TSURUTA Fuminori
- Affiliation
- Institute of Life and Environmental Sciences
- Official title
- Assistant Professor
- Research fields
Neurophysiology / General neuroscience Molecular biology - Research keywords
synapse microglia astrocyte developmental disorder neuroinflammation - Research projects
微⼩核伝播を介した髄膜マクロファージの制御 2024-11 -- 2025-11 鶴田文憲 住友財団 /基礎科学研究助成 3,000,000Yen Alteration of microglial characteristics regulated by micronuclear propagation and its impacts on aged cerebral blood vessels. 2024-10 -- 2028-03 Fuminori Tsuruta The Japan Agency for Medical Research and Development (AMED)/-Bridging the fundamental mechanism of aging and the effective treatment of age-related disease associated with impaired functional system- 52,000,000Yen 二光子励起顕微鏡を用いた脳内微小核のin vivo imaging 2024-04 -- 2025-03 鶴田文憲 大学共同利用機関法人自然科学研究機構/計画共同研究(動物資源共同利用研究センター) 290,000Yen フレイル予防を目的とした加齢性神経炎症を抑制するペプチドの開発 2024-04 -- 2025-03 鶴田文憲 筑波大学/2024年度 系横断R&Dプロジェクト 1,500,000Yen プリン代謝によるミクログリア分化成熟の制御メカニズム 2024-01 -- 2024-12 鶴田文憲 公益財団法人 痛風・尿酸財団/ 400,000Yen Disruption of the neurovascular unit and the effect on developmental disorders 2022-11 -- 2023-03 Fuminori Tsuruta 筑波大学/幸多き⼈⽣100 年時代を創る「知」活⽤プログラム 500,000Yen 微小核伝搬を介した脳微小血管老化の新規メカニズム 2022-11 -- 2022-12 Fuminori Tsuruta 花王健康科学研究会/花王健康科学研究助成 1,000,000Yen HPRT1による性差特異的なミクログリア成熟の制御 2022-01 -- 2022-12 鶴田文憲 公益財団法人 痛風・尿酸財団/ 600,000Yen 細胞外微小核によるミクログリア活性制御と創薬への応用 2021-09 -- 2022-03 鶴田文憲 筑波大学/令和3年度シーディングプログラム 5,000,000Yen プリンヌクレオチド代謝による発達過程ミクログリアの形質制御 - HPRT1 変異はなぜレッシュナイハン症候群になるか? - 2021-01 -- 2021-12 鶴田文憲 公益財団法人 痛風・尿酸財団/ 700,000Yen more... - Career history
2019-02 -- 2019-03 Stanford University School of MedicineDepartment of Psychiatry and Behavioral SciencesVisiting assistant professor 2018-04 -- 2018-11 Duke University School of MedicineDepartment of Cell BiologyVisiting assistant professor 2009-10 -- (current) University of Tsukuba生命環境系助教 2004-09 -- 2009-08 Stanford University School of MedicineDepartment of NeurobiologyPostdoctral fellow 2003-04 -- 2004-08 東京大学分子細胞生物学研究所博士研究員 1998-04 -- 1999-12 Mochida pharmaceutical Co., LTD.総合研究所研究員 - Academic background
1992-04 -- 1996-03 Tokyo Metropolitan University Faculty of Science 化学科 1996-04 -- 1998-03 Tokyo Metropolitan University Graduate School, Division of Natural Science 化学専攻 2000-04 -- 2003-03 The University of Tokyo Graduate School, Division of Engineering 化学生命工学専攻 - Degree
2003-03 博士(工学) The University of Tokyo - Academic societies
2023-02 -- (current) THE JAPANESE SOCIETY FOR NEUROCHEMISTRY 2012-09 -- (current) THE JAPAN NEUROSCIENCE SOCIETY 2017-05 -- (current) Society for Neuroscience 2010-10 -- (current) 日本分子生物学会 - Articles
- RBM3 enhances cold resistance by regulating thermogenic gene expressions
NAKAMURA Junnosuke; UNO Megumi; TAKETOMI Takumi; YADAV...
bioRxiv, 2024-08 - Molecular basis of neuronal and microglial states in the aging brain and impact on cerebral blood vessels
MAEDA Chihiro; TSURUTA Fuminori
Int J Mol Sci, 2024-04 - Molecular Basis of Neuronal and Microglial States in the Aging Brain and Impact on Cerebral Blood Vessels
Maeda Chihiro; Tsuruta Fuminori
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES/25(8), 2024-03 - USP4 regulates TUT1 ubiquitination status in concert with SART3
Jaehyun Kim; Takumi Taketomi; Atsuma Yamada; Yukino U...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/701, 2024-01 - Towards an Understanding of Microglia and Border-Associated Macrophages
Taketomi Takumi; Tsuruta Fuminori
BIOLOGY-BASEL/12(8), 2023-08 - Cold shock protein RBM3 is upregulated in the autophagy-deficient brain
Nakamura Junnosuke; Aihara Takuma; Chiba Tomoki; Tsuru...
MicroPubl Biol., 2022-12 - Propagation of neuronal micronuclei regulates microglial states
Yano Sarasa; Asami Natsu; Kishi Yusuke; Kubotani Hika...
bioRxiv, 2023-8 - RBM3 deficiency impairs body temperature control in response to cold stimulation
Nakamura Junnosuke; Taketomi Takumi; Tsuruta Fuminori
bioRxiv, 2023-5 - Towards an understanding of microglia and non-parenchymal macrophages
Taketomi Takumi; Tsuruta Fuminori
Biology (Basel) /12(1091), 2023-08 - ミクログリアの発生・分化・多様性獲得のメカニズム
浅見奈都; 照屋林一郎; 鶴田文憲
BIO Clinica, 2023-03 - Proteasome-Associated Proteins, PA200 and ECPAS, Are Essential for Murine Spermatogenesis
Ban Sato; Jiwoo Kim; Kazunori Morohoshi; Woojin Kang; ...
BIOMOLECULES/13(4)/p.586, 2023-03-24 - Regulation of microglial diversity during brain development
照屋林一郎; 鶴田 文憲
Medical Science Digest/46(11)/pp.39-41, 2022-12 - Mutations in Hevin/Sparcl1 and risk of autism spectrum disorder
Taketomi Takumi; Tsuruta Fuminori
NEURAL REGENERATION RESEARCH/18(7)/pp.1499-1500, 2023-07 - Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability
Tsuruta Fuminori; Taketomi Takumi
Scientific Reports/p.11891, 2022-07 - Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability
Takumi Taketomi; Yasuda Takunori; Morita Rikuri; Kim ...
bioRxiv/12(1), 2022-04-13 - A MATLAB-based program for three-dimensional quantitative analysis of micronuclei reveals that neuroinflammation induces micronuclei formation in the brain
Yano Sarasa; Akiyama Kaito; Tsuchiya Rio; Kubotani Hikar...
SCIENTIFIC REPORTS/11(1), 2021-09 - Exploring genes that control microglial heterogeneity and transition.
Tsuruta Fuminori; Okajima Tomomi
Neural Regen Res./16(12)/pp.2397-2398, 2021-04 - Prevention of necrosis caused by transient expression in Nicotiana benthamiana by application of ascorbic acid
Nosaki Shohei; Kaneko Mika K; Tsuruta Fuminori; Yoshid...
Plant physiology/186(2)/pp.832-835, 2021-02 - USP15 deubiquitinates TUT1 associated with RNA metabolism and maintains cerebellar homeostasis
Kim Jaehyun; Nakamura Junnosuke; Hamada Chiharu; Taketomi...
Mol Cell Biol/40(21)/pp.e00098-20, 2020-10 - Atypical cadherin FAT3 is a novel mediator for morphological changes of microglia
Okajima Tomomi; Gu Yichen; Teruya Rin-Ichiro; Yano Sa...
eNeuro/7(6), 2020-08 - Microglial dynamics during brain development
Okajima Tomomi; Tsuruta Fuminori
NEURAL REGENERATION RESEARCH/13(2)/pp.222-223, 2018-02 - KLHL7 promotes TUT1 ubiquitination associated with nucleolar integrity: Implications for retinitis pigmentosa
Kim Jaehyun; Tsuruta Fuminori; Okajima Tomomi; Yano S...
Biochemical and biophysical research communications/494(1-2)/pp.220-226, 2017-12 - Quantification of Endosome and Lysosome Motilities in Cultured Neurons Using Fluorescent Probes
Tsuruta Fuminori; Okajima Tomomi; Yano Sarasa; Chiba ...
Journal of visualized experiments : JoVE/(123), 2017-05 - CACUL-1/CAC1 attenuates p53 activity through PML post-translational modification
Fukuda Tomomi; Kigoshi-Tansho Yu; Naganuma Takao; Kazaand...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/482(4)/pp.863-869, 2017-01 - USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression
Fukagai Kousuke; Waku Tsuyoshi; Chowdhury A. M. Masudu...
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS/478(1)/pp.363-370, 2016-09 - more...
- RBM3 enhances cold resistance by regulating thermogenic gene expressions
- Books
- USP15
鶴田文憲; 金材炫; 千葉智樹
脳内環境辞典/メディカル ドゥ/pp.142-143, 2017-3
- USP15
- Conference, etc.
- Autism-associated Hevin/Sparcl1 mutants are secreted as dimers and induce inflammatory responses
武富 巧; 鶴田 文憲
TARAセミナー・生理研研究会/2024-10-29--2024-10-30 - A novel mechanism for altering microglial properties mediated by purine metabolisms
照屋林一郎; 上田健太郎; 森田陸離; 保田拓範; 原田隆平; 鶴田 文憲
TARAセミナー・生理研研究会/2024-10-29--2024-10-30 - Autism-associated Sparcl1/Hevin mutant has impacts on persistent angiogenesis
TAKETOMI Takumi; YASUDA Takunori; UEDA Kentaro; MORITA...
Society for Neuroscience 2024/2024-10-5--2024-10-9 - Effects of social stress on CSF penetration into periventricular regions
Konno Hana; TSURUTA Fuminori
TGSW2024/2024-09-30--2024-10-04 - Soluble Trem2 regulates microglial characteristics
YAMADA Atsuma; TSURUTA Fuminori
TGSW2024/2024-09-30--2024-10-04 - New insight into the microglial brain infiltration through vessel
KIKUKAWA Hirone; TSURUTA Fuminori
TGSW2024/2024-09-30--2024-10-04 - Effects of nuclear structural abnormalities and micronuclear propagation on neurovascular aging
MAEDA Chihiro; TSURUTA Fuminori
TGSW2024/2024-09-30--2024-10-04 - 非定型カドヘリンFat3は新生仔期のミクログリアの形態を制御する
上田健太郎; 照屋林一郎; (岡島)智美 高橋; 鶴田文憲
Neuro2024/2024-07-24--2024-07-27 - 老化因子が脳血管周囲のミクログリアに与える影響
鶴田文憲; 山下直輝
Neuro2024/2024-07-24--2024-07-27 - 脳室周辺のグリア細胞による体温維持機能の解明
宇野めぐみ; 中村準之助; 鶴田文憲
Neuro2024/2024-07-24--2024-07-27 - 神経血管の老化における核構造異常と微小核伝播の影響
前田ちひろ; 鶴田文憲
Neuro2024/2024-07-24--2024-07-27 - プリン代謝を介した発達過程におけるミクログリア形質制御メカニズム
照屋林一郎; 上田健太郎; 鶴田文憲
Neuro2024/2024-07-24--2024-07-27 - 低温環境下の体温維持におけるRBM3の機能の解析
中村準之助; 宇野めぐみ; 鶴田 文憲
Neuro2024/2024-07-24--2024-07-27 - ASD関連Sparcl1/Hevin変異体は持続的な血管新生を誘導する
TAKETOMI Takumi; TSURUTA Fuminori
Neuro2024/2024-07-24--2024-07-27 - Neuronal micronuclei regulate microglia and macrophages in the brain microenvironment.
TSURUTA Fuminori; YANO Sarasa; MAEDA Chihiro; ASAMI N...
Neuro2024/2024-07-24--2024-07-27 - 神経血管の老化における核構造の異常と微小核伝播の影響
前田ちひろ; 鶴田 文憲
第56回 日本結合組織学会学術大会/2024-06-15--2024-06-16 - cGASによるCNS関連マクロファージ制御と髄膜形成への影響
平木智尋; 鶴田 文憲
第56回 日本結合組織学会学術大会/2024-06-15--2024-06-16 - Sparcl1のASD関連変異による脳血管の形成異常
武富巧; 鶴田 文憲
第56回 日本結合組織学会学術大会/2024-06-15--2024-06-16 - 非定型カドヘリンFat3はプリン代謝と連携してミクログリアを制御する
上田健太郎; 鶴田 文憲
第17回神経発生討論会/2024-03-08--2024-03-09 - ⽼化期の神経細胞の核構造の異常と微⼩核伝播の影響
前田ちひろ; 鶴田 文憲
第17回神経発生討論会/2024-03-08--2024-03-09 - Propagation of neuronal micronuclei regulates microglial states
Tsuruta Fuminori
Research Unit “Peripheral-Central Interaction in Stress” Kickoff Symposium, Exploring Biological Mechanisms of Peripheral-Central Interaction in Stress/2024-03-14 - 非定型カドヘリンFat3はプリン代謝と連携してミクログリアを制御する
上田健太郎; 鶴田 文憲
第17回神経発生討論会/2023-03-08--2023-03-09 - ⽼化期の神経細胞の核構造の異常と微⼩核伝播の影響
前田ちひろ; 鶴田 文憲
第17回神経発生討論会/2023-03-08--2023-03-09 - 非定型カドヘリンFat3はミクログリアの状態を制御する
上田健太郎; 照屋 林⼀郎; 鶴田 文憲
第8回KTTライフサイエンス研究会/2023-11-25 - 老化因子が血管周囲においてミクログリアに与える影響
山下直輝; 鶴田 文憲
第8回KTTライフサイエンス研究会/2023-11-25 - more...
- Autism-associated Hevin/Sparcl1 mutants are secreted as dimers and induce inflammatory responses
- Intellectural property rights
- 細胞死抑制剤及び細胞死抑制方法
三浦 謙治; 鶴田文憲
- 細胞死抑制剤及び細胞死抑制方法
- Teaching
2024-04 -- 2024-08 Special Research in Humanics IIIa University of Tsukuba. 2024-10 -- 2025-02 Special Seminars in Humanics IIIb University of Tsukuba. 2024-10 -- 2025-02 Basic Experiments in Human Biology University of Tsukuba. 2024-04 -- 2024-08 Special Seminars in Human Biology I University of Tsukuba. 2024-10 -- 2025-02 Special Lectures in Humanics IIIb University of Tsukuba. 2024-04 -- 2024-08 Special Lectures in Humanics IIIa University of Tsukuba. 2024-04 -- 2024-08 Special Seminars in Humanics IIIa University of Tsukuba. 2024-10 -- 2025-02 Special Seminars in Human Biology II University of Tsukuba. 2024-10 -- 2025-02 Special Lectures in Human Biology II University of Tsukuba. 2024-10 -- 2025-02 Special Research in Human Biology II University of Tsukuba. more... - Talks
- はたらく”グリア”細胞 -脳内グリアの生理と病態生理-
鶴田 文憲
第171回 バイオeカフェ 筑波大学/2023-11-05 - MatriCellフォーラム
鶴田 文憲
発達脳における細胞連携のメカニズムと細胞外制御因⼦の役割/2022-09-10--2022-09-11
- はたらく”グリア”細胞 -脳内グリアの生理と病態生理-
- University Management
2022-04 -- 2024-03 筑波大学国際交流支援室企画・審査委員会 留学生受入れ小委員会 2022-04 -- 2024-03 筑波大学留学生後援会基金運営委員 2021-04 -- (current) 生命環境学群英語プログラム運営委員 2014-04 -- (current) 生物科学専攻国際化推進担当委員 2012-04 -- (current) 生物科学専攻カリキュラム・FD委員 2014-04 -- (current) 生物学類国際交流員 2021-04 -- (current) HBP運営委員 2013-04 -- (current) HBP教務委員 2013-04 -- (current) HBP広報委員 2012-04 -- (current) HBPサブネットワーク管理委員
(Last updated: 2024-11-03)