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Sakaguchi Masanori

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Affiliation
International Institute for Integrative Sleep Medicine
Official title
Associate Professor
URL
Email
 
Office
Sakaguchi lab
Research projects
睡眠が記憶の固定化に果たす役割2015 -- 2016Kato Memorial Bioscience Foundation/2,000,000Yen
光遺伝子にて明らかにする睡眠2016 -- (current)Inamori Research Grants Program/1,000,000Yen
成体脳のニューロン新生から明らかにする睡眠依存的な記憶固定化の分子メカニズム -- (current)Ichiro Kanehara Foundation/1,000,000Yen
REM睡眠中の新生ニューロンの興奮2016 -- (current)公益財団法人 先進医薬研究振興財団/1,000,000Yen
質量分析計と光遺伝学による眠気の分子実体の同定2016-12 -- 2018-10Shimadzu Science Foundation/1,000,000Yen
光遺伝学による睡眠中のトラウマ記憶消失2017 -- (current)Takeda Science Foundation/2,000,000Yen
成体脳で新生するニューロンが実現する睡眠中の記憶固定化2021 -- 2022Tokyo Biochemical Research Foundation/3,000,000Yen
脳の同期活動をもとにした意識の動作原理2021 -- 2024-04公益財団法人　上原記念生命科学財団　/9,000,000Yen
不安障害の背後にある可塑的な神経回路の機能破綻2021 -- (current)Takeda Science Foundation/10,000,000Yen
睡眠中の、新生ニューロンの記録回路への組み込み2015-11 -- 2018-03日本学術振興会/科学研究費助成事業 特別研究員奨励費2,300,000Yen
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Career history
2018-10 -- (current)筑波大学 国際統合睡眠医科学研究機構 PI
2013-04 -- 2018-09Tsukuba University International Institute for Integrative Sleep Medicine Co-PI
2013-01 -- 2013-03Univ. Tsukuba WPI-IIIS Researcher
2011-04 -- 2012-12RIKEN Special Postdoctoral Fellow (SPD)
2010-10 -- 2012-12RIKEN Brain Science Institute Researcher
2009-04 -- 2010-09Japan Society for the Promotion of Science Overseas Research Fellowships
2007-04 -- 2009-03SickKids
2005-04 -- 2007-03Keio University 医学部生理学教室 assistant
2001-04 -- 2005-03Keio University School of Medicine Physiological Laboratory Research Student
Academic background
2001-04 -- 2005-03Tsukuba University Conprehensive Human Sciences Medicine Doctural CourseCompleted
1995-04 -- 2001-03Tsukuba University School of Medicine Department of MedicineGraduated
Degree
2005-03分子統合生体統御医学Tsukuba University
Licenses and qualifications
2001-06Medical license
2014-04HSK level4
Articles
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Books
  • 神経幹細胞
    坂口 昌徳
    医学のあゆみ 212巻10号, 2005
  • “神経再生医療”看護のための最新医学講座
    坂口 昌徳
    神経再生医療, 2005
  • 脳・神経の発生・再生
    坂口 昌徳
    発生・再生イラストマップ, 2005-12
  • Neural stem cells: Isolation and self-renewal.
    Sakaguchi Masanori
    Tissue Stem Cells, 2006-11
  • 糖鎖結合タンパク質Galectin-1は成体脳内の神経幹細胞の増殖を促進させる
    坂口 昌徳
    細胞工学, 2006
  • 分子細胞治療
    坂口 昌徳
    先端医学社 6, 2007
  • 脳内で新生するニューロンと中枢神経再生への応用
    坂口 昌徳
    ブレインサイエンスレビュー, 2016-02
  • 心的外傷直後の場所刺激が記憶犯科に与える影響
    坂口 昌徳
    医学の歩み258(13), 2016
  • トラウマ記憶を弱めるには – マウスの記憶・睡眠研究から考えるPTSDケア
    坂口 昌徳
    academistJournal, 2017-07
  • 記憶と睡眠
    坂口 昌徳
    睡眠学第2版, 2019
Conference, etc.
  • 成体脳の新生ニューロンが睡眠中の記憶固定化に果たすメカニズムの解明
    伊代 小柳; 禹騰 汪; Sakthivel Srinivasan; 佳卉 于; 紀枝 ...
    第44回日本神経科学大会/2021-07
  • Function of adult neurogenesis in visual discrimination memory
    坂口 昌徳
    Symposium on Behavioral Molecular Neuroscience/2013-02
  • Neural stem cells,adult neurogenesis and memory
    坂口 昌徳
    IIIS, Symposium/2013-03
  • Selective and precise temporal ablation of adult born neurons in the hippocampus reveals their function in memory
    坂口 昌徳
    department seminar, New York University/2013-11
  • Japan Regeneration of neural circuits in the adult brain
    坂口 昌徳
    Academic Exchange for Japan-Korea Medical Students/2014-07-28
  • How memory engram is formed?
    坂口 昌徳
    The Adult Neurogenesis Conference/2014-12-06
  • Regeneration of neural circuits in the adult brain
    坂口 昌徳
    KAIST seminar series/2014-12-09
  • Function of adult-born neurons elucidated by sleep stage specific optogenetics.
    坂口 昌徳
    The 21st TMFC meeting/2015-07-03--2015-07-04
  • The function of adult born neurons during sleep
    坂口 昌徳
    The Japan Neuroscience Society/2015-07-28--2015-07-31
  • Brain regeneration
    坂口 昌徳
    Ophthalmology department seminar/2015-09-03
  • Memory formation process during sleep elucidated by optogenetic manipulation of adult-born neurons
    坂口 昌徳
    Comparative memory research symposium/2015-10-08--2015-10-09
  • Function of adult-born neurons in memory formation during sleep
    坂口 昌徳
    The 4th annual IIIS symposium/2016-02-26
  • Adult neurogenesis plays critical role in sleep stage dependent memory formation
    坂口 昌徳
    Brain-liver center symposium/2016-03-07
  • Relation between memory and sleep elucidated by optogenetic manipulation of adult-born neurons
    坂口 昌徳
    The 89th Annual meeting of the Japanese pharmacological society/2016-03-09--2016-03-11
  • Role of adult-born neuron in memory consolidation during sleep
    坂口 昌徳
    The 41st Japanese society of sleep research/2016-07-07--2016-07-08
  • The activity of adult born neurons are necessary for memory consolidation during sleep
    坂口 昌徳
    NCTC seminar/2016-04-24
  • Function of the adult-born neurons in memory consolidation during sleep
    坂口 昌徳
    Memory meeting 2016/2016-07-23
  • Function of the adult-born neurons in memory consolidation during sleep
    坂口 昌徳
    RIKEN PDFA Pizza and Science Seminars/2016-10-19
  • Elucidation of traumatic memory processing in the brain using mouse optogenetics
    坂口 昌徳
    The 1st Japanese Association of Psychological Medicine/2016-11-02--2016-11-03
  • Metabolomic analysis for memory consolidation of the adult-born neurons during sleep
    坂口 昌徳
    The Adult Neurogenesis Conference/2017-02-18
  • Japan Adult-born neurons in memory consolidation during sleep
    坂口 昌徳
    Neuro Global International cooperative graduate program seminar/2017-01-16
  • Japan Function of adult-born neurons during sleep
    坂口 昌徳
    Department Seminar at Tokyo medical and dental university/2017-03-14
  • Mechanism of memory consolidation during sleep
    坂口 昌徳
    Molecular Cellular Informatics Seminar/2017-03-16
  • Function of adult-born neurons in memory consolidation during sleep
    坂口 昌徳
    Neurogenesis in Developing and Adult Primate Brain - Challenges for Therapeutic Applications/2017-05-19--2017-05-20
  • Function of the adult-born neurons in memory consolidation during sleep
    坂口 昌徳
    Department seminar at Peking University/2017-05-28
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Intellectural property rights
  • 判定装置、光照射装置、及びプログラム
    手塚 太郎; 坂口昌徳
  • 小型撮像装置
    手塚 太郎; 細川拓馬; 坂口昌徳
  • 判定装置,光照射装置,及びプログラム
    坂口 昌徳
  • 小型撮像装置
    坂口 昌徳
  • Method of promoting subsistence and/or proliferation of neural stem cell and promoting extension of neurite, promoter therefor, pharmaceutical composition containing neural stem cell, method of assay and method of screening
    坂口 昌徳
  • Method of inducing growth of nerve stem cells.
    坂口 昌徳
  • therefore pharmaceutical compositions containing neural stem cells assay methods and screening methods.
    坂口 昌徳
  • Agent for inhibiting proliferation of neural stem cells.
    坂口 昌徳
Teaching
2021-04 -- 2021-08Research Methods in Kansei, Behavioral and Brain Sciences 2AUniversity of Tsukuba.
2021-10 -- 2022-02Special Research in Human Biology IIUniversity of Tsukuba.
2021-10 -- 2022-03Seminar in `Mind and Brain' Science 4BUniversity of Tsukuba.
2021-10 -- 2022-02Special Lecture in Kansei, Behavioral and Brain Sciences 1University of Tsukuba.
2021-04 -- 2021-08Special Lecture in Kansei, Behavioral and Brain Sciences 1University of Tsukuba.
2021-10 -- 2022-03Neuroscience Dissertation Research 6University of Tsukuba.
2021-10 -- 2022-02Special Lecture in Kansei , Behavioral and Brain Sciences 6University of Tsukuba.
2021-04 -- 2021-08Special Lecture in Kansei , Behavioral and Brain Sciences 6University of Tsukuba.
2021-10 -- 2022-02Research in Kansei Sciences BUniversity of Tsukuba.
2021-10 -- 2022-02Special Seminars in Human Biology IIUniversity of Tsukuba.
more...
Other educational activities
2013-04 -- 2014-03研究室実習University of Tsukuba
University Management
2014-04 -- (current)ヒューマンバイオロジープログラム運営委員会学位審査委員会委員
Other activities
2013-03 -- (current)ホームページ公開による研究公開活動 http://sakurai-sakaguchi.wpi-iiis.tsukuba.ac.jp/
Message
一旦大人になると、哺乳類の脳では神経細胞が新しく産まれてくることは希です。これは脳の病気の治療がとても困難である原因のひとつです。しかしヒトの海馬では例外的に毎日数千個の神経細胞が産まれ、記憶に重要な働きをすることが判明しています。筑波大学にある私の研究室では、レム睡眠中の僅かな新生神経細胞の活動が、記憶の固定化に必要であることを発見しました(Kumar et al., Neuron, 2020)。この発見をもとに脳の病気を治療を目指した様々な基礎研究を行っております。ご興味がある方はお気軽にご連絡ください。 Youtube: https://youtu.be/Fuk2sVK-D6k Twitter: https://twitter.com/masanorisaka

(Last updated: 2021-09-10)