and Functional Analysis of protozoan mRNA capping enzyme
    HO KIONG
    20th RNA Meeting in Japan/2018-07-09--2018-07-12
  • The messenger RNA recapping pathway in Trypanosome
    Ho Kiong
    88th Japan Parasitology Meeting/2019-03-14--2019-03-16
  • Structural and Functional Analysis of Trypanosoma RNA Triphosphatase
    HO KIONG
    第88回日本寄生虫学会大会/2019-03-14--2019-03-16
  • RNA methylation at the 5’-end of the mRNA stimulates Trypanosoma mRNA recapping activities
    Ho Kiong
    Cold Spring Harbor Meeting, Translational Control Meeting/2018-09-04--2018-09-08
  • Structure and mechanism of archaeal ATP-dependent RNA ligase
    Ho Kiong; Yoshinari Shigeo; Murakami Katsuhiko S.
    Cutting Edge Developments in RNA Biology for the Control of Gene Expression/2017-11-13--2017-11-17
  • Messenger RNA recapping enzyme is regulated by hypermethylation at the 5’-end of the RNA
    Ho Kiong; Ignatochkina Anna V.; Iguchi Jesavel; Kore Anil...
    Cutting Edge Developments in RNA Biology for the Control of Gene Expression/2017-11-13--2017-11-17
  • Molecular Mechanism of mRNA Recapping in Trypanosome
    HO KIONG
    2017年度生命科学系学会合同年次大会/2017-12-06--2017-12-09
  • Identification and characterization of a novel 5'-monophosphate RNA kinase in Trypanosoma brucei
    Ho Kiong
    21th Annual RNA Society Meeting/2016-06-28--2016-07-02
  • Recapping the Message: The mRNA Decapping and Recapping Pathway in Trypanosomes
    Ho Kiong
    21th Annual RNA Society International Meeting/2016-06-28--2016-07-02
  • Inhibitor Screening Against Trypanosoma cruzi RNA Triphosphatase
    Ho Kiong; Takagi Yuko; Kuwabara Naoyuki; Tani Osamu; Saka...
    Kinetoplastid Molecular Cell Biology 2017/2017-04-22--2017-04-26
  • Archaea RNA Ligase is Required for Circularizing Small Non-Coding RNA.
    Ho Kiong; Liu Yancheng; Takagi Yuko; Hirata Akira; Hori H...
    RNA Meeting 2017 in Toyama/2017-07-19--2017-07-21
  • Trypanaosome mRNA recapping activity is modulated by hypermethylation derived from cap 4 structure
    Ho Kiong; Ignatochkina Anna V.; Iguchi Jesavel; Kore Anil...
    RNA Meeting 2017 in Toyama/2017-07-19--2017-07-21
Teaching
2019-10 -- 2020-02International Medical Sciences Exchange Program IIUniversity of Tsukuba.
2019-04 -- 2019-08International Medical Sciences Exchange Program IIUniversity of Tsukuba.
2019-10 -- 2020-02Advanced Exercise on Public HealthUniversity of Tsukuba.
2019-04 -- 2019-08Advanced Exercise on Public HealthUniversity of Tsukuba.
2019-10 -- 2020-02International Medical Sciences Exchange Program IIIUniversity of Tsukuba.
2019-04 -- 2019-08International Medical Sciences Exchange Program IIIUniversity of Tsukuba.
2019-10 -- 2020-02Seminars on Global Issues B-IUniversity of Tsukuba.
2019-10 -- 2020-02International Medical Sciences Exchange Program IUniversity of Tsukuba.
2019-04 -- 2019-08International Medical Sciences Exchange Program IUniversity of Tsukuba.
2019-04 -- 2019-08Internship IUniversity of Tsukuba.
Other educational activities
2019-02 -- 2019-02Gene Editing Workshop, Experimental Course in Biotechnology and MedicineHCM Biotechnology Center
2019-03 -- 2019-04Biomedical Research Workshop in South East AsiaUdayana University, Indonesia
2019-02 -- 2019-02Transcriptosome Analysis, Experimental Course in Biotechnology and MedicineUniversity of Medicine and Pharmacy HCMC
2018-08 -- 2018-08Infection Diagnosis WorkshopHCM Biotechnology Center
2018-08 -- 2018-08International Medical Science Training Course in HCMCUniversity of Medicine and Pharmacy HCMC
2018-01 -- 2018-03Undergraduate Medical Science Training Course in Tsukuba筑波大学、医療科学
2018-03 -- 2018-03Biomedical Research Workshop in South East AsiaUniversity of Indonesia Medical Campus
2018-01 -- 2018-02Experimental Course in Biotechnology and MedicineBiotechnology Center of HCMC
2018-01 -- 2018-02Infection Diagnosis WorkshopBiotechnology Center of HCMC
2017-08 -- 2017-09Infection Diagnosis WorkshopBiotechnology Center of HCMC
Talks
  • Structure and Mechanism of RNA Repair Enzymes
    Ho Kiong
    生命と機能とかたち/2018-03-07--2018-03-07
University Management
2018-04 -- (current)全学学群教育課程委員会委員
2016-04 -- (current)医学フロンティア 国際連携委員会委員
2018-04 -- (current)全学国際戦略委員会委員
2018-04 -- (current)医学医療系 国際連携委員会副委員長
2014-04 -- (current)医学生命システム 国際連携委員会委員
2018-04 -- (current)医療科学類 G30 国際連携委員会委員長
2016-04 -- (current)医療科学類 国際連携委員会委員
2018-04 -- (current)医療科学類 情報/広告委員会委員
2018-04 -- (current)医療科学類 カリキュラム委員会委員
2016-04 -- (current)HBP Academic Degree Committeemember

(Last updated: 2019-08-20)