Sakaguchi Masanori
- Affiliation
- Faculty of Medicine
- Official title
- Associate Professor
- Sex
- Male
- KAKEN ID
- 60407088
- URL
- C0|(|$2 %&I*|0|I#-@OK|)2*+&I102(2}|I| I'-
- Office
- Sakaguchi lab
- Research projects
Elucidation of patter sepration mechanism based on new and old neruon interaction. 2022-10 -- 2023-09 坂口 昌徳 公益財団法人三菱財団/2022年度自然科学研究助成 9,000,000Yen PTSDの恐怖記憶と情動反応の分子基盤の解明と治療 2022-04 -- 2025-03 金吉晴 日本学術振興会/科学研究費補助金/基盤研究(A) 5,200,000Yen 再編成を続ける記憶回路におけるシナプス刈り込みの意義の解明 2021-09 -- 2023-03 坂口 昌徳 日本学術振興会/科学研究費助成事業 学術変革領域研究(A) 13,000,000Yen 睡眠中の記憶固定化の仕組みの解明 2021-12 -- 2022-08 坂口 昌徳 公益信託五峯ライフサイエンス国際基金/ 2,500,000Yen 新生ニューロンが睡眠中に記憶を固定化するメカニズムの解明 2021-09 -- 2024-03 坂口 昌徳 日本学術振興会/科学研究費助成事業 特別研究員奨励費 2,300,000Yen Study of the principles of consciousness 2021-08 -- 2024-03 坂口昌徳 Japan Agency for Medical Research and Development/AMED領域横断的かつ萌芽的脳研究プロジェクト 46,800,000Yen 不安障害の背後にある可塑的な神経回路の機能破綻 2021-04 -- 2022-03 坂口 昌徳 Takeda Science Foundation/2021年生命科学研究助成 10,000,000Yen 睡眠と冬眠:2 つの「眠り」の解明と操作 2021-04 -- 2024-03 柳沢 正史 Japan Agency for Medical Research and Development/Moonshot 84,000,000Yen 脳の同期活動をもとにした意識の動作原理 2021-01 -- 2024-04 坂口 昌徳 公益財団法人 上原記念生命科学財団 /特定研究助成金B 9,000,000Yen 睡眠中の記憶固定化におけるシナプス可塑性の意義の解明 2020-04 -- 2023-03 坂口 昌徳 Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B) 17,550,000Yen more... - Career history
2022-04 -- (current) Univ TsukubaFaculty of MedicineAssc Prof (tenure) 2021-10 -- 2023-03 National Center of Neurology and PsychiatryNational Institute of Mental Health客員研究員 2018-10 -- (current) 筑波大学国際統合睡眠医科学研究機構PI 2013-04 -- 2018-09 Tsukuba UniversityInternational Institute for Integrative Sleep MedicineCo-PI 2013-01 -- 2013-03 Univ. TsukubaWPI-IIISResearcher 2011-04 -- 2012-12 RIKENSpecial Postdoctoral Fellow (SPD) 2010-10 -- 2012-12 RIKENBrain Science InstituteResearcher 2009-04 -- 2010-09 Japan Society for the Promotion of ScienceOverseas Research Fellowships 2007-04 -- 2009-03 SickKids Research Intsitute 2005-04 -- 2007-03 Keio University医学部生理学教室assistant more... - Academic background
2001-04 -- 2005-03 Tsukuba University Conprehensive Human Sciences Medicine Doctural Course 1995-04 -- 2001-03 Tsukuba University School of Medicine Department of Medicine - Degree
2005-03 分子統合生体統御医学 Tsukuba University - Licenses and qualifications
2001-06 Medical license 2014-04 HSK level4 - Articles
- Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation
Kumar Deependra; Koyanagi Iyo; Carrier-Ruiz Alvaro; Verga...
Neuron/107(3)/pp.552-+, 2020-05 - Classification of power spectra of EEG by non-negative matrix factorization
小山一樹; 伊藤真理子; 坂口 昌徳; 大西立顕
信学技報/121(444)/pp.111-116, 2022-03 - Contribution of adult-born neurons to memory consolidation during rapid eye movement sleep
Ohba Akinobu; Sakaguchi Masanori
Neural regeneration research/17(2)/pp.307-308, 2022-02-01 - Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological Diseases
Soares Luana C.; Al-Dalahmah Osama; Hillis James; Youn...
CELLS/10(11), 2021-11 - [Adult-Born Neurons in the Dentate Gyrus Consolidate Memories during Sleep]
Sugaya Yuki; Sakaguchi Masanori
Brain and nerve = Shinkei kenkyu no shinpo/73(7)/pp.813-817, 2021-07-01 - Fear generalization immediately after contextual fear memory consolidation in mice
Yu Jiahui; Naoi Toshie; Sakaguchi Masanori
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/558/pp.102-106, 2021-06 - Real-time, automatic, open-source sleep stage classification system using single EEG for mice
Tezuka Taro; Kumar Deependra; Singh Sima; Koyanagi Iy...
Scientific reports/11(1), 2021-05 - Open-Source Software for Real-time Calcium Imaging and Synchronized Neuron Firing Detection
Taniguchi Masaki; Tezuka Taro; Vergara Pablo; Srinivas...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference/2021/pp.2997-3003, 2021-04-01 - Remapping of Adult-Born Neuron Activity during Fear Memory Consolidation in Mice
Vergara Pablo; Kumar Deependra; Srinivasan Sakthivel; ...
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/22(6), 2021-03 - Calcium imaging of adult-born neurons in freely moving mice
Carrier-Ruiz Alvaro; Sugaya Yuki; Kumar Deependra; Ver...
STAR protocols/2(1), 2021-03 - Metabolic fingerprints of fear memory consolidation during sleep
Koyanagi Iyo; Sonomura Kazuhiro; Naoi Toshie; Ohnishi ...
Molecular Brain/14(1), 2021-02 - Mechanisms Underlying Memory Consolidation by Adult-Born Neurons During Sleep
Vergara Pablo; Sakaguchi Masanori
FRONTIERS IN CELLULAR NEUROSCIENCE/14, 2020-11 - Progressive Changes in Sleep and Its Relations to Amyloid-beta Distribution and Learning in Single App Knock-In Mice
Maezono Sakura Eri B; Kanuka Mika; Tatsuzawa Chika; Morit...
eNeuro, 2020-08 - Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation
Kumar Deependra; Koyanagi Iyo; Carrier-Ruiz Alvaro; Verga...
Neuron/107(3)/pp.552-+, 2020-05 - Progressive Changes in Sleep and Its Relations to Amyloid-beta Distribution and Learning in Single App Knock-In Mice
Maezono Sakura Eri B; Kanuka Mika; Tatsuzawa Chika; Mo...
eNeuro/7(2), 2020-03 - Miniaturized microscope with flexible light source input for neuronal imaging and manipulation in freely behaving animals
Srinivasan Sakthivel; Hosokawa Takuma; Vergara Pablo; ...
Biochemical and biophysical research communications/517(3)/pp.520-524, 2019-09 - Memory consolidation during sleep and adult hippocampal neurogenesis
Koyanagi Iyo; Akers Katherine G.; Vergara Pablo; Srini...
NEURAL REGENERATION RESEARCH/14(1)/pp.20-23, 2019-01 - Regulatory influence of sleep and epigenetics on adult hippocampal neurogenesis and cognitive and emotional function
Akers Katherine G; Chérasse Yoan; Fujita Yuki; Srinivasan...
Stem Cells/36(7)/pp.969-976, 2018-02 - Auditory conditioned stimulus presentation during NREM sleep impairs fear memory in mice
Purple Ross J; Sakurai Takeshi; Sakaguchi Masanori
Scientific reports/7, 2017-04 - Effect of context exposure after fear learning on memory generalization in mice
Fujinaka Ayano; Li Ruoshi; Hayashi Masanobu; Kumar De...
MOLECULAR BRAIN/9/p.2, 2016-01 - Inhibiting the Activity of CA1 Hippocampal Neurons Prevents the Recall of Contextual Fear Memory in Inducible ArchT Transgenic Mice
Sakaguchi Masanori; Kim Karam; Yu Lily Mae Yee; Hashik...
PLOS ONE/10(6), 2015-06 - Posttraining ablation of adult-generated olfactory granule cells degrades odor-reward memories
Arruda-Carvalho Maithe; Akers Katherine G; Guskjolen A...
The Journal of neuroscience : the official journal of the Society for Neuroscience/34(47)/pp.15793-15803, 2014-11-19 - Catching the engram: strategies to examine the memory trace
Sakaguchi Masanori; Hayashi Yasunori
Molecular brain/5/p.32, 2012-09-21 - Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb
Hirota Yuki; Sawada Masato; Kida Yasuyuki S; Huang Sh...
Stem cells (Dayton, Ohio)/30(8)/pp.1726-1733, 2012-08-01 - Neural stem cells, adult neurogenesis, and galectin-1: from bench to bedside
Sakaguchi Masanori; Okano Hideyuki
Developmental neurobiology/72(7)/pp.1059-1067, 2012-07-01 - more...
- Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation
- Books
- 神経幹細胞
坂口 昌徳
医学のあゆみ 212巻10号, 2005 - “神経再生医療”看護のための最新医学講座
坂口 昌徳
神経再生医療, 2005 - 脳・神経の発生・再生
坂口 昌徳
発生・再生イラストマップ, 2005-12 - Neural stem cells: Isolation and self-renewal.
Sakaguchi Masanori
Tissue Stem Cells, 2006-11 - 糖鎖結合タンパク質Galectin-1は成体脳内の神経幹細胞の増殖を促進させる
坂口 昌徳
細胞工学, 2006 - 分子細胞治療
坂口 昌徳
先端医学社 6, 2007 - 脳内で新生するニューロンと中枢神経再生への応用
坂口 昌徳
ブレインサイエンスレビュー, 2016-02 - 心的外傷直後の場所刺激が記憶犯科に与える影響
坂口 昌徳
医学の歩み258(13), 2016 - トラウマ記憶を弱めるには – マウスの記憶・睡眠研究から考えるPTSDケア
坂口 昌徳
academistJournal, 2017-07 - 記憶と睡眠
坂口 昌徳
睡眠学第2版, 2019
- 神経幹細胞
- Conference, etc.
- Transient recruitment of an adult-born neuron ensemble for fear memory consolidation in REM sleep
Srinivasan Sakthivel; Koyanagi Iyo; Wang Yuteng; Vergara ...
JST-CREST "Opt Bio" / WPI-IIIS Joint Symposium/2022-03-16--2022-03-18 - 成体脳の新生ニューロンが睡眠中の記憶固定化に果たすメカニズムの解明
伊代 小柳; 禹騰 汪; Sakthivel Srinivasan; 佳卉 于; 紀枝 直井; 彰展 大庭; Ku...
第44回日本神経科学大会/2021-07 - Function of adult neurogenesis in visual discrimination memory
坂口 昌徳
Symposium on Behavioral Molecular Neuroscience/2013-02 - Neural stem cells,adult neurogenesis and memory
坂口 昌徳
IIIS, Symposium/2013-03 - Selective and precise temporal ablation of adult born neurons in the hippocampus reveals their function in memory
坂口 昌徳
department seminar, New York University/2013-11 - Japan Regeneration of neural circuits in the adult brain
坂口 昌徳
Academic Exchange for Japan-Korea Medical Students/2014-07-28 - How memory engram is formed?
坂口 昌徳
The Adult Neurogenesis Conference/2014-12-06 - Regeneration of neural circuits in the adult brain
坂口 昌徳
KAIST seminar series/2014-12-09 - Function of adult-born neurons elucidated by sleep stage specific optogenetics.
坂口 昌徳
The 21st TMFC meeting/2015-07-03--2015-07-04 - The function of adult born neurons during sleep
坂口 昌徳
The Japan Neuroscience Society/2015-07-28--2015-07-31 - Brain regeneration
坂口 昌徳
Ophthalmology department seminar/2015-09-03 - Memory formation process during sleep elucidated by optogenetic manipulation of adult-born neurons
坂口 昌徳
Comparative memory research symposium/2015-10-08--2015-10-09 - Function of adult-born neurons in memory formation during sleep
坂口 昌徳
The 4th annual IIIS symposium/2016-02-26 - Adult neurogenesis plays critical role in sleep stage dependent memory formation
坂口 昌徳
Brain-liver center symposium/2016-03-07 - Relation between memory and sleep elucidated by optogenetic manipulation of adult-born neurons
坂口 昌徳
The 89th Annual meeting of the Japanese pharmacological society/2016-03-09--2016-03-11 - Role of adult-born neuron in memory consolidation during sleep
坂口 昌徳
The 41st Japanese society of sleep research/2016-07-07--2016-07-08 - The activity of adult born neurons are necessary for memory consolidation during sleep
坂口 昌徳
NCTC seminar/2016-04-24 - Function of the adult-born neurons in memory consolidation during sleep
坂口 昌徳
Memory meeting 2016/2016-07-23 - Function of the adult-born neurons in memory consolidation during sleep
坂口 昌徳
RIKEN PDFA Pizza and Science Seminars/2016-10-19 - Elucidation of traumatic memory processing in the brain using mouse optogenetics
坂口 昌徳
The 1st Japanese Association of Psychological Medicine/2016-11-02--2016-11-03 - Metabolomic analysis for memory consolidation of the adult-born neurons during sleep
坂口 昌徳
The Adult Neurogenesis Conference/2017-02-18 - Japan Adult-born neurons in memory consolidation during sleep
坂口 昌徳
Neuro Global International cooperative graduate program seminar/2017-01-16 - Japan Function of adult-born neurons during sleep
坂口 昌徳
Department Seminar at Tokyo medical and dental university/2017-03-14 - Mechanism of memory consolidation during sleep
坂口 昌徳
Molecular Cellular Informatics Seminar/2017-03-16 - Function of adult-born neurons in memory consolidation during sleep
坂口 昌徳
Neurogenesis in Developing and Adult Primate Brain - Challenges for Therapeutic Applications/2017-05-19--2017-05-20 - more...
- Transient recruitment of an adult-born neuron ensemble for fear memory consolidation in REM sleep
- Intellectural property rights
- 判定装置、光照射装置、及びプログラム
手塚 太郎; 坂口昌徳 - 小型撮像装置
手塚 太郎; 細川拓馬; 坂口昌徳 - 判定装置,光照射装置,及びプログラム
坂口 昌徳 - 小型撮像装置
坂口 昌徳 - Method of promoting subsistence and/or proliferation of neural stem cell and promoting extension of neurite, promoter therefor, pharmaceutical composition containing neural stem cell, method of assay and method of screening
坂口 昌徳 - Method of inducing growth of nerve stem cells.
坂口 昌徳 - therefore pharmaceutical compositions containing neural stem cells assay methods and screening methods.
坂口 昌徳 - Agent for inhibiting proliferation of neural stem cells.
坂口 昌徳
- 判定装置、光照射装置、及びプログラム
- Teaching
2022-10 -- 2023-02 Basic Experiments in Human Biology University of Tsukuba. 2022-10 -- 2023-02 Special Lecture in Kansei , Behav ioral and Brain Sciences 5 University of Tsukuba. 2022-04 -- 2022-08 Special Lecture in Kansei , Behav ioral and Brain Sciences 5 University of Tsukuba. 2022-04 -- 2022-08 Special Practice in Human Biology III University of Tsukuba. 2022-10 -- 2023-02 Special Practice in Human Biology III University of Tsukuba. 2022-10 -- 2023-02 Research in Kansei Sciences B University of Tsukuba. 2022-04 -- 2022-08 Advanced Exercise on Public Health University of Tsukuba. 2022-10 -- 2023-02 Advanced Exercise on Public Health University of Tsukuba. 2022-10 -- 2023-02 Special Seminars in Human Biology II University of Tsukuba. 2022-10 -- 2023-02 Research Methods in Kansei, Behavioral and Brain Sciences 2B University of Tsukuba. more... - Other educational activities
2013-04 -- 2014-03 研究室実習 University of Tsukuba - University Management
2014-04 -- (current) ヒューマンバイオロジープログラム運営委員会 学位審査委員会委員 - Message
-
私たちの研究室では、睡眠中にどのように記憶が処理されるかを研究しています。最近私たちは、レム睡眠中のわずかな新生神経細胞の活動が、記憶の固定化に必要であることを発見しました(Kumar et al., Neuron, 2020)。この発見をもとに脳の病気を治療を目指した様々な基礎研究を行っております。ご興味がある方はお気軽にご連絡ください。 Youtube: https://youtu.be/Fuk2sVK-D6k Twitter: https://twitter.com/masanorisaka
(Last updated: 2022-07-05)