Hagiwara Daisuke

Affiliation

Faculty of Life and Environmental Sciences

Official title

Associate Professor

Research fields

Applied microbiology

Bacteriology (including mycology)

Research keywords

微生物相互作用、糸状菌二次代謝、環境応答、シグナル伝達、病原性、薬剤耐性、トランスクリプトーム、マイコウイルス

Research projects

前例の無い大規模探索によるマイコウイルス学の創生と糸状菌育種への挑戦

2021 -- 2024

萩原 大祐

Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Research (Pioneering)

26,000,000Yen

Degree

2006-03

Ph.D.(Agriculture)

Nagoya University

Academic societies

2020 -- (current)	Pesticide Science Society of Japan
2019 -- (current)	JAPANESE SOCIETY OF SOIL MICROBIOLOGY
2001 -- (current)	JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY
2011 -- (current)	THE JAPANESE SOCIETY FOR MEDICAL MYCOLOGY
2006 -- 2020	Society of Genome Microbiolgy, Japan
2005 -- (current)	Fungal Molecular Biology Society of Japan

Honors & Awards

2019-10	日本医真菌学会奨励賞
2012	糸状菌遺伝子研究会奨励賞

Refereed academic journal/Refereed international conference paper

• Interspecies Genomic Variation and Transcriptional Activeness of Secondary Metabolism-Related Genes in Aspergillus Section Fumigati
  Takahashi Hiroki; Umemura Maiko; Ninomiya Akihiro; Kusuya...
  Frontiers in Fungal Biology, 2021-04
• Phenotypic and Molecular Biological Analysis of Polymycovirus AfuPmV-1M From : Reduced Fungal Virulence in a Mouse Infection Model
  Takahashi-Nakaguchi Azusa; Shishido Erika; Yahara Misa; U...
  Frontiers in microbiology/11, 2020-04
  PubMed
• Discovery of divided RdRp sequences and a hitherto unknown genomic complexity in fungal viruses
  Chiba Yuto; Oiki Sayoko; Yaguchi Takashi; Urayama Syun-Ic...
  Virus evolution/7(1), 2021-01
  PubMed
• Chemical genetic approach using beta-rubromycin reveals that a RIO kinase-like protein is involved in morphological development in Phytophthora infestans
  Tani Shuji; Nishio Naotaka; Kai Kenji; Hagiwara Daisuke; ...
  SCIENTIFIC REPORTS/10(1), 2020-12
  PubMed
• Diverged and Active Partitiviruses in Lichen
  Urayama Syun-ichi; Doi Nobutaka; Kondo Fumie; Chiba Yuto;...
  FRONTIERS IN MICROBIOLOGY/11, 2020-10
  PubMed
• Fungal mycelia and bacterial thiamine establish a mutualistic growth mechanism
  Gayan Abeysinghe; Kuchira Momoka; Masuo Shunsuke; Takahas...
  LIFE SCIENCE ALLIANCE/3(12), 2020-09
  PubMed
• Genome Mining-Based Discovery of Fungal Macrolides Modified by glycosylphosphatidylinositol (GPI)-Ethanolamine Phosphate Transferase Homologues
  Morishita Yohei; Aoki Yu; Ito Mei; Hagiwara Daisuke; Tori...
  Organic letters/22(15)/pp.5876-5879, 2020-08
  PubMed
• Mycovirus-Induced Tenuazonic Acid Production in a Rice Blast FungusMagnaporthe oryzae
  Ninomiya Akihiro; Urayama; Suo Rei; Itoi Shiro; Fuji Shin...
  FRONTIERS IN MICROBIOLOGY/11, 2020-07
  PubMed Tsukuba Repository
• A method for the preparation of electrocompetent cells to transform unicellular green algae, Coccomyxa (Trebouxiophyceae, Chlorophyta) strains Obi and KJ
  Tatara Hiroshi; Sato Yusuke; Kasai Yuki; Hagiwara Daisuke...
  ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS/48, 2020-06
• Viral RNA Genomes Identified from Marine Macroalgae and a Diatom
  Chiba Yuto; Tomaru Yuji; Shimabukuro Hiromori; Kimura Kei...
  Microbes and Environments/35(3), 2020-05
  CiNii PubMed
• Isolation of azole-resistant Aspergillus fumigatus from imported plant bulbs in Japan and the effect of fungicide treatment
  Hagiwara Daisuke
  Journal of Pesticide Science/45(3-4)/pp.147-150, 2020-05
  CiNii PubMed
• dsRNA-seq Reveals Novel RNA Virus and Virus-Like Putative Complete Genome Sequences from Hymeniacidon sp. Sponge
  Urayama Syun-Ichi; Takaki Yoshihiro; Hagiwara Daisuke; Nu...
  Microbes and environments/35(2), 2020-04
  CiNii PubMed
• Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and -Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus
  Chihara Yuria; Tanaka Yutaka; Izumi Minoru; Hagiwara Dais...
  mSphere/5(1), 2020-04
  PubMed
• The Cell Wall Integrity Pathway Contributes to the Early Stages of Asexual Development
  Rocha Marina Campos; Fabri João Henrique Tadini Marilhano...
  Applied and environmental microbiology/86(7), 2020-03
  PubMed
• Nutritional Heterogeneity Among Strains Has Consequences for Virulence in a Strain- and Host-Dependent Manner
  Ries Laure Nicolas Annick; Steenwyk Jacob L; de Castro Pa...
  Frontiers in microbiology/10/p.854, 2019-04
  PubMed
• A Novel Antifungal Compound Z-705 Specifically Inhibits Protein Kinase C of Filamentous Fungi
  Sugahara Asumi; Yoshimi Akira; Shoji Fumio; Fujioka Tomon...
  Applied and environmental microbiology/85(10), 2019-03
  PubMed
• AtrR Is an Essential Determinant of Azole Resistance in Aspergillus fumigatus
  Paul Sanjoy; Stamnes Mark; Thomas Grace Heredge; Liu Hong...
  mBio/10(2), 2019-03
  PubMed Tsukuba Repository
• Heterogeneity in Pathogenicity-related Properties and Stress Tolerance in Aspergillus fumigatus Clinical Isolates
  Hagiwara Daisuke; Takahashi Hiroki; Takagi Hiroshi; Watan...
  Medical Mycology Journal/59(4)/pp.E63-E70, 2018-04
  CiNii PubMed
• Current Status of Azole-resistant Aspergillus fumigatus Isolates in East Asia:China, Japan, Korea, and Taiwan
  Hagiwara Daisuke
  Medical Mycology Journal/59(4)/pp.E71-E76, 2018-04
  CiNii PubMed
• Protein Kinase A and High-Osmolarity Glycerol Response Pathways Cooperatively Control Cell Wall Carbohydrate Mobilization in
  de Assis Leandro José; Manfiolli Adriana; Mattos Eliciane...
  mBio/9(6), 2018-11
  PubMed Tsukuba Repository
• Emerging Antifungal Drug Resistance in Aspergillus fumigatus and Among Other Species of Aspergillus
  Toyotome Takahito; Hagiwara Daisuke; Takahashi Hiroki; Wa...
  CURRENT FUNGAL INFECTION REPORTS/12(3)/pp.105-111, 2018-09
• Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase
  Hagiwara Daisuke; Arai Teppei; Takahashi Hiroki; Kusuya Y...
  EMERGING INFECTIOUS DISEASES/24(10)/pp.1889-1897, 2018-10
• Epidemiological and Genomic Landscape of Azole Resistance Mechanisms in Aspergillus Fungi
  Hagiwara Daisuke; A Watanabe; K Kamei; GH Goldman
  Front Microbiol, 2016-09
  PubMed
• Comparative transcriptome analysis revealing dormant conidia and germination associated genes in Aspergillus species: an essential role for AtfA in conidial dormancy
  Hagiwara Daisuke; H Takahashi; Y Kusuya; S Kawamoto; K Ka...
  BMC Genomics, 2016-05
  PubMed
• Genome-wide transcriptome analysis of Aspergillus fumigatus exposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakA(HOG1) and MpkC dependent
  L Pereira Silva; P Alves de Castro; TF Dos Reis; MH Pazia...
  Cell Microbiol, 2017-04
  PubMed

more...

Other articles

• S3-5 Exploring fungal potential to produce novel compounds toward drug discovery
  萩原 大祐
  Program and Abstracts of Annual Meeting of the Japanese Society for Medical Mycology/60/p.64, 2019
  CiNii

Books

• Moonshot R&D MILLENNIA Program “Research on Post-Antropocentric Values, Behavioural Styles, Science and Technology” Initiative Report
  秋山 肇; 浦山 俊一; 和田 絢太郎; 山口 大空翔; 大村 美桜; ...
  Japan Science and Technology Agency, 2021-07
• Aspergillus: Molecular Biology and Genomics
  Daisuke Hagiwara
  Caister Academic Press, 2010-01
• Stress Biology of Yeasts and Fungi: Applications for Industrial Brewing and Fermentation
  Daisuke Hagiwara
  Springer, 2015-02

Conference, etc.

• 糸状菌を用いたRNAウイルス多様性の再検証
  千葉悠斗; 浦山 俊一; 矢口貴志; 萩原大祐
  日本微生物生態学会　第33回大会/2019-09-10--2019-09-13
• 糸状菌における細胞外膜小胞産生能の探索
  岩橋由佳; 浦山俊一; 桝尾俊介; 兼松周作; 高谷直樹; 野村暢...
  日本農芸化学会関東支部2020年度大会/2020-11--2020-11
• 糸状菌が産生する細胞外膜小胞の特性
  岩橋由佳; 浦山俊一; 桝尾俊介; 兼松周作; 高谷直樹; 野村暢...
  第8回糸状菌若手の会WS/2020-11--2020-11
• 輸入植物球根から分離されたヒト病原真菌における農薬耐性進化の可能性
  萩原 大祐; 老木紗予子; 楠屋陽子; 高橋弘喜
  日本農薬学会第46回大会/2021-03-08--2021-03-10
• 相互作用を利用した糸状菌の二次代謝研究
  萩原 大祐
  日本農芸化学会2021年度大会/2021-03-18--2021-03-21
• 非滅菌もみ殻に接種したTrichoderma reesei の動態とバイオマス分解に及ぼす影響
  岩波明季; 浦山 俊一; 萩原大祐
  糸状菌分子生物学研究会若手の会　第8回WS＠web/2020-11-13--2020-11-13
• The effect of Trichoderma reesei on microbial community and degradation of rice husk
  Iwanami Aki; Urayama Shunichi; Hagiwara Daisuke
  International Union of Microbiological Societies 2020 Congress/2020-10-12--2020-10-16
• The influence of Trichoderma reesei on the microbial community and degradation of rice husk
  Iwanami Aki; Urayama Shunichi; Hagiwara Daisuke
  Tsukuba Global Science Week(TGSW)2020/2020-12-02--2020-12-12
• Pigment production in Aspergillus niger triggered by a fungal-fungal co-culture
  Tsuji Haruka; Ninomiya Akihiro; Kai Kenji; Urayama Shunic...
  International Union of Microbiological Societies 2020 Congress/2020-10-12--2020-10-16
• 糸状菌Aspergillus nigerにおける共培養誘導型の黄色色素生産とその生合成遺伝子の決定
  辻晴佳; 二宮章洋; 甲斐建次; 竹下典男; 浦山 俊一; 萩原大祐
  日本農芸化学大会2021年度仙台大会/2021-03-18--2021-03-21
• 共培養により誘導されるAspergillus nigerの色素生産と生合成遺伝子の解析
  辻 晴佳; 二宮 章洋; 甲斐 建次; 浦山 俊一; 萩原 大祐
  日本農芸化学会関東支部2020年度大会/2020-11-28--2020-11-28
• 共培養により誘導されるAspergillus nigerの色素生産と生合成遺伝子の解析
  辻晴佳; 二宮章洋; 甲斐建次; 浦山 俊一; 萩原大祐
  糸状菌分子生物学研究会若手の会　第8回WS＠web/2020-11-13--2020-11-13
• 糸状菌Aspergillus nidulansとAspergillus fumigatusの共培養が抗生物質産生を促進する機構の解析
  二宮 章洋; 浦山 俊一; 萩原 大祐
  日本農芸化学会関東支部2020年度大会/2020-11-28--2020-11-28
• 菌類ウイルスがイネいもち病菌の二次代謝に与える影響の解析
  二宮章洋; 浦山 俊一; 周防 玲; 藤 晋一; 森山 裕充; 萩原 大祐
  日本農芸化学大会2021年度仙台大会/2021-03-18--2021-03-21
• 天然由来抗菌物質によるPenicillium属菌二次代謝の覚醒とその解析
  波形 匠; 老木 紗予子; 二宮 章洋; 矢口 貴志; 浦山 俊一; 萩...
  日本農芸化学大会2021年度仙台大会/2021-03-18--2021-03-21
• 植物由来精油成分に対するAspergillus fumigatusの応答機構
  老木紗予子; 二宮章洋; 浦山 俊一; 萩原大祐
  糸状菌分子生物学研究会若手の会　第8回WS＠web/2020-11-13--2020-11-13
• ピロールニトリンに対するPenicillium属糸状菌の獲得耐性
  老木紗予子; 矢口貴志; 萩原大祐
  日本農薬学会第46回大会/2021-03-08--2021-03-10
• 植物由来精油成分ファルネソールに対する 糸状菌Aspergillus fumigatusの応答機構
  老木紗予子; 二宮章洋1; 浦山 俊一; 萩原大祐
  日本農芸化学大会2021年度仙台大会/2021-03-18--2021-03-23
• 白癬菌が産生する抗菌活性物質とその生合成遺伝子の同定
  増田圭恭; 二宮章洋; 上野圭吾; 柳原尚; 清水公徳; 矢口貴志;...
  糸状菌分子生物学研究会若手の会　第8回WS＠web/2020-11-13--2020-11-13
• 白癬菌が産生する抗菌活性物質とその生合成遺伝子の同定
  増田圭恭; 二宮章洋; 上野圭吾; 柳原尚; 清水公徳; 矢口貴志;...
  日本農芸化学大会2021年度仙台大会/2021-03-18--2021-03-23
• Penicillium chrysogenum の細胞外膜小胞画分における抗菌活性の検討
  三上力輝; 岩橋由佳; 二宮章洋; 古屋俊樹; 浦山俊一; 萩原大祐
  日本農芸化学大会2021年度仙台大会/2021-03-18--2021-03-23
• Study on Aspergillus nidulans in soil culture and interaction between fungi and soil microbiome
  Takata Marina; Kawauchi Moriyuki; Ohnishi Yasuo; Senoo Ke...
  Tsukuba Global Science Week(TGSW)2020/2020-12-02--2020-12-12
• Evaluation of the ecological role of Aspergillus nidulans in a soil culture system
  Takata Marina; Kawauchi Moriyuki; Ohnishi Yasuo; Senoo Ke...
  International Union of Microbiological Societies 2020 Congress/2020-10-12--2020-10-16
• 土壌培養におけるモデル糸状菌Aspergillus nidulansと土壌微生物叢との相互作用の解析
  高田万里奈; 河内護之; 大西康夫; 妹尾啓史; 清水公徳; 浦山...
  糸状菌分子生物学研究会若手の会　第8回WS＠web/2020-11-13--2020-11-13
• 土壌環境における糸状菌Aspergillus nidulansの二次代謝の生態的な役割の解析
  高田万里奈; 河内護之; 大西康夫; 妹尾啓史; 清水公徳; 浦山 ...
  日本農芸化学大会2021年度仙台大会/2021-03-18--2021-03-21

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Teaching

2021-10 -- 2022-02	Fungal Interaction and Molecular Biology I	University of Tsukuba.
2021-04 -- 2021-08	Fungal Interaction and Molecular Biology I	University of Tsukuba.
2021-10 -- 2022-02	Research in Fungal Molecular Microbiology II	University of Tsukuba.
2021-04 -- 2021-08	Research in Fungal Molecular Microbiology II	University of Tsukuba.
2021-10 -- 2022-02	Seminar in Fungal Molecular Microbiology II	University of Tsukuba.
2021-04 -- 2021-08	Seminar in Fungal Molecular Microbiology II	University of Tsukuba.
2021-12 -- 2022-02	Fundamental Biology Laboratory	University of Tsukuba.
2021-10 -- 2022-02	Fungal Interaction and Molecular Biology III	University of Tsukuba.
2021-04 -- 2021-08	Fungal Interaction and Molecular Biology III	University of Tsukuba.
2021-10 -- 2022-02	Fungal Interaction and Molecular Biology II	University of Tsukuba.

more...

Professional activities

2021 -- (current)	Pesticide Science Society of Japan	編集委員
2020 -- (current)	THE JAPANESE SOCIETY FOR MEDICAL MYCOLOGY	代議員
2020 -- (current)	Frontiers in Fungal Biology	Associate Editor
2019 -- 2020	Frontiers in Microbiology	Associate Editor
2018 -- (current)	PLoS One	Academic Editor
2012 -- 2018	糸状菌分子生物学研究会若手の会	運営委員（会計）

(Last updated: 2021-08-16)