SAKAGUCHI Masanori

Affiliation
Institute of Medicine
Official title
Associate Professor
ORCID
0000-0002-7211-9452
Sex
Male
KAKEN ID
60407088
URL
Email
+H6@6<J8=>aB6H6a;EXgcJaIHJ@J76a68a?E
Office
Sakaguchi lab
Other affiliation
国立精神神経医療研究センター・精神保健研究所 行動医学部研究部客員研究員
Research projects
睡眠中の⾳刺激によるPTSDの新規治療法の開発2024-05 -- 2027-03SAKAGUCHI MasanoriJapan Agency for Medical Research and Development (AMED)/令和６年度「橋渡し研究プログラム」・preF26,000,000Yen
睡眠中の音刺激による環世界マニピレーション2024-04 -- 2027-03SAKAGUCHI MasanoriJapan Society for the Promotion of Science/Grant-in-Aid for Transformative Research Areas(B)53,690,000Yen
Deciphering the mysteries of sleep:creating a global network of sleep neurobiologists2022-12 -- 2029-03YANAGISAWA MasashiJapan Society for the Promotion of Science (JSPS)/Fund for the Promotion of Joint International Research (International Leading Research)11,700,000Yen
Function of fear memory retrieval during REM sleep2023-04 -- 2026-03SAKAGUCHI MasanoriJSPS/Grant-in-Aid for Scientific Research (B)18,460,000Yen
Elucidation of the mechanism by which adult-born neurons consolidate memories during sleep2023-03 -- 2024-03SAKAGUCHI MasanoriJapan Society for the Promotion of Science (JSPS)/Grant-in-Aid for JSPS Fellows2,300,000Yen
Elucidation of patter sepration mechanism based on new and old neruon interaction.2022-10 -- 2023-09SAKAGUCHI MasanoriMitsubishi Foundation/the Research Grants in the Natural Sciences 20229,000,000Yen
Molecular Research and Treatment of Fear Memory in PTSD2022-04 -- 2025-03KIM YoshiharuJapan Society for the Promotion of Science (JSPS)/Grant-in-Aid for Scientific Research (A)5,200,000Yen
Function of synapse pruning in the regenerating memory circuit.2021-09 -- 2023-03SAKAGUCHI MasanoriJapan Society for the Promotion of Science (JSPS)/Grant-in-Aid for Transformative Research Areas (A)13,000,000Yen
睡眠中の記憶固定化の仕組みの解明2021-12 -- 2022-08坂口　昌徳公益信託五峯ライフサイエンス国際基金/2,500,000Yen
Study of the principles of consciousness2021-08 -- 2024-03SAKAGUCHI MasanoriJapan Agency for Medical Research and Development (AMED)/AMED領域横断的かつ萌芽的脳研究プロジェクト52,195,000Yen
more...
Career history
2022-04 -- (current)Univ TsukubaFaculty of MedicineAssc Prof (tenure)
2021-10 -- 2023-03National Center of Neurology and PsychiatryNational Institute of Mental Health客員研究員
2018-10 -- (current)筑波大学国際統合睡眠医科学研究機構PI
2013-04 -- 2018-09Tsukuba UniversityInternational Institute for Integrative Sleep MedicineCo-PI
2013-01 -- 2013-03Univ. TsukubaWPI-IIISResearcher
2011-04 -- 2012-12RIKENSpecial Postdoctoral Fellow (SPD)
2010-10 -- 2012-12RIKENBrain Science InstituteResearcher
2009-04 -- 2010-09Japan Society for the Promotion of ScienceOverseas Research Fellowships
2007-04 -- 2009-03SickKids Research Intsitute
2005-04 -- 2007-03Keio University医学部生理学教室assistant
more...
Academic background
2001-04 -- 2005-03Tsukuba University Conprehensive Human Sciences Medicine Doctural Course
1995-04 -- 2001-03Tsukuba University School of Medicine Department of Medicine
Degree
2005-03分子統合生体統御医学Tsukuba University
Licenses and qualifications
2001-06Medical license
2014-04HSK level4
Articles
Books
  • トラウマ記憶を弱めるには – マウスの記憶・睡眠研究から考えるPTSDケア
    坂口 昌徳
    academistJournal, 2017-07
  • レム睡眠中の脳の再生能力が記憶を定着させる – 睡眠中の記憶固定化のメカニズムにせまる
    坂口 昌徳
    academistJournal, 2020-08
  • 睡眠中の新生ニューロンの活動とその記憶固定化への役割の解明
    坂口 昌徳
    日本神経化学学会 神経化学トピックス, 2020-08
  • 睡眠中の脳の再生能力が記憶を定着する：怖い体験が夢でよみがえるしくみ
    小柳 伊代; 坂口 昌徳
    実験医学2020年11月号 カレントトピックス/羊土社, 2020-11
  • 成体脳で新生するニューロンが、睡眠中に恐怖記憶を固定化する
    坂口 昌徳
    医学のあゆみ, 2023-7
  • 睡眠と記憶
    小柳 伊代; 坂口 昌徳
    睡眠学第2版/朝倉書店, 2020-11
  • シナプス可塑性
    坂口 昌徳
    睡眠学百科事典/丸善出版, 2024-6
  • PTSDの恐怖記憶処理と新しい治療技術の開発
    坂口 昌徳
    トラウマティック・ストレス, 2022-06
  • PTSDの汎化における海馬歯状回の役割
    坂口 昌徳
    精神科Resident, 2022-05
  • 成体海馬の新生ニューロンが、睡眠中に記憶を固定化する
    坂口 昌徳
    BRAIN and NERVE, 2021-07
  • PTSD の脳内機構 PTSD，恐怖記憶のメカニズムの動物実験に基づいた知見について
    坂口 昌徳
    Clinical Neuroscience, 2021-06
  • 新生ニューロンの低頻度活動が睡眠中の記憶固定化に必要
    坂口 昌徳
    神経科学ニュース, 2021-02
  • 睡眠中の脳の再生能力が記憶を定着する
    坂口 昌徳
    実験医学, 2020-10
  • 神経幹細胞
    坂口 昌徳
    医学のあゆみ 212巻10号, 2005
  • “神経再生医療”看護のための最新医学講座
    坂口 昌徳
    神経再生医療, 2005
  • 脳・神経の発生・再生
    坂口 昌徳
    発生・再生イラストマップ, 2005-12
  • Neural stem cells: Isolation and self-renewal.
    Sakaguchi Masanori
    Tissue Stem Cells, 2006-11
  • 糖鎖結合タンパク質Galectin-1は成体脳内の神経幹細胞の増殖を促進させる
    坂口 昌徳
    細胞工学, 2006
  • 分子細胞治療
    坂口 昌徳
    先端医学社 6, 2007
  • 脳内で新生するニューロンと中枢神経再生への応用
    坂口 昌徳
    ブレインサイエンスレビュー, 2016-02
  • 心的外傷直後の場所刺激が記憶犯科に与える影響
    坂口 昌徳
    医学の歩み258(13), 2016
  • 記憶と睡眠
    坂口 昌徳
    睡眠学第2版, 2019
Conference, etc.
  • Elucidating REM Sleep Functions in Trace Fear Memory by a Novel Sleep Deprivation Method
    Nagai Kazuki; KOYANAGI Iyo; Kawakami Chinatsu; Chavan ...
    The 48th Annual Meeting of the Japan Neuroscience Society/2025-07-24--2025-07-27
  • Manipulation of fear memory during sleep by targeted memory reactivation
    Kawakami Chinatsu; KOYANAGI Iyo; Tamai Hayato; Naoi T...
    The 48th Annual Meeting of the Japan Neuroscience Society/2025-07-24--2025-07-27
  • The Role of Long-Term Depression in Adult-Born Dentate Gyrus Neurons during REM Sleep for Memory Consolidation
    KOYANAGI Iyo; Hashimotodani Yuki; Wang Yuteng; Ohba A...
    The 48th Annual Meeting of the Japan Neuroscience Society/2025-07-24--2025-07-27
  • Mechanisms of adult-born neurons for memory consolidation during sleep
    Koyanagi I; Wang Y; Srinivasan S; Yu J; Naoi T; Ohba...
    Annual Meeting of the Japan Neuroscience Society/2021-07
  • Fully automatic sleep stage-specific intervention using single EEG in mice
    Koyanagi Iyo; Tezuka Taro; Yu Jiahui; Srinivasan Sakt...
    SfN2022/2022-11
  • Transient recruitment of adult-born neurons for fear memory consolidation in REM sleep
    Srinivasan Sakthivel; Koyanagi Iyo; Vergara Pablo; Wan...
    The 11th Annual WPI-IIIS Symposium/2023-02-22--2023-02-22
  • Memory consolidation during sleep through the interaction of theta oscillation and adult-born neurons in the hippocampus.
    小柳 伊代; 汪 禹腾; Srinivasan Sakthivel; 于 佳卉; 直井 紀枝; 大庭 ...
    The 46th annual meeting of the Japan Neuroscience Society/2023-08-01--2023-08-04
  • Analyses of the effects of artificially increased REM sleep on the behavior after social stress exposure in mice
    安垣 進之助; 柏木 光昭; 鹿糠 実香; 小柳 伊代; 坂口 昌徳; 柳沢 正史; 林 悠
    The 47th Annual Meeting of the Molecular Biology Society of Japan (MBSJ2024)/2023-12-06--2023-12-08
  • 人為的レム睡眠操作が社会的ストレスにより惹起される行動変容に与える影響の検討
    安垣 進之助; 柏木 光昭; 鹿糠 実香; 小柳 伊代; 坂口 昌徳; 柳沢 正史; 林 悠
    日本動物学会関東支部第76回大会/2024-03-16
  • Bidirectional relationship between REM sleep and stress: a study using a social stress model
    安垣 進之助; 柏木 光昭; 鹿糠 実香; 小柳 伊代; 坂口 昌徳; 柳沢 正史; 林 悠
    The 48th Annual Meeting of Japanese Society of Sleep Research/2024-05-08
  • Reactivation of hippocampal adult-born neurons representing fear memory in REM sleep for memory consolidation
    Koyanagi Iyo; Srinivasan Sakthivel; Vergara Pablo; Wan...
    Eurogenesis 2024/2024-06-12--2024-06-14
  • CaliAli: A Comprehensive Suite for extracting Neuron Signals Across Multiple sessions in One-Photon Calcium Imaging
    Vergara Pablo; Wang Yuteng; Srinivasan Sakthivel; Koya...
    The 47th JNS annual meeting/2024-07-24--2024-07-27
  • Electrophysiological activity of a novel REM sleep regulating neuron in the dorsal pons in sleep/wake cycles
    Arai Yoshifumi; Kashiwagi Mitsuaki; Kanuka Mika; Sugan...
    Functions and Regulation of Sleep, Cold Spring Harbor Asia/2024-09-09--2024-09-13
  • Synchronized adult-born neuron activities during REM sleep are necessary for memory consolidation.
    Koyanagi Iyo; Srinivasan Sakthivel; Vergara Pablo; Wan...
    The 17th Annual Meeting of Chinese Neuroscience Society/2024-09-26--2024-09-29
  • Reactivation of hippocampal adult-born neurons representing fear memory in REM sleep for memory consolidation
    Sakaguchi Masanori; Srinivasan Sakthivel; Koyanagi Iyo...
    Neuroscience 2024 (Society for Neuroscience)/2024-10-05--2024-10-09
  • Reactivation of Adult-Born Neurons During REM Sleep: A Critical Mechanism for Associative Fear Memory Consolidation
    Iyo KOYANAGI; Sakthivel Srinivasan; Pablo Vergara; Yut...
    The 13th Annual WPI-IIIS Symposium/2024-11-25--2024-11-25
  • Fear memory update by sound stimulation during sleep
    Kawakami Chinatsu; Koyanagi Iyo; Naoi Toshie; Tezuka ...
    IIIS Symposium/2024-11-25
  • Fear memory consolidation by reactivation of newborn neurons and synchronization of theta waves during sleep.
    Koyanagi Iyo; Srinivasan Sakthivel; Vergara Pablo; Wan...
    The 21st Adult Neurogenesis Conference/2024-11-30
  • 睡眠中の恐怖記憶処理機構
    坂口 昌徳
    子どもの発達とトラウマ研究会/2022-3-2--2022-3-2
  • Hippocampal Adult-Born Neurons for Memory Consolidation during REM Sleep
    坂口 昌徳
    U of T Brain and Bee seminar/2022-11-18--2022-11-18
  • Memory consolidation during sleep by the adult-born neurons
    坂口 昌徳
    第19回成体脳ニューロン新生懇談会/2022-10-29--2022-10-29
  • 睡眠中の恐怖記憶処理メカニズムの解明とPTSDの治療開発
    坂口 昌徳
    第118回日本精神神経学会学術総会/2022-06-16--2022-06-18
  • Transient recruitment of an adult-born neuron ensemble for fear memory consolidation in REM sleep
    Srinivasan Sakthivel; Koyanagi Iyo; Wang Yuteng; Verga...
    JST-CREST "Opt Bio" / WPI-IIIS Joint Symposium/2022-03-16--2022-03-18
  • 成体脳の新生ニューロンが睡眠中の記憶固定化に果たすメカニズムの解明
    伊代 小柳; 禹騰 汪; Sakthivel Srinivasan; 佳卉 于; 紀枝 直井; 彰展 大庭; Ku...
    第44回日本神経科学大会/2021-07
  • Function of adult neurogenesis in visual discrimination memory
    坂口 昌徳
    Symposium on Behavioral Molecular Neuroscience/2013-02
  • more...
Intellectural property rights
  • 判定装置、光照射装置、及びプログラム
    手塚 太郎; 坂口昌徳
  • 小型撮像装置
    手塚 太郎; 細川拓馬; 坂口昌徳
  • Method of promoting subsistence and/or proliferation of neural stem cell and promoting extension of neurite, promoter therefor, pharmaceutical composition containing neural stem cell, method of assay and method of screening
    坂口 昌徳
  • Method of inducing growth of nerve stem cells.
    坂口 昌徳
  • therefore pharmaceutical compositions containing neural stem cells assay methods and screening methods.
    坂口 昌徳
  • Agent for inhibiting proliferation of neural stem cells.
    坂口 昌徳
Teaching
2024-04 -- 2024-08Special Research in Humanics IIIaUniversity of Tsukuba.
2024-10 -- 2025-02Special Seminars in Humanics IIIbUniversity of Tsukuba.
2024-10 -- 2025-02Basic Experiments in Human BiologyUniversity of Tsukuba.
2024-10 -- 2025-02Special Lecture in Kansei , Behav ioral and Brain Sciences 4University of Tsukuba.
2024-04 -- 2024-08Special Lecture in Kansei , Behav ioral and Brain Sciences 4University of Tsukuba.
2024-04 -- 2024-08Special Seminars in Human Biology IUniversity of Tsukuba.
2024-10 -- 2025-02Special Lectures in Humanics IIIbUniversity of Tsukuba.
2024-04 -- 2024-08Special Lectures in Humanics IIIaUniversity of Tsukuba.
2024-04 -- 2024-08Special Seminars in Humanics IIIaUniversity of Tsukuba.
2024-10 -- 2025-02Special Lecture in Kansei , Behavioral and Brain Sciences 6University of Tsukuba.
more...
Other educational activities
2013-04 -- 2014-03研究室実習University of Tsukuba
University Management
2014-04 -- (current)ヒューマンバイオロジープログラム運営委員会学位審査委員会委員
Message
私たちの研究室では、睡眠中にどのように記憶が処理されるかを研究しています。最近私たちは、レム睡眠中のわずかな新生神経細胞の活動が、記憶の固定化に必要であることを発見しました(Kumar Neuron 2020)。また睡眠中の音刺激によって恐怖記憶を無意識下で操作できることを示し（Purple Sci Rep 2017)、これをPTSDの新しい治療技術開発へ向けた臨床研究へ応用しています。ご興味がある方はお気軽にご連絡ください。 Youtube: https://youtu.be/Fuk2sVK-D6k Twitter: https://twitter.com/masanorisaka

(Last updated: 2025-05-15)