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Yanagisawa Hiromi

Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA)
Official title
Extracellular environment and cellular responses in development and disease
Research fields
Cardiovascular medicine
General medical chemistry
Cardiovascular surgery
Pathological medical chemistry
Research keywords
extracellular microenvironment
extracellular matrix
Vascular Biology
aortic aneurysm
cerebrovascular system
elastic fibers
vascular remodeling
tissue stem cell
Research projects
メカノトランスダクションを基軸とした大動脈瘤発症機序の解明と破裂予測の基盤研究2020-04 -- 2023-03Hiromi YanagisawaJSPS/Grant-in-Aid for Scientific Research (B)17,810,000Yen
メカニカルストレス応答の破綻に着目した大動脈瘤形成メカニズムの解明2017 -- 2020柳沢 裕美Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B)17,290,000Yen
Role of fibulin-7, a new member of fibulin ECM proteins, in development and disease2012-01 -- 2015-08Hiromi YanagisawaAmerican Heart Association/Established Investigator Award
Loss of extracellular matrix regulation and development of aortic aneurysms2010-12 -- 2015-08Hiromi YanagisawaNational Institute of Health (NIH)/R01
Protease regulation and integrity of connective tissues of the pelvic floor2010-08 -- 2015-08Hiromi Yanagisawa and R.Ann WordNational Institute of Health (NIH)/R01
Elastic fiber homeostasis in the vaginal wall2007-07 -- 2015-08R. Ann Word and Hiromi YanagisawaNational Institute of Health (NIH)/R01
Investigation of the potential role of fibulin-4 in the pathogenesis of Marfan syndrome2009-01 -- 2010-12Hiromi YanagisawaNational Marfan Foundation/
Fibulin-5 as a regulator of tumor angiogenesis2010-07 -- 2014-06Rolf BrekkenAmerican Cancer Society/Research Grant
Fibulin-5 modulates integrin-mediated signaling and alters microenvironment of the vascular wall.2008-07 -- 2010-06Hiromi YanagisawaAmerican Heart Association/Grant-in-Aid
Genetic dissection of Hand genes during neural crest development in vivo.2006-06 -- 2010-06Hiromi YanagisawaMarch of Dimes Birth Defects Foundation/Research Grant
Career history
2015-09 -- (current)University of Tsukuba TARA Center Professor
2014-09 -- 2015-08University of Tsukuba TARA Center Professor
1998-01 -- 2015-08University of Texas Southwestern Medical Center Department of Molecular Biology インストラクター 助教授 准教授(テニュア)
1991-10 -- 1997-12University of Texas Southwestern Medical Center Department of Biochemistry ポスドク研究員
1986-06 -- 1988-03University of Tsukuba Hospital Internal Medicine レジデント
Academic background
1980 -- 1986University of Tsukuba School of MedicineGraduated
1993Ph.D.University of Tsukuba
Licenses and qualifications
Academic societies
2019 -- (current)The Molecular Biology Society of Japan
2019 -- (current)The Japanese Biochemical Society
2016 -- (current)老化促進モデルマウス(SAM)学会
2016 -- (current)日本循環器学会
2015 -- (current)日本心血管内分泌代謝学会
2015 -- (current)日本血管生物医学会
2015 -- (current)Jananese Society for Matirx Biology and Medicine
2015 -- (current)Japan Elastin Meeting
2004 -- (current)North American Vascular Biology Organization
Honors & Awards
2016Mizutani Foundation for Glycoscience
2012Established Investigator Award (AHA)
2008Junior Investigator Award (ASMB)
Conference, etc.
  • Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP signaling pathway in the remodeling of blood vessels
    Yamashiro Yoshito; Thang Bui Quoc; Ramirez Karina; Shin S...
    Gordon Research Conference, Fibronectin, Integrins and Related Molecules/2019-05-05--2019-05-10
  • Role of thrombospondin-1 in mechanotransduction and development of thoracic aortic aneurysm
    Yamashiro Yoshito; Quoc Thang Bui; Shin Seung Jae; Lino C...
    Phosphatase Workshop/2018-10-23--2018-10-25
  • Role of thrombospondin-1 in mechanotransduction and development of thoracic aortic aneurysm
    Yamashiro Yoshito; Yanagisawa Hiromi
    GenTAC Aortic Disease Summit/2018-10-06--2018-10-07
  • Comprehensive analysis of gene expression profiles between aneurysmal and non-aneurysmal aortic wall in Marfan patients.
    Thang Bui Quoc; 山城義人; Chiho Tokunaga; Hiroaki Sakamot...
  • Role of PAR1-Egr1 in the initiation of thoracic aortic aneurysm
    Shin Seung Jae; Yamashiro Yoshito; Yanagisawa Hiromi
    2nd JCS Council on basic cardiovascular research/2018-09-22--2018-09-23
  • The integrity of extracellular matrix affects transduction of mechanical stress in the aortic wall.
    Quoc Thang Bui; Yamashiro Yoshito; Shin Seung Jae; Sakamo...
    The 2nd JCS council on basic cardiovascular research/2018-09-22--2018-09-23
  • Molecular mechanism of aortic wall remodeling associated with ascending thoracic aortic aneurysm –Comparison to abdominal aortic aneurysm.
    Thang Quoc Bui; 山城義人; Chiho Tokunaga; Hiroaki Sakamot...
    The 70th Annual Scientific Meeting of the Japanese Association for Thoracic Surgery/2017-09-26--2017-09-30
  • Label-free Raman imaging of elastic fibers in diseased and healthy mouse aortic tissues
    杉山夏緒里; Brauchle Eva; Yanagisawa Hiromi; Schenke-Layl...
    Joint meeting of the German and Swiss Soceity for Matrix Biology/2018-03-22--2018-03-24
  • Label-free Raman imaging of elastic fibers in disease and healthy mouse aortic tissues
    杉山夏緒里; Julia Marzi; Eva Brauchle; 山城義人; Katja Sc...
    Raman Fest 2018/2018-06-25--2018-06-25
  • Inhibition of Thrombosponding-1 protects against ascending aortic aneurysm in fibulin-4 mutant mice
    Yanagisawa Hiromi; Shin Seung Jae; Bui Quoc Thang; Yamash...
    The 1st JCS Council on Basic CardioVascular Research/2018-01-06--2018-01-07
  • ラベルフリー・ラマンイメージング法による大動脈疾患モデルマウスの弾性線維と膠原線維の解析
    杉山夏緒里; Julia Marzi; Eva Brauchle; 山城義人; Katja Sc...
  • Label-free Raman imaging for non-invasive diagnostic tools of thoracic aortic aneurysm
    Sugiyama Kaori; Marzi Julia; Brauchle Eva; Ando Masahiro;...
    Gordon Research Conference on Elastin, Elastic fibers, and Microfibrils/2019-07-21--2019-07-26
  • Contribution of matrix mechanotransduction in vascular remodeling
    Yanagisawa Hiromi
    Gordon Research Conference/2019-07-21--2019-07-26
  • Dual role of thrombospondin-1 in aortic remodeling and disease
    Yanagisawa Hiromi
    FASEB Science Research Conference/2019-07-14--2019-07-19
  • Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis
    Changarathil G; Ramirez K; Isoda H; Yanagisawa H; Sada A
    Gordon Research Conference, Epithelial Differentiation and Keratinization/2019-07-07--2019-07-12
  • 家族性大動脈弁上狭窄症における新規エラスチン遺伝子変異の同定と解析
    杉山 夏緒里; 堀米 仁志; 村上 卓; 林 立申; 野崎 良寛; 塩野...
  • Maintenance of heterogeneous epidermal stem cell populations by the distinct niche
    Oinam L; Changarathil G; Tsunezumi J; Yanagisawa H; Sada A
    Gordon Research Conference, Epithelial Differentiation and Keratinization/2019-07-07--2019-07-12
  • Short fibulins in development and disease
    Yanagisawa Hiromi
    Japanese Society of Podocyte Biology/2019-03-16--2019-03-16
  • Maintenance of heterogeneous epidermal stem cell populations by the distinct niche
    Oinam L; Changarathil G; Tsunezumi J; Yanagisawa H; Sada A
    The 17th Stem Cell Research Symposium/2019-05-24--2019-05-25
  • Differential surface protein modifications during epidermal stem cell aging
    Oinam L; Changarathil G; Kawazoe K; Tateno H; Sada A; Yan...
    The 19th International Joint Mini-Symposium on Molecular and Cell Biology/2019-05-03--2019-05-04
  • Roles of Mechanotransduction and Thrombospondin-1 in Development of Thoracic Aortic Aneursysm
    Yanagisawa Hiromi
    Japanese Circulation Society/2019-03-29--2019-03-31
  • メカニカルストレス応答破綻による大動脈瘤形成とトロンボスポンディンの役割
    柳沢 裕美
  • Role of Short Fibulas in Maintenance of Vessel Walls
    Yanagisawa Hiromi
    American Society for Matrix Biology/2018-10-13--2018-10-17
  • 腎・血管における短鎖Fibulins の役割
    柳沢 裕美
    Annual Meeting of the Japanese Biochemical Society/2018-09-25--2018-09-26
  • 動脈弾性板ー平滑筋細胞連結による大動脈壁の維持機構
    山城義人; Bui Quoc Thang; 柳沢 裕美
2020-04 -- 2020-05Serendipity in Human BiologyHBP
2019 -- (current)Cellular BiologyMedical Science
2018 -- (current)Human BiologyBiology
2018 -- (current)Recent topics of life science technology, oncology, and stem cell biology in basic medical sciencesSchool of Medicine
2018 -- (current)Cellular BiologySchool of Medicine
2018 -- (current)G30 BiochemistryUniversity of Tsukuba
2016-10 -- (current)Topics in Vascular BiologyUniversity of Tsukuba.
2017-05 -- (current)Stem Cell TherapyHBP
2017-04 -- 2017-05Serendipity in Human BiologyHBP
2016-10 -- (current)Seminar in Human Medical Biology IIUniversity of Tsukuba.
Other educational activities
2020-03 -- 2020-03女性研究者・職員向け研修「次世代型インクルーシブ・リーダーの育成」ダイバーシティ研究環境イニシアティブ
2019-10 -- 2019-10Tsukuba Scientific English Conference 2019Tsukuba Global Science Week
2018-09 -- 2018-09TGSW 2018 Beyond the borderつくばグローバルサイエンスウィーク
2018-06 -- 2018-06上位層育成プログラム「多様な人材の評価」オープンセッションダイバーシティ研究環境実現イニシアティブ
2017-12 -- 2017-12ダイバーシティリーダー育成講座 III, TIDE シンポジウムダイバーシティ研究環境実現イニシアティブ
2017-11 -- 2017-11ダイバーシティリーダー育成講座 II 「女性研究者・技術者がリーダーシップを発揮する活動テーマとチームを組織横断で生み出そう!」ダイバーシティー研究環境実現イニシアティブ
2017-03 -- 2017-03アンコンシャス・バイアスのインパクトとマネジメント ラウンドテーブル ディスカッションダイバーシティ・アクセシビリティー・キャリアセンター
2017-07 -- 2017-07ダイバーシティーリーダー育成講座 I 「女性のネットワーキング・組織化と活用ーCOSMOSの歴史から学ぶー」ダイバーシティー研究環境実現イニシアティブ
2017-01 -- 2017-01プレセッション 「イノベーション創出へ、女性研究者・技術者の潮流を起こす」ダイバーシティー研究環境実現イニシアティブ
2016-09 -- 2016-09「女性トップ研究者と語る夕べ」セッションTsukuba Global Science Week
Professional activities
2020-07 -- 2022-06North American Vascular Biology OrganizationNAVBO Diversity committee
2019 -- 2022日本血管生物医学会評議員
2016 -- 2018American Society for Matrix BiologyBiennial Meeting of ASMB Program committee member
2018 -- (current)GenTAC Alliance Basic/Translational Science Working Groupmember
2018 -- 2018エラスチン関連分子研究会第3回学術集会会頭
2017 -- (current)Jananese Society for Matirx Biology and Medicine評議員
2016 -- (current)エラスチン関連分子研究会幹事
2013 -- 2016American Society for Matrix BiologyCouncil member
University Management
2020 -- (current)学長補佐室室員
2019 -- (current)ヒューマニクス学位プログラム 広報委員会委員、広報委員長(2020-)
2019 -- (current)TARA センターセンター長特別補佐
2018 -- (current)Humanics Graduate ProgramFaculty Mentor
2018 -- (current)HBP運営委員会委員
2017 -- (current)HBP教務委員会委員, 教務委員長(2019-)
2017 -- (current)医学医療系生命医科学域運営委員会委員
2016 -- 2018筑波大学研究戦略室室員
2015 -- (current)TARAセンター運営委員会委員
2015 -- (current)生命システム医学大学院運営委員会委員

(Last updated: 2020-07-08)