Sakaguchi Masanori

Affiliation
Faculty of Medicine
Official title
Associate Professor
Sex
Male
KAKEN ID
60407088
URL
Email
C0|(|$2 %&I*|0|I#-@OK|)2*+&I102(2}|I| I'-
Office
Sakaguchi lab
Research projects
Elucidation of patter sepration mechanism based on new and old neruon interaction.2022-10 -- 2023-09坂口　昌徳公益財団法人三菱財団/2022年度自然科学研究助成9,000,000Yen
PTSDの恐怖記憶と情動反応の分子基盤の解明と治療2022-04 -- 2025-03金吉晴日本学術振興会/科学研究費補助金/基盤研究(A)5,200,000Yen
再編成を続ける記憶回路におけるシナプス刈り込みの意義の解明2021-09 -- 2023-03坂口　昌徳日本学術振興会/科学研究費助成事業 学術変革領域研究(A)13,000,000Yen
睡眠中の記憶固定化の仕組みの解明2021-12 -- 2022-08坂口　昌徳公益信託五峯ライフサイエンス国際基金/2,500,000Yen
新生ニューロンが睡眠中に記憶を固定化するメカニズムの解明2021-09 -- 2024-03坂口　昌徳日本学術振興会/科学研究費助成事業 特別研究員奨励費2,300,000Yen
Study of the principles of consciousness2021-08 -- 2024-03坂口昌徳Japan Agency for Medical Research and Development/AMED領域横断的かつ萌芽的脳研究プロジェクト46,800,000Yen
不安障害の背後にある可塑的な神経回路の機能破綻2021-04 -- 2022-03坂口　昌徳Takeda Science Foundation/2021年生命科学研究助成10,000,000Yen
睡眠と冬眠：2 つの「眠り」の解明と操作2021-04 -- 2024-03柳沢　正史Japan Agency for Medical Research and Development/Moonshot84,000,000Yen
脳の同期活動をもとにした意識の動作原理2021-01 -- 2024-04坂口　昌徳公益財団法人　上原記念生命科学財団　/特定研究助成金B9,000,000Yen
睡眠中の記憶固定化におけるシナプス可塑性の意義の解明2020-04 -- 2023-03坂口 昌徳Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B)17,550,000Yen
more...
Career history
2022-04 -- (current)Univ TsukubaFaculty of MedicineAssc Prof (tenure)
2021-10 -- 2023-03National Center of Neurology and PsychiatryNational Institute of Mental Health客員研究員
2018-10 -- (current)筑波大学国際統合睡眠医科学研究機構PI
2013-04 -- 2018-09Tsukuba UniversityInternational Institute for Integrative Sleep MedicineCo-PI
2013-01 -- 2013-03Univ. TsukubaWPI-IIISResearcher
2011-04 -- 2012-12RIKENSpecial Postdoctoral Fellow (SPD)
2010-10 -- 2012-12RIKENBrain Science InstituteResearcher
2009-04 -- 2010-09Japan Society for the Promotion of ScienceOverseas Research Fellowships
2007-04 -- 2009-03SickKids Research Intsitute
2005-04 -- 2007-03Keio University医学部生理学教室assistant
more...
Academic background
2001-04 -- 2005-03Tsukuba University Conprehensive Human Sciences Medicine Doctural Course
1995-04 -- 2001-03Tsukuba University School of Medicine Department of Medicine
Degree
2005-03分子統合生体統御医学Tsukuba University
Licenses and qualifications
2001-06Medical license
2014-04HSK level4
Articles
Books
  • 神経幹細胞
    坂口 昌徳
    医学のあゆみ 212巻10号, 2005
  • “神経再生医療”看護のための最新医学講座
    坂口 昌徳
    神経再生医療, 2005
  • 脳・神経の発生・再生
    坂口 昌徳
    発生・再生イラストマップ, 2005-12
  • Neural stem cells: Isolation and self-renewal.
    Sakaguchi Masanori
    Tissue Stem Cells, 2006-11
  • 糖鎖結合タンパク質Galectin-1は成体脳内の神経幹細胞の増殖を促進させる
    坂口 昌徳
    細胞工学, 2006
  • 分子細胞治療
    坂口 昌徳
    先端医学社 6, 2007
  • 脳内で新生するニューロンと中枢神経再生への応用
    坂口 昌徳
    ブレインサイエンスレビュー, 2016-02
  • 心的外傷直後の場所刺激が記憶犯科に与える影響
    坂口 昌徳
    医学の歩み258(13), 2016
  • トラウマ記憶を弱めるには – マウスの記憶・睡眠研究から考えるPTSDケア
    坂口 昌徳
    academistJournal, 2017-07
  • 記憶と睡眠
    坂口 昌徳
    睡眠学第2版, 2019
Conference, etc.
  • Transient recruitment of an adult-born neuron ensemble for fear memory consolidation in REM sleep
    Srinivasan Sakthivel; Koyanagi Iyo; Wang Yuteng; Vergara ...
    JST-CREST "Opt Bio" / WPI-IIIS Joint Symposium/2022-03-16--2022-03-18
  • 成体脳の新生ニューロンが睡眠中の記憶固定化に果たすメカニズムの解明
    伊代 小柳; 禹騰 汪; Sakthivel Srinivasan; 佳卉 于; 紀枝 直井; 彰展 大庭; Ku...
    第44回日本神経科学大会/2021-07
  • Function of adult neurogenesis in visual discrimination memory
    坂口 昌徳
    Symposium on Behavioral Molecular Neuroscience/2013-02
  • Neural stem cells,adult neurogenesis and memory
    坂口 昌徳
    IIIS, Symposium/2013-03
  • Selective and precise temporal ablation of adult born neurons in the hippocampus reveals their function in memory
    坂口 昌徳
    department seminar, New York University/2013-11
  • Japan Regeneration of neural circuits in the adult brain
    坂口 昌徳
    Academic Exchange for Japan-Korea Medical Students/2014-07-28
  • How memory engram is formed?
    坂口 昌徳
    The Adult Neurogenesis Conference/2014-12-06
  • Regeneration of neural circuits in the adult brain
    坂口 昌徳
    KAIST seminar series/2014-12-09
  • Function of adult-born neurons elucidated by sleep stage specific optogenetics.
    坂口 昌徳
    The 21st TMFC meeting/2015-07-03--2015-07-04
  • The function of adult born neurons during sleep
    坂口 昌徳
    The Japan Neuroscience Society/2015-07-28--2015-07-31
  • Brain regeneration
    坂口 昌徳
    Ophthalmology department seminar/2015-09-03
  • Memory formation process during sleep elucidated by optogenetic manipulation of adult-born neurons
    坂口 昌徳
    Comparative memory research symposium/2015-10-08--2015-10-09
  • Function of adult-born neurons in memory formation during sleep
    坂口 昌徳
    The 4th annual IIIS symposium/2016-02-26
  • Adult neurogenesis plays critical role in sleep stage dependent memory formation
    坂口 昌徳
    Brain-liver center symposium/2016-03-07
  • Relation between memory and sleep elucidated by optogenetic manipulation of adult-born neurons
    坂口 昌徳
    The 89th Annual meeting of the Japanese pharmacological society/2016-03-09--2016-03-11
  • Role of adult-born neuron in memory consolidation during sleep
    坂口 昌徳
    The 41st Japanese society of sleep research/2016-07-07--2016-07-08
  • The activity of adult born neurons are necessary for memory consolidation during sleep
    坂口 昌徳
    NCTC seminar/2016-04-24
  • Function of the adult-born neurons in memory consolidation during sleep
    坂口 昌徳
    Memory meeting 2016/2016-07-23
  • Function of the adult-born neurons in memory consolidation during sleep
    坂口 昌徳
    RIKEN PDFA Pizza and Science Seminars/2016-10-19
  • Elucidation of traumatic memory processing in the brain using mouse optogenetics
    坂口 昌徳
    The 1st Japanese Association of Psychological Medicine/2016-11-02--2016-11-03
  • Metabolomic analysis for memory consolidation of the adult-born neurons during sleep
    坂口 昌徳
    The Adult Neurogenesis Conference/2017-02-18
  • Japan Adult-born neurons in memory consolidation during sleep
    坂口 昌徳
    Neuro Global International cooperative graduate program seminar/2017-01-16
  • Japan Function of adult-born neurons during sleep
    坂口 昌徳
    Department Seminar at Tokyo medical and dental university/2017-03-14
  • Mechanism of memory consolidation during sleep
    坂口 昌徳
    Molecular Cellular Informatics Seminar/2017-03-16
  • Function of adult-born neurons in memory consolidation during sleep
    坂口 昌徳
    Neurogenesis in Developing and Adult Primate Brain - Challenges for Therapeutic Applications/2017-05-19--2017-05-20
  • more...
Intellectural property rights
  • 判定装置、光照射装置、及びプログラム
    手塚 太郎; 坂口昌徳
  • 小型撮像装置
    手塚 太郎; 細川拓馬; 坂口昌徳
  • 判定装置,光照射装置,及びプログラム
    坂口 昌徳
  • 小型撮像装置
    坂口 昌徳
  • Method of promoting subsistence and/or proliferation of neural stem cell and promoting extension of neurite, promoter therefor, pharmaceutical composition containing neural stem cell, method of assay and method of screening
    坂口 昌徳
  • Method of inducing growth of nerve stem cells.
    坂口 昌徳
  • therefore pharmaceutical compositions containing neural stem cells assay methods and screening methods.
    坂口 昌徳
  • Agent for inhibiting proliferation of neural stem cells.
    坂口 昌徳
Teaching
2022-10 -- 2023-02Basic Experiments in Human BiologyUniversity of Tsukuba.
2022-10 -- 2023-02Special Lecture in Kansei , Behav ioral and Brain Sciences 5University of Tsukuba.
2022-04 -- 2022-08Special Lecture in Kansei , Behav ioral and Brain Sciences 5University of Tsukuba.
2022-04 -- 2022-08Special Practice in Human Biology IIIUniversity of Tsukuba.
2022-10 -- 2023-02Special Practice in Human Biology IIIUniversity of Tsukuba.
2022-10 -- 2023-02Research in Kansei Sciences BUniversity of Tsukuba.
2022-04 -- 2022-08Advanced Exercise on Public HealthUniversity of Tsukuba.
2022-10 -- 2023-02Advanced Exercise on Public HealthUniversity of Tsukuba.
2022-10 -- 2023-02Special Seminars in Human Biology IIUniversity of Tsukuba.
2022-10 -- 2023-02Research Methods in Kansei, Behavioral and Brain Sciences 2BUniversity of Tsukuba.
more...
Other educational activities
2013-04 -- 2014-03研究室実習University of Tsukuba
University Management
2014-04 -- (current)ヒューマンバイオロジープログラム運営委員会学位審査委員会委員
Message
私たちの研究室では、睡眠中にどのように記憶が処理されるかを研究しています。最近私たちは、レム睡眠中のわずかな新生神経細胞の活動が、記憶の固定化に必要であることを発見しました(Kumar et al., Neuron, 2020)。この発見をもとに脳の病気を治療を目指した様々な基礎研究を行っております。ご興味がある方はお気軽にご連絡ください。 Youtube: https://youtu.be/Fuk2sVK-D6k Twitter: https://twitter.com/masanorisaka

(Last updated: 2022-07-05)